CN1203092A - Anticancer oral liquor and its preparing process - Google Patents

Abstract

An anticancer oral liquid especially suitable for esophagus cancer, liver cancer and rectum cancer in metaphase and late phase is prepared from Chinese medicinal materials such as pangolin scales, paris polyphylla, pinellia tuber, etc. through compounding under a certain processing technology and features no toxic by-effect, and curing cancers without radiotherapy and operation.

Description

A kind of antitumor oral liquid and compound method thereof

The present invention relates to a kind of antitumor oral liquid and compound method thereof, especially a kind of oral liquid and compound method that is used for the treatment of cancer in digestive system.

At present, it is a lot of to treat method for cancer both at home and abroad, mainly adopts means such as operation, radiotherapy, chemotherapy, and patient will bear huge misery, medical expense is higher and only be applicable to early, mid-term not the cancer of diffusion transfer and body strong in, young cancer patient.

Adopt the prescription of treatment by Chinese herbs a lot of in recent years, also have many in, the prescription of western medical treatment cancer, Chinese patent CN1112427A discloses a kind of anti-cancer oral liquor and compound method, this antitumor oral liquid is with strengthening vital QI to eliminate pathogenic factors, anti pathologic immunity is a principle, can kill and wound, anticancer growth, stop the cancerous cell diffusion.

Because the prescription difference of various treatment cancers, action effect also is not quite similar, and the purpose of this invention is to provide a kind of antitumor oral liquid, is used for the treatment of esophageal carcinoma, gastric cancer, hepatocarcinoma, the middle and terminal cancer of various gi systems such as rectal cancer.With strengthening the body resistance, replenishing QI to invigorate the spleen, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, softening the hard mass loose and are combined into principle, and relief of symptoms palliates the agonizing sufferings effectively, builds up resistance, and promotes the food drink, life-saving.The present invention also will provide a kind of method of preparing this oral liquid for this reason.

Technical scheme of the present invention is: a kind of antitumor oral liquid,, boiled through pulverizing by the Chinese herbal medicine of certain prescription, steps such as filtration are processed into, and contain effective extracting solution of following composition in 25000 milliliters of oral liquids, Herba Scutellariae Barbatae 150-250 gram, Squama Manis (system) 200-250 gram, Agkistrodon 50-100 gram, Rhizoma Pinelliae (processed) 150-183 gram, Scolopendra 150-200 gram, Rhizoma Paridis (system) 200-225 gram, Rhizoma Gastrodiae 200-225 gram, Cordyceps 200-250 gram, Radix Notoginseng 200-250 gram.

The effective extracting solution that also contains following composition in described 25000 milliliters of oral liquids: Endothelium Corneum Gigeriae Galli 800-883 gram, Bulbus Fritillariae Uninbracteatae 150-250 gram, Calculus Bovis 5-10 gram; first 100-142 gram on the Trionyx sinensis Wiegmann; Radix Panacis Quinquefolii 800-883 gram, Radix Aucklandiae (Radix Vladimiriae) 200-250 gram, Cornu Saigae Tataricae 100-125 gram; Pericarpium Citri Reticulatae 150-250 gram; Scorpio 200-250 gram, Herba Solani Nigri 100-225 gram, Semen Coicis 100-225 gram; Cornu Cervi Pantotrichum 800-883 gram, Flos Lonicerae 650-800 gram.

A kind of method for preparing antitumor oral liquid, this method comprise following a few step:

(1) above 22 flavor medicines are given as one thinks fit cataclasm, add water (amount of water be middle dose 2-3 doubly) soak after 1-1.5 hour and use 1-2kg/cm ²Steam pressure boiled 1-1.5 hour, herb liquid is leached, add again water (amount of water be middle dose 2-3 doubly) use 0.8-1.5kg/cm ²Steam pressure boil after 30-60 minute medicinal liquid leached add for the third time water (amount of water be middle dose 2-3 doubly) use 0.8-1.5kg/cm ²Steam pressure boiled 30-60 minute, medicinal liquid is leached except that medicinal residues.

(2) merge three filtrates, mixing, natural sedimentation 1-3 hour filter filtrate and add 95% ethanol and makes the alcohol concentration of medicinal liquid reach 75% postprecipitation 20-26 hour, and reclaim under reduced pressure ethanol is used 0.75kg/cm ²Steam pressure be concentrated into 25000 milliliters of medicinal liquids and be cooled to 30 ℃ of left and right sides fills and make 100 bottles, 100 ℃ of sterilizations of flowing steam got final product in 30 minutes.

Clinical data of the present invention is as follows:

1,1993-1996 these antitumor oral liquids carry out clinical trial in People's Armed Police Henan hospital of army unit oncology, accept middle and terminal cancer patient 107 examples altogether for medical treatment, male 62 examples, women 45 examples, at 35 years old-70 years old age, average 54 years old, comprise esophageal carcinoma, gastric cancer, hepatocarcinoma, rectal cancer, colon cancer.

2, case choice criteria: the inpatient that all are accepted for medical treatment, all be on ground (city) level with cancer middle and advanced stage patient of the judgement of going to the hospital, after through my institute's oncology further consultation, judgement is defined as the patient of above-mentioned cancer, for other disease not within scope of statistics.

3, Therapeutic Method: all middle and terminal cancer patients take antitumor oral liquid, a 50ml, and one day secondary, 10 days is a course of treatment, evaluates curative effect after observing 3 courses of treatment continuously.

