CN109966314A - A kind of composition of the anti-sensitivity of tooth containing strontium salt - Google Patents

A kind of composition of the anti-sensitivity of tooth containing strontium salt Download PDF

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CN109966314A
CN109966314A CN201910285782.0A CN201910285782A CN109966314A CN 109966314 A CN109966314 A CN 109966314A CN 201910285782 A CN201910285782 A CN 201910285782A CN 109966314 A CN109966314 A CN 109966314A
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tooth
strontium
composition
sensitivity
sodium
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吕天宽
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

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Abstract

The composition of the invention discloses a kind of anti-sensitivity of tooth containing strontium salt, the composition can also alleviate gingivitis and periodontitis, consist of the following components in percentage by mass: alkali metal salt 1%~80%, object containing strontium 0.01%~5%, strontium salt anion provide agent 0.01%~3%；Tooth powder containing the composition, the mass percent that the composition accounts for entire tooth powder is 1.02%~88%；The mass percent that green tea accounts for entire tooth powder is 1%~40%；The mass percent that tea polyphenols account for entire tooth powder is 0.1%~40%；Also disclose the preparation method of the composition and the tooth powder containing the composition；The composition and its tooth powder of the invention has anti-sensitivity of tooth effect.

Description

A kind of composition of the anti-sensitivity of tooth containing strontium salt
Technical field
The composition and its tooth powder of the present invention relates to a kind of oral care product that can resist sensitivity of tooth containing strontium salt and Preparation method, the composition can also alleviate gingivitis and periodontitis, belong to oral care implement field.
Background technique
Sensitivity of tooth, also known as dentine hypersensitivity, are called dental hypersensitiveness, resident with advancing age, due to each Kind factor leads to the symptoms such as acid etching, enamel abrasion, wedge-shaped defect, gingival atrophy, when tooth encounters the cold and hot sour-sweet equal or external world When stimulation, cause of short duration and sharp discomfort or pain, it is serious to show as the aching and limp inability of tooth.
Dentine exposure and open tubules are the major reasons for generating dentine hypersensitivity.Sensitivity of tooth, gingivitis It is three kinds of oral cavity chronic disease with periodontitis.
The nearly dental pulp one end of dentinal tubule is thicker, and diameter is about 2.5 μm, more thinner to surface;It is about 1 μ near surface M, and arrange sparse.Dentine the ratio between tubule number in nearly marrow end and near surface per unit area is about 4:1, dentinal tubule Surface is stretched to from dental pulp end, separates many collateral, and the collateral matches mutually with neighbouring tubule on the way.
It is at present generally to use the substance of strontium salt, that is, strontium chloride and sylvite such as potassium nitrate as anti-sensitivity of tooth.
Potassium and sodium belong to alkali metal, have the same or similar physicochemical properties.Sodium ion and potassium ion maintain human body Osmotic pressure when metabolic is the important element of human metabolism.
Alkali metal salt sodium sulphate is known as the compound of glauber-salt and liquorice in traditional Chinese medicine, is anhydrous sodium sulfate.Saltcake is the sodium sulphate containing the crystallization water, Has the function of detumescence of relieving inflammation or internal heat, for controlling abscess of throat, aphthae, swelling and aching of gum etc. outside.
Sodium benzoate, Potassium Benzoate are common food preservatives, have inhibiting effect to microorganism.
Toothpaste with fluoride is widely used in China and in the world, and fluoride is well known anti-caries agent.
Fluorine ion can promote remineralization of teeth.
Tealeaves especially green tea contains tea polyphenols, and refreshing and detoxicating, some researches show that tea polyphenols can alleviate oral inflammation, right Gum reparation has effect.
In the patent document of 101123939 A of publication number CN, it is described below content: oral care composition, including wood Sugar alcohol and water-soluble calcium salt, wherein the big xylitol and the calcium salt exist with the weight ratio of at least about 10:1.It can The calcium salt for being dissolved in water is selected from: calcium chloride, calcium acetate, calcium butyrate, calcium citrate, calcium lactate, calcium salicylate, calcium glycerophosphate and Its mixture.Agent is provided including fluoride, wherein it is sodium monofluorophosphate that the fluoride, which provides agent,.Wherein the fluoride provides The existing amount of agent is enough to provide about 200ppm to 3000ppm fluoride ion, and the fluoride provides agent with about 0.001% to about 3% weight is present in the composition.
