CN105726787A - Traditional Chinese medicine enema for treating ulcerative colitis and preparing method of traditional Chinese medicine enema - Google Patents
Traditional Chinese medicine enema for treating ulcerative colitis and preparing method of traditional Chinese medicine enema Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine enema for treating ulcerative colitis and a preparing method of the traditional Chinese medicine enema.The traditional Chinese medicine enema is prepared from, by weight, 15-25 parts of spiny amarauth herb or roots, 15-25 parts of spreading hedyotis herb, 10-20 parts of wild chrysanthemum flowers, 10-20 parts of dahurian patrinia herb, 10-20 parts of humifuse euphorbia herb, 8-16 parts of folium callicarpae formosanae, 5-15 parts of sargentgloryvine stems, 5-15 parts of myrrh, 5-15 parts of rape seeds, 2-8 parts of radix rubiae, 2-8 parts of pomegranate bark and 1-5 parts of cutch.According to the traditional Chinese medicine enema for treating ulcerative colitis, common traditional Chinese medicine materials are adopted as raw materials, the formula is scientific, preparation is easy, and cost is low; besides, the enema preparation is adopted, the active ingredients of the medicine can directly act on an affected part, the medicine effect is remarkable, no side effect is caused, relapse is not likely to occur, and the traditional Chinese medicine enema has the effects of clearing away heat and toxic materials, prompting blood circulation to remove blood stasis, cooling blood and stopping bleeding, and relieving swelling and promote tissue regeneration, and can effectively treat ulcerative colitis.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicinal enema treating ulcerative colitis and preparation method thereof.
Background technology
Ulcerative colitis is a kind of cause of disease colon the most fully aware of and rectum chronic nonspecific inflammation disease, and primary disease sees any age, is mainly in the person between twenty and fifty in 20-40 year.Pathological changes is mainly limited to colonic mucosa and Submucosa, based on ulcer.This disease is relatively common in American-European countries.Along with going deep into primary disease understanding and being gradually improved of diagnostic means, China's morbidity is the most substantially increased, and the most often has serious symptom to report.This disease onset is slow, minority Acute onset, and the course of disease is a kind of chronic process, shows as stage of attack and is alternately present with the catabasis, but also some patients symptomatic gradually increases the weight of.Clinic mainly shows as just defecation with blood and pus mucus, with stomachache, abdominal tenderness, tenesmus, heating, the accessible pallial siphuncle of left lower quadrant and abdominal mass；Intestinal mirror, pathology finding, colon has the hyperemia of typical mucosa, edema, erosion, ulcer, and mucosa is the most hemorrhage.
The cause of disease and the pathogenesis of ulcerative colitis are not clear, it is now recognized that mainly the most not normal with immune system, genetic predisposition, environment is relevant with the many factors such as spiritual.In view of primary disease has recurrent exerbation, constantly increase the weight of, prolonged do not heal, and have certain canceration rate etc., therefore seek effective therapy and seem the most urgent.At present, mainly having operative treatment and Drug therapy, operative treatment risk is big, and is easily generated sequela and complication；Doctor trained in Western medicine is mainly sulfasalazine Salicylic Acid Formulations, corticosteroid, immunosuppressant etc. to the medicine that primary disease is treated, although disease can be controlled in a short time, alleviate the state of an illness, but this type of medicine has bigger toxic and side effects, long-term abuse easily produces drug dependence, and the state of an illness is the most repeatedly.