4, clinical efficacy: late cancer patient in 107 examples, what wherein alleviate fully is 36 examples, what part was alleviated is 43 examples, unconverted is 9 examples, deterioration be 6 examples, total effective rate is 73.8%.

5, toxicity: at period in a medicine the patient is carried out safety and observe, comprise general health check-up project, blood, urine, the inspection that routinizes just, the heart, liver, kidney function test, the result does not have tangible toxic reaction.

Provide embodiment below, get Endothelium Corneum Gigeriae Galli 850 grams, Bulbus Fritillariae Uninbracteatae 200 grams, Herba Scutellariae Barbatae 200 grams; Squama Manis (system) 225 grams, Agkistrodon 75 grams, Cordyceps 225 grams, Radix Panacis Quinquefolii 850 grams; Radix Aucklandiae (Radix Vladimiriae) 225 grams, first 125 grams on the Trionyx sinensis Wiegmann, Cornu Saigae Tataricae 110 grams, Rhizoma Pinelliae (processed) 165 grams; Pericarpium Citri Reticulatae 125 grams, Radix Notoginseng 225 grams, Scorpio 225 grams, Scolopendra 175 grams; Herba Solani Nigri 110 grams, Rhizoma Paridis (system) 210 grams, Rhizoma Gastrodiae 210 grams, Calculus Bovis 6 grams; Semen Coicis 110 grams, Cornu Cervi Pantotrichum 850 grams, Flos Lonicerae 725 grams.Carry out above 22 flavor medicines cataclasm, add water 10000-15000 milliliter, soak and use 1-2kg/cm after 1-1.5 hour ²Steam pressure boil and then use 0.8-1.5kg/cm instead ²Steam pressure boiled 1-1.5 hour, medicinal liquid was leached add water 6000-10000 milliliter again, used 0.8-1.5kg/cm ²Steam pressure boil after 30-60 minute medicinal liquid leached, add water 6000-10000 milliliter 0.8-1.5kg/cm for the third time ²Steam pressure boiled 30-60 minute, liquid is leached, remove medicinal residues.

Merge three times filtrate, mixing, natural sedimentation 1-3 hour, filtration filtrate adds 95% ethanol made the alcohol concentration of medicinal liquid reach 75% postprecipitation 20-26 hour, and reclaim under reduced pressure ethanol is used 0.75kg/cm ²Steam pressure be concentrated into 25000 milliliters of medicinal liquids and be cooled to 30 ℃ of left and right sides fills and make 100 bottles, 100 ℃ of sterilizations of flowing steam got final product in 30 minutes.The invention is not restricted to an above-mentioned embodiment.

Claims (3)

1, a kind of antitumor oral liquid, is boiled through pulverizing by the Chinese herbal medicine of certain prescription, steps such as filtration are processed into, and it is characterized in that: contain effective extracting solution of following composition in 25000 milliliters of oral liquids, Herba Scutellariae Barbatae 150-250 gram, Squama Manis (system) 200-250 gram, Agkistrodon 50-100 gram, Rhizoma Pinelliae (processed) 150-183 gram, Scolopendra 150-200 gram, Rhizoma Paridis (system) 200-225 gram, Rhizoma Gastrodiae 200-225 gram, Cordyceps 200-250 gram, Radix Notoginseng 200-250 gram.

2, antitumor oral liquid according to claim 1 is characterized in that: the effective extracting solution that also contains following composition in described 25000 milliliters of oral liquids: Endothelium Corneum Gigeriae Galli 800-883 gram, Bulbus Fritillariae Uninbracteatae 150-250 gram; Calculus Bovis 5-10 gram, first 100-142 gram on the Trionyx sinensis Wiegmann, Radix Panacis Quinquefolii 800-883 gram; Radix Aucklandiae (Radix Vladimiriae) 200-250 gram; Cornu Saigae Tataricae 100-125 gram, Pericarpium Citri Reticulatae 150-250 gram, Scorpio 200-250 gram; Herba Solani Nigri 100-225 gram; Semen Coicis 100-225 gram, Cornu Cervi Pantotrichum 800-883 gram, Flos Lonicerae 650-800 gram.

3, a kind of method for preparing antitumor oral liquid is characterized in that this method comprises following a few step:

(1) above 22 flavor medicines are given as one thinks fit cataclasm, add water (amount of water be middle dose 2-3 doubly) soak after 1-1.5 hour and use 1-2kg/cm ²Steam pressure boiled 1-1.5 hour, herb liquid is leached, add again water (amount of water be middle dose 2-3 doubly) use 0.8-1.5kg/cm ²Steam pressure boil after 30-60 minute medicinal liquid leached add for the third time water (amount of water be middle dose 2-3 doubly) use 0.8-1.5kg/cm ²Steam pressure boiled 30-60 minute, medicinal liquid is leached except that medicinal residues.

(2) merge three filtrates, mixing, natural sedimentation 1-3 hour filter filtrate and add 95% ethanol and makes the alcohol concentration of medicinal liquid reach 75% postprecipitation 20-26 hour, and reclaim under reduced pressure ethanol is used 0.75kg/cm ²Steam pressure be concentrated into 25000 milliliters of medicinal liquids and be cooled to 30 ℃ of left and right sides fills and make 100 bottles, 100 ℃ of sterilizations of flowing steam got final product in 30 minutes.