AU2009335931B2 - Arylcyclopropylacetamide derivatives useful as glucokinase activators - Google Patents

Arylcyclopropylacetamide derivatives useful as glucokinase activators Download PDF

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Publication number
AU2009335931B2
AU2009335931B2 AU2009335931A AU2009335931A AU2009335931B2 AU 2009335931 B2 AU2009335931 B2 AU 2009335931B2 AU 2009335931 A AU2009335931 A AU 2009335931A AU 2009335931 A AU2009335931 A AU 2009335931A AU 2009335931 B2 AU2009335931 B2 AU 2009335931B2
Authority
AU
Australia
Prior art keywords
pharmaceutically acceptable
acceptable salt
diabetes
compound
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009335931A
Other languages
English (en)
Other versions
AU2009335931A1 (en
Inventor
Francisco Javier Agejas-Chicharro
Ana Belen Bueno Melendo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2009335931A1 publication Critical patent/AU2009335931A1/en
Application granted granted Critical
Publication of AU2009335931B2 publication Critical patent/AU2009335931B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2009335931A 2008-12-19 2009-12-11 Arylcyclopropylacetamide derivatives useful as glucokinase activators Ceased AU2009335931B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08380341.1 2008-12-19
EP08380341 2008-12-19
US15378109P 2009-02-19 2009-02-19
US61/153,781 2009-02-19
PCT/US2009/067603 WO2010080333A1 (en) 2008-12-19 2009-12-11 Arylcyclopropylacetamide derivatives useful as glucokinase activators

Publications (2)

Publication Number Publication Date
AU2009335931A1 AU2009335931A1 (en) 2011-07-07
AU2009335931B2 true AU2009335931B2 (en) 2012-05-31

Family

ID=40545955

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009335931A Ceased AU2009335931B2 (en) 2008-12-19 2009-12-11 Arylcyclopropylacetamide derivatives useful as glucokinase activators

Country Status (34)

Country Link
US (1) US8063079B2 (cg-RX-API-DMAC10.html)
EP (1) EP2379517B1 (cg-RX-API-DMAC10.html)
JP (1) JP5497064B2 (cg-RX-API-DMAC10.html)
KR (1) KR101290437B1 (cg-RX-API-DMAC10.html)
CN (1) CN102256952B (cg-RX-API-DMAC10.html)
AR (1) AR074470A1 (cg-RX-API-DMAC10.html)
AU (1) AU2009335931B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0923183B1 (cg-RX-API-DMAC10.html)
CA (1) CA2746746C (cg-RX-API-DMAC10.html)
CO (1) CO6382120A2 (cg-RX-API-DMAC10.html)
CR (1) CR20110342A (cg-RX-API-DMAC10.html)
DK (1) DK2379517T3 (cg-RX-API-DMAC10.html)
DO (1) DOP2011000197A (cg-RX-API-DMAC10.html)
EA (1) EA019055B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP11011150A (cg-RX-API-DMAC10.html)
ES (1) ES2435242T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20130983T1 (cg-RX-API-DMAC10.html)
IL (1) IL213210A (cg-RX-API-DMAC10.html)
JO (1) JO2979B1 (cg-RX-API-DMAC10.html)
MA (1) MA32902B1 (cg-RX-API-DMAC10.html)
MX (1) MX2011006434A (cg-RX-API-DMAC10.html)
MY (1) MY180567A (cg-RX-API-DMAC10.html)
NZ (1) NZ592930A (cg-RX-API-DMAC10.html)
PA (1) PA8851901A1 (cg-RX-API-DMAC10.html)
PE (1) PE20120339A1 (cg-RX-API-DMAC10.html)
PL (1) PL2379517T3 (cg-RX-API-DMAC10.html)
PT (1) PT2379517E (cg-RX-API-DMAC10.html)
SG (1) SG172256A1 (cg-RX-API-DMAC10.html)
SI (1) SI2379517T1 (cg-RX-API-DMAC10.html)
TN (1) TN2011000294A1 (cg-RX-API-DMAC10.html)
TW (1) TWI395748B (cg-RX-API-DMAC10.html)
UA (1) UA104742C2 (cg-RX-API-DMAC10.html)
WO (1) WO2010080333A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201103944B (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2800498C (en) 2010-03-31 2021-11-16 The Scripps Research Institute Reprogramming cells
WO2015075942A1 (ja) * 2013-11-22 2015-05-28 国立大学法人 東京大学 薬剤送達用のキャリア、コンジュゲートおよびこれらを含んでなる組成物並びにこれらの投与方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058923A1 (en) * 2004-12-03 2006-06-08 Novo Nordisk A/S Heteroaromatic glucokinase activators

