CN102228679B - Chicken interferon gamma combined medicament and application - Google Patents
Chicken interferon gamma combined medicament and application Download PDFInfo
- Publication number
- CN102228679B CN102228679B CN 201110160737 CN201110160737A CN102228679B CN 102228679 B CN102228679 B CN 102228679B CN 201110160737 CN201110160737 CN 201110160737 CN 201110160737 A CN201110160737 A CN 201110160737A CN 102228679 B CN102228679 B CN 102228679B
- Authority
- CN
- China
- Prior art keywords
- interferon gamma
- extract
- chicken
- chicken interferon
- combined medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to a chicken interferon gamma combined medicament and application, and belongs to the technical field of livestock raising medicaments. Each liter of chicken interferon gamma combined medicament injection is prepared from the following raw materials: 400-500ml of chicken interferon gamma, 100-180g of astragalus extract, 100-180g of corktree extract, 100-180g of coptis extract, 20-30g of pilose asiabell root extract, 40-80g of licorice root extract and 2-8g of bursin. The chicken interferon gamma combined medicament injection has an excellent effect during treatment and prevention of infectious bronchitis of chicken and infectious bursal disease of chicken; and the effective prevention rate is more than 80 percent.
Description
Technical field
The present invention relates to a kind of chicken interferon gamma combined medicament and application, belong to the herding technical field of pharmaceuticals.
Background technology
Interferon gamma is that Wheelock found in 1956, and it is to be produced by the T cell that activates and NK cell, has stronger antiviral and immunoloregulation function.Its biologic activity mainly comprises:
1, immunoregulation effect: interferon gamma can increase the Fc expression of receptor of IgG, thereby is conducive to macrophage to the engulfing of antigen, and the NK cell kills and wounds and the activation of T lymphocyte and bone-marrow-derived lymphocyte target cell, thus the enhancing human body immunity responsibility.
2, antivirus action: interferon gamma is to play a role by some protein that cytogene is encoded, and at first is combined with cell surface receptor, enters cell, induces synthetic antiviral protein, thus the performance antivirus action.
The recombinant fowlpox vaccine virus of the gamma interferon of the expression chickens such as Sun Yongke and infectious bronchitis virus S gene can obviously improve immunity of organisms, promotes the maturation of CD8+T cell, enhancing body poison ability.Ming kun hsieh etc. are the IFN-r Gene of fabricius bursa VP243 gene and chicken restructuring co expression albumen, and the immunity of chicken is obviously improved.Find simultaneously many antigen combined chicken cell immune levels that can improve such as chicken interferon-gamma and newcastle, have adjuvant effect.Lambrecht equals also to express genetic engineering ChIFN-γ in 1999, and proof is similar to natural ChIFN-γ, and genetic engineering ChIFN-γ has antiviral and immunoregulatory activity equally.Existing part laboratory has obtained genetic engineering ChIFN-γ product both at home and abroad now, and carry out the experiments such as parasiticide, antiviral and immunomodulating, particularly aspect immunomodulating, genetic engineering ChIFN-γ has obtained numerous scholars' great attention as the immunological adjuvant aspect of vaccine.
Viral infectious is perplexing the development of China's poultry husbandry always in recent years, chicken interferon gamma does not have good effect and yet not remarkable as the vaccine adjuvant effect for the treatment of virosis separately both at home and abroad at present, the chicken interferon gamma combined medicament that a kind of antiviral and immunological enhancement are good will play vital effect in the viral disease of control chicken.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of chicken interferon gamma combined medicament and application are provided.
A kind of chicken interferon gamma combined medicament injection, every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 400～500ml, Radix Astragali extract 100～180g, Cortex Phellodendri extract 100～180g, Rhizoma Coptidis extract 100～180g, the 20～30g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～80g, bursin peptide 2～8g;
Preferably, described every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 400～460ml, Radix Astragali extract 100～150g, Cortex Phellodendri extract 100～150g, Rhizoma Coptidis extract 100～150g, the 20～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～60g, bursin peptide 2～5g;
Further preferred, described every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 430～460ml, Radix Astragali extract 120～150g, Cortex Phellodendri extract 120～150g, Rhizoma Coptidis extract 120～150g, the 22～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 50～60g, bursin peptide 3.5～5g;
Optimum, described every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 460ml, Radix Astragali extract 150g, Cortex Phellodendri extract 150g, Rhizoma Coptidis extract 150g, the 25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 60g, bursin peptide 5g;
Described chicken interferon gamma antiviral activity is 1 * 10
4IU/ml.Chicken interferon gamma described in the present invention, every IU unit chicken interferon gamma is equivalent to 0.1 microgram.
