CN102245202A - 含有突变型h因子结合蛋白的疫苗组合物 - Google Patents

含有突变型h因子结合蛋白的疫苗组合物 Download PDF

Info

Publication number
CN102245202A
CN102245202A CN2009801480003A CN200980148000A CN102245202A CN 102245202 A CN102245202 A CN 102245202A CN 2009801480003 A CN2009801480003 A CN 2009801480003A CN 200980148000 A CN200980148000 A CN 200980148000A CN 102245202 A CN102245202 A CN 102245202A
Authority
CN
China
Prior art keywords
factor
composition
binding protein
immune response
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801480003A
Other languages
English (en)
Chinese (zh)
Inventor
R·埃克斯利
C·唐
S·M·利亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ip2ipo Innovations Ltd
Original Assignee
Imperial Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Innovations Ltd filed Critical Imperial Innovations Ltd
Priority to CN201510119007.XA priority Critical patent/CN105412920A/zh
Publication of CN102245202A publication Critical patent/CN102245202A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801480003A 2008-10-25 2009-10-26 含有突变型h因子结合蛋白的疫苗组合物 Pending CN102245202A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510119007.XA CN105412920A (zh) 2008-10-25 2009-10-26 含有突变型ｈ因子结合蛋白的疫苗组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0819633.9A GB0819633D0 (en) 2008-10-25 2008-10-25 Composition
GB0819633.9 2008-10-25
PCT/GB2009/051439 WO2010046715A1 (en) 2008-10-25 2009-10-26 Vaccine compositions comprising a mutated factor h binding protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510119007.XA Division CN105412920A (zh) 2008-10-25 2009-10-26 含有突变型ｈ因子结合蛋白的疫苗组合物

Publications (1)

Publication Number Publication Date
CN102245202A true CN102245202A (zh) 2011-11-16

Family

ID=40133849

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2009801480003A Pending CN102245202A (zh) 2008-10-25 2009-10-26 含有突变型h因子结合蛋白的疫苗组合物
CN201510119007.XA Pending CN105412920A (zh) 2008-10-25 2009-10-26 含有突变型ｈ因子结合蛋白的疫苗组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510119007.XA Pending CN105412920A (zh) 2008-10-25 2009-10-26 含有突变型ｈ因子结合蛋白的疫苗组合物

Country Status (23)

Country Link
US (1) US20120052092A1 (enExample)
EP (2) EP2355845B1 (enExample)
JP (2) JP5676458B2 (enExample)
KR (3) KR20190011836A (enExample)
CN (2) CN102245202A (enExample)
AU (1) AU2009306114B2 (enExample)
BR (1) BRPI0919926A2 (enExample)
CA (1) CA2741619A1 (enExample)
CO (1) CO6382140A2 (enExample)
DK (1) DK3501534T5 (enExample)
ES (1) ES2970878T3 (enExample)
FI (1) FI3501534T3 (enExample)
GB (1) GB0819633D0 (enExample)
HR (1) HRP20240226T1 (enExample)
HU (1) HUE065348T2 (enExample)
LT (1) LT3501534T (enExample)
MX (1) MX2011004322A (enExample)
NZ (2) NZ601538A (enExample)
PL (1) PL3501534T3 (enExample)
PT (1) PT3501534T (enExample)
RU (1) RU2559528C2 (enExample)
SI (1) SI3501534T1 (enExample)
WO (1) WO2010046715A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074939A (zh) * 2014-08-20 2017-08-18 桑昆血液供给基金会 H因子增强抗体及其用途