In publication number CN 1528260A patent document, following content is described: containing in toothpaste component and account for entire component Weight percent is respectively 0.1%~10% strontium salt and 0.1%~5% sylvite.And the toothpaste containing sylvite and strontium salt can be true Reduce and prevent in fact the sensitivity phenomenon of patient.
The 2nd phase of volume 22 " dentistry research " in April, 2006, " Sodium Chloride Treatment on Remineralization of Dentin Influence " (Harbin Medical University School of Stomatology Endodontics Li Hai clear etc.) be described below content: abstract conclusion: The effect of demineralization dentine remineralization can be improved in 0.5mol/L sodium chloride solution, and the crystal lattices of production are more stable.
" toothpaste industry " the 1st phase in 2002, " salt and strontium salt compound the application in toothpaste " (ChongQing cosmetic Factory week Filial piety is high) it is described below content: abstract describes effect, feature and the application in toothpaste of salt and strontium salt herein.
" salt industry and chemical industry " the 1st phase of volume 36, " inhibiting effect of the sodium chloride to several frequently seen bacterium " (Tianjin science and technology is big Learn, the south etc. of grandson) it is described below content: abstract experimental result provides data for NaCl bacteriostasis and supports.
" oral health blue book " P128-132, " the B.12 method of clinic control dentine hypersensitivity ".
" dentistry research " in April, 2007 the 2nd phase " experiment of tricalcium silicate obstruction dentinal tubule of volume 23 Research " in (key lab, Jilin University's School of Stomatology oral cavity biomedical engineering Jilin Province Wang Xiao rainbow etc.) be described below Hold: abstract purpose: block capability of the evaluation tricalcium silicate to dentinal tubule.Conclusion: tricalcium silicate not only passes through self-curing mistake Journey blocks dentinal tubule, and can induce dentine remineralization under physiological environment.Therefore, it is contemplated that be used as treatment dentine The active drug of allergy.
" Shanghai Second Emdical University's journal " Vol.19 No.1 1999, " tea polyphenols act on oral cavity and throat pathogenic bacteria Experiment in vitro " in (No.9 People's Hospital Attached to Shanghai No.2 Medical Univ Dental Research Institute Liu Li Mingyu is just) be described below Hold: abstract purpose: a possibility that evaluation tea polyphenols are as oral health medication.As a result: tea polyphenols are to oral cavity and throat principal causative Bacterium is sensitive, and synthesizing glucan ability and people's salivary amylase activity to cariogenic bacteria has inhibition.
" Practical oral medical journal " (J P ract Stom a to l) 2007 Jul, 23 (4)) " green tea polyphenols pair The inhibiting effect of inflammatory agents in gingival epithelial cells " (hat educates flourish Pan Yaping) be described below content: abstract purpose: inquire into green The effect of nutgall catechin and gallate (EGCg) to the inflammatory reaction of human gingival epithelial cells in tea polyphenols.To be tooth Safely and effectively periodontal disease inhibitor provides foundation for the prevention and treatment exploitation of all diseases.Conclusion: (EGCg) is thin to gingival epithelium The inflammatory reaction of born of the same parents is inhibited, has the potential as periodontal disease inhibitor.
Sensitivity of tooth, periodontitis, gingivitis are three kinds of oral cavity chronic diseases, research and develop it is a kind of containing strontium salt to be both resistant to tooth quick Sense, and the oral-cavity article of gingivitis and periodontitis can be alleviated.
Summary of the invention
It is an object of the present invention to provide a kind of composition with anti-sensitivity of tooth and its tooth powder and preparation method, the compositions Gingivitis and periodontitis can also be alleviated.
The present invention realizes its purpose technical solution.
Using one or more slightly solubles or it is insoluble in the particle of water, size is sufficiently small, and it is small to can enter open dentine Pipe, blocks open dentinal tubule, and achieve the purpose that anti-sensitivity of tooth with alkali metal salt collective effect.Molecule and micel Size with regard to sufficiently small, can enter open dentinal tubule under van der Waals interaction, block open dentinal tubule.It can To select the slightly soluble for having this characteristic or the strontium salt for being insoluble in water if any strontium fluoride, single fluorophosphoric acid strontium, strontium phosphate and strontium carbonate Deng molecule and micel.Certain density alkali metal salt has inhibiting bacteria and diminishing inflammation effect, reaches alleviation gingivitis and periodontitis Purpose.
