CN102204875B - Total effect toothpaste and preparation method thereof - Google Patents
Total effect toothpaste and preparation method thereof Download PDFInfo
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- CN102204875B CN102204875B CN201110123383A CN201110123383A CN102204875B CN 102204875 B CN102204875 B CN 102204875B CN 201110123383 A CN201110123383 A CN 201110123383A CN 201110123383 A CN201110123383 A CN 201110123383A CN 102204875 B CN102204875 B CN 102204875B
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Abstract
The invention discloses total effect toothpaste with functions of whitening, preventing caries and resisting allergy and the like and a preparation method thereof and aims to solve the problem of single function existing in the conventional toothpaste. The total effect toothpaste consists of the following components in percentage by weight: 2-6 percent of strontium substituted hydroxyapatite, 8-16 percent of beta-tricalcium phosphate, 0.5-1 percent of rhizoma drynariae, 0.1-0.5 percent of astragalus, 0.1-0.3 percent of chitosan, 0.05-0.2 percent of vitamin A and the balance of toothpaste substrate. The total effect toothpaste has whitening, caries prevention, anti-allergy and gum protection functions, comprehensive effect and good oral health effect.
Description
Technical field
The present invention relates to the toothpaste production technical field, full effective toothpaste of functions such as particularly a kind of Pear Power, preventing decayed tooth and antiallergic and preparation method thereof.
Background technology
Toothpaste is the indispensable daily necessities of a kind of human lives, in the oral cavity, uses, and helps people's cleaning oral cavity, fresh breath.Along with the life of consumer improves constantly, make the transition to effect type toothpaste from clean type toothpaste.Different efficacies toothpaste is arranged on market at present: like preventing decayed tooth, antiallergic, antiinflammatory, protect gum, various effect toothpaste such as whiten, but the effect of these toothpaste is comparatively single, can't satisfy the user demand of modern's diversification.
The disclosure of the Invention of publication number CN1864661A a kind of highly effective plaque-removing whitening toothpaste and manufacturing approach thereof, this toothpaste is formulated by its percentage by weight by following raw material: nanometer fine silicon dioxide 30～40, natural glycerin 10～15, sorbitol 18～30, hydroxy methocel 0.5～1.2, hydroxyethyl-cellulose 0.1～0.3, lauroyl sarcosine 1.5～2.5, compound enzyme 0.01～0.1, brighten particle 1.5～5, EDTA-2Na 0.1～0.3, zinc citrate 0.5～3.5, pure propolis 0.3～0.8, strontium chloride 0.5～0.8, saccharin sodium 0.2～0.3, D-panthenol 0.8～1.0, spice 0.8～1.2, deionized water surplus.The effect of this toothpaste is that stain is whitened, and still has the single problem of effect.
Summary of the invention
The objective of the invention is to solve the single problem of effect that existing toothpaste exists, a kind of full effective toothpaste is provided, its is Pear Power, preventing decayed tooth, antiallergic and protect the gum effect simultaneously, and effect is comprehensive, and oral cavity health is effective.
Another object of the present invention is to provide a kind of method for preparing of full effective toothpaste.
The technical solution adopted for the present invention to solve the technical problems is: a kind of full effective toothpaste; Described full effective toothpaste is grouped into by following one-tenth by weight percentage: strontium-doped hydroxyapatite 2 ~ 6%, bata-tricalcium phosphate 8 ~ 16%, Rhizoma Drynariae 0.5 ~ 1%; The Radix Astragali 0.1 ~ 0.5%; Chitosan 0.1 ~ 0.3%, vitamin A 0.05 ~ 0.2%, surplus is a toothpaste matrix.
Strontium-doped hydroxyapatite has good bone guided property; Can promote the anti-dental caries ability of enamel surface remineralization, enhancing enamel; Strontium-doped hydroxyapatite has the favorable tissue compatibility, can promote the reparation of damaged alveolar bone, effectively prevents the atrophy of frontal resorption; The strontium-doped hydroxyapatite biological degradability is good, and cytotoxicity is little, is beneficial to the reparation fully of alveolar bone function.Strontium-doped hydroxyapatite, bata-tricalcium phosphate are the alveolar bone impairment renovation materials.
Strontium-doped hydroxyapatite has absorption, antibacterial. effects such as remineralization, antiallergic. and because of its favorable tissue compatibility of strontium-doped hydroxyapatite, bone guided property and biological degradability, be a kind of extremely desirable bone reparation, bone replacing material.
Rhizoma Drynariae, the Radix Astragali are the antibacterial Chinese medicine ingredients of nutrition, and the Radix Astragali has the blood circulation of improvement, effect such as antibacterial, and the Radix Astragali is applied topically to periodontal, can inhibitory action be arranged to the periodontal pathogenic bacterium, and can effectively promote the formation of bone; Rhizoma Drynariae has the favorable tissue compatibility, promotes osteoblastic proliferation activity, promotion calcium, phosphorus deposition, thereby promotes bone injury healing, improves bone density.
Chitosan and human body cell have good affinity; Nontoxic, non-immunogenicity; Chitosan has bacteriostatic activity preferably; Chitosan can be to many cell adhesions and differentiation: like fibroblast, keratinocyte, endotheliocyte, osteoblast, chondrocyte etc., for cell provides better adhesion growing environment.Vitamin A quickens the release that proteoglycan combines calcium phosphorus, promotes tissue calcification.
The present invention through mix the strontium nanometer hydroxyapatite, bata-tricalcium phosphate is uniformly dispersed in organic facies, and interacts with the antibacterial Chinese medicinal ingredients of nutrition such as Rhizoma Drynariae, the Radix Astragali and chitosan and vitamin A, promotes periodontal ligament cell adhesive bond regeneration propagation.In the process of brushing teeth, make the surface of tooth defect reach reparation, to tooth Pear Power, preventing decayed tooth, protect gum, antiallergic effect.
As preferably, the doping of strontium is 6 wt% ~ 10 wt% in the described strontium-doped hydroxyapatite.Hydroxyapatite is a kind of defect repair of bone preferably, replacing material, but after the hydroxyapatite immersion tissue, is not easy degraded, is unfavorable for the reparation fully of bone function.Strontium is one of trace element of needed by human, and the effect of preventing decayed tooth and enhance bone intensity is arranged, and after hydroxyapatite is mixed strontium, has changed its crystallinity, and biological degradability is good, and cytotoxicity is little, is beneficial to the reparation fully of bone function.
As preferably, described toothpaste matrix comprises abrasivus, wetting agent, adhesive, foaming agent, sweeting agent, deionized water and spice, and by the percentage ratio that accounts for full effective toothpaste gross weight: abrasivus is 20 ~ 40%; Wetting agent is 15 ~ 35%; Adhesive is 0.8 ~ 1.5%, and foaming agent is 1.5 ~ 2.5%, and sweeting agent is 0.1 ~ 0.3%; Deionized water is 18 ~ 30%, and spice is 0.8 ~ 1.4%.
As preferably, described abrasivus is selected from one or both the combination in calcium hydrogen phosphate, the calcium carbonate.Abrasivus of the present invention is a calcic class material, is playing preventing decayed tooth, can provide the capacity tooth required phosphorus calcium source when repairing the tooth defect surface like this.
As preferably, described wetting agent is by a kind of the combining in sorbitol and glycerol, Polyethylene Glycol, the propylene glycol.
As preferably, described adhesive is selected from one or more the combination in Carboxymethyl cellulose sodium, hydroxyethyl-cellulose, carrageenan, xanthan gum, the guar gum.
As preferably, described foaming agent is selected from one or both the combination in sodium lauryl sulphate, the sodium lauroyl sarcosine.
