CN105833115A - Traditional Chinese medicine for treating precancerous lesions of gastric cancer - Google Patents
Traditional Chinese medicine for treating precancerous lesions of gastric cancer Download PDFInfo
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- CN105833115A CN105833115A CN201610276694.0A CN201610276694A CN105833115A CN 105833115 A CN105833115 A CN 105833115A CN 201610276694 A CN201610276694 A CN 201610276694A CN 105833115 A CN105833115 A CN 105833115A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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Abstract
The invention discloses a traditional Chinese medicine for treating precancerous lesions of a gastric cancer, and relates to the technical field of pharmaceutical compositions for treating the precancerous lesions of the gastric cancers .The traditional Chinese medicine is a traditional Chinese medicine preparation which is prepared from, by weight, 10-20 parts of spreading hedyotis herb, 10-20 parts of herba taraxaci, 8-15 parts of herba artemisiae anomalae, 8-16 parts of cortex lycii radicis, 8-16 parts of radix lithospermi and 10-20 parts of raw coix seeds according to a conventional method .The traditional Chinese medicine has the advantages of being simple in medicine composition, convenient to take, safe, reliable, free of toxic and side effects, capable of promoting repairing of gastric mucosae and improving the self-healing capacity of a patient and significant in effect.
Description
Technical field
The present invention relates to treat the pharmaceutical composition technical field of gastric precancerous lesion.
Background technology
The precancerous lesion of stomach refers to that a class is susceptible to dysplasia and the intestinal epithelial metaplasia of the gastric mucosa pathological histology change of canceration, i.e. gastric mucosa, and main companion is stored in chronic atrophic gastritis.
Gastric cancer is one of modal malignant tumor of China, serious harm human health.And gastric mucosa cancerous protuberance is not to be become cancerous cell by normal cell " jumps ", but the process of a multi-step canceration, i.e. chronic superficial gastritis → atrophic gastritis → intestinal epithelial metaplasia → dysplasia → gastric cancer, the pathological changes occurred in the meantime is referred to as precancerous lesion.The most often companion's intestinal epithelial metaplasia, dysplasia are referred to as precancerous lesions of chronic atrophic gastritis or gastric precancerous lesion.More than companion's moderate dysplasia and the biggest visible peristalsis visible intestinal peristalsis metaplasia are then referred to as real preventing precancerous lesion of stomach cancer.
Chronic atrophic gastritis is susceptible to canceration, it is generally acknowledged that its canceration rate is: within 5～10 years, canceration rate is 3%～5%, within more than 10 years, be 10%, 10 years canceration rates of slight dysplasia are 2.5%～11%, 10 years canceration rates 4%～35% of moderate dysplasia, 10 years canceration rates of severe dysplasia are 10%～83%.
Therefore preventing or treat gastric precancerous lesion, stoping precancerous lesion to be converted into gastric cancer is to prevent and treat an important channel of gastric cancer, significant for reducing China's cancer morbidity and patient death rate.
At present, the treatment to gastric precancerous lesion would generally be taken Western medicine and treated, although instant effect; but major part medication can only respite patient ailing, be difficult to radical cure sufferer, relapse rate is high; and Western medicine is expensive, long-term taking also can produce certain toxic and side effects to health.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine treating gastric precancerous lesion, has medicine composition simple, and it is convenient to take, safe and reliable, has no side effect, and promotes the reparation of gastric mucosa, improves patient's self-healing ability, the significant advantage of effect.
For solving above-mentioned technical problem, the technical solution used in the present invention is: a kind of Chinese medicine treating gastric precancerous lesion, the Chinese medicine preparation with including that the raw material of Chinese medicine of following weight proportioning is made according to a conventional method: Herba Hedyotidis Diffusae 10-20 part, Herba Taraxaci 10-20 part, Herba Artemisiae Anomalae 8-15 part, Cortex Lycii 8-16 part, Radix Arnebiae (Radix Lithospermi) 8-16 part, Semen Coicis 10-20 part.
Preferably, with the Chinese medicine preparation including that the raw material of Chinese medicine of following weight proportioning is made according to a conventional method: Herba Hedyotidis Diffusae 15 parts, Herba Taraxaci 15 parts, Herba Artemisiae Anomalae 12 parts, Cortex Lycii 12 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Semen Coicis 15 parts.
Preferably, the Chinese medicine preparation made by decocting method.
It is further preferred that decocting method is first 15-25 DEG C of cold water of raw material of Chinese medicine of described weight proportion to be soaked 30-60 point of kind, after then decocting 30-40 minute, leaches medicinal liquid and get final product.
Further preferred, decocting method is first 15-25 DEG C of cold water of raw material of Chinese medicine of described weight proportion to be soaked 40 points of kinds, after then decocting 30 minutes, leaches medicinal liquid and get final product.Every day decoction being taken warmly at twice.
In Chinese medicine of the present invention, each component pharmacological action is as follows:
Herba Hedyotidis Diffusae: heat clearing away, dampness removing, removing toxic substances.Can be used for alimentary tract cancer, tumor etc..
Herba Taraxaci: heat-clearing and toxic substances removing, can be used for heat toxin syndrome, is especially apt to removing heat from the liver, treats liver-heat conjunctival congestion and swelling pain, and multi-infection, purulent disease.
Herba Artemisiae Anomalae: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.It has hemostasis of curing the wound, the effect of appetizing of being amusing.
Cortex Lycii: heat clearing away, removing heat from blood.Control carbuncle, malignant boil.
Radix Arnebiae (Radix Lithospermi): clearing away heat and cooling blood, invigorates blood circulation, rash of detoxifying.Contain for heat in blood poison.
Semen Coicis: there is effect of spleen invigorating, heat clearing away, dampness removing.Can use and control acute appendicitis.
In above-mentioned six medicaments, Herba Hedyotidis Diffusae, Herba Taraxaci heat-clearing and toxic substances removing are monarch drug, and Semen Coicis invigorating spleen to remove dampness is ministerial drug, Radix Arnebiae (Radix Lithospermi), Herba Artemisiae Anomalae, Cortex Lycii clearing away heat and cooling blood, and removing blood stasis dysmenorrhea is adjuvant altogether, and all medicines share, effect that the heat-clearing and toxic substances removing that gathers altogether is anticancer.
Use and have the beneficial effects that produced by technique scheme:
The present invention, with pure Chinese medicine side, has medicine composition simple, and it is convenient to take, safe and reliable, has no side effect, and promotes the reparation of gastric mucosa, improves patient's self-healing ability, the significant advantage of effect, and treatment gastric precancerous lesion total effective rate reaches 97%.
Below in conjunction with clinical trial and model case, the present invention is further detailed explanation.
One, clinical trial
1, clinical data: be chronic atrophic gastritis companion's (or not accompanying) intestinal epithelial metaplasia and the patient of atypical hyperplasia by 220 example clinical diagnosises, is randomly divided into treatment group 110 example and matched group 110 example.Clinical symptoms: have a stomach-ache, flatulence, belch, heartburn acid regurgitation, indigestion and loss of appetite, dry mouth with bitter taste, big dry stool, yellow urine.
2, Therapeutic Method:
Treatment group gives Chinese medicine of the present invention, Herba Hedyotidis Diffusae 10-20g, Herba Taraxaci 10-20g, Herba Artemisiae Anomalae 8-15g, Cortex Lycii 8-16g, Radix Arnebiae (Radix Lithospermi) 8-16g, Semen Coicis 10-20g, above-mentioned Six-element Chinese medicine, cold water soaks about 40 points of kinds, decocts 30 minutes, extracting juice 300ml, every day 1 dose, decoction being taken warmly at twice.Matched group gives WEIFUCHUN PIAN, and each 4, three times a day, ante cibum, 30min took.All to be 1 course for the treatment of March, treat 2 courses for the treatment of altogether for two groups.The medicine of other treatment chronic gastritis is all disabled when treatment.
3, efficacy assessment standard:
Clinical symptoms: have a stomach-ache, flatulence, belch, heartburn acid regurgitation, indigestion and loss of appetite, dry mouth with bitter taste, big dry stool, yellow urine.
Cure: clinical symptom disappearance or substantially disappear；
Effective: clinical symptoms is obviously improved；
Effective: clinical symptoms makes moderate progress；
Invalid: clinical symptoms is not improved or increases the weight of.
Total effective rate=(cure+effective+effectively)/total number of cases × 100%.
4, therapeutic outcome:
After two courses for the treatment of, treatment group is superior to matched group in terms of clinical efficacy total effective rate and gastroscope improvement, two groups of statistical procedures differences the most statistically significant (P ＜ 0.05).
Treatment group is through to 110 example gastric precancerous lesion patient treatment statistics, and curing number is 50 people, and effective number is 46 people, and significant figure is 11 people, and total significant figure is 107 people, and total effective rate is 97%；Invalid number 3 people, inefficiency 3%.Matched group is through to 110 example gastric precancerous lesion patient treatment statistics, and curing number is 25 people, and effective number is 39 people, and significant figure is 10 people, and total significant figure is 74 people, and total effective rate is 67%；Invalid number 36 people, inefficiency 33%.
Two: model case
High so-and-so, man, 63 years old, primary symptom: vague epigastralgia, belch, distension and fullness in the abdomen painful abdominal mass plug, indigestion and loss of appetite, it is greasy not well that epigastrium has tenderness, defecation to stick, and the dark red thick, yellow and greasy fur of tongue, stringy pulse is fine and smooth.Electronic gastroscope shows: chronic atrophic gastritis.Pathology shows: antral gastric mucosa chronic inflammatory disease, body of gland is slight dysplasia.Tcm diagnosis: gastric abscess, accumulates card in turbid poison.Western medicine diagnose: gastric precancerous lesion.Prescription is as follows: Herba Hedyotidis Diffusae 10-20g, Herba Taraxaci 10-20g, Herba Artemisiae Anomalae 8-15g, Cortex Lycii 8-16g, Radix Arnebiae (Radix Lithospermi) 8-16g, Semen Coicis 10-20g, above-mentioned Six-element Chinese medicine, and cold water soaks about 40 points of kinds, decoct 30 minutes, extracting juice 300ml, every day potion, decoction being taken warmly at twice.
Taking medicine after 7 pairs, patient's vague epigastralgia and belch all alleviate, and distension and fullness in the abdomen painful abdominal mass plug sense takes a turn for the better earlier above, and appetite increases.After still abide by front method for the treatment of with card plus-minus, after 6 months check gastroscope show: chronic superficial gastritis, pathology shows: gastric mucosa chronic inflammatory disease.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further detailed explanation.
Embodiment 1
A kind of Chinese medicine treating gastric precancerous lesion, it includes that the raw material of Chinese medicine of following weight proportioning is made: Herba Hedyotidis Diffusae 15g, Herba Taraxaci 15g, Herba Artemisiae Anomalae 12g, Cortex Lycii 12g, Radix Arnebiae (Radix Lithospermi) 12g, Semen Coicis 15g.
Preparation and application, comprises the steps: first to be soaked by 15-25 DEG C of cold water of raw material of Chinese medicine of above-mentioned weight proportion 40 points of kinds, after then decocting 30 minutes, extracting juice 300ml, every day potion, every day decoction being taken warmly at twice.
Embodiment 2
A kind of Chinese medicine treating gastric precancerous lesion, it includes that the raw material of Chinese medicine of following weight proportioning is made: Herba Hedyotidis Diffusae 10g, Herba Taraxaci 20g, Herba Artemisiae Anomalae 10g, Cortex Lycii 8g, Radix Arnebiae (Radix Lithospermi) 8g, Semen Coicis 15g.
Preparation and application, comprises the steps: first to be soaked by 15-25 DEG C of cold water of raw material of Chinese medicine of above-mentioned weight proportion 30 points of kinds, after then decocting 40 minutes, extracting juice 300ml, every day potion, every day decoction being taken warmly at twice.
Embodiment 3
A kind of Chinese medicine treating gastric precancerous lesion, it includes that the raw material of Chinese medicine of following weight proportioning is made: Herba Hedyotidis Diffusae 18g, Herba Taraxaci 15g, Herba Artemisiae Anomalae 15g, Cortex Lycii 12g, Radix Arnebiae (Radix Lithospermi) 10g, Semen Coicis 20g.