A kind of composition with anti-sensitivity of tooth provides agent by alkali metal salt, object containing strontium and strontium salt anion and forms.? In aqueous solution or saliva, object containing strontium discharges strontium ion, and strontium salt anion provides agent release anion such as single fluorophosphoric acid radical ion, Strontium ion and single fluorophosphoric acid radical ion generate the single fluorapatite molecule and micel for being slightly soluble in water in saliva of buccal cavity, the molecule and Micel enters open dentinal tubule, blocks open dentinal tubule, reaches anti-tooth with alkali metal salt collective effect Sensitivity, inhibiting bacteria and diminishing inflammation, the purpose for alleviating gingivitis and periodontitis.
Based on the above-mentioned technical proposal, a kind of composition with anti-sensitivity of tooth is invented, the composition can alleviate periodontal again Scorching and gingivitis, the constituent mass percentage of the composition is: alkali metal salt 1%~80%, object containing strontium 0.01%~5%, strontium salt yin Ion provides agent 0.01%~3%.
Alkali metal salt.
Alkali metal salt has enough water-soluble to discharge sodium ion, potassium ion in water or saliva.Suitable alkali metal Salt includes inorganic alkaline metal salt, organic alkali metal salt and its mixture.
Inorganic alkaline metal salt includes sodium chloride, sodium bromide, sodium iodide, sodium nitrate, sodium sulphate, sodium sulfite, thiosulfuric acid Sodium, sodium carbonate, sodium bicarbonate, sodium phosphate, dibastic sodium phosphate, sodium dihydrogen phosphate, sodium pyrophosphate, sodium hypophosphite, Boratex, chlorination Potassium, potassium bromide, potassium iodide, potassium nitrate, potassium sulfate, potassium sulfite, potassium thiosulfate, potassium carbonate, saleratus, potassium phosphate, phosphorus Potassium hydrogen phthalate, potassium dihydrogen phosphate, potassium pyrophosphate, potassium hypophosphite, potassium borate and its mixture.
Organic alkali metal salt includes sodium glutamate, Sodium Glycinate, sodium lactate, sodium citrate, natrium malicum, gluconic acid Sodium, sodium ascorbate, sodium sorbate, dehydroactic acid sodium, sodium benzoate, potassium glutamate, glycine potassium, potassium lactate, potassium citrate, Potassium malate, K-IAO, potassium ascorbate, potassium sorbate, dehydroactic acid potassium, sodium benzoate and its mixture.
Preferably, the alkali metal salt is soluble and remains soluble in water or saliva, the preferred alkali metal salt It is inorganic alkaline metal salt, preferred inorganic alkaline metal salt is potassium chloride, and mass percent is 1%~80%.
Preferably, potassium chloride mass percent is 30%~65%.
Object containing strontium.
Water-soluble object containing strontium is soluble and remains soluble in water or saliva and discharges strontium ion, and suitable object containing strontium includes Strontium salt, strontium oxide strontia, strontium hydroxide and its mixture.
Strontium salt.
Strontium salt includes inorganic strontium salt and organic salts of strontium and its mixture.
Inorganic strontium salt include strontium nitrite, strontium nitrate, strontium sulfate, strontium sulfite, strontium thiosulfate, strontium bromide, strontium iodide, Hypochlorous acid strontium, strontium chlorate, perchloric acid strontium, hypobromous acid strontium, strontium bromate, hyperbromic acid strontium, hypoiodous acid strontium, strontium iodate, periodic acid strontium, sulphur Hydrogenate strontium, strontium rhodanate, strontium bicarbonate, strontium biphosphate, hypophosphorous acid strontium, hydrogen phosphite strontium and its mixture.
Organic salts of strontium includes strontium formate, strontium acetate, propionic acid strontium, butyric acid strontium, strontium citrate, strontium lactate, strontium salicylate, grape Saccharic acid strontium, ascorbic acid strontium, benzoic acid strontium, Strontium Ranelate, strontium malate and its mixture.
Preferably, water-soluble strontium salt is soluble and remains soluble in water or saliva, and the preferred strontium salt is Inorganic strontium salt, preferred inorganic strontium salt are strontium chlorides, and strontium chloride mass percent is 0.01%~5%.
Preferably, strontium chloride mass percent is 0.5%~3.5%.