Above-mentioned chicken interferon gamma combined medicament injection makes as follows:
Take by weighing above-mentioned raw materials, after ice bath mixed 15min, water for injection added to 1000ml, made liquid suspension, and 0.22 μ m cellulose membrane filtration sterilization namely gets the chicken interferon gamma combined medicament injection.
Above-mentioned ice bath is 4 ℃ of ice baths.
The application of above-mentioned chicken interferon gamma combined medicament injection in treatment and prevention infectious bronchitis of chicken and infectious bursal disease.
Beneficial effect
1, chicken interferon gamma combined medicament injection of the present invention has good effect in treatment and prevention infectious bronchitis of chicken and infectious bursal disease process, effectively prevention rate is more than 80%.
2, chicken interferon gamma combined medicament injection of the present invention has the biologic activity of antiviral and enhancing immunity, has reached the purpose of preventing and treating viral disease.
3, chicken interferon gamma combined medicament injection of the present invention, production technology is simple, and cost of manufacture is cheap, has solved independent use chicken interferon gamma poor effect, problem that cost is high, is conducive to promoting the use of of chicken interferon gamma.
The specific embodiment
Below in conjunction with embodiment the present invention is further elaborated, but institute of the present invention protection domain is not limited to this.
Chicken interferon gamma among the embodiment is the product that Shandong Sinostar Bioscience and Technology Co., Ltd.'s external disclosure is sold, trade name: Ying Tefei (chicken genetic engineering interferon), antiviral activity 1 * 10
4IU/ml; Bursin peptide is available from the international Pharmaceutical in new Asia, Hong Kong group company, and Radix Astragali extract, Cortex Phellodendri extract, Rhizoma Coptidis extract, Radix Codonopsis extract, Radix Glycyrrhizae extract are available from Zhengzhou litchi promise bio tech ltd.
Embodiment 1
A kind of chicken interferon gamma combined medicament injection, every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 400ml, Radix Astragali extract 100g, Cortex Phellodendri extract 100g, Rhizoma Coptidis extract 100g, the 20g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40g, bursin peptide 2g;
Above-mentioned chicken interferon gamma combined medicament injection makes as follows:
Take by weighing above-mentioned raw materials, after ice bath mixed 15min, water for injection added to 1000ml, made liquid suspension, 0.22 the filtration sterilization of μ m cellulose membrane namely gets the chicken interferon gamma combined medicament injection, then, divide in the bottle ware that installs to sterilization quality inspection warehouse-in, 4 ℃ of preservations of finished product.
Embodiment 2
Chicken interferon gamma combined medicament injection as described in Example 1, difference is that every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 430ml, Radix Astragali extract 120g, Cortex Phellodendri extract 120g, Rhizoma Coptidis extract 120g, the 22g of Radix Codonopsis extract, Radix Glycyrrhizae extract 50g, bursin peptide 3.5g.
Embodiment 3
Chicken interferon gamma combined medicament injection as described in Example 1, difference is that every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 460ml, Radix Astragali extract 150g, Cortex Phellodendri extract 150g, Rhizoma Coptidis extract 150g, the 25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 60g, bursin peptide 5g.
Test example
One, chicken interferon gamma combination medicine control infections chicken cloacal bursa virus infection experiment
1, test material
1.1 medicine
Chicken interferon gamma: the product that Shandong Sinostar Bioscience and Technology Co., Ltd.'s external disclosure is sold, trade name: Ying Tefei (chicken genetic engineering interferon).
Chicken interferon gamma combined medicament injection A: made by embodiment 1.
Chicken interferon gamma combined medicament injection B: made by embodiment 2.
Chicken interferon gamma combined medicament injection C: made by embodiment 3.
1.2 virus
Infections chicken cloacal bursa virus provides for Agricultural University Of Nanjing.
1.3 laboratory animal
The healthy chick of 21 ages in days is available from periphery chicken farm, Weifang.
2, test procedure
2.1 the minimum morbidity dosimetry of infections chicken cloacal bursa virus
With 50 healthy chickens, be divided at random 5 groups, 10 every group, infections chicken cloacal bursa virus is made doubling dilution.First group to the 4th group difference oral 10
1-10
4Viral dilution liquid 1ml, the 5th group is the blank group, oral 1ml normal saline.With the minimum counteracting toxic substances dosage of morbidity group in 48 hours as the minimum morbidity dosage of infections chicken cloacal bursa virus.