As preferably, described sweeting agent is selected from one or more combination of glucide, acesulfame potassium, saccharin sodium.Acesulfame potassium is claimed acesulfame potassium again.
A kind of method for preparing of full effective toothpaste, described method for preparing may further comprise the steps:
Step 1: with wetting agent, adhesive and chitosan mix jelly;
Step 2: the jelly that step 1 is obtained, sweeting agent and vitamin A add that mix homogeneously makes glue in the deionized water;
Step 3: the glue that step 2 is obtained sucks in the toothpaste Manufacturing medicine extract machine; In the toothpaste Manufacturing medicine extract machine, add abrasivus, strontium-doped hydroxyapatite, bata-tricalcium phosphate, Rhizoma Drynariae, the Radix Astragali, spice and foaming agent simultaneously; Mix; Vacuum outgas is 45 ~ 60 minutes under the environment of negative pressure 0.096pa ~ 0.1, gets product after the fill.
As preferably, the consumption of each composition is by weight percentage: strontium-doped hydroxyapatite 2 ~ 6%, bata-tricalcium phosphate 8 ~ 16%, Rhizoma Drynariae 0.5 ~ 1%; The Radix Astragali 0.1 ~ 0.5%, chitosan 0.1 ~ 0.3%, vitamin A 0.05 ~ 0.2%, abrasivus 20 ~ 40%; Wetting agent 15 ~ 35%, adhesive 0.8 ~ 1.5%, foaming agent 1.5 ~ 2.5%, sweeting agent 0.1 ~ 0.3%; Deionized water 18 ~ 30%, spice 0.8 ~ 1.4%, the doping of strontium is 6 wt% ~ 10 wt% in the described strontium-doped hydroxyapatite.
The invention has the beneficial effects as follows:
The comprehensive multicomponent raw material of the present invention is compound, can anti-inflammation, nutrient, active cell, the remineralization source is provided, and Pear Power, preventing decayed tooth, antiallergic and protect the gum effect, effect is comprehensive, and oral cavity health is effective.
Strontium-doped hydroxyapatite is the active material of high whiteness, can increase enamel density degree through its remineralization effect, improves enamel hardness, reduces the space face, improves and recovers adamantine natural beauty white light pool, plays the effect of tooth-whitening.
Dental caries is that a kind of hard tooth tissue that is caused by multiple factor compound action in the oral cavity carries out the sexually transmitted disease (STD) damage, shows as inanimate matter demineralization and organic matter decomposition, the evolution process that decreases to formation essence sexually transmitted disease (STD) from color change with course of disease development.Interact through hydroxyapatite, bata-tricalcium phosphate, chitosan and Rhizoma Drynariae, through absorption, antibacterial, remineralization promotes osteoblastic proliferation activity, promotion calcium, phosphorus deposition, thereby promotes bone injury healing, improves bone density, plays anti-caries effect.
Gingivitis is that the invasion by antibacterial causes, and shows as gingival hemorrhage, redness, distending pain, continues development and invades sclerous tissues, produces periodontal disease.So the Rhizoma Drynariae in prescription, Huang Shi and chitosan can both play the bactericidal effect, play and protect the gum effect.
Antiallergic is through the strontium ion in the strontium-doped hydroxyapatite, and strontium ion reduces Dentinal permeability through the form sealing dentinal tubule of calcification saamite, and the dentin hypersensitiveness symptom is had certain mitigation.Strontium-doped hydroxyapatite has the double activity of strontium and hydroxyapatite concurrently, can bring into play dual cooperative effect, directly acts on dentinal tubule, and desensitization is than single strontium chloride or hydroxyapatite better effects if.
The specific embodiment
Through specific embodiment, technical scheme of the present invention is further specified below.
Embodiment 1:
Step 1: with wetting agent (sorbitol 20kg+ glycerol 8kg), adhesive (Carboxymethyl cellulose sodium 0.8kg) and 0.1kg chitosan stir jelly;
Step 2: with jelly, sweeting agent (acesulfame potassium 0.15kg) and the 0.05kg vitamin A that step 1 obtains, mix homogeneously makes glue in the adding 18kg deionized water;
Step 3: the glue that step 2 is obtained sucks in the toothpaste Manufacturing medicine extract machine; In the toothpaste Manufacturing medicine extract machine, add abrasivus (calcium hydrogen phosphate 20kg+ calcium carbonate 20kg), the hydroxyapatite 2kg that mixes strontium 10%, bata-tricalcium phosphate 8kg, Rhizoma Drynariae 0.5kg, Radix Astragali 0.1kg, spice (essence 0.8kg) and foaming agent (sodium lauryl sulphate 1.5kg) simultaneously; Mix; At least vacuum outgas 45 minutes under the environment of negative pressure 0.096pa gets product after the fill.
Embodiment 2:
Step 1: with wetting agent (sorbitol 10kg+ Polyethylene Glycol 5kg), adhesive (xanthan gum 1.3kg) and 0.15kg chitosan mix jelly;
Step 2: with jelly, sweeting agent (glucide 0.2kg) and the 0.15kg vitamin A that step 1 obtains, mix homogeneously makes glue in the adding 28kg deionized water;
Step 3: the glue that step 2 is obtained sucks in the toothpaste Manufacturing medicine extract machine; In the toothpaste Manufacturing medicine extract machine, add abrasivus (calcium hydrogen phosphate 37kg), the hydroxyapatite 2.5kg that mixes strontium 6%, bata-tricalcium phosphate 12kg, Rhizoma Drynariae 0.7kg, Radix Astragali 0.3kg, spice (essence 1kg) and foaming agent (sodium lauryl sulphate 1.7kg) simultaneously; Mix; At least vacuum outgas 60 minutes under the environment of negative pressure 0.096pa gets product after the fill.
Embodiment 3:
Step 1: with wetting agent (sorbitol 18kg+ Polyethylene Glycol 2.5kg), adhesive (Carboxymethyl cellulose sodium 1kg+ carrageenan 0.5) and 0.3kg chitosan mix jelly;
Step 2: with jelly, sweeting agent (saccharin sodium 0.2kg+ glucide 0.1kg) and the 0.2kg vitamin A that step 1 obtains, mix homogeneously makes glue in the adding 30kg deionized water;
Step 3: the glue that step 2 is obtained sucks in the toothpaste Manufacturing medicine extract machine; In the toothpaste Manufacturing medicine extract machine, add abrasivus (calcium hydrogen phosphate 20kg), the hydroxyapatite 6kg that mixes strontium 8%, bata-tricalcium phosphate 16kg, Rhizoma Drynariae 1kg, Radix Astragali 0.5kg, spice (essence 1.2kg) and foaming agent (sodium lauryl sulphate 1.5kg+ sodium lauroyl sarcosine 1kg) simultaneously; Mix; Vacuum outgas is 50 minutes under the environment of negative pressure 0.096pa, gets product after the fill.
Embodiment 4:
Step 1: with wetting agent (sorbitol 27kg+ propylene glycol 8kg), adhesive (hydroxyethyl-cellulose 1kg) and 0.2kg chitosan mix jelly;
Step 2: with jelly, sweeting agent (acesulfame potassium 0.1kg) and the 0. kg vitamin A that step 1 obtains, mix homogeneously makes glue in the adding 20kg deionized water;
Step 3: the glue that step 2 is obtained sucks in the toothpaste Manufacturing medicine extract machine; In the toothpaste Manufacturing medicine extract machine, add abrasivus (calcium carbonate 26kg), the hydroxyapatite 3kg that mixes strontium 7%, bata-tricalcium phosphate 10kg, Rhizoma Drynariae 0.8kg, Radix Astragali 0.4kg, spice (essence 1.4kg) and foaming agent (sodium lauroyl sarcosine 2kg) simultaneously; Mix; At least vacuum outgas 55 minutes under the environment of negative pressure 0.096pa gets product after the fill.
Select normal population 20 experimenters by name, the age was divided into experimental group and matched group at 20 ~ 25 years old, every group 10 people, more than, the lip cheek tongue palate side of mandibular first molar and incisor is the test position.Routine examination and write down the experimenter dental plaque index, antiallergic perception can, send out toothpaste of the present invention to experimental group, send out toothpaste blank to matched group; The experimenter brushes teeth twice every day, uses toothpaste 1g at every turn, and brushing time is about 3 minutes; Back detection of 3 weeks and record experimenter's dental plaque index; Toothpaste dental plaque index reduction effect of the present invention is excellent, and the degree that reduces plaque index is 3 times of blank toothpaste, and it is effective that gum is protected in toothpaste antibacterial of the present invention; Toothpaste antiallergic perception of the present invention can be good, and the degree of Schiff cold air Sensitivity Index is 7 times (seeing table 1) of blank toothpaste, and toothpaste antiallergic sense effective percentage of the present invention is 100%, and toothpaste antiallergic perception of the present invention is good.
Use toothpaste of the present invention and blank toothpaste to handle three groups of artificial dental caries one weeks of glaze of equal state respectively, testing result is following after the week: the artificial dental caries glaze of handling through toothpaste of the present invention has tangible remineralization characteristic, and glaze is even, smooth pure white; Through the artificial dental caries glaze that blank toothpaste is handled, there are demineralization and slight remineralization and deposit characteristic, toothpaste of the present invention is whitened, anticaries efficacy is good.Use toothpaste of the present invention and blank toothpaste to handle the artificial dental caries hardness of glaze surface value in back and see that (microhardness detects table 2; Measure load 50g, effect 10s with German Lai Zi factory full-automatic microhardness meter; Form the prismatic impression; Survey catercorner length, and be converted into the webster hardness value, unit is 9.81MPa).
The contrast of the artificial dental caries hardness of glaze surface of table 2 value
| Group | Hardness of glaze surface value (meansigma methods) |
| Experimental group | 135.7 |
| Matched group | 65.3 |
Claims (7)
1. full effective toothpaste; It is characterized in that: described full effective toothpaste is grouped into by following one-tenth by weight percentage: strontium-doped hydroxyapatite 2 ~ 6%, bata-tricalcium phosphate 8 ~ 16%, Rhizoma Drynariae 0.5 ~ 1%; The Radix Astragali 0.1 ~ 0.5%; Chitosan 0.1 ~ 0.3%, vitamin A 0.05 ~ 0.2%, surplus is a toothpaste matrix; The doping of strontium is 6 wt% ~ 10 wt% in the described strontium-doped hydroxyapatite, and described toothpaste matrix comprises abrasivus, wetting agent, adhesive, foaming agent, sweeting agent, deionized water and spice, and by the percentage ratio that accounts for full effective toothpaste gross weight: abrasivus is 20 ~ 40%; Wetting agent is 15 ~ 35%; Adhesive is 0.8 ~ 1.5%, and foaming agent is 1.5 ~ 2.5%, and sweeting agent is 0.1 ~ 0.3%; Deionized water is 18 ~ 30%, and spice is 0.8 ~ 1.4%.
2. a kind of full effective toothpaste according to claim 1 is characterized in that: described abrasivus is selected from one or both the combination in calcium hydrogen phosphate, the calcium carbonate.
3. a kind of full effective toothpaste according to claim 1 is characterized in that: described wetting agent is by a kind of the combining in sorbitol and glycerol, Polyethylene Glycol, the propylene glycol.
4. a kind of full effective toothpaste according to claim 1 is characterized in that: described adhesive is selected from one or more the combination in Carboxymethyl cellulose sodium, hydroxyethyl-cellulose, carrageenan, xanthan gum, the guar gum.
