CN102256952B - 用作葡萄糖激酶激活剂的芳基环丙基乙酰胺衍生物 - Google Patents
用作葡萄糖激酶激活剂的芳基环丙基乙酰胺衍生物 Download PDFInfo
- Publication number
- CN102256952B CN102256952B CN200980150686XA CN200980150686A CN102256952B CN 102256952 B CN102256952 B CN 102256952B CN 200980150686X A CN200980150686X A CN 200980150686XA CN 200980150686 A CN200980150686 A CN 200980150686A CN 102256952 B CN102256952 B CN 102256952B
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- China
- Prior art keywords
- compound
- acceptable salt
- glucose
- pharmaceutically acceptable
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08380341.1 | 2008-12-19 | ||
| EP08380341 | 2008-12-19 | ||
| US15378109P | 2009-02-19 | 2009-02-19 | |
| US61/153,781 | 2009-02-19 | ||
| PCT/US2009/067603 WO2010080333A1 (en) | 2008-12-19 | 2009-12-11 | Arylcyclopropylacetamide derivatives useful as glucokinase activators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102256952A CN102256952A (zh) | 2011-11-23 |
| CN102256952B true CN102256952B (zh) | 2013-12-11 |
Family
ID=40545955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980150686XA Active CN102256952B (zh) | 2008-12-19 | 2009-12-11 | 用作葡萄糖激酶激活剂的芳基环丙基乙酰胺衍生物 |
Country Status (34)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| WO2015075942A1 (ja) * | 2013-11-22 | 2015-05-28 | 国立大学法人 東京大学 | 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004063179A1 (en) * | 2003-01-06 | 2004-07-29 | Eli Lilly And Company | Substituted arylcyclopropylacetamides as glucokinase activators |
| WO2006058923A1 (en) * | 2004-12-03 | 2006-06-08 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
| WO2007051847A1 (en) * | 2005-11-03 | 2007-05-10 | Prosidion Ltd | Tricyclo substituted amides as glucokinase modulators |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1282612B1 (en) | 2000-05-03 | 2004-12-29 | F. Hoffmann-La Roche Ag | Alkynyl phenyl heteroaromatic glucokinase activators |
| BR0110704A (pt) | 2000-05-08 | 2003-01-28 | Hoffmann La Roche | Fenil - acetamidas substituìdas e seu uso como ativadores de glicocinase |
| MXPA02010795A (es) | 2000-05-08 | 2003-03-27 | Hoffmann La Roche | Activadores de glucocinasa de fenilamida sustituida por para-amino. |
| MY141521A (en) * | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
| JP4621198B2 (ja) | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ（シクロ）置換アミドグルコキナーゼ活性化化合物 |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| WO2004076420A1 (ja) * | 2003-02-26 | 2004-09-10 | Banyu Pharmaceutical Co., Ltd. | ヘテロアリールカルバモイルベンゼン誘導体 |
| EA012204B1 (ru) | 2004-04-21 | 2009-08-28 | Прозидион Лимитед | Три(цикло)замещённые амидные соединения |
| MX2007001650A (es) | 2004-08-12 | 2007-07-13 | Prosidion Ltd | Fenilacetamidas substituidas y su uso como activadores de glucocinasa. |
| BRPI0612582A2 (pt) | 2005-07-01 | 2010-11-23 | Novartis Ag | combinação de compostos orgánicos |
| RU2420525C2 (ru) | 2005-07-11 | 2011-06-10 | Мицубиси Танабе Фарма Корпорейшн | Производные оксимов и их получение |
| WO2007017649A1 (en) * | 2005-08-09 | 2007-02-15 | Astrazeneca Ab | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
