CN102212126A - 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 - Google Patents
具有抑制内皮细胞生长活性的重组EDI-8t蛋白 Download PDFInfo
- Publication number
- CN102212126A CN102212126A CN2010101416158A CN201010141615A CN102212126A CN 102212126 A CN102212126 A CN 102212126A CN 2010101416158 A CN2010101416158 A CN 2010101416158A CN 201010141615 A CN201010141615 A CN 201010141615A CN 102212126 A CN102212126 A CN 102212126A
- Authority
- CN
- China
- Prior art keywords
- polypeptide
- edi
- polynucleotide
- sequence
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
最初的残基 | 代表性的取代 | 优选的取代 |
Ala(A) | Val;Leu;Ile | Val |
Arg(R) | Lys;Gln;Asn | Lys |
Asn(N) | Gln;His;Lys;Arg | Gln |
Asp(D) | Glu | Glu |
Cys(C) | Ser | Ser |
Gln(Q) | Asn | Asn |
Glu(E) | Asp | Asp |
Gly(G) | Pro;Ala | Ala |
His(H) | Asn;Gln;Lys;Arg | Arg |
Ile(I) | Leu;Val;Met;Ala;Phe | Leu |
Leu(L) | Ile;Val;Met;Ala;Phe | Ile |
Lys(K) | Arg;Gln;Asn | Arg |
Met(M) | Leu;Phe;Ile | Leu |
Phe(F) | Leu;Val;Ile;Ala;Tyr | Leu |
Pro(P) | Ala | Ala |
Ser(S) | Thr | Thr |
Thr(T) | Ser | Ser |
Trp(W) | Tyr;Phe | Tyr |
Tyr(Y) | Trp;Phe;Thr;Ser | Phe |
Val(V) | Ile;Leu;Met;Phe;Ala | Leu |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010141615 CN102212126B (zh) | 2010-04-08 | 2010-04-08 | 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010141615 CN102212126B (zh) | 2010-04-08 | 2010-04-08 | 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102212126A true CN102212126A (zh) | 2011-10-12 |
CN102212126B CN102212126B (zh) | 2013-06-19 |
Family
ID=44743690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201010141615 Active CN102212126B (zh) | 2010-04-08 | 2010-04-08 | 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102212126B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997017988A1 (en) * | 1995-11-13 | 1997-05-22 | Fibrogen, Inc. | Type ix collagen and chimeras |
CN1207046A (zh) * | 1995-11-13 | 1999-02-03 | 菲布洛根有限公司 | Ix型胶原蛋白和嵌合体 |
CN1386753A (zh) * | 2001-05-23 | 2002-12-25 | 中国科学院上海生物化学研究所 | 具有抑制内皮细胞生长活性的重组人内皮生长抑制蛋白 |
CN1884527A (zh) * | 2006-06-09 | 2006-12-27 | 郑金平 | 利用内源性血管生成抑制因子Arresten基因制备蛋白的方法 |
-
2010
- 2010-04-08 CN CN 201010141615 patent/CN102212126B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997017988A1 (en) * | 1995-11-13 | 1997-05-22 | Fibrogen, Inc. | Type ix collagen and chimeras |
CN1207046A (zh) * | 1995-11-13 | 1999-02-03 | 菲布洛根有限公司 | Ix型胶原蛋白和嵌合体 |
CN1386753A (zh) * | 2001-05-23 | 2002-12-25 | 中国科学院上海生物化学研究所 | 具有抑制内皮细胞生长活性的重组人内皮生长抑制蛋白 |
