CN102225195A - Porcine interferon-gamma composite medicament and application thereof - Google Patents
Porcine interferon-gamma composite medicament and application thereof Download PDFInfo
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- CN102225195A CN102225195A CN2011101607200A CN201110160720A CN102225195A CN 102225195 A CN102225195 A CN 102225195A CN 2011101607200 A CN2011101607200 A CN 2011101607200A CN 201110160720 A CN201110160720 A CN 201110160720A CN 102225195 A CN102225195 A CN 102225195A
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Abstract
The invention relates to a porcine interferon-gamma composite medicament and application thereof, belonging to the technical field of rear livestock medicaments. Per liter of porcine interferon-gamma composite medicament injection is prepared from the following raw materials: 400-500ml of porcine interferon-gamma, 100-180g of astragalus mongholicus extract, 100-180g of golden cypress extract, 100-180g of coptis extract, 20-30g of codonopsis extract, 40-80g of licorice extract and 2-8g of bursin. The porcine interferon-gamma composite medicament injection has a good effect in the processes of treating and preventing piglet infectious gastroenteritis and pig epidemic diarrhea, and the effective prevention rate is above 85%.
Description
Technical field
The present invention relates to a kind of pig interferon γ composition of medicine and application, belong to the herding technical field of pharmaceuticals.
Background technology
Interferon gamma is that Wheelock found in 1956, and it is to be produced by activated T cells and NK cell, has stronger antiviral and immunoloregulation function.Its biologic activity mainly comprises:
1, immunoregulation effect: interferon gamma can increase the Fc expression of receptor of IgG, engulfs antigenic thereby help macrophage, and the NK cell kills and wounds and the activation of T lymphocyte and bone-marrow-derived lymphocyte target cell, thus the enhancing human body immunity responsibility.
2, antivirus action: interferon gamma is to play a role by some protein that cytogene is encoded, and at first combines with cell surface receptor, enters cell, induces synthetic antiviral protein, thus the performance antivirus action.
Vandenbroeck etc. react at discover IgG and IgA after pig gamma interferon can be strengthened Pseudorabies virus inactivated vaccine secondary immunity in 1998, and can alleviate the heating paresthesia behind the Pseudorabies virus counteracting toxic substances; Zuckermann etc. studies show that pig interferon γ can strengthen the immune protective effect of pseudorabies vaccine; Suradhat etc. discover that pig gamma interferon also plays a significant role in the cellular immunization of swine fever virus resistant; Bautista etc. studies show that pig interferon γ can obviously suppress the propagation of pig breeding and breathing syndrome virus (PRRSV), and Vandenboerek etc. studies show that pig interferon γ plays a crucial role to the scar exanthema virus of removing persistent infection among the central nervous system.In addition, other studies show that pig interferon γ is all obtaining good effect aspect the viral infection such as opposing pig bubble stomatitis, foot and mouth disease, influenza.
China is the big country of raising pigs, viral infectious is perplexing the development of China's pig industry always in recent years, the treatment that at present domestic and international pig interferon γ is used for virosis does not separately have good effect, the pig interferon γ combination medicine that a kind of antivirus action is good will play crucial effects in the viral disease of control pig.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of pig interferon γ composition of medicine and application are provided.
A kind of pig interferon γ composite medicinal injection, every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 400～500ml, Radix Astragali extract 100～180g, Cortex Phellodendri extract 100～180g, Rhizoma Coptidis extract 100～180g, the 20～30g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～80g, bursin peptide 2～8g;
Preferably, described every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 400～460ml, Radix Astragali extract 100～150g, Cortex Phellodendri extract 100～150g, Rhizoma Coptidis extract 100～150g, the 20～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～60g, bursin peptide 2～5g;
Further preferred, described every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 430～460ml, Radix Astragali extract 120～150g, Cortex Phellodendri extract 120～150g, Rhizoma Coptidis extract 120～150g, the 22～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 50～60g, bursin peptide 3.5～5g;
Optimum, described every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 460ml, Radix Astragali extract 150g, Cortex Phellodendri extract 150g, Rhizoma Coptidis extract 150g, the 25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 60g, bursin peptide 5g;
Described pig interferon γ antiviral activity is 1 * 10
4IU/ml.The γ of pig interferon described in the present invention, every pig interferon γ of IU unit is equivalent to 0.1 microgram.
Above-mentioned pig interferon γ composite medicinal injection makes as follows:
Take by weighing above-mentioned raw materials, after ice bath mixed 15min, water for injection added to 1000ml, made liquid suspension, and 0.22 μ m cellulose membrane filtration sterilization promptly gets pig interferon γ composite medicinal injection.
Above-mentioned ice bath is 4 ℃ of ice baths.
The application of above-mentioned pig interferon γ composite medicinal injection in treatment and prevention piglet transmissible gastroenteritis (TGE) and porcine epizootic diarrhea (PED).
Beneficial effect
1, pig interferon γ composite medicinal injection of the present invention has good effect in treatment and prevention piglet transmissible gastroenteritis and porcine epizootic diarrhea process, effectively prevention rate is more than 85%.
2, pig interferon γ composite medicinal injection of the present invention has the biologic activity of antiviral and enhancing immunity, has reached the purpose of preventing and treating viral disease.
3, pig interferon γ composite medicinal injection of the present invention, production technology is simple, and cost of manufacture is cheap, has solved independent use pig interferon γ poor effect, problem that cost is high, helps promoting the use of of pig interferon γ.
The specific embodiment
Below in conjunction with embodiment the present invention is further elaborated, but institute of the present invention protection domain is not limited thereto.
Pig interferon γ among the embodiment is the product of the external public offering of Shandong Sinostar Bioscience and Technology Co., Ltd., trade name: Ying Tefei (pig is used genetic engineering interferon), antiviral activity 1 * 10
4IU/ml; Bursin peptide is available from the international Pharmaceutical in new Asia, Hong Kong group company, and Radix Astragali extract, Cortex Phellodendri extract, Rhizoma Coptidis extract, Radix Codonopsis extract, Radix Glycyrrhizae extract are available from Zhengzhou litchi promise bio tech ltd.
Embodiment 1
A kind of pig interferon γ composite medicinal injection, every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 400ml, Radix Astragali extract 100g, Cortex Phellodendri extract 100g, Rhizoma Coptidis extract 100g, the 20g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40g, bursin peptide 2g;
Above-mentioned pig interferon γ composite medicinal injection makes as follows:
Take by weighing above-mentioned raw materials, after ice bath mixed 15min, water for injection added to 1000ml, made liquid suspension, 0.22 the filtration sterilization of μ m cellulose membrane promptly gets pig interferon γ composite medicinal injection, then, divide in the bottle ware that installs to sterilization quality inspection warehouse-in, 4 ℃ of preservations of finished product.
Embodiment 2
As embodiment 1 described pig interferon γ composite medicinal injection, difference is that every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 430ml, Radix Astragali extract 120g, Cortex Phellodendri extract 120g, Rhizoma Coptidis extract 120g, the 22g of Radix Codonopsis extract, Radix Glycyrrhizae extract 50g, bursin peptide 3.5g.
Embodiment 3
As embodiment 1 described pig interferon γ composite medicinal injection, difference is that every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 460ml, Radix Astragali extract 150g, Cortex Phellodendri extract 150g, Rhizoma Coptidis extract 150g, the 25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 60g, bursin peptide 5g.
The test example
One, pig interferon γ combination medicine control piglet Transmissible gastroenteritis virus infection experiment
1, test material
1.1 medicine
Pig interferon γ: the product of the external public offering of Shandong Sinostar Bioscience and Technology Co., Ltd., trade name: Ying Tefei (pig is used genetic engineering interferon).
Pig interferon γ composite medicinal injection A: make by embodiment 1.
Pig interferon γ composite medicinal injection B: make by embodiment 2.
Pig interferon γ composite medicinal injection C: make by embodiment 3.
1.2 virus
Piglet Transmissible gastroenteritis virus (TGEV) provides for Agricultural University Of Nanjing.
1.3 laboratory animal
The healthy piglet of 3 ages in days is available from periphery pig farm, Weifang.
2, test procedure
2.1 the minimum morbidity dosimetry of transmissible gastro-enteritis virus
With 10 the 3 healthy piglets of age in days, be divided into 5 groups at random, two every group, TGEV is made doubling dilution.First group to the 4th group difference oral 10
1-10
4Viral dilution liquid 1ml, the 5th group is the blank group, oral 1ml normal saline.With the minimum counteracting toxic substances dosage of morbidity group in 30 hours as the minimum morbidity dosage of TGEV.
2.2 pig interferon γ composition of medicine prevention TGEV infection experiment
With 60 the 3 healthy piglets of age in days, be divided into 6 groups at random, every group 10, first group of intramuscular injection pig interferon γ 0.5ml/kg, second group of intramuscular injection pig interferon γ composite medicinal injection A 0.5ml/kg, the 3rd group of intramuscular injection pig interferon γ composite medicinal injection B 0.5ml/kg, the 4th group of intramuscular injection pig interferon γ composite medicinal injection C 0.5ml/kg, the 5th group is the blank group, and the 6th group is the counteracting toxic substances matched group.After the administration 2 hours, the 5th group piglet oral normal saline 1ml, the TGEV of 10 times of minimum morbidity dosage of pig oral vaccination of other each groups observed 30 hours.
3, result of the test
3.1 the minimum morbidity dosage of transmissible gastroenteritis of swine result
Clinical symptoms performance behind the piglet inoculation various dose TGEV sees Table 1, the TGEV of inoculation high concentration, and piglet was suffered from diarrhoea at 8-10 hour, and the 4th group is connecing the slight diarrhoea of poison generation in back 22 hours, and blank group piglet is acted normally.So with 1ml 10
4The TGEV virus liquid of dilution is as the minimum morbidity dosage of piglet transmissible gastroenteritis.
Clinical manifestation behind the table 1 piglet inoculation various dose TGEV
| Group | TGEV connects the poison amount | Begin the diarrhoea time (h) | Connect the state of poison back 30h |
| First group | 10 -1 | ?8-10 | Serious diarrhoea |
| Second group | 10 -2 | ?13-15 | Serious diarrhoea |
| The 3rd group | 10 -3 | ?15-20 | Serious diarrhoea |
| The 4th group | 10 -4 | ?22-25 | Slight diarrhoea |
| The 5th group | Blank |
3.2 pig interferon γ composition of medicine prevention TGEV infection experiment result
Connect the sickness rate of respectively organizing piglet behind the poison and see Table 2, the piglet of intramuscular injection pig gamma interferon had 6 pigs slight diarrhoea to occur at 20-22 hour, and is lighter than the piglet diarrhea degree that connects malicious matched group.And the piglet of intramuscular injection pig interferon γ composite medicinal injection A and pig interferon γ composite medicinal injection B has only 1 hair to give birth to slight diarrhoea, and pig interferon γ composite medicinal injection C the no symptom of diarrhea appearance of all acting normally.10 piglet clinical manifestations of blank group are normal, do not suffer from diarrhoea.
Table 2 connects the sickness rate of respectively organizing piglet behind the poison
4, conclusion (of pressure testing)
Pig interferon γ composite medicinal injection A, pig interferon γ composite medicinal injection B, pig interferon γ composite medicinal injection C all are better than pig interferon γ to the prevention effect of piglet transmissible gastroenteritis disease.Pig interferon γ composite medicinal injection C prevention effect the best.
Two, pig interferon γ combination medicine control Porcine epidemic diarrhea virus (PEDV) infection experiment
1, test material
1.1 medicine
Pig interferon γ: the product of the external public offering of Shandong Sinostar Bioscience and Technology Co., Ltd., trade name: Ying Tefei (pig is used genetic engineering interferon).
Pig interferon γ composite medicinal injection A: make by embodiment 1.
Pig interferon γ composite medicinal injection B: make by embodiment 2.
Pig interferon γ composite medicinal injection C: make by embodiment 3.