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100379757C (zh) 1998-05-01 2008-04-09 希龙公司 脑膜炎奈瑟球菌抗原和组合物
BR0010721A (pt) 1999-05-19 2002-06-11 Chiron Spa Composições de neisserias combinadas
PT2275551E (pt) 1999-10-29 2015-06-29 Novartis Vaccines & Diagnostic Péptidos antigénicos de neisseria
ES2281409T3 (es) 2000-02-28 2007-10-01 Novartis Vaccines And Diagnostics S.R.L. Expresion heterologa de proteinas de neisseria.
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
DK2353608T3 (da) 2002-10-11 2020-02-10 Novartis Vaccines And Diagnostics S R L Polypeptid-vacciner til bred beskyttelse mod hypervirulente meningokok-linjer
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
WO2009104097A2 (en) 2008-02-21 2009-08-27 Novartis Ag Meningococcal fhbp polypeptides
AU2009223613B2 (en) 2008-03-10 2014-09-25 Children's Hospital & Research Center At Oakland Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use
CA2756522C (en) 2009-03-24 2018-06-26 Novartis Ag Adjuvanting meningococcal factor h binding protein
WO2010127172A2 (en) 2009-04-30 2010-11-04 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) and methods of use
US20130022633A1 (en) * 2009-10-27 2013-01-24 University Of Florence MENINGOCOCCAL fHBP POLYPEPTIDES
JP2013521326A (ja) * 2010-03-10 2013-06-10 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
BR122021020829B8 (pt) * 2010-03-30 2022-12-27 Children´S Hospital & Res Center At Oakland Proteína de ligação ao fator h de ocorrência não natural (fhbp), composição, e célula hospedeira de neisseria meningitidis geneticamente modificada
US10478483B2 (en) 2010-06-25 2019-11-19 Glaxosmithkline Biologicals Sa Combinations of meningococcal factor H binding proteins
BR112014019166A2 (pt) 2012-02-02 2017-07-04 Novartis Ag promotores para expressão aumentada de proteína em meningococos
WO2013186753A1 (en) 2012-06-14 2013-12-19 Novartis Ag Vaccines for serogroup x meningococcus
HK1205138A1 (en) 2012-07-27 2015-12-11 Institut National De La Santé Et De La Recherche Médicale (Inserm) Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
US20160030544A1 (en) * 2013-03-14 2016-02-04 Isis Innovation Limited Immunogenic composition to neisseria
BR112016002150A2 (pt) 2013-08-02 2017-09-12 Children´S Hospital & Res Center At Oakland proteínas de ligação de fator h de ocorrência natural (fhbp) e métodos de uso das mesmas
AU2015222121B2 (en) 2014-02-28 2018-01-18 Glaxosmithkline Biologicals Sa Modified meningococcal fHbp polypeptides
KR102761870B1 (ko) 2014-07-23 2025-02-05 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 인자 h 결합 단백질 변이체 및 이의 사용 방법
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
MX2021007539A (es) 2018-12-21 2021-09-21 Univ Griffith Composiciones, metodos y usos para provocar una respuesta inmune.
CA3147314A1 (en) * 2019-07-08 2021-01-14 J. McLeod GRIFFISS Methods of making and using lipooligosaccharide compositions and vaccines
BR112022000739A2 (pt) 2019-07-17 2022-04-12 Gemini Therapeutics Sub Inc Anticorpos de potencialização de fator h e usos dos mesmos
CA3211240A1 (en) 2021-02-19 2022-08-25 Sanofi Pasteur Inc. Meningococcal b recombinant vaccine
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87104828A (zh) * 1986-06-18 1988-05-04 斯克里普斯临床学与研究基金会 用作疫苗和诊断标记的淋病奈瑟氏菌植物凝血素及其制备方法
CN1124456A (zh) * 1993-04-06 1996-06-12 波士顿市健康与医院理事会 淋球菌抗个体基因型抗体及其使用方法和组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
KR20060019515A (ko) * 2003-04-16 2006-03-03 와이어쓰 홀딩스 코포레이션 수막구균 질환의 예방 및 치료용 신규 면역원성 조성물
SI2682126T1 (sl) * 2005-01-27 2017-03-31 Children's Hospital & Research Center At Oakland Cepiva na osnovi veziklov, osnovanih na GNA1870, za širokospektralno zaščito proti boleznim, povzročenim z Neisserio meningitidisom
GB0524066D0 (en) * 2005-11-25 2006-01-04 Chiron Srl 741 ii
CA2656474A1 (en) * 2006-06-29 2008-01-03 Novartis Ag Polypeptides from neisseria meningitidis
CN102596240B (zh) * 2009-08-27 2015-02-04 诺华股份有限公司 包括脑膜炎球菌fHBP序列的杂交多肽
BR122021020829B8 (pt) * 2010-03-30 2022-12-27 Children´S Hospital & Res Center At Oakland Proteína de ligação ao fator h de ocorrência não natural (fhbp), composição, e célula hospedeira de neisseria meningitidis geneticamente modificada

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87104828A (zh) * 1986-06-18 1988-05-04 斯克里普斯临床学与研究基金会 用作疫苗和诊断标记的淋病奈瑟氏菌植物凝血素及其制备方法
CN1124456A (zh) * 1993-04-06 1996-06-12 波士顿市健康与医院理事会 淋球菌抗个体基因型抗体及其使用方法和组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VEGA MASIGNANI等: "Vaccination against Neisseria meningitidis using three variants of the Lipoprotein GNA1870", 《J.EXP.MED》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074939A (zh) * 2014-08-20 2017-08-18 桑昆血液供给基金会 H因子增强抗体及其用途
CN107074939B (zh) * 2014-08-20 2021-09-07 桑昆血液供给基金会 H因子增强抗体及其用途

Also Published As

Publication number Publication date
DK3501534T3 (da) 2024-02-05
ES2970878T3 (es) 2024-05-31
JP2015063558A (ja) 2015-04-09
EP2355845B1 (en) 2018-12-05
GB0819633D0 (en) 2008-12-03
NZ601538A (en) 2014-01-31
AU2009306114A1 (en) 2010-04-29
RU2011120706A (ru) 2012-11-27
CA2741619A1 (en) 2010-04-29
LT3501534T (lt) 2024-03-12
FI3501534T3 (fi) 2024-02-09
NZ592444A (en) 2012-11-30
MX2011004322A (es) 2011-06-16
KR20170000390A (ko) 2017-01-02
KR20190011836A (ko) 2019-02-07
BRPI0919926A2 (pt) 2016-02-16
JP6076326B2 (ja) 2017-02-08
CN105412920A (zh) 2016-03-23
CO6382140A2 (es) 2012-02-15
HUE065348T2 (hu) 2024-05-28
JP2012506411A (ja) 2012-03-15
JP5676458B2 (ja) 2015-02-25
RU2559528C2 (ru) 2015-08-10
US20120052092A1 (en) 2012-03-01
EP3501534A1 (en) 2019-06-26
PT3501534T (pt) 2024-02-07
EP2355845A1 (en) 2011-08-17
AU2009306114B2 (en) 2015-10-01
SI3501534T1 (sl) 2024-03-29
PL3501534T3 (pl) 2024-04-02
HRP20240226T1 (hr) 2024-05-10
WO2010046715A1 (en) 2010-04-29
EP3501534B1 (en) 2023-11-29
KR20110092282A (ko) 2011-08-17
DK3501534T5 (da) 2024-09-02

Similar Documents

Publication Publication Date Title
CN102245202A (zh) 含有突变型h因子结合蛋白的疫苗组合物
JP5215275B2 (ja) 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物
JP6494565B2 (ja) オリゴマー特異アミロイドベータエピトープおよび抗体
EA012407B1 (ru) Гуманизированный иммуноглобулин, который специфически связывается с бета-амилоидным пептидом, и способы его применения
Granoff et al. A novel mimetic antigen eliciting protective antibody to Neisseria meningitidis
US20140127215A1 (en) Clostridium difficile antigens
US11319348B2 (en) Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers
CA3076250A1 (en) Compounds to inhibit bacterial s-layer protein assembly
CN111647569B (zh) AT-CoaR6融合蛋白及在制备抗金葡菌感染的双组分疫苗中的应用
Park et al. Anti-idiotypic antibody as a potential candidate vaccine for Neisseria meningitidis serogroup B
US9913889B2 (en) Immunogenic TP0751 fragments
Lambert Identification and Description of Burkholderia pseudomallei Proteins that Bind Host Complement-Regulatory Proteins via in silico and in vitro Analyses
Kumru Surface localization determinants of Borrelia burgdorferi lipoproteins
EP3450556B1 (en) Peptide inhibiting colonization by pathogenic bacteria, and colonization inhibitor including same
AU2017245320A1 (en) Vaccine compositions comprising a mutated factor h binding protein
Hartsock et al. Antiadhesin peptide-based vaccines for Pseudomonas aeruginosa
Seifert et al. A cis-acting DNA element upstream of the pilin expression locus is required for pilin antigenic variation
Stevens Three Dimensional Structure Determination of Botulinum Neurotoxin

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned

Effective date of abandoning: 20151104

C20 Patent right or utility model deemed to be abandoned or is abandoned