CN109846730A - A kind of composition of the anti-sensitivity of tooth containing strontium salt and its application - Google Patents

Abstract

The composition of the invention discloses a kind of anti-sensitivity of tooth containing strontium salt, consists of the following components in percentage by mass: object containing strontium 0.01%~5%, strontium salt anion provide agent 0.01%~3%；Tooth powder containing the composition, the mass percent that the composition accounts for entire tooth powder is 0.02%~8%；The mass percent that green tea accounts for entire tooth powder is 1%~40%；The mass percent that tea polyphenols account for entire tooth powder is 0.1%~40%；Also disclose the preparation method of the composition and the tooth powder containing the composition；The composition and its tooth powder of the invention has good anti-sensitivity of tooth effect.

Description

A kind of composition of the anti-sensitivity of tooth containing strontium salt and its application

Technical field

The composition and its tooth powder of the present invention relates to a kind of oral care product that can resist sensitivity of tooth containing strontium salt and Preparation method belongs to oral care implement field.

Background technique

Sensitivity of tooth, also known as dentine hypersensitivity, are called dental hypersensitiveness, resident with advancing age, due to each Kind factor leads to the symptoms such as acid etching, enamel abrasion, wedge-shaped defect, gingival atrophy, when tooth encounters the cold and hot sour-sweet equal or external world When stimulation, cause of short duration and sharp discomfort or pain, it is serious to show as the aching and limp inability of tooth.

Dentine exposure and open tubules are the major reasons for generating dentine hypersensitivity.

The nearly dental pulp one end of dentinal tubule is thicker, and diameter is about 2.5 μm, more thinner to surface;It is about 1 μ near surface M, and arrange sparse.Dentine the ratio between tubule number in nearly marrow end and near surface per unit area is about 4:1, dentinal tubule Surface is stretched to from dental pulp end, separates many collateral, and the collateral matches mutually with neighbouring tubule on the way.

It is at present generally to use the substance of strontium salt, that is, strontium chloride and sylvite such as potassium nitrate as anti-sensitivity of tooth.

Toothpaste with fluoride is widely used in China and in the world, and fluoride is well known anti-caries agent.

Fluorine ion can promote remineralization of teeth.

Tealeaves especially green tea contains tea polyphenols, and refreshing and detoxicating, some researches show that tea polyphenols can alleviate oral inflammation, right The effect that gum reparation has.

In the patent document of 101123939 A of publication number CN, it is described below content: oral care composition, including xylose Pure and mild water-soluble calcium salt, wherein the big xylitol and the calcium salt exist with the weight ratio of at least about 10:1.It is solvable Be selected from the calcium salt of water: calcium chloride, calcium acetate, calcium butyrate, calcium citrate, calcium lactate, calcium salicylate, calcium glycerophosphate and its Mixture.Agent is provided including fluoride, wherein it is sodium monofluorophosphate that the fluoride, which provides agent,.Wherein the fluoride provides agent Existing amount is enough to provide about 200ppm to 3000ppm fluoride ion, and the fluoride provides agent with about 0.001% to about 3% Weight is present in the composition.

" oral health blue book " P128-132, " the B.12 method of clinic control dentine hypersensitivity ".

The 2nd phase of volume 23 " dentistry research " in April, 2007, " experiment of tricalcium silicate obstruction dentinal tubule was ground Study carefully " (key lab, Jilin University's School of Stomatology oral cavity biomedical engineering Jilin Province Wang Xiao rainbow etc.) be described below content: Abstract purpose: block capability of the evaluation tricalcium silicate to dentinal tubule.Conclusion: tricalcium silicate not only passes through self-curing process Block dentinal tubule, and can induce dentine remineralization under physiological environment.Therefore, it is contemplated that be used as treatment dentine mistake Quick active drug.