5. a kind of full effective toothpaste according to claim 1 is characterized in that: described foaming agent is selected from one or both the combination in sodium lauryl sulphate, the sodium lauroyl sarcosine.
6. a kind of full effective toothpaste according to claim 1 is characterized in that: described sweeting agent is selected from one or more combination of glucide, acesulfame potassium, saccharin sodium.
7. the method for preparing of a full effective toothpaste, it is characterized in that: described method for preparing may further comprise the steps:
Step 1: with wetting agent, adhesive and chitosan mix jelly;
Step 2: the jelly that step 1 is obtained, sweeting agent and vitamin A add that mix homogeneously makes glue in the deionized water;
Step 3: the glue that step 2 is obtained sucks in the toothpaste Manufacturing medicine extract machine; In the toothpaste Manufacturing medicine extract machine, add abrasivus, strontium-doped hydroxyapatite, bata-tricalcium phosphate, Rhizoma Drynariae, the Radix Astragali, spice and foaming agent simultaneously; Mix; Vacuum outgas is 45 ~ 60 minutes under the environment of negative pressure 0.096pa ~ 0.1, gets product after the fill;
The consumption of each composition is by weight percentage: strontium-doped hydroxyapatite 2 ~ 6%, bata-tricalcium phosphate 8 ~ 16%, Rhizoma Drynariae 0.5 ~ 1%, the Radix Astragali 0.1 ~ 0.5%; Chitosan 0.1 ~ 0.3%, vitamin A 0.05 ~ 0.2%, abrasivus 20 ~ 40%, wetting agent 15 ~ 35%; Adhesive 0.8 ~ 1.5%, foaming agent 1.5 ~ 2.5%, sweeting agent 0.1 ~ 0.3%; Deionized water 18 ~ 30%, spice 0.8 ~ 1.4%, the doping of strontium is 6 wt% ~ 10 wt% in the described strontium-doped hydroxyapatite.
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| CN201110123383A CN102204875B (en) | 2011-05-13 | 2011-05-13 | Total effect toothpaste and preparation method thereof |
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| CN201110123383A CN102204875B (en) | 2011-05-13 | 2011-05-13 | Total effect toothpaste and preparation method thereof |
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| CN102204875A CN102204875A (en) | 2011-10-05 |
| CN102204875B true CN102204875B (en) | 2012-08-29 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546541A (en) * | 2015-01-26 | 2015-04-29 | 莫治玲 | Chitosan toothpaste |
| ITUB20156918A1 (en) * | 2015-12-10 | 2017-06-10 | Curasept A D S S R L | BEING REPLACED MULTI AND THEIR USE IN THE REMAINING AND REDUCTION OF SENSITIVITY? DENTAL |
| CN105476930A (en) * | 2015-12-16 | 2016-04-13 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Desensitizing and whitening toothpaste containing nano carbon crystal |
| CN105534805B (en) * | 2016-01-11 | 2018-10-19 | 广西大学 | A kind of Chinese herbal toothpaste of antibacterial anti hemorrhagic |
| CN106236612B (en) * | 2016-08-27 | 2020-06-26 | 广东罗浮山国药股份有限公司 | Toothpaste and preparation method thereof |
| CN112891234B (en) * | 2019-12-03 | 2022-11-08 | 谭生龙 | Biphase calcium-phosphorus material and toothpaste containing biphase calcium-phosphorus material |
| CN112754980A (en) * | 2021-02-26 | 2021-05-07 | 西南医科大学附属中医医院 | Toothpaste with antibacterial effect and preparation method thereof |
| CN115025013A (en) * | 2022-05-13 | 2022-09-09 | 广州医家仁生物科技有限责任公司 | Rosa roxburghii tratt probiotic toothpaste and processing technology thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
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2011
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
Non-Patent Citations (1)
| Title |
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| 林英光等.掺锶羟基磷灰石及其在口腔保健领域中的应用.《日用化学工业》.2006,第36卷(第3期),182，184-185. * |
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