Strontium salt anion provides agent.
Strontium salt anion, which provides agent, has enough water solubilitys to discharge anion or anionic group in water or saliva, Anion or anionic group and strontium ion generate slightly soluble or are insoluble in the compound of water.Suitable strontium salt anion provides agent packet Include fluoride provide agent, phosphate, phosphite, metaphosphate, carbonate, sulfate, sulphite, tungstates, molybdate, Borate, acylate and its mixture.
Fluoride provides agent.
Fluoride, which provides agent, has enough water solubilitys to discharge fluoride anion in water or saliva.Suitable fluorination Object provides agent and provides agent for inorganic fluoride.
It includes fluoride salt, fluosilicate, mono-fluor phosphate, difluorophosphoric acid salt, hexafluorophosphate that inorganic fluoride, which provides agent, And borofluoride, including ammonium fluoride, lithium fluoride, sodium fluoride, potassium fluoride, rubidium fluoride RbF, cesium fluoride, stannous fluoride, ammonium fluosilicate, fluorine Lithium metasilicate, prodan, potassium fluosilicate, rubidium fluosilicate, cesium fluosilicate, magnesium fluosilicate, ammonium fluozirconate, fluorine zirconic acid lithium, fluorine zirconic acid Sodium, potassium fluorozirconate, fluorine zirconic acid rubidium, fluorine zirconic acid caesium, single fluorophosphoric acid ammonium, single lithium fluophosphate, sodium monofluorophosphate, single fluorophosphoric acid potassium, list Fluorophosphoric acid rubidium, single fluorophosphoric acid caesium, difluorophosphoric acid ammonium, difluorophosphate, difluorophosphoric acid sodium, difluorophosphoric acid potassium, difluorophosphoric acid rubidium, two Fluorophosphoric acid caesium, ammonium hexafluorophosphate, lithium hexafluoro phosphate, sodium hexafluoro phosphate, Potassium Hexafluorophosphate, hexafluorophosphoric acid rubidium, hexafluorophosphoric acid caesium, fluorine Ammonium borate, lithium fluoroborate, sodium fluoborate, potassium fluoborate, fluoboric acid rubidium, fluoboric acid caesium and its mixture.
Phosphate.
Phosphate has enough water-soluble to discharge phosphate anion or dihydrogen phosphate ions, phosphorus in water or saliva A sour hydrogen radical ion.Suitable phosphate includes ammonium phosphate, lithium phosphate, sodium phosphate, potassium phosphate, phosphoric acid rubidium, phosphoric acid caesium, phosphoric acid Magnesium, ammonium dihydrogen phosphate, lithium dihydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, biphosphate rubidium, cesium dihydrogen phosphate, biphosphate Magnesium, monoammonium phosphate, one hydrogen lithium of phosphoric acid, disodium-hydrogen, potassium phosphate,monobasic, one hydrogen rubidium of phosphoric acid, one hydrogen caesium of phosphoric acid, one hydrogen of phosphoric acid Magnesium and its mixture.
Phosphite.
Phosphite has enough water solubilitys to discharge orthophosphite ions in water or saliva.Suitable phosphite Including ammonium phosphite, sodium phosphite, potassium phosphite, phosphorous acid rubidium, phosphorous acid caesium and its mixture.
Metaphosphate.
Metaphosphate has enough water solubilitys to discharge metaphosphate ion in water or saliva.Suitable phosphite Including ammonium metaphosphate, sodium metaphosphate, potassium metaphosphate, metaphosphoric acid rubidium, metaphosphoric acid caesium and its mixture.
Carbonate.
Carbonate has enough water solubilitys to discharge carbanion in water or saliva.Suitable carbonate includes carbon Sour lithium, sodium carbonate, potassium carbonate, rubidium carbonate, cesium carbonate, ammonium carbonate, magnesium carbonate and its mixture.
Sulfate.
Sulfate has enough water solubilitys to discharge sulfate ion in water or saliva, and suitable sulfate includes sulphur Sour ammonium, lithium sulfate, sodium sulphate, potassium sulfate, rubidium sulfate, cesium sulfate, aluminum sulfate, magnesium sulfate, zinc sulfate, titanium sulfate and its mixing Object.
Sulphite.
Sulphite has enough water solubilitys to discharge sulfite ion, suitable sulphite in water or saliva Including ammonium sulfite, lithium sulfite, sodium sulfite, potassium sulfite, sulfurous acid rubidium, sulfurous acid caesium, magnesium sulfite, aluminium sulfite, Zinc sulfite, sulfurous acid titanium and its mixture.
Tungstates.
Tungstates has enough water solubilitys to discharge tungstate ion in water or saliva, and suitable tungstates includes tungsten Sour ammonium, tungstate lithium, sodium tungstate, potassium tungstate, wolframic acid rubidium, wolframic acid caesium, magnesium tungstate and its mixture.
Molybdate.
Molybdate has enough water solubilitys to discharge molybdenum acid ion in water or saliva, and suitable molybdate includes molybdenum Sour ammonium, lithium molybdate, sodium molybdate, potassium molybdate, molybdic acid rubidium, cesium molybdate and its mixture.
Borate.
Borate has enough water solubilitys to discharge borate ion in water or saliva, and suitable borate includes boron Sour ammonium, Boratex, potassium borate, boric acid rubidium, boric acid caesium and its mixture.
Acylate.
Acylate has enough water solubilitys to discharge organic acid anions or anionic group in water or saliva, has Machine hydrochlorate include unary fatty acid salt, di-fatty hydrochlorate, alkyl sulfate, alkylphosphonic, amino-acid salt, sulfonate and Its mixture.
Unary fatty acid salt includes its ammonium salt, lithium salts, sodium salt and sylvite, carbochain C9-C20Range, such as ammonium laurate, laurel Sour lithium, sodium laurate, potassium laurate, palmitic acid ammonium, sodium palmitate, palmitic acid potassium, ammonium stearate, lithium stearate, odium stearate, Potassium stearate and its mixture.
Di-fatty hydrochlorate includes ammonium oxalate, lithium oxalate, sodium oxalate, potassium oxalate, malonic acid ammonium, Lithium malonate, malonic acid Sodium, malonic acid potassium, ammonium succinate, succinic acid lithium, sodium succinate, potassium succinate, glutaric acid ammonium, glutaric acid lithium, Sodium glutarate, penta Diacid potassium, ammonium adipate, lithium adipate, adipic acid sodium, Potassium Adipate, ammonium tartrate, ammonium tartrate, lithium tartrate, tartaric acid Sodium, potassium tartrate and its mixture.
Alkyl sulfate includes its ammonium salt, lithium salts, sodium salt and sylvite, alkyl carbon chain C12-C18Range, such as dodecyl sulphur Sour ammonium, lithium dodecyl sulfate, lauryl sodium sulfate, dodecyl sulphate potassium, n-hexadecyl sodium sulphate, n-octadecane base Sodium sulphate and its mixture.
Alkylphosphonic includes its ammonium salt, lithium salts, sodium salt and sylvite, alkyl carbon chain C12-C18Range, such as dodecyl phosphorus Sour ammonium, dodecylphosphoric acid lithium, ferric tri-dodecanesulfonate, Potassium dodecyl phosphate, n-hexadecyl sodium phosphate, n-octadecane base Sodium phosphate and its mixture.
Amino-acid salt includes sodium lauroyl sarcosine, potassium lauroyl sarcosine, sodium lauroyl glutamate, lauroyl glutamate Potassium, cocoyl Sodium Glycinate, cocoyl glycine potassium, cocoyl Sodium L-alaninate, sodium dodecyl aminopropionitrile, Pork and beans Guan acyl sodium glutamate, palmityl sodium glutamate, stearoyl-glutamic acid sodium and its mixture.
Sulfonate includes ammonium salt, lithium salts, sodium salt and the sylvite of alkylsulfonate, alkyl carbon chain C12-C20Range, such as 12 Alkyl sulfonic acid ammonium, dodecyl sodium sulfonate lithium, dodecyl sodium sulfate, potassium dodecanesulfonate, there are also two butyric acid dioctyl ester sulfonic acid Sodium, neopelex, nekal and its mixture.
Preferably, water-soluble strontium salt anion offer agent is soluble and remains soluble in water or saliva, preferably The strontium salt anion to provide agent be that fluoride provides agent, it is sodium monofluorophosphate, quality hundred that preferred fluoride, which provides agent, Divide than being 0.01%~3%.
Preferably, sodium monofluorophosphate mass percent is 0.5%~1.5%.