" Shanghai Second Emdical University's journal " Vol.19 No.1 1999, " tea polyphenols act on oral cavity and throat pathogenic bacteria Experiment in vitro " in (No.9 People's Hospital Attached to Shanghai No.2 Medical Univ Dental Research Institute Liu Li Mingyu is just) be described below Hold: abstract purpose: a possibility that evaluation tea polyphenols are as oral health medication.As a result: tea polyphenols are to oral cavity and throat principal causative Bacterium is sensitive, and synthesizing glucan ability and people's salivary amylase activity to cariogenic bacteria has inhibition.

" Practical oral medical journal " (J P ract Stom a to l) 2007 Jul, 23 (4)) " green tea polyphenols are to tooth The inhibiting effect of inflammatory factor in gingival epithelial cells " (hat educates flourish Pan Yaping) be described below content: abstract purpose: inquire into green tea The effect of nutgall catechin and gallate (EGCg) to the inflammatory reaction of human gingival epithelial cells in polyphenol.To be periodontal Safely and effectively periodontal disease inhibitor provides foundation for the prevention and treatment exploitation of disease.Conclusion: (EGCg) is to human gingival epithelial cells Inflammatory reaction it is inhibited, have as periodontal disease inhibitor potential.

A kind of dentinal tubule that can block opening containing strontium salt is researched and developed, to be resistant to the oral-cavity article of sensitivity of tooth.

Summary of the invention

It is an object of the present invention to provide a kind of composition with anti-sensitivity of tooth and its tooth powder and preparation methods.

The present invention realizes its purpose technical solution.

Using one or more slightly solubles or it is insoluble in the particle of water, size is sufficiently small, and it is small to can enter open dentine Pipe, blocks open dentinal tubule, achievees the purpose that anti-sensitivity of tooth.The size of molecule and micel is with regard to sufficiently small, in model It can enter open dentinal tubule under the effect of moral China power, block open dentinal tubule.Selection has the micro- of this characteristic Molecule and micel of the strontium salt that is molten or being insoluble in water if any strontium fluoride, single fluorophosphoric acid strontium, strontium phosphate and strontium carbonate etc..

A kind of composition with anti-sensitivity of tooth provides agent by object containing strontium and strontium salt anion and forms.In aqueous solution or In saliva, object containing strontium discharges strontium ion, and strontium salt anion provides agent release anion such as single fluorophosphoric acid radical ion, in saliva of buccal cavity Middle strontium ion and single fluorophosphoric acid radical ion generate the single fluorapatite molecule for being slightly soluble in water and micel, the molecule and micel into Enter open dentinal tubule, block open dentinal tubule, achievees the purpose that anti-sensitivity of tooth.

Based on the above-mentioned technical proposal, a kind of composition with anti-sensitivity of tooth, the constituent mass hundred of the composition are invented Divide ratio to be: object containing strontium 0.01%~5%, strontium salt anion provide agent 0.01%~3%.

Object containing strontium.

Water-soluble object containing strontium is soluble and remains soluble in water or saliva and discharges strontium ion, and suitable object containing strontium includes Strontium salt, strontium oxide strontia, strontium hydroxide and its mixture.

Strontium salt.

Strontium salt includes inorganic strontium salt and organic salts of strontium and its mixture.

Inorganic strontium salt include strontium nitrite, strontium nitrate, strontium sulfate, strontium sulfite, strontium thiosulfate, strontium bromide, strontium iodide, Hypochlorous acid strontium, strontium chlorate, perchloric acid strontium, hypobromous acid strontium, strontium bromate, hyperbromic acid strontium, hypoiodous acid strontium, strontium iodate, periodic acid strontium, sulphur Hydrogenate strontium, strontium rhodanate, strontium bicarbonate, strontium biphosphate, hydrogen phosphite strontium, hypophosphorous acid strontium and its mixture.

Organic salts of strontium includes strontium formate, strontium acetate, propionic acid strontium, butyric acid strontium, strontium citrate, strontium lactate, strontium salicylate, grape Saccharic acid strontium, ascorbic acid strontium, benzoic acid strontium, Strontium Ranelate, strontium malate and its mixture.

Preferably, water-soluble strontium salt is soluble and remains soluble in water or saliva, and the preferred strontium salt is Inorganic strontium salt, preferred inorganic strontium salt are strontium chlorides, and strontium chloride mass percent is 0.01%~5%.

Preferably, strontium chloride mass percent is 0.5%~3.5%.

Strontium salt anion provides agent.

Strontium salt anion, which provides agent, has enough water solubilitys to discharge anion or anionic group in water or saliva, Anion or anionic group and strontium ion generate slightly soluble or are insoluble in the compound of water.Suitable strontium salt anion provides agent packet Include fluoride provide agent, phosphate, phosphite, metaphosphate, carbonate, sulfate, sulphite, tungstates, molybdate, Borate, acylate and its mixture.

Fluoride provides agent.

Fluoride, which provides agent, has enough water solubilitys to discharge fluoride anion in water or saliva.Suitable fluorination Object provides agent and provides agent for inorganic fluoride.

It includes fluoride salt, fluosilicate, mono-fluor phosphate, difluorophosphoric acid salt, hexafluorophosphate that inorganic fluoride, which provides agent, And borofluoride, including ammonium fluoride, lithium fluoride, sodium fluoride, potassium fluoride, rubidium fluoride RbF, cesium fluoride, stannous fluoride, ammonium fluosilicate, fluorine Lithium metasilicate, prodan, potassium fluosilicate, rubidium fluosilicate, cesium fluosilicate, magnesium fluosilicate, ammonium fluozirconate, fluorine zirconic acid lithium, fluorine zirconic acid Sodium, potassium fluorozirconate, fluorine zirconic acid rubidium, fluorine zirconic acid caesium, single fluorophosphoric acid ammonium, single lithium fluophosphate, sodium monofluorophosphate, single fluorophosphoric acid potassium, list Fluorophosphoric acid rubidium, single fluorophosphoric acid caesium, difluorophosphoric acid ammonium, difluorophosphate, difluorophosphoric acid sodium, difluorophosphoric acid potassium, difluorophosphoric acid rubidium, two Fluorophosphoric acid caesium, ammonium hexafluorophosphate, lithium hexafluoro phosphate, sodium hexafluoro phosphate, Potassium Hexafluorophosphate, hexafluorophosphoric acid rubidium, hexafluorophosphoric acid caesium, fluorine Ammonium borate, lithium fluoroborate, sodium fluoborate, potassium fluoborate, fluoboric acid rubidium, fluoboric acid caesium and its mixture.

Phosphate.

Phosphate has enough water-soluble to discharge phosphate anion or dihydrogen phosphate ions, phosphorus in water or saliva A sour hydrogen radical ion.Suitable phosphate includes ammonium phosphate, lithium phosphate, sodium phosphate, potassium phosphate, phosphoric acid rubidium, phosphoric acid caesium, phosphoric acid Magnesium, ammonium dihydrogen phosphate, lithium dihydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, biphosphate rubidium, cesium dihydrogen phosphate, biphosphate Magnesium, monoammonium phosphate, one hydrogen lithium of phosphoric acid, disodium-hydrogen, potassium phosphate,monobasic, one hydrogen rubidium of phosphoric acid, one hydrogen caesium of phosphoric acid, one hydrogen of phosphoric acid Magnesium and its mixture.

Phosphite.

Phosphite has enough water solubilitys to discharge orthophosphite ions in water or saliva.Suitable phosphite Including ammonium phosphite, sodium phosphite, potassium phosphite, phosphorous acid rubidium, phosphorous acid caesium and its mixture.

Metaphosphate.

Metaphosphate has enough water solubilitys to discharge metaphosphate ion in water or saliva.Suitable phosphite Including ammonium metaphosphate, sodium metaphosphate, potassium metaphosphate, metaphosphoric acid rubidium, metaphosphoric acid caesium and its mixture.

Carbonate.

Carbonate has enough water solubilitys to discharge carbanion in water or saliva.Suitable carbonate includes carbon Sour lithium, sodium carbonate, potassium carbonate, rubidium carbonate, cesium carbonate, ammonium carbonate, magnesium carbonate and its mixture.