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1282612B1 (en) 2000-05-03 2004-12-29 F. Hoffmann-La Roche Ag Alkynyl phenyl heteroaromatic glucokinase activators
BR0110704A (pt) 2000-05-08 2003-01-28 Hoffmann La Roche Fenil - acetamidas substituìdas e seu uso como ativadores de glicocinase
MXPA02010795A (es) 2000-05-08 2003-03-27 Hoffmann La Roche Activadores de glucocinasa de fenilamida sustituida por para-amino.
MY141521A (en) * 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
WO2004063179A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Substituted arylcyclopropylacetamides as glucokinase activators
JP4621198B2 (ja) 2003-02-11 2011-01-26 プロシディオン・リミテッド トリ（シクロ）置換アミドグルコキナーゼ活性化化合物
PL378117A1 (pl) 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
WO2004076420A1 (ja) * 2003-02-26 2004-09-10 Banyu Pharmaceutical Co., Ltd. ヘテロアリールカルバモイルベンゼン誘導体
EA012204B1 (ru) 2004-04-21 2009-08-28 Прозидион Лимитед Три(цикло)замещённые амидные соединения
MX2007001650A (es) 2004-08-12 2007-07-13 Prosidion Ltd Fenilacetamidas substituidas y su uso como activadores de glucocinasa.
BRPI0612582A2 (pt) 2005-07-01 2010-11-23 Novartis Ag combinação de compostos orgánicos
RU2420525C2 (ru) 2005-07-11 2011-06-10 Мицубиси Танабе Фарма Корпорейшн Производные оксимов и их получение
WO2007017649A1 (en) * 2005-08-09 2007-02-15 Astrazeneca Ab Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes
CA2626475A1 (en) 2005-11-03 2007-05-10 Prosidion Limited Tricyclo substituted amides
US20080293741A1 (en) 2005-11-03 2008-11-27 Matthew Colin Thor Fyfe Tricyclo Substituted Amides as Glucokinase Modulators
JP2009514836A (ja) 2005-11-03 2009-04-09 プロシディオン・リミテッド トリシクロ置換型アミド
JP2009544648A (ja) * 2006-07-24 2009-12-17 エフ．ホフマン−ラ ロシュ アーゲー グルコキナーゼ活性化剤としてのピラゾール類
WO2008084872A1 (ja) * 2007-01-10 2008-07-17 Mitsubishi Tanabe Pharma Corporation ヒドラゾン誘導体
CN102089291B (zh) 2008-04-28 2016-08-17 杏林制药株式会社 环戊基丙烯酰胺衍生物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058923A1 (en) * 2004-12-03 2006-06-08 Novo Nordisk A/S Heteroaromatic glucokinase activators

Also Published As

Publication number Publication date
UA104742C2 (uk) 2014-03-11
EP2379517A1 (en) 2011-10-26
CR20110342A (es) 2011-09-14
EA201170845A1 (ru) 2011-12-30
BRPI0923183A8 (pt) 2017-09-12
KR101290437B1 (ko) 2013-07-29
EP2379517B1 (en) 2013-08-28
IL213210A (en) 2015-03-31
US8063079B2 (en) 2011-11-22
CN102256952B (zh) 2013-12-11
BRPI0923183A2 (pt) 2016-02-16
CA2746746C (en) 2013-09-24
DOP2011000197A (es) 2011-09-15
ES2435242T3 (es) 2013-12-17
ECSP11011150A (es) 2011-07-29
TWI395748B (zh) 2013-05-11
JP2012512874A (ja) 2012-06-07
PE20120339A1 (es) 2012-04-16
MY180567A (en) 2020-12-02
PL2379517T3 (pl) 2014-01-31
KR20110086751A (ko) 2011-07-29
ZA201103944B (en) 2012-11-28
WO2010080333A1 (en) 2010-07-15
US20100160395A1 (en) 2010-06-24
EA019055B1 (ru) 2013-12-30
BRPI0923183B1 (pt) 2019-03-19
HRP20130983T1 (hr) 2013-11-22
TW201029999A (en) 2010-08-16
MX2011006434A (es) 2011-07-19
MA32902B1 (fr) 2011-12-01
AU2009335931A1 (en) 2011-07-07
NZ592930A (en) 2013-01-25
DK2379517T3 (da) 2013-09-30
SG172256A1 (en) 2011-07-28
IL213210A0 (en) 2011-07-31
PA8851901A1 (es) 2010-07-27
AR074470A1 (es) 2011-01-19
TN2011000294A1 (en) 2012-12-17
CO6382120A2 (es) 2012-02-15
JP5497064B2 (ja) 2014-05-21
CA2746746A1 (en) 2010-07-15
SI2379517T1 (sl) 2013-10-30
CN102256952A (zh) 2011-11-23
PT2379517E (pt) 2013-11-21
JO2979B1 (en) 2016-03-15

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired