CN102187887A - Sandwich biscuit with functions of losing weight and regulating blood sugar and production method thereof - Google Patents
Sandwich biscuit with functions of losing weight and regulating blood sugar and production method thereof Download PDFInfo
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Abstract
The invention provides a health-care biscuit capable of according with the healthy weight-losing principle and controlling the blood sugar and a production method thereof, which solve the problems existing in the traditional method for losing weight by medicines, diet and peinotherapy, which are generally adopted by people at present as well as a surgery operation. The health-care biscuit comprises the raw materials in a formula of entire wheat flour, buckwheat flour, oat flour, palm oil, dehydrated black fungus flour, konjaku flour, sea backthern extract, polygonatum odoratum extract, dehydrated celery powder and fructo-oligosaccharide. The preparation process comprises the following steps of: respectively pre-treating high-quality black fungus and fresh celery to obtain the dehydrated black fungus flour and the dehydrated celery powder for later use; mixing the dehydrated black fungus flour and the dehydrated celery powder with the palm oil, the fructo-oligosaccharide, the dehydrated black fungus flour, the dehydrated celery powder, the sea backthern extract, the polygonatum odoratum extract and the konjaku flour according to proportions to obtain a core material for later use; feeding the entire wheat flour, the oat flour and the buckwheat flour into a dough kneading machine to form a dough, fermenting and then forming; and refining to obtain a biscuit product with a function of losing weight by adopting a process of feeding core, sandwiching and packaging.
Description
One, technical field
The invention belongs to Ricipe for health care food and fabricating technology field, relate to a kind of biscuit and preparation method thereof with fat-reducing and function of blood sugar reduction.
Two, background technology
The medical expert thinks that obesity is a kind of chronic disease, and it can bring out such as diseases such as diabetes B, coronary heart disease, hypertension.Fat will become 21 century main " Social Medicine " problem of facing of countries in the world.The statistics of announcing according to China relevant department shows: the adult overweight ratio of China has reached 20%～30%, and the adult overweight ratio in big city is more up to 40%,
The medical expert discovers, fat cause is relevant with familial inheritance, also improves with living standard, absorbs high caloric diet and physical exertion for a long time and reduces relevant.The overweight people is because the insulin receptor quantity of insulin target cell reduces, or the defective of cell internal reaction after insulin and the receptors bind produces insulin resistance in the body, and therefore obesity is the major incentive of type ii diabetes generation.
Find between obese degree and the type ii diabetes confidential relation is arranged by the census of population.In being the research of Nurses Cohort, a key name finds that BMI (body mass index) is too high to be the main hazard factor of type ii diabetes morbidity.Along with the rising of BMI (body mass index), the possibility of onset diabetes is multiplied.The influence of deduction age factor, others compares less than 21 the same sex with BMI, and BMI raises 93 times and 42 times respectively greater than the danger that 35 women and the male sex suffer from diabetes.
Medical research shows that the main cause of most of obesities and hyperglycemia population morbidity is all reasonable with diet structure, overnutrition is in close relations.The present invention adopts dietetic treatment, and reasonable formula is made a kind of crude fibre sandwich biscuits, and obese people and hyperglycemia population diet every day absorption energy are controlled.Promptly rationally the control heat is supplied with, and reaches and keeps SBW; Balanced diet, the purpose of assurance nutritional need.
Three, summary of the invention
The objective of the invention is to: the traditional weight reduction with drugs that generally adopts at present people, go on a diet, hunger cure and adopt the more existing problems of operation provides a kind of sandwich biscuits and method for making thereof that had not only adapted to health slimming principle and theory but also can control blood sugar.
Modern nutriology studies show that wholemeal has antiobesity action.Wholemeal contains the unexistent wheat bran of long patent flour, and the main component of wheat bran is a cellulose.Per 100 gram fine gritses produce 350 kilocalories of (1 kilocalorie=4.10 kilojoule) heats approximately, and 317 kilocalories of equivalent wholemeal heat production, produce heat and lack about 10% than general flour so eat wholemeal.The dietary fiber that wholemeal is rich in, human body not only can not be absorbed, water that also can big 5～25 times of weight of absorptance oneself, under one's belt the time of staying longer, can increase satiety and reduce feed.
Buckwheat: according to the nutritional labeling analysis of health research institute of the Chinese Academy of Medical Sciences to China's main food, the protein content of Buckwheat flour is apparently higher than rice, millet, wheat, Chinese sorghum, corn flour and zanba, roasted qingke barley flour.Buckwheat flour also contains 18 seed amino acids, and buckwheat also contains trace element, and as calcium, phosphorus, iron, magnesium, zinc, chromium and multivitamin, these materials play an important role in the physiological metabolism of human body.In addition, the amylose ratio is higher in the buckwheat starch, can influence hydrone and enter, and postpones gelatinization and digestion rate, thereby can suppress the rising of postprandial blood sugar effectively.