Sulfate.

Sulfate has enough water solubilitys to discharge sulfate ion in water or saliva, and suitable sulfate includes sulphur Sour ammonium, lithium sulfate, sodium sulphate, potassium sulfate, rubidium sulfate, cesium sulfate, aluminum sulfate, magnesium sulfate, zinc sulfate, titanium sulfate and its mixing Object.

Sulphite.

Sulphite has enough water solubilitys to discharge sulfite ion, suitable sulphite in water or saliva Including ammonium sulfite, lithium sulfite, sodium sulfite, potassium sulfite, sulfurous acid rubidium, sulfurous acid caesium, magnesium sulfite, aluminium sulfite, Zinc sulfite, sulfurous acid titanium and its mixture.

Tungstates.

Tungstates has enough water solubilitys to discharge tungstate ion in water or saliva, and suitable tungstates includes tungsten Sour ammonium, tungstate lithium, sodium tungstate, potassium tungstate, wolframic acid rubidium, wolframic acid caesium, magnesium tungstate and its mixture.

Molybdate.

Molybdate has enough water solubilitys to discharge molybdenum acid ion in water or saliva, and suitable molybdate includes molybdenum Sour ammonium, lithium molybdate, sodium molybdate, potassium molybdate, molybdic acid rubidium, cesium molybdate and its mixture.

Borate.

Borate has enough water solubilitys to discharge borate ion in water or saliva, and suitable borate includes boron Sour ammonium, Boratex, potassium borate, boric acid rubidium, boric acid caesium and its mixture.

Acylate.

Acylate has enough water solubilitys to discharge organic acid anions or anionic group in water or saliva, has Machine hydrochlorate include unary fatty acid salt, di-fatty hydrochlorate, alkyl sulfate, alkylphosphonic, amino-acid salt, sulfonate and Its mixture.

Unary fatty acid salt includes its ammonium salt, lithium salts, sodium salt and sylvite, carbochain C₉-C₂₀Range, such as ammonium laurate, laurel Sour lithium, sodium laurate, potassium laurate, palmitic acid ammonium, sodium palmitate, palmitic acid potassium, ammonium stearate, lithium stearate, odium stearate, Potassium stearate and its mixture.

Di-fatty hydrochlorate includes ammonium oxalate, lithium oxalate, sodium oxalate, potassium oxalate, malonic acid ammonium, Lithium malonate, malonic acid Sodium, malonic acid potassium, ammonium succinate, succinic acid lithium, sodium succinate, potassium succinate, glutaric acid ammonium, glutaric acid lithium, Sodium glutarate, penta Diacid potassium, ammonium adipate, lithium adipate, adipic acid sodium, Potassium Adipate, ammonium tartrate, ammonium tartrate, lithium tartrate, tartaric acid Sodium, potassium tartrate and its mixture.

Alkyl sulfate includes its ammonium salt, lithium salts, sodium salt and sylvite, alkyl carbon chain C₁₂-C₁₈Range, such as dodecyl sulphur Sour ammonium, lithium dodecyl sulfate, lauryl sodium sulfate, dodecyl sulphate potassium, n-hexadecyl sodium sulphate, n-octadecane base Sodium sulphate and its mixture.

Alkylphosphonic includes its ammonium salt, lithium salts, sodium salt and sylvite, alkyl carbon chain C₁₂-C₁₈Range, such as dodecyl phosphorus Sour ammonium, dodecylphosphoric acid lithium, ferric tri-dodecanesulfonate, Potassium dodecyl phosphate, n-hexadecyl sodium phosphate, n-octadecane base Sodium phosphate and its mixture.

Amino-acid salt includes sodium lauroyl sarcosine, potassium lauroyl sarcosine, sodium lauroyl glutamate, lauroyl glutamate Potassium, cocoyl Sodium Glycinate, cocoyl glycine potassium, cocoyl Sodium L-alaninate, sodium dodecyl aminopropionitrile, Pork and beans Guan acyl sodium glutamate, palmityl sodium glutamate, stearoyl-glutamic acid sodium and its mixture.