CN1884527A (zh) * | 2006-06-09 | 2006-12-27 | 郑金平 | 利用内源性血管生成抑制因子Arresten基因制备蛋白的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102212126B (zh) | 2013-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100400657C (zh) | 磷酸激酶及其应用 | |
WO2005121176A1 (fr) | Proteine chimerique inhibitrice d'angiogenese et utilisation associee | |
CN109072255A (zh) | 用于治疗皮肤的伤口、病症和疾病的组合物和方法 | |
CN102584976B (zh) | 一种人血清淀粉样蛋白a1及其制备方法和应用 | |
CN101524529B (zh) | HNF4α诱导分化治疗人体恶性实体瘤 | |
CN108840947A (zh) | 牛白蛋白-干扰素α-白介素2融合蛋白、制备方法及其编码基因、一种牛长效干扰素 | |
CN101070349B (zh) | 具有选择性杀伤肿瘤新生血管内皮细胞作用的融合蛋白与应用 | |
CN104177492A (zh) | FGFR2c胞外段类似物及其编码基因与应用 | |
CN103319605A (zh) | 一种肝靶向肽与血管生成抑制因子融合蛋白及其制备方法与应用 | |
CN102212126B (zh) | 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 | |
CN1952129B (zh) | Angptl4缺失突变体及其应用 | |
CN103159848B (zh) | 人胰高血糖素样肽-2二串体蛋白及其制备方法 | |
CN101173003A (zh) | 尖吻蝮蛇毒凝血酶原激活剂、其编码序列及用途 | |
CN102475893B (zh) | 肝细胞核因子1α治疗人体恶性实体瘤 | |
CN101560247A (zh) | 大肠杆菌热敏性肠毒素双突变体作为疫苗黏膜免疫佐剂 | |
CN103864939A (zh) | mGM-CSF/βhCG融合蛋白及其制备方法和应用 | |
CN100999725A (zh) | 细胞周期重要调控激酶pftk1 | |
CN103865899B (zh) | 具有vegfr2/kdr受体特异性的融合毒素及其编码基因与应用 | |
CN101298611B (zh) | 衣原体蛋白酶体样活性因子的活性片段及其表达方法 | |
CN101890153A (zh) | 肝细胞核因子4α治疗慢性肝病 | |
CN100480264C (zh) | 一种广谱抑制癌细胞生长的蚯蚓蛋白及其编码序列 | |
CN107254000A (zh) | 一种由羊白蛋白与羊干扰素γ组成的融合蛋白及其制备方法和一种重组羊长效干扰素γ | |
CN107253999A (zh) | 一种重组羊长效干扰素γ及制备此长效干扰素γ的融合蛋白及其制备方法 | |
CN107286251A (zh) | 一种由牛白细胞介素2、牛干扰素γ和牛干扰素α组成的融合蛋白及其制备方法 | |
CN102153644A (zh) | 一种表皮生长因子受体二聚化抗原肽 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI YUYUAN BIO-PHARMACEUTICAL RESEARCH + DEVE Free format text: FORMER OWNER: SHANGHAI APELOA PHARMACEUTICAL INSTITUTE CO., LTD. Effective date: 20131121 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201314 NANHUI, SHANGHAI TO: 201300 PUDONG NEW AREA, SHANGHAI |
|
TR01 | Transfer of patent right |
Effective date of registration: 20131121 Address after: Shanghai Road Pudong New Area town Shanghai City, No. 9628, 201300 Patentee after: SHANGHAI YUYUAN BIOLOGICAL MEDICINE RESEARCH AND DEVELOPMENT Co.,Ltd. Address before: 201314 No. 1399 middle Garden Road, Nanhui Industrial Park, Shanghai Patentee before: SHANGHAI APELOA PHARMACEUTICAL RES Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221012 Address after: 201306 building C, No. 888, Huanhu West 2nd Road, Lingang New District, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai Patentee after: Shanghai Puluochuangzhi Pharmaceutical Technology Co.,Ltd. Patentee after: APELOA PHARMACEUTICAL CO.,LTD. Address before: 201300 No. 9628, Hunan Road, Huinan Town, Pudong New Area, Shanghai Patentee before: SHANGHAI YUYUAN BIOLOGICAL MEDICINE RESEARCH AND DEVELOPMENT Co.,Ltd. |