1.2 virus
Porcine epidemic diarrhea virus (PEDV) provides for Agricultural University Of Nanjing.
1.3 laboratory animal
21 age in days health pig are available from periphery pig farm, Weifang
2, test procedure
2.1 the minimum morbidity dosimetry of Porcine epidemic diarrhea virus (PEDV)
With 10 21 age in days health pig, be divided into 5 groups at random, two every group, PEDV is made doubling dilution.First group to the 4th group difference oral 10
1-10
4Viral dilution liquid 1ml, the 5th group is the blank group, oral 1ml normal saline.With the minimum counteracting toxic substances dosage of morbidity group in 20 hours as the minimum morbidity dosage of PEDV.
2.2 pig interferon γ combination medicine prevention PEDV infection experiment
With 90 the 21 healthy piglets of age in days, be divided into 6 groups at random, every group 15, first group of intramuscular injection pig interferon γ 0.5ml/kg, second group of intramuscular injection pig interferon γ composite medicinal injection A 0.5ml/kg, the 3rd group of intramuscular injection pig interferon γ composite medicinal injection B 0.5ml/kg, the 4th group of intramuscular injection pig interferon γ composite medicinal injection C 0.5ml/kg, the 5th group is the blank group, and the 6th group is the counteracting toxic substances matched group.After the administration 2 hours, the 5th group piglet oral normal saline 1ml, the PEDV of 10 times of minimum morbidity dosage of pig oral vaccination of other each groups observed 20 hours.
3, result of the test
3.1 the minimum morbidity dosage of porcine epizootic diarrhea result
Clinical symptoms performance behind the piglet inoculation various dose PEDV sees Table 3, the PEDV of inoculation high concentration, and pig was suffered from diarrhoea at 4-6 hour, and the 4th group is connecing the slight diarrhoea of poison generation in back 12 hours, and blank group pig is acted normally.So with 1ml 10
4The PEDV virus liquid of dilution is as the minimum morbidity dosage of piglet transmissible gastroenteritis.
Clinical manifestation behind the table 3 pig inoculation various dose PEDV
| Group | PEDV connects the poison amount | Begin the diarrhoea time (h) | Connect the state of poison back 20h |
| First group | 10 -1 | ?4-6 | Serious diarrhoea |
| Second group | 10 -2 | ?6-8 | Serious diarrhoea |
| The 3rd group | 10 -3 | ?10-12 | Serious diarrhoea |
| The 4th group | 10 -4 | ?12-14 | Slight diarrhoea |
| The 5th group | Blank | - | - |
3.2 pig interferon γ composition of medicine prevention PEDV infection experiment result
Connect the sickness rate of respectively organizing pig behind the poison and see Table 4,8 of the piglet morbidities of intramuscular injection pig gamma interferon, the diarrhoea degree is lower than matched group.And the piglet of intramuscular injection pig interferon γ combination medicine has only 2 hairs to give birth to slight diarrhoea, and 15 piglet clinical manifestations of blank group are normal, not morbidity.
Table 4 connects the sickness rate of respectively organizing pig behind the poison
4, conclusion (of pressure testing)
Pig interferon γ composite medicinal injection A, pig interferon γ composite medicinal injection B, pig interferon γ composite medicinal injection C all are better than pig interferon γ to the prevention effect of porcine epizootic diarrhea.Pig interferon γ composite medicinal injection C prevention effect the best.
Claims (8)
1. a pig interferon γ composite medicinal injection is characterized in that, every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 400～500ml, Radix Astragali extract 100～180g, Cortex Phellodendri extract 100～180g, Rhizoma Coptidis extract 100～180g, the 20～30g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～80g, bursin peptide 2～8g.
2. pig interferon γ composite medicinal injection as claimed in claim 1 is characterized in that, described every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 400～460ml, Radix Astragali extract 100～150g, Cortex Phellodendri extract 100～150g, Rhizoma Coptidis extract 100～150g, the 20～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～60g, bursin peptide 2～5g.
3. pig interferon γ composite medicinal injection as claimed in claim 2 is characterized in that, described every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 430～460ml, Radix Astragali extract 120～150g, Cortex Phellodendri extract 120～150g, Rhizoma Coptidis extract 120～150g, the 22～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 50～60g, bursin peptide 3.5～5g.
4. pig interferon γ composite medicinal injection as claimed in claim 3 is characterized in that, described every liter of pig interferon γ composite medicinal injection is made by following raw material:
Pig interferon γ 460ml, Radix Astragali extract 150g, Cortex Phellodendri extract 150g, Rhizoma Coptidis extract 150g, the 25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 60g, bursin peptide 5g.
5. pig interferon γ composite medicinal injection as claimed in claim 1 is characterized in that, described pig interferon γ antiviral activity is 1 * 10
4IU/ml.
6. the preparation method of the described pig interferon γ of claim 1 composite medicinal injection is characterized in that, makes as follows:
Take by weighing above-mentioned raw materials, after ice bath mixed 15min, water for injection added to 1000ml, made liquid suspension, and 0.22 μ m cellulose membrane filtration sterilization promptly gets pig interferon γ composite medicinal injection.
7. preparation method as claimed in claim 6 is characterized in that, described ice bath is 4 ℃ of ice baths.
8. the application of the described pig interferon γ of claim 1 composite medicinal injection in treatment and prevention piglet transmissible gastroenteritis and porcine epizootic diarrhea.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588773A (en) * | 2020-04-23 | 2020-08-28 | 浙江理工大学绍兴生物医药研究院有限公司 | Traditional Chinese medicine composition for preventing and treating newborn piglet diarrhea through sow medicine taking and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101139390A (en) * | 2007-08-14 | 2008-03-12 | 中国科学院微生物研究所 | Pig gamma interferon and encoding genes and use thereof |
| CN101475635A (en) * | 2008-12-29 | 2009-07-08 | 山东华辰生物科技有限公司 | Recombinant porcine interferon-alpha, as well as preparation method and use thereof |
| CN101880314A (en) * | 2010-06-03 | 2010-11-10 | 山东华辰生物科技有限公司 | Bursin-like peptide of gene engineering as well as expression gene and application thereof |
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2011
- 2011-06-15 CN CN 201110160720 patent/CN102225195B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101139390A (en) * | 2007-08-14 | 2008-03-12 | 中国科学院微生物研究所 | Pig gamma interferon and encoding genes and use thereof |
| CN101475635A (en) * | 2008-12-29 | 2009-07-08 | 山东华辰生物科技有限公司 | Recombinant porcine interferon-alpha, as well as preparation method and use thereof |
| CN101880314A (en) * | 2010-06-03 | 2010-11-10 | 山东华辰生物科技有限公司 | Bursin-like peptide of gene engineering as well as expression gene and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588773A (en) * | 2020-04-23 | 2020-08-28 | 浙江理工大学绍兴生物医药研究院有限公司 | Traditional Chinese medicine composition for preventing and treating newborn piglet diarrhea through sow medicine taking and application thereof |
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Denomination of invention: Porcine interferon-gamma composite medicament and application thereof Effective date of registration: 20150113 Granted publication date: 20130102 Pledgee: Rizhao bank Limited by Share Ltd Weifang branch Pledgor: Shandong Sinostar Bioscience and Technology Co., Ltd. Registration number: 2015980000001 |
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Inventor after: Jiang Zhengjun Inventor after: Su Xiaoming Inventor after: Kuang Baoxiao Inventor after: Wang Shaojuan Inventor after: Tian Jianguo Inventor after: Liu Lulu Inventor after: Wang Maochao Inventor after: Wang Yanyu Inventor before: Jiang Zhengjun Inventor before: Su Xiaoming Inventor before: Tian Jianguo Inventor before: Liu Lulu Inventor before: Wang Maochao Inventor before: Wang Yanyu |
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Address after: 261061 Weifang high tech Zone, Shandong Chang Shun Street, No. 207 Patentee after: Shandong Huachen Pharmaceutical Co., Ltd. Address before: 262610 Weifang high tech Zone, Jin Road, No. 516, No. Patentee before: Shandong Sinostar Bioscience and Technology Co., Ltd. |
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