Sulfonate includes ammonium salt, lithium salts, sodium salt and the sylvite of alkylsulfonate, alkyl carbon chain C₁₂-C₂₀Range, such as 12 Alkyl sulfonic acid ammonium, dodecyl sodium sulfonate lithium, dodecyl sodium sulfate, potassium dodecanesulfonate, there are also two butyric acid dioctyl ester sulfonic acid Sodium, neopelex, nekal and its mixture.

Preferably, water-soluble strontium salt anion offer agent is soluble and remains soluble in water or saliva, preferably The strontium salt anion to provide agent be that fluoride provides agent, it is sodium monofluorophosphate, quality hundred that preferred fluoride, which provides agent, Divide than being 0.01%~3%.

Preferably, sodium monofluorophosphate mass percent is 0.5%~1.5%.

Preferably, a kind of mass percent of the composition with anti-sensitivity of tooth is 1%~5%, by following quality The group of percentage is grouped as: strontium chloride 0.5%~3.5%, sodium monofluorophosphate 0.5%~1.5%.

A kind of application of above-mentioned composition in tooth powder.

Application of the composition in tooth powder, preferably, the mass percent that the composition accounts for whole components is 1%~5%.

A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, sweetener, tea polyphenols, also include the above technical side Composition described in case, mass percent of the composition in tooth powder are 0.02%~8%, preferably 1%~5%.

Mass percent of the tea polyphenols in tooth powder is 0.1%~40%, preferably 1%~20%.

A kind of tooth powder with anti-sensitivity of tooth, comprising rubbing agent, sweetener, tealeaves, also include above technical scheme The composition, mass percent of the composition in tooth powder are 0.02%~8%, preferably 1%~5%.

The tealeaves is black tea, green tea, Partial fermentation tea, preferably green tea, and the mass percent in tooth powder is 1% ~40%, preferably 5%~20%.

The composition is in mouthwass, collutory, the agent of liquid tooth, powder of gargling, mouthwash, the agent of solid tooth, tooth film, tooth Application in item, gel paint, tooth bead, pastille, toothpaste, tooth gel and tooth latex, including mouthwass, gargle Agent, the agent of liquid tooth, powder of gargling, mouthwash, the agent of solid tooth, tooth film, gear rack, gel paint, tooth bead, pastille, toothpaste, tooth, which are used, to coagulate Glue and tooth latex etc. can be single-item before entering oral cavity and is also possible to combined article.The composition accounts for the quality of whole components Percentage is 0.02%~8%.

A kind of preparation method of above-mentioned tooth powder includes the following steps: green tea, rubbing agent, sweetener, also includes anti-tooth Sensitive composition, is respectively prepared powder, and the component by every kind of content no more than 10% is first uniformly mixed in a reservoir, so Remaining component is put into the container afterwards to be stirred for being uniformly mixed and obtains mixture, is sieved, screenings is finished product tooth powder, tooth Powder preparation is completed.

A kind of preparation method of above-mentioned tooth powder includes the following steps: tea polyphenols, rubbing agent, sweetener, also includes anti-tooth The composition of tooth sensitivity, is respectively prepared powder, and the component by every kind of content no more than 10% is first uniformly mixed in a reservoir, Then remaining component being put into the container to be stirred for being uniformly mixed and obtains mixture, be sieved, screenings is finished product tooth powder, Tooth powder preparation is completed.

The beneficial effects of the present invention are: the composition of the anti-sensitivity of tooth for oral care of the invention, can block Open dentinal tubule plays the role of alleviating sensitivity of tooth pain, achievees the effect that anti-sensitivity of tooth, then including the group It closes and tea polyphenols or green tea is added in the tooth powder of object, there is inhibiting bacteria and diminishing inflammation, alleviate the effect of gum discomfort.

Specific embodiment

Below with reference to embodiment, the invention will be further described, but not thereby limiting the invention.