2.2 chicken interferon gamma combined medicament prevention infections chicken cloacal bursa virus infection experiment
With 120 healthy chickens, be divided at random 6 groups, every group 20, first group of intramuscular injection chicken interferon gamma 0.5ml/kg, second group of intramuscular injection chicken interferon gamma combined medicament injection A 0.5ml/kg, the 3rd group of intramuscular injection chicken interferon gamma combined medicament injection B0.5ml/kg, the 4th group of intramuscular injection chicken interferon gamma combined medicament injection C 0.5ml/kg, the 5th group is the blank group, and the 6th group is the counteracting toxic substances matched group.After the administration 2 hours, the 5th group chick oral normal saline 1ml, the infections chicken cloacal bursa virus of 10 times of minimum morbidity dosage of chicken collunarium inoculation of other each groups was observed 48 hours.
3, result of the test
3.1 the minimum morbidity Dose Results of infections chicken cloacal bursa virus
Clinical symptoms performance behind the chicken inoculation various dose infections chicken cloacal bursa virus sees Table 1, the infections chicken cloacal bursa virus of inoculation high concentration, it is depressed that chicken at 30 hours spirit occurs, feed intake reduces, drinking-water increases, and some arranges the typical fabricius bursa symptoms such as white water sample loose stool from the anus pecking door, the 4th group light symptoms occurred in rear 48 hours connecing poison, and blank group chick is acted normally.So with 1ml 10
4The infections chicken cloacal bursa virus virus liquid of dilution is as the minimum morbidity dosage of infections chicken cloacal bursa.
Clinical manifestation behind the table 1 chicken inoculation various dose infections chicken cloacal bursa virus
3.2 chicken interferon gamma combined medicament prevention infections chicken cloacal bursa virus infection experiment result
Connect the sickness rate of respectively organizing chicken behind the poison and see Table 2, the chick of intramuscular injection chicken IFN-γ had 12 chickens typical infectious bursal disease symptom to occur about 48 hours.And intramuscular injection chicken interferon gamma combined medicament injection A and chicken interferon gamma combined medicament injection B and chicken interferon gamma combined medicament injection C group morbidity number are 4,2,1.20 chick clinical manifestations of blank group are normal, not morbidity.
Table 2 connects the sickness rate of respectively organizing chicken behind the poison
4, conclusion (of pressure testing)
Chicken interferon gamma combined medicament injection A, chicken interferon gamma combined medicament injection B, chicken interferon gamma combined medicament injection C all are better than chicken interferon gamma to the prevention effect of infectious bursal disease.Chicken interferon gamma combined medicament injection C prevention effect is best.
Two, chicken interferon gamma combination medicine control avian infectious bronchitis virus infection experiment
1, test material
1.1 medicine
Chicken interferon gamma: the product that Shandong Sinostar Bioscience and Technology Co., Ltd.'s external disclosure is sold, trade name: Ying Tefei (chicken genetic engineering interferon).
Chicken interferon gamma combined medicament injection A: made by embodiment 1.
Chicken interferon gamma combined medicament injection B: made by embodiment 2.
Chicken interferon gamma combined medicament injection C: made by embodiment 3.
1.2 virus
Avian infectious bronchitis virus provides for Agricultural University Of Nanjing.
1.3 laboratory animal
The healthy chick of 21 ages in days is available from periphery chicken farm, Weifang.
2, test procedure
2.1 the minimum morbidity dosimetry of avian infectious bronchitis virus
With 50 healthy chickens, be divided at random 5 groups, 10 every group, avian infectious bronchitis virus is made doubling dilution.First group to the 4th group difference oral 10
1-10
4Viral dilution liquid 1ml, the 5th group is the blank group, oral 1ml normal saline.With the minimum counteracting toxic substances dosage of morbidity group in 48 hours as the minimum morbidity dosage of avian infectious bronchitis virus.
2.2 chicken interferon gamma combined medicament prevention avian infectious bronchitis virus infection experiment
With 120 healthy chickens, be divided at random 6 groups, every group 20, first group of intramuscular injection chicken interferon gamma 0.5ml/kg, second group of intramuscular injection chicken interferon gamma combined medicament injection A 0.5ml/kg, the 3rd group of intramuscular injection chicken interferon gamma combined medicament injection B0.5ml/kg, the 4th group of intramuscular injection chicken interferon gamma combined medicament injection C 0.5ml/kg, the 5th group is the blank group, and the 6th group is the counteracting toxic substances matched group.After the administration 2 hours, the 5th group chick oral normal saline 1ml, the avian infectious bronchitis virus of 10 times of minimum morbidity dosage of chicken collunarium inoculation of other each groups was observed 30 hours.