Oatmeal: soluble dietary fibre content is higher than wheat and other cereal in the oatmeal, contains mineral matters such as protein, fat, Cobastab group, calcium, phosphorus, iron etc. in addition.Dietary fiber has the wriggling that increases stomach and shortens food in the enteron aisle time of staying, eliminates constipation, promotes digestion, produces full abdomen, promotes enterogastric peristalsis, loses weight.Oatmeal can also improve blood circulation, alleviate the pressure that life and work brings, to skin maintenance, fat-reducing, anti-ageing useful especially.
Konjaku: perennial Araeceae draft plant, its main component glucomannans is a kind of macromolecular compound, has very strong water imbibition, the inflatable 80-100 of suction back volume doubly is difficult for after the food being digested and assimilated.It contains soluble dietary fiber, raises evident in efficacy to suppressing postprandial blood sugar; Konjaku flour is diabetic's a desirable antihypelipidemic foodstuff, can alleviate the pancreas islet burden after the application.
Black fungus: modern medicine study is found, black fungus is nutritious, except that containing the necessary nutritional labelings of human body such as a large amount of protein, carbohydrate, calcium, iron and potassium, sodium, little fat, crude fibre, vitamin B1, vitamin B2, vitamin C, carrotene, also contain lecithin, cephalin, sphingomyelins and ergosterol etc.Contain abundant cellulose and a kind of special plant colloid in the black fungus, these two kinds of materials can both promote gastrointestinal peristalsis, thereby promote the discharge of fat food in the enteron aisle, reduce the absorption of food fat, play preventing obesity and antiobesity action.Traditional Chinese medicine is thought, often eats black fungus energy " beneficial gas is not hungry, the strong will of making light of one's life by commiting suicide ".
Hippophae rhamnoides: modern pharmacological research proof hippophae rhamnoides has hypoglycemic activity.In the zoopery to the influence of blood glucose in diabetic mice.Increase with alloxan modeling animal performance feed, drinking-water, urine amount; After the medication (hippophae rhamnoides) the 5th day, basic, normal, high dosage group spirit takes a turn for the better, and fur gloss is gradually good, and drinking-water, urine amount reduce; And the model group ordinary circumstance is relatively poor, and fur is thick random and matt, the muscle power decay, and drinking-water, urine amount increase obviously.Alloxan is a species specific β cytotoxic agent, and the beta Cell of islet that optionally damages multiple animal causes the animal used as test diabetes.This experimental result confirms that hippophae rhamnoides can effectively reduce the fasting blood sugar of alloxan diabetes mouse, and this shows that hippophae rhamnoides can control the symptom of diabetes effectively, and its effect is better than the clinical application diabetes pill.Hippophae rhamnoides is nontoxic level food, oral safety.
Rhizoma Polygonati Odorati extract: originating is the rhizome of liliaceous plant radix polygonati officinalis, and the sweet property of distinguishing the flavor of is flat cold not dry, attaches to the lung and stomach meridians.Have Yin nourishing and lung moistening and reinforcing stomach reg fluid effect, the traditional Chinese medical science is usually used in lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior heat disease such as quench one's thirst, and has multiple physiologically active.Show that through experimental study fragrant solomonseal rhizome polyoses can reduce serum glucose and the triglyceride level of mouse after the modeling, rising serum insulin level very significantly; Prove that through modern pharmacological research fragrant solomonseal rhizome polyoses has the obvious functions of blood sugar effect.
FOS: claiming fructooligosaccharide again, is the mixture that is combined ketose, Nystose and the GF4 etc. that generate by 1～3 fructosyl by β (2-1) glycosidic bond and the fructosyl in the sucrose.According to surveying and determination, the calorific value of FOS is below the 1.5Kcal/g, and sucrose calorific value 4.6Kcal/g, its low heat energy value can not cause fat, and has played antiobesity action.Simultaneously, FOS seldom can be decomposed by hydrochloric acid in gastric juice in the alimentary canal and enzyme, and extremely difficulty is absorbed by the body.Therefore, concerning the diabetic, FOS also is a kind of good sweetener.
Technical scheme of the present invention is:
A kind of biscuit and method for making thereof with fat-reducing and function of blood sugar reduction, its prescription feature is: 5～13 parts of wholemeals, 5～20 parts of buckwheats, 5～15 parts of oatmeals, 2～20 parts of konjaku flours, 1～3 part of palm oil, 2～20 parts in dehydration auricularia auriculajudae powder, 1～3 part in dehydration celery powder, 1～2 part of FOS, 1～3 part of hippophae rhamnoides, 1～3 part of Rhizoma Polygonati Odorati extract.
A kind of have fat-reducing and the biscuit manufacture craft of function of blood sugar reduction as follows:
(1) preparation of dehydration auricularia auriculajudae powder
Get high-quality black fungus, behind emerge in worm water, pull out and wash bubble with clear water and send out, selected, ultrasonic extraction dehydrates, and pulverize the back, crosses 100 mesh sieves, and the auricularia auriculajudae powder that must dewater is standby.
(2) preparation of dehydration celery powder
Get fresh celery, use the clear water cleaning, drying, pulverize, cross 100 mesh sieves, the celery powder that must dewater, standby.
(3) preparation of konjaku flour
Get slice food made from Amorphophallus rivieri (bar, angle) and process through the edible alcohol wet method through physical dry or fresh Amorphophallus rivieri, the granularity that makes is at the particle of 0.125mm, and is standby.
