CN102258611A - Oral antibacterial liquid made of sophora alopecuroide and preparation method thereof - Google Patents
Oral antibacterial liquid made of sophora alopecuroide and preparation method thereof Download PDFInfo
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Abstract
The invention provides an oral antibacterial liquid made of sophora alopecuroide and a preparation method thereof. The preparation method comprises the following steps of: (1) adding radix angelicae, long pepper, rheum officinale and sculellaria barbata into an extracting tank, adding distilled water to obtain extracting solution by extraction and marking the obtained solution as liquid medicine A; (2) adding ethanol into the sophora alopecuroide for soaking, then carrying out backflowing and extraction in a backflow extractor, obtaining filtrate which is added into the liquid medicine A, then carrying out alcohol precipitation and filtering, adding distilled water for precipitation, filtering the retained filtrate, and marking the obtained solution as liquid medicine B; and (3) utilizing a volatile oil extractor to extract in wild ginger, pepper and cocklebur fruit, obtaining the total volatile oil, marking as volatile oil A, then carrying out filtering, concentration, alcohol precipitation and filtering on the extracted liquid, recovering alcohol, obtaining filtrate, then adding the volatile A and the filtrate into the liquid medicine B to obtain liquid medicine C, dissolving mint ice with alcohol, then adding the dissolved mint ice into the liquid medicine C, and obtaining a finished product. By utilization of the oral antibacterial liquid prepared by the method provided by the invention, the common oral diseases such as toothache and the like can be quickly and efficiently treated.
Description
Technical field
The present invention relates to a kind of Herba Sophorae alopecuroidis oral bacteriostasis liquid and preparation method thereof.
Background technology
Having a toothache is the common multiple diseases of people, and common symptom has red swelling of gingiva, tooth pain etc.The cause of disease of having a toothache often comprises exopathogenic factor and endogenous cause of ill.Say owing to the untimely removing of food residual between unclean, the tooth teeth space of oral hygiene, grow noxious bacteria or hair growth promoting moth etc. and cause from exopathogenic factor, and endogenous cause of ill is owing to throw off restraint the improper flaming up of stomach-fire that causes of the hot stimulation food of food, the interior excess-heat of giving birth to causes passages through which vital energy circulates retardance, disharmony between QI and blood, amass the silt heat-transformation for a long time, changing corruption is due to pus, cohesion are not loose.At the above symptom and the cause of disease, can adopt oral medicine or external-use lotion to carry out the dispenser treatment, because external-use lotion particularly external Chinese medicine lotion can directly be returned the medicine priming through, through sick institute, does not have negative interaction substantially, so be the preferable medicament that a kind of treatment is had a toothache.But also there is the lower deficiency of the absorption rate of medicine in the Chinese medicine external-use lotion, and this just has higher requirement to the therapeutic efficiency of Chinese medicine external-use lotion.The Chinese medicine external-use lotion that at present existing multiple treatment is had a toothache, for example, publication number is the production method that the Chinese patent application of CN101444565 has been announced the oral bacteriostasis dropping liquid that a kind of treatment is had a toothache, process is for getting Flos Caryophylli, Fructus Zanthoxyli, Herba Asari coarse powder respectively, adding distil water extracts, and isolates volatile oil and preserves; Get Herba Andrographis, Rhizoma Polygoni Cuspidati coarse powder, Fructus Gardeniae coarse powder respectively and add ethanol, withdrawal liquid after the extracted twice is mixed extracting liq, filter, and flings to ethanol with heating in water bath, to the extractum shape; Above volatile oil is mixed with extractum, add Borneolum Syntheticum, Mentholum, Radix Sophorae Flavescentis total alkaloids again, mix back adding ethanol and leave standstill after-filtration and reclaim ethanol, get finished product at last.Although this oral bacteriostasis dropping liquid has therapeutical effect to the common symptom of having a toothache.But because Chinese medicine external drop has the lower deficiency of above-mentioned absorption rate, the therapeutic efficiency of this oral bacteriostasis dropping liquid is desirable not enough, is necessary prescription and preparation technology are improved the externally applied spray of the better effects if of having a toothache to obtain medical treatment.