Motherland's medical science thinks that ulcerative colitis belongs to the categories such as " having loose bowels ", " intestinal ", " dysentery " of the traditional Chinese medical science, and the cause of disease is many by experiencing six climate exopathogens heresy poison, internal injury diet seven emotions, undermine taste, damp and hot under the pressure of large intestine, make intestinal mechanism of qi block, venation is impaired, and blood loses that meat is rotten, internal ulceration becomes infections.Medicine can be directly acted on intestinal wall by herbal enema preparation, utilizes the semi-transparent permeability of the membrane of intestinal wall to be rapidly absorbed, and causes the therapeutical effect of whole body, and toxic and side effects is little, and can preferably play the advantage of Chinese medicine.In existing patent document, Authorization Notice No. CN102988559B(application number 201210547982.7) Chinese patent literature disclose a kind of Chinese medicinal enema treating ulcerative colitis, it is characterised in that in this, enema is made up of the Chinese medicine of following weight portion: Cortex syzygii cumini 20-25 part, Caulis Arcangelisiae 21-23 part, Herba Pteridis multifidae 10-12 part, Herba Houttuyniae 7-9 part, Herba Onychii japonici 18-20 part, Herba Stellariae paniculigerae 15-17 part, Cortex Phellodendri 7-9 part, little 8-10 part, Radix Sophorae Flavescentis 6-8 part, Rhizoma Corydalis 12-15 part, Radix Paeoniae Alba 10-12 part, Fructus pruni pubescentis 7-9 part, Radix Glycyrrhizae 4-6 part.
Although at present more Chinese medicinal enema having occurred, and there is significant curative effect, but being mostly Chinese herbs decoction, needing to face with preparing, in-convenience in use.
Summary of the invention
An object of the present invention is to overcome the deficiencies in the prior art, it is provided that one is prepared simply, evident in efficacy, the Chinese medicinal enema of the treatment ulcerative colitis be difficult to recurrence, having no side effect.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is:
A kind of Chinese medicinal enema treating ulcerative colitis, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from: Amaranthus spinosus L. 15-25 part, Herba Hedyotidis Diffusae 15-25 part, Flos Chrysanthemi Indici 10-20 part, Herba Patriniae 10-20 part, Herba Euphorbiae Humifusae 10-20 part, Folium Callicarpae Formosanae 8-16 part, Caulis Sargentodoxae 5-15 part, Myrrha 5-15 part, Semen Brassicae Campestris 5-15 part, Radix Rubiae 2-8 part, Pericarpium Granati 2-8 part, catechu 1-5 part.
A kind of Chinese medicinal enema treating ulcerative colitis, preferably scheme, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from: Amaranthus spinosus L. 18-22 part, Herba Hedyotidis Diffusae 18-22 part, Flos Chrysanthemi Indici 13-17 part, Herba Patriniae 13-17 part, Herba Euphorbiae Humifusae 13-17 part, Folium Callicarpae Formosanae 10-14 part, Caulis Sargentodoxae 8-12 part, Myrrha 8-12 part, Semen Brassicae Campestris 8-12 part, Radix Rubiae 4-6 part, Pericarpium Granati 4-6 part, catechu 2-4 part.
A kind of Chinese medicinal enema treating ulcerative colitis, scheme more preferably, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from: Amaranthus spinosus L. 20 parts, Herba Hedyotidis Diffusae 20 parts, Flos Chrysanthemi Indici 15 parts, Herba Patriniae 15 parts, Herba Euphorbiae Humifusae 15 parts, Folium Callicarpae Formosanae 12 parts, Caulis Sargentodoxae 10 parts, Myrrha 10 parts, Semen Brassicae Campestris 10 parts, 5 parts of Radix Rubiae, Pericarpium Granati 5 parts, 3 parts of catechu.
It is a further object of the present invention to provide the preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis.
A kind of preparation method of the Chinese medicinal enema treating ulcerative colitis, step is as follows:
Step one: after Myrrha remove impurity, smashing to pieces, puts slow fire in pot and fries to after smoldering, the rice vinegar of spray raw materials quality 0.05-0.1 times, then fries when showing glossy gloss to surface, and taking-up cools, and is crushed to the fine powder of 200 mesh, standby；
Step 2: catechu is removed impurity, is crushed to the fine powder of 200 mesh, standby；
Step 3: Amaranthus spinosus L., Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Herba Patriniae, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, Caulis Sargentodoxae, Semen Brassicae Campestris, Radix Rubiae, Pericarpium Granati are cleaned respectively, dried, then one piece be crushed to the coarse powder of 20 mesh after, add the water soaking 40-60min of raw material weight 5-15 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 30-50min under the conditions of ultrasonic power 60W, obtain extracting solution, standby；
Step 4: the fine powder that step one and step 2 obtain is joined in the extracting solution of step 3, mix homogeneously, under the conditions of 80 DEG C after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtain the herbal enema preparation of the present invention.
The preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis, sprays the rice vinegar of raw materials quality 0.06-0.08 times in step one；Preferably, the rice vinegar of raw materials quality 0.07 times is sprayed.
The preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis, step 3 will be crushed in the coarse powder of 20 mesh add the water soaking 45-55min of raw material weight 8-12 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 35-45min under the conditions of ultrasonic power 60W, obtain extracting solution；Preferably, by being crushed in the coarse powder of 20 mesh add the water soaking 50min of raw material weight 10 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 40min under the conditions of ultrasonic power 60W, obtains extracting solution.
Used by the present invention, the pharmacology of main raw material of Chinese medicine is as follows:
Amaranthus spinosus L.: sweet, light is cool.Return stomach warp, spleen channel, large intestine channel.Effect and effect: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis.With controlling dysentery, abdominal pain due to damp-heat, bleeding hemorrhoids, nebulousurine, stranguria with blood, skin eczema.
Herba Hedyotidis Diffusae: mildly bitter flavor, micro-sweet, cool in nature.Return stomach warp, large intestine channel, small intestine meridian.Effect and effect: heat clearing away, dampness removing, removing toxic substances, anticancer.There is antitumor, strengthen immunity, adrenal cortex reinforcing function and the effect such as antiulcer, suppression spermatogenesis.With controlling dyspnea and cough due to lung-heat, laryngopharynx swelling and pain；Jaundice due to damp-heat, gastritis, cholecystitis, cholelithiasis；Enteritis, dysentery, pyelonephritis, urethritis, pelvic inflammatory disease；Pathopyretic ulcer, lung abscess, acute appendicitis, venom.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent.Return lung meridian, Liver Channel.Effect and effect: heat-clearing and toxic substances removing, detumescence, removing heat in the liver for improving eyesight.Orally taken for curing furuncle carbuncle, conjunctival congestion and swelling pain, headache dizziness.
Herba Patriniae: cool in nature, acrid in the mouth, hardship.Return stomach warp, large intestine channel, Liver Channel.Effect and effect: heat-clearing and toxic substances removing, removing blood stasis and expelling pus.By appendicitis curing, dysentery, enteritis, hepatitis, eye conjunctivitis, postnatal blood stasis stomachache.
Herba Euphorbiae Humifusae: property is put down, bitter in the mouth, pungent.Return Liver Channel, large intestine channel.Effect and effect: heat-clearing and toxic substances removing, cooling blood for hemostasis.With control dysentery, enteritis, spitting of blood, hematuria, have blood in stool, metrorrhagia, furuncle carbuncle.Have antibacterial, stop blooding and the effect of neutralizing a toxin etc..
Folium Callicarpae Formosanae: cool in nature is bitter in the mouth, puckery.Return Liver Channel, lung meridian, stomach warp.Effect and effect: astringing to arrest bleeding, heat-clearing and toxic substances removing.With controlling various hemorrhages caused by heat in blood, especially preferable with digestive tract, respiratory tract hemorrhage effect；External treatment skin sore, venom；Pyretic toxicity laryngopharynx swelling and pain, conjunctival congestion and swelling pain etc..
Caulis Sargentodoxae: property is put down, bitter in the mouth.Return large intestine channel, Liver Channel.Effect and effect: heat-clearing and toxic substances removing, promoting blood circulation by removing wind, pain relieving.With controlling abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.