Preferably, a kind of mass percent of the composition with anti-sensitivity of tooth is 31%~70%, by following matter The group of amount percentage is grouped as: potassium chloride 30%~65%, strontium chloride 0.5%~3.5%, sodium monofluorophosphate 0.5%~1.5%.
A kind of application of above-mentioned composition in tooth powder.
Application of the composition in tooth powder, preferably, the mass percent that the composition accounts for whole components is 31%~70%.
A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, sweetener, tea polyphenols, also include the above technical side Composition described in case, mass percent of the composition in tooth powder are 1.02%~88%, preferably 31%~70%.
Mass percent of the tea polyphenols in tooth powder is 0.1%~40%, preferably 1%~20%.
A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, sweetener, tealeaves, also include above technical scheme The composition, mass percent of the composition in tooth powder are 1.02%~88%, preferably 31%~70%.
The tealeaves is black tea, green tea, Partial fermentation tea, preferably green tea, and the mass percent in tooth powder is 1% ~40%, preferably 5%~20%.
The composition is applied in mouthwass, collutory, mouthwash, the agent of liquid tooth, the agent of solid tooth, tooth film, gear rack, gel Application in agent, tooth bead, pastille, toothpaste, tooth gel and tooth latex, including mouthwass, collutory, mouthwash, The agent of liquid tooth, the agent of solid tooth, tooth film, gear rack, gel paint, tooth bead, pastille, toothpaste, tooth gel and tooth latex etc. exist It can be single-item before into oral cavity and be also possible to combined article.The composition account for whole components mass percent be 1.02%~ 80%。
A kind of preparation method of above-mentioned tooth powder includes the following steps: green tea, rubbing agent, sweetener, also includes anti-tooth Sensitive composition, is respectively prepared powder, and the component by every kind of content no more than 10% is first uniformly mixed in a reservoir, so Remaining component is put into the container afterwards to be stirred for being uniformly mixed and obtains mixture, is sieved, screenings is finished product tooth powder, tooth Powder preparation is completed.
A kind of preparation method of above-mentioned tooth powder includes the following steps: tea polyphenols, rubbing agent, sweetener, also includes anti-tooth The composition of tooth sensitivity, is respectively prepared powder, and the component by every kind of content no more than 10% is first uniformly mixed in a reservoir, Then remaining component being put into the container to be stirred for being uniformly mixed and obtains mixture, be sieved, screenings is finished product tooth powder, Tooth powder preparation is completed.
The beneficial effects of the present invention are: the composition of the anti-sensitivity of tooth for oral care of the invention, can block Open dentinal tubule plays the work for alleviating sensitivity of tooth pain and inhibiting bacteria and diminishing inflammation with alkali metal salt potassium chloride collective effect With achieving the effect that anti-sensitivity of tooth while alleviating gingivitis and periodontitis, then tea is added in the tooth powder comprising the composition Polyphenol or green tea play the role of alleviating gum discomfort, reduce oral peculiar smell.
Specific embodiment
Below with reference to embodiment, the invention will be further described, but not thereby limiting the invention.
Experimental method in following embodiments is unless otherwise instructed conventional method.
Embodiment 1 has the composition of anti-sensitivity of tooth.
Embodiment 1 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: potassium chloride 1%~ 80%, strontium chloride 0.01%~5%, sodium monofluorophosphate 0.01%~3%.
Embodiment 2 has the composition of anti-sensitivity of tooth.
Embodiment 2 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: potassium chloride 1%, chlorine Change strontium 0.01%, sodium monofluorophosphate 0.01%.
Embodiment 3 has the composition of anti-sensitivity of tooth.
Embodiment 3 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: potassium chloride 10%~ 25%, strontium chloride 0.5%~1.5%, sodium monofluorophosphate 0.3%~1%.
Embodiment 4 has the composition of anti-sensitivity of tooth.
Embodiment 4 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: potassium chloride 31%~ 45%, strontium chloride 0.5%~2%, sodium monofluorophosphate 0.5%~1.5%.
Embodiment 5 has the composition of anti-sensitivity of tooth.
Embodiment 5 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: potassium chloride 45%~ 65%, strontium chloride 0.5%~3.5%, sodium monofluorophosphate 0.5%~1.5%.
Embodiment 6 has the composition of anti-sensitivity of tooth.
