CN102209705A - 芬戈莫德盐酸盐的结晶形式 - Google Patents

芬戈莫德盐酸盐的结晶形式 Download PDF

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Publication number
CN102209705A
CN102209705A CN200980144998XA CN200980144998A CN102209705A CN 102209705 A CN102209705 A CN 102209705A CN 200980144998X A CN200980144998X A CN 200980144998XA CN 200980144998 A CN200980144998 A CN 200980144998A CN 102209705 A CN102209705 A CN 102209705A
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China
Prior art keywords
salt
fty720
peak
weak
ray powder
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CN200980144998XA
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English (en)
Chinese (zh)
Inventor
M·马兹
G·约尔丁
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Novartis AG
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Novartis AG
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Priority to CN201510141353.8A priority Critical patent/CN104788325A/zh
Priority to CN201710377640.8A priority patent/CN107233336A/zh
Publication of CN102209705A publication Critical patent/CN102209705A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980144998XA 2008-11-11 2009-11-10 芬戈莫德盐酸盐的结晶形式 Pending CN102209705A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510141353.8A CN104788325A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式
CN201710377640.8A CN107233336A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08168865 2008-11-11
EP08168865.7 2008-11-11
PCT/EP2009/064891 WO2010055028A2 (en) 2008-11-11 2009-11-10 Organic compounds

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201710377640.8A Division CN107233336A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式
CN201510141353.8A Division CN104788325A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式

Publications (1)

Publication Number Publication Date
CN102209705A true CN102209705A (zh) 2011-10-05

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN200980144998XA Pending CN102209705A (zh) 2008-11-11 2009-11-10 芬戈莫德盐酸盐的结晶形式
CN201510141353.8A Pending CN104788325A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式
CN201710377640.8A Pending CN107233336A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201510141353.8A Pending CN104788325A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式
CN201710377640.8A Pending CN107233336A (zh) 2008-11-11 2009-11-10 芬戈莫德的结晶形式

Country Status (14)

Country Link
US (2) US8530522B2 (https=)
EP (1) EP2356090B1 (https=)
JP (4) JP2012508216A (https=)
KR (2) KR20130109254A (https=)
CN (3) CN102209705A (https=)
AU (1) AU2009315736B2 (https=)
BR (1) BRPI0921826A2 (https=)
CA (1) CA2743232C (https=)
ES (1) ES2643161T3 (https=)
MX (1) MX2011004962A (https=)
PL (1) PL2356090T3 (https=)
PT (1) PT2356090T (https=)
RU (2) RU2549899C2 (https=)
WO (1) WO2010055028A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014036865A1 (zh) * 2012-09-05 2014-03-13 中国科学院上海药物研究所 芬戈莫德粘酸盐及其晶体的制备方法和用途
CN106667981A (zh) * 2017-01-16 2017-05-17 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗药物性肝损伤药物中的应用
CN106860440A (zh) * 2017-01-16 2017-06-20 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗系统性红斑狼疮脑病药物中的应用

Families Citing this family (23)

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WO2012041358A1 (en) 2010-10-01 2012-04-05 Synthon B.V. Process for making fingolimod hydrochloride crystals
EP2632889B1 (en) 2010-10-28 2018-08-29 Mapi Pharma Limited Intermediate compounds and process for the preparation of fingolimod
WO2012071524A1 (en) 2010-11-24 2012-05-31 Ratiopharm Gmbh Arylsulfonate salts of fingolimod and processes for preparation thereof
WO2012070059A1 (en) * 2010-11-25 2012-05-31 Shilpa Medicare Limited Fingolimod polymorphs and their processes
WO2012089238A1 (en) 2010-12-28 2012-07-05 Synthon Bv Process for making fingolimod hydrochloride crystals
WO2012097330A2 (en) * 2011-01-14 2012-07-19 University Of Washington Compositions and methods for treating degenerative muscle conditions
US9216943B2 (en) 2011-04-29 2015-12-22 Dr. Reddy's Laboratories Ltd. Preparation of fingolimod and its salts
DK2809318T3 (da) 2011-05-26 2019-07-22 Gri Bio Inc Ammoniumholdige sulfonsyre-, phosphonsyre- og carboxylsyrederivater og disses medicinske anvendelse
WO2012160186A1 (en) 2011-05-26 2012-11-29 Jado Technologies Gmbh Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use
DK2739606T3 (en) 2011-05-26 2016-07-25 Jado Tech Gmbh Hydroxy-substituted amino and ammonium derivatives and their medical use
US9186333B2 (en) 2011-08-01 2015-11-17 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutical compositions of fingolimod
WO2013091704A1 (en) * 2011-12-22 2013-06-27 Synthon Bv Pharmaceutical composition comprising fingolimod
AU2014206588A1 (en) * 2013-01-17 2015-07-23 Shilpa Medicare Limited Process for preparation of Fingolimod and its salts
US9815772B2 (en) * 2013-03-05 2017-11-14 Biocon Limited Process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof
EP3027174B1 (en) 2013-07-29 2019-07-24 Aizant Drug Research Solutions Private Limited Pharmaceutical compositions of fingolimod
WO2016042493A1 (en) * 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
RU2627691C1 (ru) * 2016-07-06 2017-08-10 Олег Ростиславович Михайлов Кристаллическая η-модификация 2-амино-2-(2-(4-октилфенил)этил)пропан-1,3-диол гидрохлорида, способ её получения и фармацевтическая композиция на её основе
GR1009654B (el) 2018-08-31 2019-11-18 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου
WO2020245775A1 (en) * 2019-06-05 2020-12-10 Biocon Limited Crystalline forms of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol
JP7749552B2 (ja) 2019-10-31 2025-10-06 イドルシア・ファーマシューティカルズ・リミテッド Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤
CN115477590B (zh) 2021-05-31 2023-12-12 上海云晟研新生物科技有限公司 芬戈莫德药用盐、制备方法、含其的药物组合物及应用
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator

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US5604229A (en) * 1992-10-21 1997-02-18 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
CN1344155A (zh) * 1999-01-27 2002-04-10 概念股份公司 用高适应性的载体经鼻输送/免疫接种
CN1346348A (zh) * 1999-02-10 2002-04-24 卫福有限公司 酰胺化合物及其药物用途
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
WO2004089341A1 (en) * 2003-04-08 2004-10-21 Novartis Ag Organic compounds

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JP4079505B2 (ja) * 1998-04-28 2008-04-23 田辺三菱製薬株式会社 ２−アミノ−２−［２−（４−オクチルフェニル）エチル］プロパン−１，３−ジオールの新規な製造法
DK1129066T3 (da) * 1998-11-11 2005-03-29 Novartis Ag Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler
CN1144779C (zh) * 1999-03-11 2004-04-07 杭州中美华东制药有限公司 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物
BR0209319A (pt) * 2001-06-08 2004-07-20 Novartis Ag Tratamento ou profilaxia de rejeição de enxerto de célula produtora de insulina
US20030144712A1 (en) * 2001-12-20 2003-07-31 Jackson Streeter, M.D. Methods for overcoming organ transplant rejection
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TWI418350B (zh) * 2005-06-24 2013-12-11 Sankyo Co 含有ｐｐａｒ調節劑之醫藥組成物的用途
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US5604229A (en) * 1992-10-21 1997-02-18 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
CN1344155A (zh) * 1999-01-27 2002-04-10 概念股份公司 用高适应性的载体经鼻输送/免疫接种
CN1346348A (zh) * 1999-02-10 2002-04-24 卫福有限公司 酰胺化合物及其药物用途
WO2004089341A1 (en) * 2003-04-08 2004-10-21 Novartis Ag Organic compounds

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014036865A1 (zh) * 2012-09-05 2014-03-13 中国科学院上海药物研究所 芬戈莫德粘酸盐及其晶体的制备方法和用途
CN106667981A (zh) * 2017-01-16 2017-05-17 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗药物性肝损伤药物中的应用
CN106860440A (zh) * 2017-01-16 2017-06-20 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗系统性红斑狼疮脑病药物中的应用
CN106667981B (zh) * 2017-01-16 2019-05-14 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗药物性肝损伤药物中的应用

Also Published As

Publication number Publication date
JP2014139179A (ja) 2014-07-31
US20140051766A1 (en) 2014-02-20
RU2015111229A (ru) 2015-11-20
CN104788325A (zh) 2015-07-22
EP2356090A2 (en) 2011-08-17
US20110229501A1 (en) 2011-09-22
BRPI0921826A2 (pt) 2016-01-12
US8530522B2 (en) 2013-09-10
MX2011004962A (es) 2011-05-30
RU2549899C2 (ru) 2015-05-10
KR20110069156A (ko) 2011-06-22
CA2743232C (en) 2015-12-29
WO2010055028A2 (en) 2010-05-20
EP2356090B1 (en) 2017-07-05
KR20130109254A (ko) 2013-10-07
RU2015111229A3 (https=) 2018-11-08
JP2018035160A (ja) 2018-03-08
WO2010055028A3 (en) 2010-07-08
ES2643161T3 (es) 2017-11-21
PL2356090T3 (pl) 2017-12-29
JP2012508216A (ja) 2012-04-05
RU2011123371A (ru) 2012-12-20
JP2016028056A (ja) 2016-02-25
PT2356090T (pt) 2017-10-16
AU2009315736A1 (en) 2010-05-20
KR101393994B1 (ko) 2014-05-14
CN107233336A (zh) 2017-10-10
AU2009315736B2 (en) 2013-08-29
CA2743232A1 (en) 2010-05-20

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Application publication date: 20111005