Myrrha: property is put down, acrid in the mouth, hardship.GUIXIN warp, Liver Channel, spleen channel.Effect and effect: dissipating blood stasis analgesic therapy, detumescence and promoting granulation.For obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, abdominal mass stomachache, rheumatic arthralgia, traumatic injury, carbuncle skin infection.
Semen Brassicae Campestris: property is put down, acrid in the mouth, sweet.Return Liver Channel, large intestine channel.Effect and effect: blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, loosening bowel to relieve constipation.Curing mainly prolonged lochia, abdominal pain due to blood stasis, dysmenorrhea, discharging fresh blood stool, dysentery, Fengshi Guanjie swells and ache, carbuncle erysipelas, acute mastitis, constipation, adhesive ileus.
Radix Rubiae: cold in nature, bitter in the mouth.Return Liver Channel.Effect and effect: removing heat from blood, hemostasis, blood stasis dispelling, stimulate the menstrual flow.Treatment haematemesis, epistaxis, metrorrhagia, traumatic hemorrhage, the resistance of amenorrhea block up, arthralgia, tumbling and swelling.
Pericarpium Granati: warm in nature is sour in the mouth, puckery.Return large intestine channel.Effect and effect: relieving diarrhea with astringents, hemostasis, anthelmintic.With control chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, metrorrhagia, leucorrhea, abdominal pain due to worm stagnation etc..
Catechu: cold nature is bitter in the mouth, puckery.Return lung meridian, heart channel.Effect and effect: removing dampness, granulation promoting, sore, hemostasis.With controlling ulcer being unable to heal, eczema, aphtha, falling and flutter the pain of injury, traumatic hemorrhage.
With prior art ratio, the invention have the benefit that
The present invention treats the Chinese medicinal enema of ulcerative colitis, using common Chinese medicine material as raw material, scientific formulation, preparation is simple, with low cost, and using enema agent so that active constituents of medicine can be done directly on diseased region, drug effect is notable, have no side effect, it is difficult to recurrence, there is effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis, detumescence and promoting granulation, can effectively treat ulcerative colitis.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
Embodiment 1A kind of Chinese medicinal enema treating ulcerative colitis, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from (every part takes 1g): Amaranthus spinosus L. 15 parts, Herba Hedyotidis Diffusae 15 parts, Flos Chrysanthemi Indici 10 parts, Herba Patriniae 10 parts, Herba Euphorbiae Humifusae 10 parts, Folium Callicarpae Formosanae 8 parts, Caulis Sargentodoxae 5 parts, Myrrha 5 parts, Semen Brassicae Campestris 5 parts, 2 parts of Radix Rubiae, Pericarpium Granati 2 parts, 1 part of catechu.
The preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis, step is as follows:
Step one: after Myrrha remove impurity, smashing to pieces, puts slow fire in pot and fries to after smoldering, the rice vinegar of spray raw materials quality 0.05 times, then fries when showing glossy gloss to surface, and taking-up cools, and is crushed to the fine powder of 200 mesh, standby；
Step 2: catechu is removed impurity, is crushed to the fine powder of 200 mesh, standby；
Step 3: Amaranthus spinosus L., Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Herba Patriniae, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, Caulis Sargentodoxae, Semen Brassicae Campestris, Radix Rubiae, Pericarpium Granati are cleaned respectively, dried, then one piece be crushed to the coarse powder of 20 mesh after, add the water soaking 40min of raw material weight 5 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 30min under the conditions of ultrasonic power 60W, obtain extracting solution, standby；
Step 4: the fine powder that step one and step 2 obtain is joined in the extracting solution of step 3, mix homogeneously, under the conditions of 80 DEG C after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtain the herbal enema preparation of the present invention.
Model case one:Liu xx, man, 26 years old.nullBefore 1 year, there is recurrent diarrhea without obvious inducement in patient，Stool every day 4-6 time，It mostly is brown completely mashed just，The a small amount of blood of even band or kermesinus liquid，Often companion's umbilicus week、Suffer from abdominal pain in lower-left，Occasionally there is middle upper abdominal pain，Stomachache can have respite after an action of the bowels，Exacerbation of symptoms after 1 month，Times of defecation increases earlier above，Accompany obvious tenesmus sense，Stomachache increases the weight of，Even companion's acid regurgitation、Feel sick、Dizzy，Without vomiting，Without fear of cold、Heating，After being admitted to hospital, row enteroscopy display ileocecal valve is lip-like，Ascending colon、Transverse colon、The obvious congestion and edema of descending colon，The most rotten to the corn，Surface irregularity，It is dispersed in multiple ulcers，Sigmoid colon、Mucous membrane of rectum congestion and edema，Companion's erosion，Submucosal blood vessel texture obscures，It is diagnosed as ulcerative colitis，Doctor gives the herbal drug enema in treatment in its embodiment of the present invention 1，Every day coloclysis 100mL，After one week treatment，Stomachache alleviates，Acid regurgitation、Feel sick、Dizziness disappears，Times of defecation and just middle pus and blood reduce，After continual cure 1 week，Times of defecation is normal，Just without pus and blood in，Stomachache and other malaise symptoms disappear，Cure，So far without recurrence.
Embodiment 2A kind of Chinese medicinal enema treating ulcerative colitis, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from (every part takes 1g): Amaranthus spinosus L. 25 parts, Herba Hedyotidis Diffusae 25 parts, Flos Chrysanthemi Indici 20 parts, Herba Patriniae 20 parts, Herba Euphorbiae Humifusae 20 parts, Folium Callicarpae Formosanae 16 parts, Caulis Sargentodoxae 15 parts, Myrrha 15 parts, Semen Brassicae Campestris 15 parts, 8 parts of Radix Rubiae, Pericarpium Granati 8 parts, 5 parts of catechu.
The preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis, step is as follows:
Step one: after Myrrha remove impurity, smashing to pieces, puts slow fire in pot and fries to after smoldering, the rice vinegar of spray raw materials quality 0.1 times, then fries when showing glossy gloss to surface, and taking-up cools, and is crushed to the fine powder of 200 mesh, standby；
Step 2: catechu is removed impurity, is crushed to the fine powder of 200 mesh, standby；
Step 3: Amaranthus spinosus L., Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Herba Patriniae, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, Caulis Sargentodoxae, Semen Brassicae Campestris, Radix Rubiae, Pericarpium Granati are cleaned respectively, dried, then one piece be crushed to the coarse powder of 20 mesh after, add the water soaking 60min of raw material weight 15 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 30-50min under the conditions of ultrasonic power 60W, obtain extracting solution, standby；
Step 4: the fine powder that step one and step 2 obtain is joined in the extracting solution of step 3, mix homogeneously, under the conditions of 80 DEG C after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtain the herbal enema preparation of the present invention.
Embodiment 3A kind of Chinese medicinal enema treating ulcerative colitis, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from (every part takes 1g): Amaranthus spinosus L. 18 parts, Herba Hedyotidis Diffusae 18 parts, Flos Chrysanthemi Indici 13 parts, Herba Patriniae 13 parts, Herba Euphorbiae Humifusae 13 parts, Folium Callicarpae Formosanae 10 parts, Caulis Sargentodoxae 8 parts, Myrrha 8 parts, Semen Brassicae Campestris 8 parts, 4 parts of Radix Rubiae, Pericarpium Granati 4 parts, 2 parts of catechu.
The preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis, step is as follows:
Step one: after Myrrha remove impurity, smashing to pieces, puts slow fire in pot and fries to after smoldering, the rice vinegar of spray raw materials quality 0.06 times, then fries when showing glossy gloss to surface, and taking-up cools, and is crushed to the fine powder of 200 mesh, standby；
Step 2: catechu is removed impurity, is crushed to the fine powder of 200 mesh, standby；
Step 3: Amaranthus spinosus L., Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Herba Patriniae, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, Caulis Sargentodoxae, Semen Brassicae Campestris, Radix Rubiae, Pericarpium Granati are cleaned respectively, dried, then one piece be crushed to the coarse powder of 20 mesh after, add the water soaking 45min of raw material weight 8 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 35min under the conditions of ultrasonic power 60W, obtain extracting solution, standby；
Step 4: the fine powder that step one and step 2 obtain is joined in the extracting solution of step 3, mix homogeneously, under the conditions of 80 DEG C after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtain the herbal enema preparation of the present invention.
Model case two:Wu xx, female, 56 years old.Patient's recurrent diarrhea, more than 20 years of passing stool with blood and pus, time when rushing down only, just in time have pus and blood, during stool without not well as, indigestion and loss of appetite, weak, lusterless complexion, become thin, light red tongue, tongue is white, and deficient pulse is unable, is diagnosed as ulcerative colitis.Use the Chinese medicinal enema in the embodiment of the present invention 1 to treat by doctor advised, adhere to treating after two weeks times of defecation and just in pus and blood minimizing, still have slight weak, indigestion and loss of appetite, after treating one month, malaise symptoms is wholly absent, recovery from illness, followed up a case by regular visits to after 2 years, without recurrence.
Embodiment 4A kind of Chinese medicinal enema treating ulcerative colitis, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from (every part takes 1g): Amaranthus spinosus L. 22 parts, Herba Hedyotidis Diffusae 22 parts, Flos Chrysanthemi Indici 17 parts, Herba Patriniae 17 parts, Herba Euphorbiae Humifusae 17 parts, Folium Callicarpae Formosanae 14 parts, Caulis Sargentodoxae 12 parts, Myrrha 12 parts, Semen Brassicae Campestris 12 parts, 6 parts of Radix Rubiae, Pericarpium Granati 6 parts, 4 parts of catechu.
The preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis, step is as follows:
Step one: after Myrrha remove impurity, smashing to pieces, puts slow fire in pot and fries to after smoldering, the rice vinegar of spray raw materials quality 0.08 times, then fries when showing glossy gloss to surface, and taking-up cools, and is crushed to the fine powder of 200 mesh, standby；
Step 2: catechu is removed impurity, is crushed to the fine powder of 200 mesh, standby；
Step 3: Amaranthus spinosus L., Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Herba Patriniae, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, Caulis Sargentodoxae, Semen Brassicae Campestris, Radix Rubiae, Pericarpium Granati are cleaned respectively, dried, then one piece be crushed to the coarse powder of 20 mesh after, add the water soaking 55min of raw material weight 12 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 45min under the conditions of ultrasonic power 60W, obtain extracting solution, standby；
Step 4: the fine powder that step one and step 2 obtain is joined in the extracting solution of step 3, mix homogeneously, under the conditions of 80 DEG C after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtain the herbal enema preparation of the present invention.
Embodiment 5A kind of Chinese medicinal enema treating ulcerative colitis, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from (every part takes 1g): Amaranthus spinosus L. 20 parts, Herba Hedyotidis Diffusae 20 parts, Flos Chrysanthemi Indici 15 parts, Herba Patriniae 15 parts, Herba Euphorbiae Humifusae 15 parts, Folium Callicarpae Formosanae 12 parts, Caulis Sargentodoxae 10 parts, Myrrha 10 parts, Semen Brassicae Campestris 10 parts, 5 parts of Radix Rubiae, Pericarpium Granati 5 parts, 3 parts of catechu.