3, result of the test
3.1 the minimum morbidity Dose Results of avian infectious bronchitis virus
Clinical symptoms performance behind the chicken inoculation various dose avian infectious bronchitis virus sees Table 3, the avian infectious bronchitis virus of inoculation high concentration, chicken dehisced to pant, coughs, flows nose liquid at 15 hours, trachea has the typical bronchitis symptoms such as sound of vomiting sound, the 4th group light symptoms occurred in rear 30 hours connecing poison, and blank group chick is acted normally.So with 1ml 10
4The avian infectious bronchitis virus virus liquid of dilution is as the minimum morbidity dosage of infectious bronchitis of chicken.
Clinical manifestation behind the table 3 chicken inoculation various dose avian infectious bronchitis virus
3.2 chicken interferon gamma combined medicament prevention avian infectious bronchitis virus infection experiment result
Connect the sickness rate of respectively organizing chicken behind the poison and see Table 4, the chick of intramuscular injection chicken IFN-γ had 8 chickens typical infectious bronchitis disease symptoms to occur about 48 hours.And intramuscular injection chicken interferon gamma combined medicament injection A and chicken interferon gamma combined medicament injection B and chicken interferon gamma combined medicament injection C group morbidity number are 3,1,0.20 chick clinical manifestations of blank group are normal, not morbidity.
Table 4 connects the sickness rate of respectively organizing chicken behind the poison
4, conclusion (of pressure testing)
Chicken interferon gamma combined medicament injection A, chicken interferon gamma combined medicament injection B, chicken interferon gamma combined medicament injection C all are better than chicken interferon gamma to the prevention effect of infectious bronchitis.Chicken interferon gamma combined medicament injection C prevention effect is best.
Claims (2)
1. a chicken interferon gamma combined medicament injection is characterized in that, every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 400～500ml, Radix Astragali extract 100～180g, Cortex Phellodendri extract 100～180g, Rhizoma Coptidis extract 100～180g, the 20～30g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～80g, bursin peptide 2～8g;
Described chicken interferon gamma antiviral activity is 1 * 10
4IU/ml.
2. chicken interferon gamma combined medicament injection as claimed in claim 1 is characterized in that, described every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 400～460ml, Radix Astragali extract 100～150g, Cortex Phellodendri extract 100～150g, Rhizoma Coptidis extract 100～150g, the 20～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 40～60g, bursin peptide 2～5g.
3, chicken interferon gamma combined medicament injection as claimed in claim 2 is characterized in that, described every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 430～460ml, Radix Astragali extract 120～150g, Cortex Phellodendri extract 120～150g, Rhizoma Coptidis extract 120～150g, the 22～25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 50～60g, bursin peptide 3.5～5g.
4, chicken interferon gamma combined medicament injection as claimed in claim 3 is characterized in that, described every liter of chicken interferon gamma combined medicament injection is made by following raw material:
Chicken interferon gamma 460ml, Radix Astragali extract 150g, Cortex Phellodendri extract 150g, Rhizoma Coptidis extract 150g, the 25g of Radix Codonopsis extract, Radix Glycyrrhizae extract 60g, bursin peptide 5g.
5, the preparation method of the described chicken interferon gamma combined medicament injection of claim 1 is characterized in that, makes as follows:
Take by weighing above-mentioned raw materials, after ice bath mixed 15min, water for injection added to 1000ml, made liquid suspension, and 0.22 μ m cellulose membrane filtration sterilization namely gets the chicken interferon gamma combined medicament injection.