| CA2626475A1 (en) | 2005-11-03 | 2007-05-10 | Prosidion Limited | Tricyclo substituted amides |
| JP2009514836A (ja) | 2005-11-03 | 2009-04-09 | プロシディオン・リミテッド | トリシクロ置換型アミド |
| JP2009544648A (ja) * | 2006-07-24 | 2009-12-17 | エフ．ホフマン−ラ ロシュ アーゲー | グルコキナーゼ活性化剤としてのピラゾール類 |
| WO2008084872A1 (ja) * | 2007-01-10 | 2008-07-17 | Mitsubishi Tanabe Pharma Corporation | ヒドラゾン誘導体 |
| CN102089291B (zh) | 2008-04-28 | 2016-08-17 | 杏林制药株式会社 | 环戊基丙烯酰胺衍生物 |
-
2009
- 2009-11-12 UA UAA201107562A patent/UA104742C2/uk unknown
- 2009-12-03 PA PA20098851901A patent/PA8851901A1/es unknown
- 2009-12-03 AR ARP090104672A patent/AR074470A1/es active IP Right Grant
- 2009-12-04 TW TW098141556A patent/TWI395748B/zh active
- 2009-12-06 JO JO2009467A patent/JO2979B1/en active
- 2009-12-11 MX MX2011006434A patent/MX2011006434A/es active IP Right Grant
- 2009-12-11 MY MYPI2011002765A patent/MY180567A/en unknown
- 2009-12-11 PT PT97683163T patent/PT2379517E/pt unknown
- 2009-12-11 PL PL09768316T patent/PL2379517T3/pl unknown
- 2009-12-11 KR KR1020117014073A patent/KR101290437B1/ko not_active Expired - Fee Related
- 2009-12-11 CA CA2746746A patent/CA2746746C/en active Active
- 2009-12-11 SI SI200930713T patent/SI2379517T1/sl unknown
- 2009-12-11 PE PE2011001220A patent/PE20120339A1/es active IP Right Grant
- 2009-12-11 ES ES09768316T patent/ES2435242T3/es active Active
- 2009-12-11 BR BRPI0923183-8A patent/BRPI0923183B1/pt not_active IP Right Cessation
- 2009-12-11 DK DK09768316.3T patent/DK2379517T3/da active
- 2009-12-11 AU AU2009335931A patent/AU2009335931B2/en not_active Ceased
- 2009-12-11 NZ NZ592930A patent/NZ592930A/xx not_active IP Right Cessation
- 2009-12-11 US US12/635,758 patent/US8063079B2/en active Active
- 2009-12-11 EP EP09768316.3A patent/EP2379517B1/en active Active
- 2009-12-11 CN CN200980150686XA patent/CN102256952B/zh active Active
- 2009-12-11 SG SG2011044823A patent/SG172256A1/en unknown
- 2009-12-11 JP JP2011542276A patent/JP5497064B2/ja active Active
- 2009-12-11 WO PCT/US2009/067603 patent/WO2010080333A1/en not_active Ceased
- 2009-12-11 HR HRP20130983AT patent/HRP20130983T1/hr unknown
- 2009-12-11 EA EA201170845A patent/EA019055B1/ru not_active IP Right Cessation
-
2011
- 2011-05-27 ZA ZA2011/03944A patent/ZA201103944B/en unknown
- 2011-05-30 IL IL213210A patent/IL213210A/en active IP Right Grant
- 2011-06-09 TN TN2011000294A patent/TN2011000294A1/fr unknown
- 2011-06-14 MA MA33945A patent/MA32902B1/fr unknown
- 2011-06-17 CR CR20110342A patent/CR20110342A/es unknown
- 2011-06-17 DO DO2011000197A patent/DOP2011000197A/es unknown
- 2011-06-17 EC EC2011011150A patent/ECSP11011150A/es unknown
- 2011-06-23 CO CO11079303A patent/CO6382120A2/es active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004063179A1 (en) * | 2003-01-06 | 2004-07-29 | Eli Lilly And Company | Substituted arylcyclopropylacetamides as glucokinase activators |
| WO2006058923A1 (en) * | 2004-12-03 | 2006-06-08 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
| WO2007051847A1 (en) * | 2005-11-03 | 2007-05-10 | Prosidion Ltd | Tricyclo substituted amides as glucokinase modulators |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |