CN102240254A - Snow lotus herb extract and preparation method and application thereof - Google Patents
Snow lotus herb extract and preparation method and application thereof Download PDFInfo
- Publication number
- CN102240254A CN102240254A CN2010101742072A CN201010174207A CN102240254A CN 102240254 A CN102240254 A CN 102240254A CN 2010101742072 A CN2010101742072 A CN 2010101742072A CN 201010174207 A CN201010174207 A CN 201010174207A CN 102240254 A CN102240254 A CN 102240254A
- Authority
- CN
- China
- Prior art keywords
- extract
- herba saussureae
- saussureae involueratae
- preparation
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of a snow lotus herb extract. The snow lotus herb extract acquired by the method has the effects on resisting oxidation and resisting UVA (Ultraviolet A) and UVB (Ultraviolet B) irradiation, and can be used for resisting ageing of skin, especially light aging. The snow lotus herb extract can be used as a cosmetic additive or a medicinal active component. The invention also discloses an application of the snow lotus herb extract in preparing cosmetics or medicines for resisting ageing of skin, especially light ageing.
Description
Technical field
The present invention relates to Natural Medicine Chemistry field and cosmetic field, be specifically related to a kind of aging resistance that is used in cosmetics or the medicine, the Chinese herbal medicine Herba Saussureae Involueratae of preferred anti-light aging.
Background technology
Studies show that free radical and ultraviolet all are one of factors of skin aging, and photoaging mainly by the ultraviolet B radiation in the daylight (UVB, 290～320nm) and long wave ultraviolet (UVA, 320～400nm) cause jointly.Ultraviolet has obvious facilitation to application on human skin aging, and high exposed population group's skin aging is dangerous to double than low exposed population group, and the time of origin that wears out shifts to an earlier date 10 years.Long term exposure causes skin photoage in the daylight ultraviolet, and can cause serious cosmetic problem, thereby extremely industry concern in recent years, the product of aging resistance and anti-light aging comes out one after another, correlational study is like a raging fire, but natural Chinese medicinal herb anti-light aging additive is still vacancy.
Summary of the invention
The object of the invention is to provide a kind of preparation method of Herba Saussureae Involueratae extract, and described method comprises:
(1) solvent extraction, described solvent are selected from water, methanol, ethanol, isopropyl alcohol, 1-butanols, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination.
Preferably, wherein the extraction of step (1) is selected from immersion, decoction, backflow, percolation or its combination.
Preferably, described preparation method also comprises:
(2) separation and Extraction liquid and residue obtain extracting solution;
(3) optional solvent recovery;
(4) optionally dissolving or dilution.
Preferably, wherein used solvent is selected from water, ethanol, isopropyl alcohol, 1-butanols, ethylene glycol, 1 in the step (4), 2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination.
Another purpose of the present invention is to provide the preparation method of another kind of Herba Saussureae Involueratae extract, and described method comprises:
(1) solvent extraction, described solvent are selected from methanol, ethanol, isopropyl alcohol, 1-butanols, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination;
(2) separation and Extraction liquid and residue obtain residue;
(3) residue of water extraction step (2).
Preferably, wherein the extraction of step (1) and (3) is independently selected from immersion, decoction, backflow, percolation or its combination.
Preferably, described preparation method also comprises:
(4) separate aqueous extract and residue, obtain aqueous extract;
(5) concentrate, the ethanol precipitate with ethanol separates obtaining precipitation;
(6) alternatively, the resolution of precipitate with step (5) is mixed with solution.
Preferably, wherein in the step (6) used solvent be selected from ethanol, isopropyl alcohol, 1-butanols,, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination.
Another purpose of the present invention provides the Herba Saussureae Involueratae extract according to the preparation method acquisition of the invention described above.
Preferably, the form of described Herba Saussureae Involueratae extract is selected from solution, powder, ointment, membrane or cream frost.
The Herba Saussureae Involueratae extract that the method according to this invention obtains can be directly used in the prevention skin aging, and preferred light is aging, also can be used as functional additive or active component and joins in cosmetics or the medicine and use.
Further object of the present invention provides Herba Saussureae Involueratae extract in preparation aging resistance, the cosmetics of preferred anti-light aging or the purposes in the medicine.
Preferably, described Herba Saussureae Involueratae extract is the Herba Saussureae Involueratae extract of above-mentioned prepared in accordance with the method for the present invention.
Further object of the present invention provides a kind of aging resistance, and the cosmetics or the cosmetics of preferred anti-light aging wherein contain Herba Saussureae Involueratae extract.
Preferably, described Herba Saussureae Involueratae extract is the Herba Saussureae Involueratae extract of above-mentioned prepared in accordance with the method for the present invention.
In the present invention, Herba Saussureae Involueratae is meant this medicinal part of flower of plant Herba Saussureae Involueratae.Herba Saussureae Involueratae is the herbaceous plant of Compositae phoenix hair Chrysanthemum Herba Saussureae Involueratae subgenus, mainly comprises the wounded in the battle Herb of snow lotus of big bud flower Saussurea involucrataKar.et Kir., Saussurea laniceps Saussurea laniceps Hand.-Mazz., bent Herba Saussureae Involueratae S.gnaphaloides (Royle) Sch.-Bip. of Mus, Saussurea medusa Maxim. S.medusa Maxim. etc.
The Herba Saussureae Involueratae main product in Sichuan, ground such as Yunnan, Tibet, Xinjiang, Gansu, Qinghai, between 6～July, the Herb for the treatment of to choose when the flowers are in blossom is removed earth, dries, cutting is given birth to and is used.
The Herba Saussureae Involueratae heat clearing away is nourished blood, Yin Yang balancing, and tonification, " Taoist Scriptures " before more than 1,000 year is called Herba Saussureae Involueratae " Herba mesonae chinensis in thousand ", " recall the bygone days with nostalgia trip random notes on classical poets and poetry ": " Herba Saussureae Involueratae, not changing first snow depth place in thousand has it, the likeness in form Flos Nelumbinis, height can zhang be permitted.Get with wine brewing the multiplication spring scenery.Cover negative electrode and the meaning ear of sun life." " detailed outline is picked up any lost article from the road ": " and the snow Flos Nelumbinis produces the ground that Great Cold is located in Yi Li northwest and Jinchuan etc., and the accumulated snow spring and summer does not loose, and grass is arranged in the snow, the class Flos Nelumbinis, and solely stem is lovely between tall and erect snow.”
The Herba Saussureae Involueratae extract that method of the present invention makes has the effect of the free radical of removing antioxidative; simultaneously can help skin to resist the ultraviolet radiation of UVB and UVA; protection skin; reduce cell injury; prevent the proteic minimizing of dermal collagen; effectively prevention skin aging, especially photoaging, and to the skin nonirritant.
The specific embodiment
Embodiment 1
Get Saussurea laniceps Saussurea laniceps Hand.-Mazz 100g, adding 8 times of amounts (doubly measures: the ratio that refers to solvent volume and Herba Saussureae Involueratae weight, wherein the unit of solvent volume is ml, the unit of Herba Saussureae Involueratae weight is g, down with) 75% ethanol (v/v) merceration 48 hours, filter, filtrate recycling ethanol, the extract obtained water dissolution of using is made and is contained the solution that the crude drug amount is 1000mg/ml, obtains extracting solution A.
Embodiment 2
Get bent Herba Saussureae Involueratae S.gnaphaloides (Royle) Sch.-Bip.100g of Mus, add 8 times of amount methanol eddies and extracted 2 hours, filter, filtrate is reclaimed methanol, and the extract obtained water dissolution of using is made and contained the solution that the crude drug amount is 500mg/ml, obtains extracting solution B.
Embodiment 3
Female Herba Saussureae Involueratae S.medusa Maxim.100g that fetches water decocts with 10 times of water gagings and to extract about 2 hours, concentrates, and filters, and supernatant adds water to be made and contain the solution that the crude drug amount is 1000mg/ml, obtains extracting solution C.
Embodiment 4
Get snow lotus of big bud flower Saussurea involucrata Kar.et Kir.100g, add 6 times of amount alcohol reflux, filter, 10 times of water gagings of residue reuse decoct and extracted about 2 hours, concentrate, and add 2 times of amount ethanol precipitations, filter, precipitation is used water dissolution, makes to contain the solution that the crude drug amount is 500mg/ml, obtains extracting solution D.
Embodiment 5DPPH experiment
Free radical is the chemical substance that a class character is active, have extremely strong oxidability.The irradiation of ultraviolet (UV) A/UVB can produce a large amount of free radicals, and body is caused damage, quickens old and feeble.Adopt DPPH free radical scavenging method to measure the antioxidation activity in vitro of extract among the embodiment at this.
With distilled water the extract among the embodiment is diluted to two concentration of 1% and 0.5% (v/v) respectively.Get embodiment extract 2ml then, concentration is DPPH alcoholic solution 0.5ml and the 1.5ml water of 500 μ mol/L, successively add in the same test tube, shake up, leave standstill, measure its absorbance (OD) behind the 30min at the 517nm place, and with corresponding mixed liquor as blank.The embodiment extract calculates according to following formula the clearance rate of DPPH:
Wherein:
The absorbance of T-DPPH+ embodiment extract,
The absorbance of T0-embodiment extract+solvent,
The absorbance of C-DPPH+ solvent.
Experimental result sees Table 1.
The assessment of table 1 Herba Saussureae Involueratae extract oxidation resistance
| Concentration | Free radical scavenging activity | Concentration | Free radical scavenging activity | |
| Embodiment 1 extract A | 1％ | 39.82％ | 0.5％ | 12.80％ |
| Embodiment 2 extract B | 1％ | 42.26％ | 0.5％ | 13.96％ |
| Embodiment 4 extract D | 1％ | 47.86％ | 0.5％ | 17.44％ |
Experimental result shows, embodiment 1 extract A, embodiment 2 extract B, embodiment 4 extract D all have the oxidation resistance of better removing free radical in external 1% and 0.5% concentration, wherein 0.5% free radical scavenging activity is all more than 10%, the free radical scavenging activity of 1% concentration is all more than 30%, and is best with embodiment 4 extract D effects.
Embodiment 6UV irradiation is to the protective effect of fibroblast damage
Skin photoage mainly by the ultraviolet B radiation in the daylight (UVB, 290～320nm) and long wave ultraviolet (UVA, 320～400nm) cause jointly, ultraviolet has obvious facilitation to application on human skin aging.The UVA/UVB irradiation can cause that fibroblastic damage is dead, and skin is damaged, and causes photoaging.Investigate of the resist photoaging effect of the Chinese herbal medicine extract of embodiment at this by UV irradiation experiment to the cytoprotective of UV irradiation.
Get extract 0.5ml among the embodiment respectively, add 4.5ml PBS and dilute, be made into 1/10 concentration (v/v) and carry out sucking filtration, get 0.1ml then and add the aseptic PBS of 9.9ml and be diluted to 1/1000 concentration (v/v) at last.With normal DMEM liquid cultured skin fibroblast (Fb) is matched group, cultivates back UVA (5-20J/cm with normal DMEM liquid
2)/UVB UVB (20-80J/cm
2) the Fb cell of irradiation is model group, with the embodiment extract that contains 1/1000 concentration with DMEM liquid is cultivated altogether and be the dosing group through the Fb cell of UVA/UVB irradiation.24h after the UV treatment measures the absorbance (OD value) in each hole by CCK-8 with microplate reader, and cell proliferation rate accounts for the percentage rate of negative control group OD value for each processed group OD value, and each tests triplicate.
Experimental result sees Table 2 and table 3.
Table 2UVA irradiation
| Cell proliferation rate | The P value | |
| Embodiment 1 extract A | (90.13±4.68)％ | ＜0.01 |
| Embodiment 2 extract B | (92.25±4.00)％ | ＜0.01 |
| Embodiment 4 extract D | (94.88±4.98)％ | ＜0.01 |
| Matched group | (100±4.32)％ | |
| Model group | (74.25±3.78)％ | ＜0.01 |
Table 3UVB irradiation
| Cell proliferation rate | The P value | |
| Embodiment 1 extract A | (93.27±3.51)％ | ＜0.01 |
| Embodiment 2 extract B | (95.86±2.85)％ | ＜0.01 |
| Embodiment 4 extract D | (97.54±3.53)％ | ＜0.01 |
| Matched group | (100±5.68)％ | |
| Model group | (83.63±5.15)％ | ＜0.01 |
Experimental result shows that embodiment 1 extract A, embodiment 2 extract B, embodiment 4 extract D all can reduce the UV irradiation to fibroblastic damage, and the cell appreciation rate is all returned to more than 90%, and best with the effect of embodiment 4 extract D.
Embodiment 7UV irradiation is to the experiment in vitro of dermal collagen albumen influence
Get extract 0.5ml among the embodiment respectively, add 4.5ml PBS and dilute, be made into 1/10 concentration (v/v) and carry out sucking filtration, get 0.1ml then and add the aseptic PBS of 9.9ml and be diluted to 1/1000 concentration (v/v) at last.With normal DMEM liquid cultured skin fibroblast (Fb) is matched group, cultivates back UVA (5-20J/cm with normal DMEM liquid
2)/UVB UVB (20-80J/cm
2) the Fb cell of irradiation is model group, with the embodiment extract that contains 1/1000 concentration with DMEM liquid is cultivated altogether and be the dosing group through the Fb cell of UVA/UVB irradiation.24h after the UV treatment, the collecting cell supernatant according to the method that hydroxyproline test kit (Nanjing is built up) illustrates, is measured hydroxyproline content in the culture supernatant.
Experimental result sees Table 4 and table 5.
Table 4UVA irradiation
| Collagen content (μ g/ml) | Collagen protein changes recovery ratio (with respect to model group) | |
| Embodiment 1 extract A | 4.3 | 34.38％ |
| Embodiment 2 extract B | 4.9 | 53.13％ |
| Embodiment 4 extract D | 5.1 | 59.38％ |
| Matched group | 8.2 | |
| Model group | 3.2 |
Table 5UVB irradiation
| Collagen content (μ g/ml) | Collagen protein changes recovery ratio (with respect to model group) | |
| Embodiment 1 extract A | 4.8 | 26.32％ |
| Embodiment 2 extract B | 5.4 | 42.11％ |
| Embodiment 4 extract D | 6.6 | 73.68％ |
| Matched group | 8.2 | |
| Model group | 3.8 |
Experimental result shows, embodiment 1 extract A, embodiment 2 extract B, embodiment 4 extract D all can reduce the influence of UV irradiation to the dermal fibroblast collagen content, can recover more than 25% with respect to MODEL DAMAGE group collagen protein, and it is best with the effect of embodiment 4 extract D, can recover UVA59.38%, UVB73.68%.
Skin photoage mainly by the ultraviolet B radiation in the daylight (UVB, 290～320nm) and long wave ultraviolet (UVA, 320～400nm) cause jointly, ultraviolet has obvious facilitation to application on human skin aging.The UVA/UVB irradiation can cause that fibroblastic damage is dead, and the proteic minimizing of dermal collagen, and skin is damaged.The present invention is with the UVA/UVB irradiation cultured skin fibroblast of certain intensity; hatch with Herba Saussureae Involueratae extract; can effectively reduce the influence of UV irradiation to fibroblast proliferation; can effectively reduce simultaneously the variation of dermal fibroblast collagen protein; protection skin; illustrate that Herba Saussureae Involueratae extract has the protective effect that ultra-vioket radiation damages to skin flbroblast, can defend photoaging.
Claims (14)
1. the preparation method of a Herba Saussureae Involueratae extract comprises:
(1) solvent extraction, described solvent are selected from water, methanol, ethanol, isopropyl alcohol, 1-butanols, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination.
2. preparation method as claimed in claim 1, wherein the extraction of step (1) is selected from immersion, decoction, backflow, percolation or its combination.
3. preparation method as claimed in claim 1 or 2 also comprises:
(2) separation and Extraction liquid and residue obtain extracting solution;
(3) optional solvent recovery;
(4) optionally dissolving or dilution.
4. preparation method as claimed in claim 3, wherein used solvent is selected from water, ethanol, isopropyl alcohol, 1-butanols, ethylene glycol, 1 in the step (4), 2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination.
5. the preparation method of a Herba Saussureae Involueratae extract comprises:
(1) solvent extraction, described solvent are selected from methanol, ethanol, isopropyl alcohol, 1-butanols, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination;
(2) separation and Extraction liquid and residue obtain residue;
(3) residue of water extraction step (2).
6. preparation method as claimed in claim 5, wherein the extraction of step (1) and (3) is independently selected from immersion, decoction, backflow, percolation or its combination.
7. as claim 5 or 6 described preparation methoies, also comprise:
(4) separate aqueous extract and residue, obtain aqueous extract;
(5) concentrate, the ethanol precipitate with ethanol separates obtaining precipitation;
(6) alternatively, the resolution of precipitate with step (5) is mixed with solution.