6, preparation method as claimed in claim 5 is characterized in that, described ice bath is 4 ℃ of ice baths.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110160737 CN102228679B (en) | 2011-06-15 | 2011-06-15 | Chicken interferon gamma combined medicament and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110160737 CN102228679B (en) | 2011-06-15 | 2011-06-15 | Chicken interferon gamma combined medicament and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102228679A CN102228679A (en) | 2011-11-02 |
| CN102228679B true CN102228679B (en) | 2013-01-02 |
Family
ID=44841311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110160737 Active CN102228679B (en) | 2011-06-15 | 2011-06-15 | Chicken interferon gamma combined medicament and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102228679B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397530B (en) * | 2011-11-15 | 2013-05-22 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating avian infectious encephalomyelitis and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883610B (en) * | 2006-05-19 | 2011-11-02 | 天津生机集团有限公司 | Chinese animal medicine for treating birds viral disease and method for preparing same |
| CN101297879A (en) * | 2008-04-25 | 2008-11-05 | 天津生机集团股份有限公司 | Interferon Chinese medicament inducer composition for treating avian virus disease and preparation |
| CN101856495B (en) * | 2009-04-09 | 2012-06-06 | 河南惠通天下动物药业有限公司 | Medical composition and mixture for treating chicken infectious bursal disease and preparation method thereof |
| CN101658247A (en) * | 2009-08-26 | 2010-03-03 | 王直军 | Chinese medicinal feed additive for preventing and treating common diseases of chickens |
-
2011
- 2011-06-15 CN CN 201110160737 patent/CN102228679B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102228679A (en) | 2011-11-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101023997A (en) | Anti-fowl-plague Chinese medicine and preparing method | |
| CN1839988A (en) | Traditional Chinese medicine composition for treating fowl influenza, its preparation method and uses | |
| CN101007067A (en) | Antivirus medicine for birds and its preparation method | |
| CN101209297A (en) | Compound Chinese medicinal granule for treating chicken coccidiosis | |
| CN105641031A (en) | Compound pharmaceutical composition for strengthening body resistance and removing toxin, use and feed thereof | |
| CN103083510A (en) | Chinese medicinal oral liquid for improving poultry immune function and its preparation method | |
| CN103285255B (en) | Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof | |
| CN101249113A (en) | Applications of ash tree flowers polysaccharide for preparing preventing and controlling fowl virosis medicament | |
| CN102228679B (en) | Chicken interferon gamma combined medicament and application | |
| CN107279572A (en) | A kind of Chinese herbal feed additive for preventing and treating animal viral disease | |
| CN101259160A (en) | Compound preparations for treating birdsvirosis and preparation thereof | |
| CN103860656A (en) | Traditional Chinese medicinal composition, and preparation method and application thereof | |
| CN1957997A (en) | Animal use compound medicament with effects of relieving the muscles and skin, clearing away heat, relieving darrhea, and relieving dysentery, and preparation method | |
| CN1180806C (en) | Pure Chinese medicine preparation | |
| CN105456185A (en) | Compound Astragalus polysaccharides injection and preparation method thereof | |
| CN102225195B (en) | Porcine interferon-gamma composite medicament and application thereof | |
| CN102091321A (en) | Medicament oral liquid for treating enteritis and diarrhea and preparation method thereof | |
| CN102205118B (en) | Biological product and preparation method thereof | |
| CN101797345B (en) | Traditional Chinese medicine composition for preventing and treating viral diseases of poultry and preparation method | |
| CN101376006A (en) | Chinese medicine oral liquid with heat-clearing and detoxicating, cough-suppressing and asthma-relieving functions as well as application thereof for livestock and poultry | |
| CN1939370A (en) | Animal medicament with heat-clearing and dampness-resolving functions and its preparation | |
| CN102204933B (en) | Preparation method of biological anti-tumor product | |
| CN103705533B (en) | Pharmaceutical composition of preventing and treating poultry infectious disease and its preparation method and application | |
| CN102580088A (en) | Egg yolk antibody for treating porcine circovirus disease and method for producing compound thereof | |
| CN108452014B (en) | Pharmaceutical composition for purifying seed of salmonella gallinarum |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Chicken interferon gamma combined medicament and application Effective date of registration: 20150113 Granted publication date: 20130102 Pledgee: Rizhao bank Limited by Share Ltd Weifang branch Pledgor: Shandong Sinostar Bioscience and Technology Co., Ltd. Registration number: 2015980000001 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Jiang Zhengjun Inventor after: Su Xiaoming Inventor after: Kuang Baoxiao Inventor after: Wang Shaojuan Inventor after: Tian Jianguo Inventor after: Liu Lulu Inventor after: Wang Maochao Inventor after: Wang Yanyu Inventor before: Jiang Zhengjun Inventor before: Su Xiaoming Inventor before: Tian Jianguo Inventor before: Liu Lulu Inventor before: Wang Maochao Inventor before: Wang Yanyu |
|
| CB03 | Change of inventor or designer information | ||
| CP03 | Change of name, title or address |
Address after: 261061 Weifang high tech Zone, Shandong Chang Shun Street, No. 207 Patentee after: Shandong Huachen Pharmaceutical Co., Ltd. Address before: 262610 Weifang high tech Zone, Jin Road, No. 516, No. Patentee before: Shandong Sinostar Bioscience and Technology Co., Ltd. |
|
| CP03 | Change of name, title or address |