Experimental method in following embodiments is unless otherwise instructed conventional method.

Embodiment 1 has the composition of anti-sensitivity of tooth.

Embodiment 1 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: strontium chloride 0.01% ~5%, sodium monofluorophosphate 0.01%~3%.

Embodiment 2 has the composition of anti-sensitivity of tooth.

Embodiment 2 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: strontium chloride 0.01%, Sodium monofluorophosphate 0.01%.

Embodiment 3 has the composition of anti-sensitivity of tooth.

Embodiment 3 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: strontium chloride 0.5%~ 1.5%, sodium monofluorophosphate 0.3%~1%.

Embodiment 4 has the composition of anti-sensitivity of tooth.

Embodiment 4 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: strontium chloride 1%, list Sodium fluoro phosphate 0.8%.

Embodiment 5 has the composition of anti-sensitivity of tooth.

Embodiment 5 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: strontium chloride 0.5%~ 3.5%, sodium monofluorophosphate 0.5%~1.5%.

Embodiment 6 has the composition of anti-sensitivity of tooth.

Embodiment 6 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: strontium chloride 3%~ 4%, sodium monofluorophosphate 1%~2.5%.

Embodiment 7 has the composition of anti-sensitivity of tooth.

Embodiment 7 has the composition of anti-sensitivity of tooth, consists of the following components in percentage by mass: strontium chloride 5%, list Sodium fluoro phosphate 3%.

Embodiment 8 has the tooth powder of anti-sensitivity of tooth.

Embodiment 8 prepares tooth powder in accordance with the following steps: granularity is made not less than 325 mesh powder, by rubbing agent system in green tea It is not less than 1000 mesh powder at granularity, the combination of anti-sensitivity of tooth described in any one embodiment in sweetener, embodiment 1-7 Granularity is respectively prepared not less than 100 mesh powders in object, and the component by every kind of content no more than 10% is first stirred in a reservoir It is even, then remaining component is put into the container be stirred for be uniformly mixed obtain mixture, mixture sieves with 100 mesh sieve, under sieve Object is finished product tooth powder, and tooth powder preparation is completed.

Embodiment 9 has the tooth powder of anti-sensitivity of tooth.

Embodiment 9 prepares tooth powder in accordance with the following steps: granularity is made not less than 1000 mesh powder in rubbing agent, tea polyphenols, Granularity is respectively prepared not less than 100 in the composition of anti-sensitivity of tooth described in any one embodiment in sweetener, embodiment 1-7 Mesh powder, the component by every kind of content no more than 10% are first uniformly mixed in a reservoir, then remaining component are put into It is stirred for being uniformly mixed in the container and obtains mixture, mixture sieves with 100 mesh sieve, and screenings is finished product tooth powder, tooth powder preparation It completes.

The mass percent of each component described in embodiment 8-9.

The composition 0.02%~8% of the anti-sensitivity of tooth, preferably 1%~5%.

The rubbing agent 60%~95%, preferably 70%~90%, silica, calcium monohydrogen phosphate, calcium carbonate can be used Deng.

The sweetener 0.1%~5%, preferably 0.5%~3%, neotame, Abbas's sweet tea, saccharin sodium etc. can be used.

Green tea 1%~40%, preferably 5%~20% described in embodiment 8.

Tea polyphenols 0.1%~40%, preferably 1%~20% described in embodiment 9.

Embodiment 10 contains the tooth powder measure of merit of anti-sensitivity of tooth composition.

According to the form below preparation contains the tooth powder of anti-sensitivity of tooth composition.Sensitivity of tooth patient panesthesia in usually diet is suffered from Tooth acid is gently scraped with nail and feels acid acid at the unfilled corner of the teeth roots outer surface and tooth of suffering from tooth, will after first being brushed teeth with toothpaste The tooth powder is applied on the tooth and gum of full mouth, generates saliva to oral cavity, with salivary rinse 3~7 minutes, the daily morning and evening each one Secondary, 1~1.5 gram of each dosage, after two week of tooth powder, when dining, is felt to suffer from tooth not sour, is slightly firmly scraped with nail Suffer from tooth outer surface, feel a little sour, after the tooth powder one month, feels that tooth is not sour, slightly firmly scraped with nail and suffer from tooth Outer surface, tooth is not sour, with feeling that tooth is not sour after the tooth powder three months, is slightly firmly scraped with nail and suffers from all teeth of tooth also not Acid.The tooth powder has the effect of anti-sensitivity of tooth.