Preparation and application, comprises the steps: first to be soaked by 15-25 DEG C of cold water of raw material of Chinese medicine of above-mentioned weight proportion 30 points of kinds, after then decocting 40 minutes, extracting juice 300ml, every day potion, every day decoction being taken warmly at twice.
Embodiment 4
A kind of Chinese medicine treating gastric precancerous lesion, it includes that the raw material of Chinese medicine of following weight proportioning is made: Herba Hedyotidis Diffusae 20g, Herba Taraxaci 10g, Herba Artemisiae Anomalae 8g, Cortex Lycii 16g, Radix Arnebiae (Radix Lithospermi) 16g, Semen Coicis 10g.
Preparation and application, comprises the steps: first to be soaked by 15-25 DEG C of cold water of raw material of Chinese medicine of above-mentioned weight proportion 30 points of kinds, after then decocting 35 minutes, extracting juice 300ml, every day potion, every day decoction being taken warmly at twice.
Claims (5)
1. the Chinese medicine treating gastric precancerous lesion, it is characterised in that: the Chinese medicine preparation with including that the raw material of Chinese medicine of following weight proportioning is made according to a conventional method: Herba Hedyotidis Diffusae 10-20 part, Herba Taraxaci 10-20 part, Herba Artemisiae Anomalae 8-15 part, Cortex Lycii 8-16 part, Radix Arnebiae (Radix Lithospermi) 8-16 part, Semen Coicis 10-20 part.
A kind of Chinese medicine treating gastric precancerous lesion the most according to claim 1, it is characterized in that, the Chinese medicine preparation with including that the raw material of Chinese medicine of following weight proportioning is made according to a conventional method: Herba Hedyotidis Diffusae 15 parts, Herba Taraxaci 15 parts, Herba Artemisiae Anomalae 12 parts, Cortex Lycii 12 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Semen Coicis 15 parts.
A kind of Chinese medicine treating gastric precancerous lesion the most according to claim 1, it is characterised in that the Chinese medicine preparation made by decocting method.
A kind of Chinese medicine treating gastric precancerous lesion the most according to claim 3, it is characterised in that decocting method is first 15-25 DEG C of cold water of raw material of Chinese medicine of described weight proportion to be soaked 30-60 point of kind, after then decocting 30-40 minute, leaches medicinal liquid and get final product.
A kind of Chinese medicine treating gastric precancerous lesion the most according to claim 4, it is characterised in that decocting method is first 15-25 DEG C of cold water of raw material of Chinese medicine of described weight proportion to be soaked 40 points of kinds, after then decocting 30 minutes, leaches medicinal liquid and get final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107668A (en) * | 2020-11-02 | 2020-12-22 | 相宏杰 | Traditional Chinese medicine for treating gastric precancerous lesion |
| CN115671242A (en) * | 2022-11-24 | 2023-02-03 | 江西中医药大学 | Traditional Chinese medicine compound preparation for treating gastric precancerous lesions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130002A (en) * | 2007-08-28 | 2008-02-27 | 尹克山 | Traditional Chinese medicine for treating gastric precancerous lesion |
| CN101496884A (en) * | 2008-11-21 | 2009-08-05 | 王兴民 | Capsule for treating gastric precancerous lesion |
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- 2016-04-29 CN CN201610276694.0A patent/CN105833115B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101130002A (en) * | 2007-08-28 | 2008-02-27 | 尹克山 | Traditional Chinese medicine for treating gastric precancerous lesion |
| CN101496884A (en) * | 2008-11-21 | 2009-08-05 | 王兴民 | Capsule for treating gastric precancerous lesion |
Non-Patent Citations (1)
| Title |
|---|
| 谢英彪主编: "《国医名家效验方精选》", 28 February 2014, 金盾出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107668A (en) * | 2020-11-02 | 2020-12-22 | 相宏杰 | Traditional Chinese medicine for treating gastric precancerous lesion |
| CN115671242A (en) * | 2022-11-24 | 2023-02-03 | 江西中医药大学 | Traditional Chinese medicine compound preparation for treating gastric precancerous lesions |
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