Summary of the invention
Based on above consideration, the invention provides a kind of Herba Sophorae alopecuroidis oral bacteriostasis liquid and preparation method thereof
The preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid provided by the invention may further comprise the steps:
(1) 15～20 weight portion Radixs Angelicae Dahuricae, 20～30 weight portion Fructus Piperis Longi, 25～35 weight portion Radix Et Rhizoma Rhei and 45～55 weight portion Herba Scutellariae Barbataes are added in the extraction pot, add distilled water extraction and get extracting solution, simmer down to density is the medicinal liquid of 1.05-1.1g/ml, is designated as medicinal liquid A;
(2) Herba Sophorae alopecuroidis of 25～35 weight portions was added after the soak with ethanol of 8～14 times of weight in the reflux, extract, device reflux, extract, 14～18 hours, filtrate is left and taken in filtration, to stir among this filtrate adding medicinal liquid A, precipitate with ethanol, filtration then, recovered alcohol, add distilled water in the filtrate again and precipitate, filter and leave and take filtrate, be designated as medical liquid B;
(3) with the Herba Asari of 10～20 weight portions, the Pericarpium Zanthoxyli of 40～60 weight portions, the Fructus Xanthii of 25～35 weight portions utilizes volatile oil extractor to extract, obtain total volatile oil, be designated as volatile oil A, then extracting liq is filtered, simmer down to density is 1.05-1.1g/ml, precipitate with ethanol, filter, recovered alcohol, get filtrate, volatile oil A and this filtrate are joined in the medical liquid B again, the liquid after stirring is designated as medicinal liquid C, the Mentholum of 1.5～3 weight portions is added among the medicinal liquid C after with dissolve with ethanol, stir, the alcoholic strength that adds ethanol adjusting liquid then is 8～12 degree, leaves standstill after-filtration, leave and take filtrate, this filtrate is Herba Sophorae alopecuroidis oral bacteriostasis liquid.
Preferably, the consumption of each raw material components is as follows: the Radix Angelicae Dahuricae 15～20 weight portions, Fructus Piperis Longi 22～28 weight portions, Radix Et Rhizoma Rhei 28～32 weight portions, Herba Scutellariae Barbatae 48～52 weight portions; Herba Sophorae alopecuroidis 28～32 weight portions; Herba Asari 12～18 weight portions, Pericarpium Zanthoxyli 45～55 weight portions, Fructus Xanthii 28～32 weight portions, Mentholum 1.5～2.5 weight portions.
More preferably, the consumption of each raw material components is as follows: the Radix Angelicae Dahuricae 17～19 weight portions, Fructus Piperis Longi 24～26 weight portions, Radix Et Rhizoma Rhei 29～31 weight portions, Herba Scutellariae Barbatae 48～52 weight portions; Herba Sophorae alopecuroidis 29～31 weight portions; Herba Asari 14～16 weight portions, Pericarpium Zanthoxyli 48～52 weight portions, Fructus Xanthii 29～31 weight portions, Mentholum 1.8～2.2 weight portions.
Preferably, in the step (1), described extracting solution is that the extracted twice merging gets, and adds the distilled water of 8-14 times of weight, each 1～2 hour at every turn.
Preferably, in the step (2), the time of precipitate with ethanol is 12～36 hours, and alcoholic strength reaches 55～65 degree, and adding distilled water in the filtrate again, to carry out the sedimentary time be 12～36 hours.
Preferably, in the step (3), the preparation method of described volatile oil A and filtrate is as follows: Herba Asari, Pericarpium Zanthoxyli, Fructus Xanthii are joined respectively in the volatile oil extractor, and each adds the distilled water extraction of 6～10 times of weight, extracts 6～10 hours, mix three kinds of volatile oil and be designated as volatile oil A, the extracting liq that merges three kinds of medical materials then filters, simmer down to density is 1.05-1.1g/ml, and precipitate with ethanol filters, recovered alcohol gets filtrate.
Preferably, in the step (3), the ethanol of dissolving Mentholum is that the mass concentration of 10～25 weight portions is the ethanol more than 90%.
Preferably, the Radix Angelicae Dahuricae of using, Fructus Piperis Longi, Radix Et Rhizoma Rhei, Herba Scutellariae Barbatae, Herba Sophorae alopecuroidis, Herba Asari, Pericarpium Zanthoxyli and Fructus Xanthii are 8～15 purpose coarse powder.