8. preparation method as claimed in claim 7, wherein in the step (6) used solvent be selected from ethanol, isopropyl alcohol, 1-butanols,, ethylene glycol, 1,2-propylene glycol, 1, ammediol, 1,3 butylene glycol, acetone, ethyl acetate or its combination.
9. Herba Saussureae Involueratae extract, it makes according to any one described preparation method of claim 1-8.
10. Herba Saussureae Involueratae extract as claimed in claim 9, wherein, the form of described Herba Saussureae Involueratae extract is selected from solution, powder, ointment, membrane or cream frost.
11. Herba Saussureae Involueratae extract is in preparation aging resistance, the cosmetics of preferred anti-light aging or the purposes in the medicine.
12. purposes as claimed in claim 11, wherein said Herba Saussureae Involueratae extract are claim 9 or 10 described Herba Saussureae Involueratae extracts.
13. an aging resistance, the cosmetics or the medicine of preferred anti-light aging wherein contain Herba Saussureae Involueratae extract.
14. cosmetics as claimed in claim 13, wherein said Herba Saussureae Involueratae extract are claim 9 or 10 described Herba Saussureae Involueratae extracts.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101742072A CN102240254A (en) | 2010-05-13 | 2010-05-13 | Snow lotus herb extract and preparation method and application thereof |
| AU2011252628A AU2011252628A1 (en) | 2010-05-13 | 2011-03-10 | Snow lotus extract, preparing method and application thereof |
| PCT/CN2011/071680 WO2011140856A1 (en) | 2010-05-13 | 2011-03-10 | Snow lotus extract, preparing method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101742072A CN102240254A (en) | 2010-05-13 | 2010-05-13 | Snow lotus herb extract and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102240254A true CN102240254A (en) | 2011-11-16 |
Family
ID=44913899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101742072A Pending CN102240254A (en) | 2010-05-13 | 2010-05-13 | Snow lotus herb extract and preparation method and application thereof |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN102240254A (en) |
| AU (1) | AU2011252628A1 (en) |
| WO (1) | WO2011140856A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245545A (en) * | 2016-12-29 | 2018-07-06 | 伽蓝（集团）股份有限公司 | A kind of Saussurea involucrata extract and its preparation method and application, the skin preparations for extenal use containing it |
| CN109044946A (en) * | 2018-09-27 | 2018-12-21 | 张言聚 | A kind of whitening and moisturizing facial mask liquid and its preparation process |
| CN110585100A (en) * | 2019-10-15 | 2019-12-20 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with moisturizing and anti-aging functions and preparation method and application thereof |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130177661A1 (en) * | 2012-01-05 | 2013-07-11 | National Ilan University | Saussurea Involucrate Extract, Pharmaceutical Composition and Use for Anti-Fatigue and Anti-Aging |
| CN105943484A (en) * | 2016-06-19 | 2016-09-21 | 原巍俊 | Essence for after-sun repair and cell regeneration promotion |
| TWI779251B (en) * | 2019-11-21 | 2022-10-01 | 大江基因醫學股份有限公司 | Use of a plant extraction for enhancing the gene expression of cct, atg, nadsyn, mrps5, sod3, and tert and/or increase the amount of gsh |
| CN111249218B (en) * | 2020-03-21 | 2022-05-31 | 科丽思化妆品（上海）有限公司 | Saussurea involucrate fermentation stock solution and preparation method and application thereof |
| CN115028751B (en) * | 2022-06-15 | 2023-05-16 | 中国科学院新疆理化技术研究所 | Preparation method and application of saussurea involucrata polysaccharide |
| CN115068387B (en) * | 2022-07-11 | 2024-04-26 | 润芳可(上海)生物科技有限公司 | Plant composition and application thereof in cosmetics |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1092669A (en) * | 1993-03-25 | 1994-09-28 | 中国科学院新疆化学研究所 | Natural skin-care raw material-Saussurea involucrata extract of alcohol |
| CN1513437A (en) * | 2003-08-08 | 2004-07-21 | 新疆奥斯曼生物科技有限公司 | Sunshine-proof and skin-moistening cream contg. saussurea involucrata, and its prepn. method |
| CN1965784A (en) * | 2005-10-11 | 2007-05-23 | 莱雅公司 | Use of C-glycosides for depigmenting skin |
-
2010
- 2010-05-13 CN CN2010101742072A patent/CN102240254A/en active Pending
-
2011
- 2011-03-10 WO PCT/CN2011/071680 patent/WO2011140856A1/en active Application Filing
- 2011-03-10 AU AU2011252628A patent/AU2011252628A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1092669A (en) * | 1993-03-25 | 1994-09-28 | 中国科学院新疆化学研究所 | Natural skin-care raw material-Saussurea involucrata extract of alcohol |
| CN1513437A (en) * | 2003-08-08 | 2004-07-21 | 新疆奥斯曼生物科技有限公司 | Sunshine-proof and skin-moistening cream contg. saussurea involucrata, and its prepn. method |
| CN1965784A (en) * | 2005-10-11 | 2007-05-23 | 莱雅公司 | Use of C-glycosides for depigmenting skin |
Non-Patent Citations (3)
| Title |
|---|
| 《亚太传统医药》 20071015 徐娟等 雪莲有效成分的提取及含量测定 第42-43页 1-14 第3卷, 第10期 * |
| 《北京农学院学报》 20070115 刘春兰等 西藏雪莲多糖初步分离和清除自由基活性研究 第4-7页 5-14 第22卷, 第1期 * |
| 《华西药学杂志》 20060820 陈嘉等 雪莲花的醇提工艺 第366-368页 1-14 , 第4期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245545A (en) * | 2016-12-29 | 2018-07-06 | 伽蓝（集团）股份有限公司 | A kind of Saussurea involucrata extract and its preparation method and application, the skin preparations for extenal use containing it |
| CN109044946A (en) * | 2018-09-27 | 2018-12-21 | 张言聚 | A kind of whitening and moisturizing facial mask liquid and its preparation process |
| CN110585100A (en) * | 2019-10-15 | 2019-12-20 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with moisturizing and anti-aging functions and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011252628A1 (en) | 2012-12-06 |
| WO2011140856A1 (en) | 2011-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102240254A (en) | Snow lotus herb extract and preparation method and application thereof | |
| JP2013056868A (en) | Physiologically active liquid composition and method for producing the same | |
| CN103976909B (en) | A kind of Herba Leibnitziae extracting solution and its preparation method and application | |
| CN101897656A (en) | Application of Saussurea involucrata culture as new raw material in daily chemicals | |
| CN102885726A (en) | Eucommia extract product, its preparation method and application thereof | |
| CN102552420B (en) | Anti-ageing Chinese herbal medicine composition as well as preparation method and application for same | |
| CN103191172A (en) | Gynostemma pentaphylla extract, and preparation method and application thereof | |
| CN109303794B (en) | Selenium-rich cardamine violifolia extract and application thereof in liver protection | |
| JP7141767B2 (en) | Tie2 activator, vascular maturation agent, and food and drink | |
| KR102164246B1 (en) | Cosmetic Compositions for Anti-oxidation and Protecting Skin from UV Comprising Complex Extracts of Plants | |
| CN104189140B (en) | Photinia serrulata procyanidine as well as preparation method and application thereof | |
| CN107468568A (en) | A kind of persimmon leaf polyphenol with whitening sun protection activity and its preparation method and application | |
| KR20130121324A (en) | Composition for preventing and treating hangover comprising extracts of leaves of perilla frutescens britton var | |
| JP2012211120A (en) | Skin care preparation | |
| KR102402211B1 (en) | Cosmetic Composition For Prohibiting Skin Aging By Blue-Light Comprising Cynanchum Paniculatum Extract As Active Ingredient | |
| KR101676292B1 (en) | Cosmetic composition comprising an mixed extract of tangle, okra and yam and manufacturing method thereof | |
| KR102271886B1 (en) | Cosmetic composition containing complex medicinal herbs extract for skin whitening and anti-wrinkle effect and manufacturing method thereof | |
| KR20160050527A (en) | Composition of cosmetics for anti-wrinkle containing Ulva pertusa Kjellman extracts | |
| CN104042491A (en) | Moisturizing lotion | |
| JP2010155811A (en) | Immune cell activator | |
| CN103550511A (en) | Plant composition capable of delaying skin aging, and preparation method thereof | |
| KR20170044455A (en) | External preparation for skin comprising extract of Traditional herb | |
| CN105534850B (en) | A kind of moisturising product of propolis-containing for baby and preparation method thereof | |
| CN112043650B (en) | Acne-removing repairing cosmetic preparation and preparation method thereof | |
| CN107468533A (en) | Saussurea involucrata Quercetin with radiation-resisting whitening activity and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20111116 |