Embodiment 6 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: potassium chloride 70%~ 80%, strontium chloride 2%~5%, sodium monofluorophosphate 1%~2.5%.
Embodiment 7 has the composition of anti-sensitivity of tooth.
Embodiment 7 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: potassium chloride 80%, chlorine Change strontium 5%, sodium monofluorophosphate 3%.
Embodiment 8 has the tooth powder of anti-sensitivity of tooth.
Embodiment 8 prepares tooth powder in accordance with the following steps: granularity is made not less than 325 mesh powder, by rubbing agent system in green tea It is not less than 1000 mesh powder at granularity, the combination of anti-sensitivity of tooth described in any one embodiment in sweetener, embodiment 1-7 Granularity is respectively prepared not less than 100 mesh powders in object, and the component by every kind of content no more than 10% is first stirred in a reservoir It is even, then remaining component is put into the container be stirred for be uniformly mixed obtain mixture, mixture sieves with 100 mesh sieve, under sieve Object is finished product tooth powder, and tooth powder preparation is completed.
Embodiment 9 has the tooth powder of anti-sensitivity of tooth.
Embodiment 9 prepares tooth powder in accordance with the following steps: granularity is made not less than 1000 mesh powder in rubbing agent, tea polyphenols, Granularity is respectively prepared not less than 100 in the composition of anti-sensitivity of tooth described in any one embodiment in sweetener, embodiment 1-7 Mesh powder, the component by every kind of content no more than 10% are first uniformly mixed in a reservoir, then remaining component are put into It is stirred for being uniformly mixed in the container and obtains mixture, mixture sieves with 100 mesh sieve, and screenings is finished product tooth powder, tooth powder preparation It completes.
The mass percent of each component described in embodiment 8-9.
The composition 1.02%~88% of the anti-sensitivity of tooth, preferably 31%~70%.
The rubbing agent 10%~80%, preferably 20%~60%, silica, calcium monohydrogen phosphate, calcium carbonate can be used Deng.
The sweetener 0.1%~5%, preferably 1%~4%, neotame, Abbas's sweet tea, saccharin sodium etc. can be used.
Green tea 1%~40%, preferably 5%~20% described in embodiment 8.
Tea polyphenols 0.1%~40%, preferably 1%~20% described in embodiment 9.
Embodiment 10 contains the tooth powder measure of merit of anti-sensitivity of tooth composition.
According to the form below preparation contains the tooth powder of anti-sensitivity of tooth composition.Sensitivity of tooth patient is before using the tooth powder, diet When feel tooth stimulation, be afraid of acid, acid acid felt when gently scraping the exterior of teeth for suffering from the nearly tooth root of tooth with nail, first uses Tooth paste brush After tooth, tooth powder is gently applied on the tooth and gum of full mouth, generates saliva to oral cavity, with salivary rinse 3~7 minutes, often It once in the morning and once at night, 1~1.5 gram of each dosage, after the 10 day time of the tooth powder, when diet, does not feel that suffering from tooth has acid Feel, suffers from tooth also without past excitement, when slightly firmly scraping the exterior of teeth for suffering from the nearly tooth root of tooth with nail, feel tooth Also a little sour, oral cavity refreshing, breath freshening suffers from the nearly tooth root of tooth using slightly firmly being scraped after the tooth powder one month with nail When exterior of teeth, feel that tooth is not sour, when diet suffers from tooth excitement complete incidence graph and uses nail after the tooth powder three months When slightly firmly scraping the exterior of teeth for suffering from the nearly tooth root of tooth, feel that tooth is not sour.The tooth powder has the effect of anti-sensitivity of tooth.
Serial number Component Mass percent, %
1 Calcium carbonate 40.6
2 Potassium chloride 45
3 Green tea 10
4 Neotame 2.6
5 Strontium chloride 1
6 Sodium monofluorophosphate 0.8
7 It amounts to 100
Embodiment 11 contains the tooth powder measure of merit of anti-sensitivity of tooth composition.