Herba Sophorae alopecuroidis oral bacteriostasis liquid provided by the invention is got by above-mentioned any method preparation.
The Herba Sophorae alopecuroidis oral bacteriostasis liquid that utilizes method provided by the invention preparation priming is fast returned through, the sick institute that goes directly, and plays effects such as heat-clearing and toxic substances removing, inhibiting bacteria and diminishing inflammation, wind-expelling pain-stopping, promoting blood circulation and detumescence, thereby can treat the common symptom of having a toothache quickly and efficiently.
Description of drawings
Fig. 1 is the flow chart of the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid of the present invention.
The specific embodiment
Herba Sophorae alopecuroidis oral bacteriostasis liquid of the present invention is the externally applied spray of the disease of having a toothache of the common pilosity of treatment people.Chinese medical theory is thought: common red swelling of gingiva, tooth pain, say owing to the untimely removing of food residual between unclean, the tooth teeth space of oral hygiene, grow noxious bacteria or the hair growth promoting moth is caused from exopathogenic factor, and endogenous cause of ill is owing to throw off restraint the improper flaming up of stomach-fire that causes of the hot stimulation food of food, the interior excess-heat of giving birth to causes passages through which vital energy circulates retardance, disharmony between QI and blood, amass the silt heat-transformation for a long time, changing corruption is due to pus, cohesion are not loose.Herba Sophorae alopecuroidis oral bacteriostasis liquid of the present invention, at first compatibility Radix Et Rhizoma Rhei, Herba Sophorae alopecuroidis, Herba Scutellariae Barbatae heat-clearing and toxic substances removing, antibacterial parasite killing, pathogenic fire purging antiinflammatory suppress its cause of disease in the side, playing main therapeutical effect is monarch drug, be equipped with Herba Asari, Pericarpium Zanthoxyli, Radix Angelicae Dahuricae wind-expelling pain-stopping, promoting blood circulation and detumescence, taking into account the alleviating pain symptom is ministerial drug.Fructus Piperis Longi, Fructus Xanthii not only can be strengthened the inhibiting bacteria and diminishing inflammation analgesic effect that detoxifies, but also the cold and cool property of the monarch and his subjects' medicine is an adjuvant drug.Mentholum, except that the inhibiting bacteria and diminishing inflammation effect, the suffering that it had loose volatilization property, with the medicine priming return through, sick institute goes directly.
As shown in Figure 1, the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid provided by the invention mainly may further comprise the steps:
(1) Radix Angelicae Dahuricae, Fructus Piperis Longi, Radix Et Rhizoma Rhei and Herba Scutellariae Barbatae are added in the extraction pot, add distilled water extraction and get extracting solution, be designated as medicinal liquid A;
(2) Herba Sophorae alopecuroidis is added after the soak with ethanol reflux, extract, in the reflux, extract, device, filter and leave and take filtrate, will this filtrate add among medicinal liquid A and stir, precipitate with ethanol, filtration then, recovered alcohol adds distilled water again and precipitates in the filtrate, filtrate is left and taken in filtration, is designated as medical liquid B;
(3) Herba Asari, Pericarpium Zanthoxyli, Fructus Xanthii are utilized volatile oil extractor extract, obtain total volatile oil, be designated as volatile oil A, then extracting liq filtered, concentrate, precipitate with ethanol, filtration, recovered alcohol, filtrate, again volatile oil A and this filtrate are joined in the medical liquid B, liquid after stirring is designated as medicinal liquid C, and Mentholum is added among the medicinal liquid C after with dissolve with ethanol, can obtain finished product.
Below by embodiment the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid of the present invention is described further, and describes in conjunction with the result of use of Comparative Examples to the Herba Sophorae alopecuroidis oral bacteriostasis liquid that obtains.
The preparation method of embodiment one Herba Sophorae alopecuroidis oral bacteriostasis liquid
(1) the four kinds of medicinal material coarse powder of Radix Angelicae Dahuricae 18g, Fructus Piperis Longi 25g, Radix Et Rhizoma Rhei 30g, Herba Scutellariae Barbatae 50g (10 order) after will cleaning add in the extraction pot, the distilled water that adds 12 times of weight, extract twice, each 1.5 hours, merge extracted twice liquid, simmer down to density is 1.05g/ml then, and this concentrated solution is designated as liquid A.