The preparation method of the Chinese medicinal enema of above-mentioned treatment ulcerative colitis, step is as follows:
Step one: after Myrrha remove impurity, smashing to pieces, puts slow fire in pot and fries to after smoldering, the rice vinegar of spray raw materials quality 0.07 times, then fries when showing glossy gloss to surface, and taking-up cools, and is crushed to the fine powder of 200 mesh, standby；
Step 2: catechu is removed impurity, is crushed to the fine powder of 200 mesh, standby；
Step 3: Amaranthus spinosus L., Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Herba Patriniae, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, Caulis Sargentodoxae, Semen Brassicae Campestris, Radix Rubiae, Pericarpium Granati are cleaned respectively, dried, then one piece be crushed to the coarse powder of 20 mesh after, add the water soaking 50min of raw material weight 5-15 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 40min under the conditions of ultrasonic power 60W, obtain extracting solution, standby；
Step 4: the fine powder that step one and step 2 obtain is joined in the extracting solution of step 3, mix homogeneously, under the conditions of 80 DEG C after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtain the herbal enema preparation of the present invention.
Experimental example:1, selection of clinical: in order to verify that the present invention treats the effect of the Chinese medicinal enema of ulcerative colitis, we have extracted 200 patients and have carried out the experiment of medicine, are randomly divided into two groups.Matched group 100 example, male 54 examples, female 46 example；Minimum 22 years old of age, maximum 68 years old, average (35.6 ± 3.5) year；The course of disease 5～14 years, average (9.4 ± 2.1) year.Experimental group 100 example, male 47 examples, female 53 example；Minimum 25 years old of age, maximum 66 years old, average (38.1 ± 3.4) year；The course of disease 5.5～15 years, average (9.5 ± 2.0) year.Two groups there was no significant difference through statistical analysis at aspects such as age, sex, clinical manifestations, have comparability.
2, diagnostic criteria: with loose stool, mucus bloody purulent stool, abdominal part distending pain discomfort as primary symptom.Made a definite diagnosis through fibro-colonoscope, stool for routine inspection, and got rid of Malignant gastrointestinal pathological changes, get rid of and affected gastrointestinal disease by liver, pancreas etc..
3, Therapeutic Method:
Experimental group: using the herbal enema preparation for treating treating ulcerative colitis in the embodiment of the present invention 5, early, evening, the most each 50mL, during coloclysis, fluid temperature was advisable with 37-39 DEG C, takes left lateral position 30min, and treatment cycle is 1 month.
Matched group: Azulfidine Suppository is treated, rectally, each with one after morning every day, late defecation, treatment cycle is 1 month.
4, curative effect situation criterion: can inflammatory bowel cooperative groups " National Consensus to China's diagnosis status of inflammatory bowel disease treatment specification " formulation standard in 2007 pass judgment on reference to Chinese Medical Association's disease for digest credit.Curing: clinical symptom disappearance, colonoscope check finds that mucosa is the most normal.Effective: clinical symptoms disappears substantially, colonoscope check finds that mucosa mild inflammation or pseudopolyp are formed.Invalid: after treatment, clinical symptoms, scope and pathological examination results are all without improving.
Accurately the data of two groups of experiments are added up and mathematical analysis, obtain specific experiment result such as following table:
Clinical tests prove that, the total effective rate of Chinese medicinal enema of the present invention treatment ulcerative colitis is 98%, treats compared with effect of this disease with Azulfidine Suppository, there is drug effect notable, have no side effect, drug safety, the advantage being difficult to recurrence, can effectively treat ulcerative colitis.
Claims (8)
1. the Chinese medicinal enema treating ulcerative colitis, it is characterised in that: take off and state the raw material of Chinese medicine of weight proportion and be prepared from: Amaranthus spinosus L. 15-25 part, Herba Hedyotidis Diffusae 15-25 part, Flos Chrysanthemi Indici 10-20 part, Herba Patriniae 10-20 part, Herba Euphorbiae Humifusae 10-20 part, Folium Callicarpae Formosanae 8-16 part, Caulis Sargentodoxae 5-15 part, Myrrha 5-15 part, Semen Brassicae Campestris 5-15 part, Radix Rubiae 2-8 part, Pericarpium Granati 2-8 part, catechu 1-5 part.