Serial number	Component	Mass percent, %
			1	Calcium carbonate	87.7
2	Tea polyphenols	10
			3	Strontium chloride	1
4	Sodium monofluorophosphate	0.8
			5	Saccharin sodium	0.5
6	It amounts to	100

Embodiment 11 contains the tooth powder measure of merit of anti-sensitivity of tooth composition.

The tooth powder of composition of the preparation containing anti-sensitivity of tooth, the constituent mass percentage of the tooth powder is calcium carbonate respectively 87.7%, green tea 10%, strontium chloride 1%, sodium monofluorophosphate 0.8%, saccharin sodium 0.5%.Sensitivity of tooth patient is red with slight gum Swollen, before using the tooth powder, panesthesia suffers from the stimulation of tooth acid acid when into cold food, is gently scraped outside the tooth for suffering from the nearly tooth root of tooth with nail Feel very sour when surface, after first being brushed teeth with toothpaste, by the tooth powder of preparation gently smear full mouth on tooth and gum, to oral cavity It generates saliva and once in the morning and once at night, about 1.5 grams of each dosage, used two week of tooth powder with salivary rinse 3~7 minutes Feel to suffer from that tooth is not substantially sour when afterwards, into cold food, when slightly firmly scraping the exterior of teeth for suffering from the nearly tooth root of tooth with nail, feels to suffer from Tooth is somewhat sour, after the tooth powder one month, when slightly firmly scraping the exterior of teeth of nearly tooth root with nail, feels to suffer from tooth not Acid only feels the sensitivity of tooth for having slight once in a while, suffers from the nearly tooth root of tooth with slightly firmly being scraped after the tooth powder three months with nail When exterior of teeth, feel to suffer from tooth not sour, suffers from that tooth is not sour, and gum is normal when using 6 months laggard cold foods of tooth powder, gum is uncomfortable Alleviate.The tooth powder has the effect of anti-sensitivity of tooth and alleviates gum discomfort.

Claims (6)

1. a kind of composition with anti-sensitivity of tooth containing strontium salt, which is characterized in that be grouped by the group of following mass percent At: object containing strontium 0.01%~5%, strontium salt anion provide agent 0.01%~3%.

2. object containing strontium as described in claim 1 and strontium salt anion provide agent, which is characterized in that object containing strontium is selected from strontium chloride, Strontium salt anion provides agent and is selected from sodium monofluorophosphate.

3. a kind of such as application of the described in any item compositions of claim 1-2 in tooth powder.

4. a kind of tooth powder with anti-sensitivity of tooth includes tea polyphenols, rubbing agent, sweetener, which is characterized in that also comprising having the right Benefit requires the described in any item compositions of 1-2, and mass percent of the composition in entire tooth powder is 0.02%~8%；Institute Mass percent of the tea polyphenols stated in entire tooth powder is 0.1%~40%.

5. a kind of tooth powder with anti-sensitivity of tooth includes tealeaves, rubbing agent, sweetener, which is characterized in that also comprising having the right It is required that the described in any item compositions of 1-2, mass percent of the composition in entire tooth powder is 0.02%~8%；It is described Tealeaves be selected from green tea, mass percent of the green tea in entire tooth powder be 1%~40%.

6. as the described in any item compositions of claim 1-2 in mouthwass, collutory, the agent of liquid tooth, powder of gargling, gargle Application in water, the agent of solid tooth, tooth film, gear rack, gel paint, tooth bead, pastille, toothpaste, tooth gel and tooth latex, It is characterized in that, the mass percent that the composition accounts for whole components is 0.02%~8%.