(2) with Herba Sophorae alopecuroidis 30g remove impurity, coarse powder (10 order), added 9 times of soak with ethanol Herba Sophorae alopecuroidiss 2 hours, then Herba Sophorae alopecuroidis and immersion are put into the reflux, extract, device with whole ethanol, reflux, extract, 16 hours is filtered and is left and taken filtrate.To stir in this filtrate adding liquid A, precipitate with ethanol (making the liquid alcohol degree reach 60 degree) 24 hours, filtration then, recovered alcohol adds distilled water again and precipitates 24 hours, filters and leave and take filtrate in the filtrate, and this filtrate is designated as liquid B.
(3) with Herba Asari 15g, Pericarpium Zanthoxyli 50g, the coarse powder of three kinds of medical materials of Fructus Xanthii 30g (10 order) joins in the volatile oil extractor respectively, each adds the distilled water extraction of 9 times of weight, extracted 8 hours, mix three kinds of volatile oil and be designated as volatile oil A, the extracting liq that merges three kinds of medical materials then filters, simmer down to density is 1.05g/ml, precipitate with ethanol (making the liquid alcohol degree reach 60 degree), filter, recovered alcohol, get filtrate, again volatile oil A and filtrate are joined in the liquid B, the back liquid that stirs is designated as liquid C, Mentholum 2g is added among the liquid C with ethanol (95%) 20ml dissolving, stir, the alcoholic strength that adds ethanol adjusting liquid then is 10 °, leave standstill 24 hours after-filtration, leave and take filtrate, this filtrate is finished product.
The preparation method of embodiment two Herba Sophorae alopecuroidis oral bacteriostasis liquid
(1) the four kinds of medicinal material coarse powder of Radix Angelicae Dahuricae 20g, Fructus Piperis Longi 30g, Radix Et Rhizoma Rhei 25g, Herba Scutellariae Barbatae 45g (10 order) after will cleaning add in the extraction pot, add the distilled water of 14 times of weight, extract 2 hours, and simmer down to density is 1.05g/ml then, and this concentrated solution is designated as liquid A.
(2) with Herba Sophorae alopecuroidis 30g remove impurity, coarse powder (10 order), add 10 times of soak with ethanol then and put into the reflux, extract, device after 2 hours in the lump, reflux, extract, 14 hours is filtered and is left and taken filtrate.To stir in this filtrate adding liquid A, precipitate with ethanol (making the liquid alcohol degree reach 60 degree) 30 hours, filtration then, recovered alcohol adds distilled water again and precipitates 24 hours, filters and leave and take filtrate in the filtrate, and this filtrate is designated as liquid B.
(3) with Herba Asari 10g, Pericarpium Zanthoxyli 40g, the coarse powder of three kinds of medical materials of Fructus Xanthii 35g (10 order) joins in the volatile oil extractor respectively, each adds the distilled water extraction of 8 times of weight, extracted 8 hours, mix three kinds of volatile oil and be designated as volatile oil A, the extracting liq that merges three kinds of medical materials then filters, simmer down to density is 1.05g/ml, precipitate with ethanol (making the liquid alcohol degree reach 60 degree), filter, recovered alcohol, get filtrate, again volatile oil A and filtrate are joined in the liquid B, the back liquid that stirs is designated as liquid C, Mentholum 3g is added among the liquid C with ethanol (95%) 20ml dissolving, stir, the alcoholic strength that adds ethanol adjusting liquid then is 10 °, leave standstill 24 hours after-filtration, leave and take filtrate, this filtrate is finished product.
Comparative Examples
(1) takes by weighing the Flos Caryophylli grinding and place round-bottomed flask, add 6 times of weight distilled water, heating jacket, volatile oil extractor, condensing tube are installed, shift to an earlier date then, treat that the volatile oil extraction finishes, and isolates volatile oil and preserves.Use the same method and make the volatile oil of Fructus Zanthoxyli and Herba Asari.