According to the form below preparation contains the tooth powder of anti-sensitivity of tooth composition.Feel that tooth is aching and limp when sensitivity of tooth patient eats, With periodontitis, gum is red and swollen, is slightly firmly scraped when suffering from tooth outer surface with nail, feels that tooth is very sour, will after first being brushed teeth with toothpaste The tooth powder of preparation is gently applied on the tooth and gum of full mouth, generates saliva to oral cavity, with salivary rinse 3~7 minutes, daily Once in the morning and once at night, about 1.5 grams of each dosage, using the tooth powder after a week tooth it is aching and limp feel to substantially eliminate, oral cavity refreshing, mouth Gas is pure and fresh, using the aching and limp feeling complete incidence graph of upper teeth basic after the tooth powder one month, is slightly firmly scraped with nail and suffers from tooth appearance When face, feel to suffer from that tooth is not sour, does not occur aching and limp symptom again using three months teeth of the tooth powder, persistently using after 12 months, Check that gum is normal, color of teeth becomes pink from original peony, and periodontitis is also under control, which has anti-tooth Tooth sensitizing effect also has the effect for alleviating periodontitis.
Serial number Component Mass percent, %
1 Calcium carbonate 40.6
2 Potassium chloride 45
3 Tea polyphenols 10
4 Neotame 2.6
5 Strontium chloride 1
6 Sodium monofluorophosphate 0.8
7 It amounts to 100
Embodiment 12 contains the tooth powder measure of merit of anti-sensitivity of tooth composition.
Bleeding gums patient, bleeding gums about 5 years, gum was red and swollen, sees to sting have blood on apple when eating apple, first uses tooth After cream is brushed teeth, tooth powder prepared by implementation 11 is gently applied on the tooth and gum of full mouth by he, is generated saliva to oral cavity, is used saliva Liquid is gargled 3~7 minutes, and once in the morning and once at night, about 1.5 grams of each dosage, using the tooth powder, bleeding gums obviously subtract after two weeks Few, oral cavity refreshing, breath freshening sees there is the trace of blood on apple once in a while using when eating apple after the tooth powder one month, uses the tooth Having no when eating apple after powder three months has the trace of blood on apple, persistently completely eliminated using gum redness after 6 months, gingiva color by Peony originally becomes pink, gum not bleeding, which has the effect of alleviating gingivitis.

Claims (6)

1. a kind of composition with anti-sensitivity of tooth containing strontium salt, the composition can also alleviate gingivitis and periodontitis, special Sign is, consists of the following components in percentage by mass: alkali metal salt 1%~80%, object containing strontium 0.01%~5%, strontium salt anion Agent 0.01%~3% is provided.
2. alkali metal salt as described in claim 1, object containing strontium and strontium salt anion provide agent, which is characterized in that alkali metal salt Selected from potassium chloride, object containing strontium is selected from strontium chloride, and strontium salt anion provides agent and is selected from sodium monofluorophosphate.
3. a kind of such as application of the described in any item compositions of claim 1-2 in tooth powder.
4. a kind of tooth powder with anti-sensitivity of tooth includes tea polyphenols, rubbing agent, sweetener, which is characterized in that also comprising having the right Benefit requires the described in any item compositions of 1-2, and mass percent of the composition in entire tooth powder is 1.02%~88%；Institute Mass percent of the tea polyphenols stated in entire tooth powder is 0.1%~40%.
5. a kind of tooth powder with anti-sensitivity of tooth includes tealeaves, rubbing agent, sweetener, which is characterized in that also comprising having the right It is required that the described in any item compositions of 1-2, mass percent of the composition in entire tooth powder is 1.02%~88%；It is described Tealeaves be selected from green tea, mass percent of the green tea in entire tooth powder be 1%~40%.
6. if the described in any item compositions of claim 1-2 are in mouthwass, collutory, mouthwash, the agent of liquid tooth, solid Application in tooth agent, tooth film, gear rack, gel paint, tooth bead, pastille, toothpaste, tooth gel and tooth latex, feature exist In the mass percent that the composition accounts for whole components is 1.02%~80%.
CN201910285782.0A 2019-04-10 2019-04-10 A kind of composition of the anti-sensitivity of tooth containing strontium salt Withdrawn CN109966314A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112754984A (en) * 2021-03-11 2021-05-07 傅博 Anti-sensitivity liquid toothpaste and preparation method thereof
CN112870146A (en) * 2021-02-08 2021-06-01 许耿防 Toothpaste for resisting dentin sensitivity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112870146A (en) * 2021-02-08 2021-06-01 许耿防 Toothpaste for resisting dentin sensitivity
CN112754984A (en) * 2021-03-11 2021-05-07 傅博 Anti-sensitivity liquid toothpaste and preparation method thereof

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Application publication date: 20190705