A kind of Chinese medicinal enema treating ulcerative colitis the most according to claim 1, it is characterised in that: take off and state the raw material of Chinese medicine of weight proportion and be prepared from: Amaranthus spinosus L. 18-22 part, Herba Hedyotidis Diffusae 18-22 part, Flos Chrysanthemi Indici 13-17 part, Herba Patriniae 13-17 part, Herba Euphorbiae Humifusae 13-17 part, Folium Callicarpae Formosanae 10-14 part, Caulis Sargentodoxae 8-12 part, Myrrha 8-12 part, Semen Brassicae Campestris 8-12 part, Radix Rubiae 4-6 part, Pericarpium Granati 4-6 part, catechu 2-4 part.
A kind of Chinese medicinal enema treating ulcerative colitis the most according to claim 1, it is characterised in that: take off and state the raw material of Chinese medicine of weight proportion and be prepared from: Amaranthus spinosus L. 20 parts, Herba Hedyotidis Diffusae 20 parts, Flos Chrysanthemi Indici 15 parts, Herba Patriniae 15 parts, Herba Euphorbiae Humifusae 15 parts, Folium Callicarpae Formosanae 12 parts, Caulis Sargentodoxae 10 parts, Myrrha 10 parts, Semen Brassicae Campestris 10 parts, 5 parts of Radix Rubiae, Pericarpium Granati 5 parts, 3 parts of catechu.
4. the preparation method according to the Chinese medicinal enema of the treatment ulcerative colitis described in any one of claim 1-3, it is characterised in that: step is as follows:
Step one: after Myrrha remove impurity, smashing to pieces, puts slow fire in pot and fries to after smoldering, the rice vinegar of spray raw materials quality 0.05-0.1 times, then fries when showing glossy gloss to surface, and taking-up cools, and is crushed to the fine powder of 200 mesh, standby；
Step 2: catechu is removed impurity, is crushed to the fine powder of 200 mesh, standby；
Step 3: Amaranthus spinosus L., Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici, Herba Patriniae, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, Caulis Sargentodoxae, Semen Brassicae Campestris, Radix Rubiae, Pericarpium Granati are cleaned respectively, dried, then one piece be crushed to the coarse powder of 20 mesh after, add the water soaking 40-60min of raw material weight 5-15 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 30-50min under the conditions of ultrasonic power 60W, obtain extracting solution, standby；
Step 4: the fine powder that step one and step 2 obtain is joined in the extracting solution of step 3, mix homogeneously, under the conditions of 80 DEG C after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtain the herbal enema preparation of the present invention.
The preparation method of a kind of Chinese medicinal enema treating ulcerative colitis the most according to claim 4, it is characterised in that: step one sprays the rice vinegar of raw materials quality 0.06-0.08 times.
The preparation method of a kind of Chinese medicinal enema treating ulcerative colitis the most according to claim 5, it is characterised in that: step one sprays the rice vinegar of raw materials quality 0.07 times.
The preparation method of a kind of Chinese medicinal enema treating ulcerative colitis the most according to claim 4, it is characterized in that: step 3 will be crushed in the coarse powder of 20 mesh add the water soaking 45-55min of raw material weight 8-12 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 35-45min under the conditions of ultrasonic power 60W, obtain extracting solution.
The preparation method of a kind of Chinese medicinal enema treating ulcerative colitis the most according to claim 7, it is characterized in that: step 3 will be crushed in the coarse powder of 20 mesh add the water soaking 50min of raw material weight 10 times, it is subsequently placed in ultrasonic container, ultrasonic temperature 50 DEG C, after extracting 40min under the conditions of ultrasonic power 60W, obtain extracting solution.
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