(2) take by weighing Herba Andrographis, place round-bottomed flask, add 8 times of weight of 80% ethanol, heating jacket, condensing tube are installed, extracted withdrawal liquid 2 hours; And add 6 times of weight of 80% ethanol again and extracted 1.5 hours, the back withdrawal liquid that finishes, with front and back extracted twice liquid mixing, filtration, and heating in water bath flings to ethanol, preserves to the extractum shape.Preparation Rhizoma Polygoni Cuspidati coarse powder extractum and Fructus Gardeniae coarse powder extractum use the same method.
(3) will mix with creat extract 25kg, Rhizoma Polygoni Cuspidati coarse powder extractum 15kg, Fructus Gardeniae coarse powder extractum 15kg with above-mentioned Flos Caryophylli volatile oil 5kg, Fructus Zanthoxyli volatile oil 5kg, Herba Asari coarse powder volatile oil 5kg, and add Borneolum Syntheticum 8kg, Mentholum 7kg, Radix Sophorae Flavescentis total alkaloids 15kg, add 800kg concentration 95% ethanol behind the mix homogeneously and leave standstill 48 hours after-filtration and reclaim ethanol, get finished product.
The following describes the bacteriostatic experiment effect of three kinds of products that the foregoing description one, embodiment two and Comparative Examples obtain.
One, escherichia coli bacteriostatic experiment
(1) material:
1, test strain: in the 6th generation of escherichia coli (8099), grinding institute by military medical courses in general institute stream provides
2. disinfectant: be respectively the antibacterial liquid that embodiment one, two and Comparative Examples make
3. culture medium: nutrient broth, Nutrient agar prepares according to a conventional method
4. diluent (PBS)
(2) method:
1, test basis: " disinfection technology standard " 2002 editions 2.1.11.3.2 items
2, test is a stock solution with disinfectant
3, experimental temperature is 19～22 ℃, and experiment repeats 3 times
(3) result:
The escherichia coli fungistatic effect of the product that Comparative Examples makes
The escherichia coli fungistatic effect of the product that embodiment one makes
The escherichia coli fungistatic effect of the product that embodiment two makes
(4), conclusion: according to " disposable use hygienic article sanitary standard " (GB15979-2002), Herba Sophorae alopecuroidis oral bacteriostasis liquid is under experimental condition, and stock solution effect 2min to colibacillary bacteriostasis rate＞50%, has bacteriostasis.
Two, staphylococcus aureus bacteriostatic experiment
(1) material:
1, test strain: in the 6th generation of staphylococcus aureus (ATCC6538), grinding institute by military medical courses in general institute stream provides.
2. disinfectant: be respectively the antibacterial liquid that embodiment one, two and Comparative Examples make
3. culture medium: nutrient broth, Nutrient agar
4. diluent (PBS)
(2) method:
1, test basis: " disinfection technology standard " 2002 editions 2.1.11.3.2 items
2, test is a stock solution with disinfectant
3, experimental temperature is 19～22 ℃, and experiment repeats 3 times
(3) result:
The staphylococcus aureus fungistatic effect of the product that Comparative Examples makes
The staphylococcus aureus fungistatic effect of the product that embodiment one makes
The staphylococcus aureus fungistatic effect of the product that embodiment two makes
(4), conclusion: according to " disposable use hygienic article sanitary standard " (GB15979-2002), Herba Sophorae alopecuroidis oral bacteriostasis liquid under experimental condition, stock solution effect 2min, bacteriostasis rate＞50% to big staphylococcus aureus has bacteriostasis
Three, Candida albicans bacteriostatic experiment
(1) material:
1, experimental strain: in the 5th generation of Candida albicans (ATCC10231), provide by microorganism fungus kind preservation center, Guangdong Microbes Inst
2. disinfectant: be respectively the antibacterial liquid that embodiment one, two and Comparative Examples make
3. culture medium: husky fort fluid medium, husky fort agar culture medium
4, diluent (PBS)
(2) method:
1, test basis: " disinfection technology standard " 2002 editions 2.1.11.3.2 items
2, test is a stock solution with disinfectant
3, experimental temperature is 20～22 ℃, and experiment repeats 3 times
(3) result:
The Candida albicans fungistatic effect of the product that Comparative Examples makes
The Candida albicans fungistatic effect of the product that embodiment one makes
The Candida albicans fungistatic effect of the product that embodiment two makes
Four), conclusion: according to " disposable use hygienic article sanitary standard " (GB15979-2002), Herba Sophorae alopecuroidis oral bacteriostasis liquid is under experimental condition, and stock solution effect 2min to the oidiomycetic bacteriostasis rate of white＞50%, has bacteriostasis
In addition, through clinical showing, the Herba Sophorae alopecuroidis oral bacteriostasis liquid of method preparation of the present invention is had a toothache and oral disease such as oral ulcer has significant curative effect to common.Be illustrated below.
1 patient: Liu; Sex: woman; Age: 27 years old;
Disease is described: responsive or needle point sample size or big slightly hyperemia district occur from the beginning of lesion, promptly form sharply marginated shallow aphtha in a short time.Center micro-pits, surface are covered with the faint yellow pseudomembrane of one deck, and the ulcer number is generally about 2～3.More violent burning pain is arranged behind the ulcer, obvious with the tip of the tongue place especially.Contact during food excitatory more very
Therapeutic Method: gargle with clear water earlier and clean out the oral cavity, get then Herba Sophorae alopecuroidis oral bacteriostasis liquid finished product dilution 3-5 that the method for the foregoing description one makes doubly the back rinsing the mouth keep telling after 2 minutes to 5 minutes, keep a quarter after, gargle with clear water, one day 3 times, three days courses of treatment.
Therapeutic effect: use pain relief after a day, ulcer surface reduces after the course of treatment, thoroughly cures after two courses of treatment.
2. patient: Wang; Sex: man; Age: 35 years old;
Disease is described: swelling and aching of gum pain, chew swallow or opening when movable pain obvious, along with PD pain increases the weight of; Can't dehisce in various degree even gnathospasma also can appear when serious
Therapeutic Method: gargle earlier and clean out the oral cavity, get Herba Sophorae alopecuroidis oral bacteriostasis liquid finished product that the method for the foregoing description one makes then and be sprayed on and suffer from the tooth place with clear water, keep medicinal liquid stop mouthful in 5-20 minute, one day 3 times, three days courses of treatment.
Therapeutic effect: use swelling after one day, pain relief, chew after the course of treatment and swallow normally, all transference cures after two courses of treatment.
Claims (9)
1. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid is characterized in that, may further comprise the steps:
(1) 15～20 weight portion Radixs Angelicae Dahuricae, 20～30 weight portion Fructus Piperis Longi, 25～35 weight portion Radix Et Rhizoma Rhei and 45～55 weight portion Herba Scutellariae Barbataes are added in the extraction pot, add distilled water extraction and get extracting solution, simmer down to density is the medicinal liquid of 1.05-1.1g/ml, is designated as medicinal liquid A;
(2) Herba Sophorae alopecuroidis of 25～35 weight portions was added after the soak with ethanol of 8～14 times of weight in the reflux, extract, device reflux, extract, 14～18 hours, filtrate is left and taken in filtration, to stir among this filtrate adding medicinal liquid A, precipitate with ethanol, filtration then, recovered alcohol, add distilled water in the filtrate again and precipitate, filter and leave and take filtrate, be designated as medical liquid B;
(3) with the Herba Asari of 10～20 weight portions, the Pericarpium Zanthoxyli of 40～60 weight portions, the Fructus Xanthii of 25～35 weight portions utilizes volatile oil extractor to extract, obtain total volatile oil, be designated as volatile oil A, then extracting liq is filtered, simmer down to density is 1.05-1.1g/ml, precipitate with ethanol, filter, recovered alcohol, get filtrate, volatile oil A and this filtrate are joined in the medical liquid B again, the liquid after stirring is designated as medicinal liquid C, the Mentholum of 1.5～3 weight portions is added among the medicinal liquid C after with dissolve with ethanol, stir, the alcoholic strength that adds ethanol adjusting liquid then is 8～12 degree, leaves standstill after-filtration, leave and take filtrate, this filtrate is Herba Sophorae alopecuroidis oral bacteriostasis liquid.
2. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid according to claim 1 is characterized in that, the consumption of each raw material components is as follows: the Radix Angelicae Dahuricae 15～20 weight portions, Fructus Piperis Longi 22～28 weight portions, Radix Et Rhizoma Rhei 28～32 weight portions, Herba Scutellariae Barbatae 48～52 weight portions; Herba Sophorae alopecuroidis 28～32 weight portions; Herba Asari 12～18 weight portions, Pericarpium Zanthoxyli 45～55 weight portions, Fructus Xanthii 28～32 weight portions, Mentholum 1.5～2.5 weight portions.
3. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid according to claim 1 is characterized in that, the consumption of each raw material components is as follows: the Radix Angelicae Dahuricae 17～19 weight portions, Fructus Piperis Longi 24～26 weight portions, Radix Et Rhizoma Rhei 29～31 weight portions, Herba Scutellariae Barbatae 48～52 weight portions; Herba Sophorae alopecuroidis 29～31 weight portions; Herba Asari 14～16 weight portions, Pericarpium Zanthoxyli 48～52 weight portions, Fructus Xanthii 29～31 weight portions, Mentholum 1.8～2.2 weight portions.
4. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid according to claim 1 is characterized in that, in the step (1), described extracting solution is that the extracted twice merging gets, and adds the distilled water of 8-14 times of weight, each 1～2 hour at every turn.
5. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid according to claim 1 is characterized in that, in the step (2), the time of precipitate with ethanol is 12～36 hours, and alcoholic strength reaches 55～65 degree, and adding distilled water in the filtrate again, to carry out the sedimentary time be 12～36 hours.
6. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid according to claim 1, it is characterized in that, in the step (3), the preparation method of described volatile oil A and filtrate is as follows: join Herba Asari, Pericarpium Zanthoxyli, Fructus Xanthii in the volatile oil extractor respectively, each adds the distilled water extraction of 6～10 times of weight, extracted 6～10 hours, mix three kinds of volatile oil and be designated as volatile oil A, the extracting liq that merges three kinds of medical materials then filters, simmer down to density is 1.05-1.1g/ml, precipitate with ethanol, filter, recovered alcohol gets filtrate.
7. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid according to claim 1 is characterized in that, in the step (3), the ethanol of dissolving Mentholum is that the mass concentration of 10～25 weight portions is the ethanol more than 90%.
8. the preparation method of Herba Sophorae alopecuroidis oral bacteriostasis liquid according to claim 1 is characterized in that, the Radix Angelicae Dahuricae of using, Fructus Piperis Longi, Radix Et Rhizoma Rhei, Herba Scutellariae Barbatae, Herba Sophorae alopecuroidis, Herba Asari, Pericarpium Zanthoxyli and Fructus Xanthii are 8～15 purpose coarse powder.
9. Herba Sophorae alopecuroidis oral bacteriostasis liquid is characterized in that, this Herba Sophorae alopecuroidis oral bacteriostasis liquid is got by each described method preparation of claim 1～8.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961519A (en) * | 2014-05-19 | 2014-08-06 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating saprodontia and odontalgia |
| CN109106768A (en) * | 2018-11-12 | 2019-01-01 | 张瑞武 | A kind of lozenge for treating swelling and aching of gum |
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| CN1899567A (en) * | 2006-07-13 | 2007-01-24 | 广州敬修堂（药业）股份有限公司 | Wanhua oil spray for traumatic injury and preparing method |
| CN101837044A (en) * | 2010-06-23 | 2010-09-22 | 邱宏亮 | Extraction method of wild herba Sophora alopecuroide and oral medicinal composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899567A (en) * | 2006-07-13 | 2007-01-24 | 广州敬修堂（药业）股份有限公司 | Wanhua oil spray for traumatic injury and preparing method |
| CN101837044A (en) * | 2010-06-23 | 2010-09-22 | 邱宏亮 | Extraction method of wild herba Sophora alopecuroide and oral medicinal composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961519A (en) * | 2014-05-19 | 2014-08-06 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treating saprodontia and odontalgia |
| CN109106768A (en) * | 2018-11-12 | 2019-01-01 | 张瑞武 | A kind of lozenge for treating swelling and aching of gum |
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