(4) preparation of biscuit
A. will wholemeal, oatmeal, buckwheat add in the dough mixing machine and stir, and becomes the dough after fermentation, adds palm oil and water again, stirs in the time of as far as possible lacking, and leaves standstill 10-20min.
B. dough enters the forming machine shaping through roll-in.After roll marks is shaped, directly send into 220-250 ℃ of baking oven baking, till ripe (5-6min).
C. core material modulation: earlier palm oil is heated, make it be in molten condition, put into a mixing bowl, it is evenly mixed to add dehydration auricularia auriculajudae powder, dehydration celery powder, konjaku flour, FOS, hippophae rhamnoides, Rhizoma Polygonati Odorati extract while stirring, and general mixing time is 5～10 minutes.Insulation is placed.
D. biscuit sandwich: can be sandwich after the core material modulation, turn cold and solidify with grease-proof.
E. pack: after core material clips, pack, promptly.
Four, description of drawings
Auricularia auriculajudae → selection → cleaning → drying → pulverize → sieve → the auricularia auriculajudae powder dewaters
Celery → selection → cleaning → drying → pulverize → sieve → the celery powder dewaters
Konjaku → drying → pulverize → sieve → konjaku flour
Fig. 1 is a process chart of the present invention.Wherein:
Expression is processed, is handled for material; → expression operation, material, personnel move towards and are connected; Zero expression material.
Five, the specific embodiment
Embodiment one: following specific embodiment is not that case description is as follows to unique restriction of the present invention:
Raw material: (every part 1000 gram)
10 parts of wholemeals, 12 parts of buckwheats, 12 parts of oatmeals, 10 parts of palm oils, 10 parts in dehydration auricularia auriculajudae powder, 4 parts of konjaku flours; 1 part of hippophae rhamnoides, 2 parts of Rhizoma Polygonati Odorati extracts, 3 parts in dehydration celery powder, FOS are 1 part.
The preparation method:
1. the dehydration auricularia auriculajudae powder that will prepare, the weighing of dehydration celery powder are good, standby.
2. the preparation of biscuit
(1) will be in wholemeal, oatmeal, buckwheat, the adding dough mixing machine stir about 15min, and become dough fermentation, add palm oil and water again, stir,, leave standstill 10-20min.
(2) the shortcake dough must directly not enter the forming machine shaping through roll-in.After roll marks is shaped, directly send into 250 ℃ of baking oven bakings, 6min is promptly ripe.
(3) core material modulation: earlier palm oil is heated, make it be in molten condition, put into a mixing bowl, it is evenly mixed to add FOS, dehydration auricularia auriculajudae powder, dehydration celery powder, hippophae rhamnoides, Rhizoma Polygonati Odorati extract, konjaku flour while stirring, and mixing time is 10 minutes.Insulation is placed.
(4) biscuit sandwich: carry out sandwich after the core material modulation.
(5) packing: after core material clips, pack, promptly.
The fat-reducing effect test of this example:
Body mass index=body weight (kilogram)/height
2(m
2)
Define body weight type accepted standard
Normally: male sex 21-24 is normal: women 21-24
Overweight: the male sex＞24～27 are overweight: women＞24～27
Fat: the male sex 〉=27 obesities: women 〉=27
Test method: the only edible biscuit of lunch and dinner, thousand meal doses, 70 grams, dinner is 50 grams.
Test period: 15 days (on July 16,2 days to 2010 July in 2010)
Test crowd: 25 people (enterprise staff), wherein overweight people 16 people (10 woman, 6 men); Overweight person 9 people (5 woman, 4 men)
| Lose weight | 1-2 jin | 2-4 jin | 5-6 jin | More than 9 jin |
| Number | 5 people | 4 people | 8 people | 8 people |
| Proportion (%) | 20％ | 16％ | 32％ | 32％ |
As can be seen from the above table, the person more than 5 jin that loses weight accounts for 64%, and mostly is the overweight people, this shows, takes among this biscuit crowd, and the overweight people is easy more more loses weight.
The waistline situation of change
| Waistline reduces | No change | 0.1-1 it is very little | 1-2 cun | 2-3 cun | 3-4 cun |
| Number | 3 people | 10 people | 6 people | 5 people | 1 people |
| Proportion (%) | 12％ | 40％ | 24％ | 20％ | 4％ |
As can be seen from the above table, take among this biscuit crowd, 88% waistline all reduces to some extent, and especially women's waistline reduces apparent in view.
Embodiment two: following specific embodiment is not that case description is as follows to unique restriction of the present invention:
Raw material: (every part 1000 gram)
10 parts of wholemeals, 15 parts of buckwheats, 14 parts of oatmeals, 2 parts of palm oils, 8 parts in dehydration auricularia auriculajudae powder, 3 parts of konjaku flours; 1 part of hippophae rhamnoides, 2 parts of Rhizoma Polygonati Odorati extracts, 2 parts in dehydration celery powder, FOS are 1 part.
1 materials and methods
1.1 sample: biscuit sample and placebo are provided by Zhang Lifen, are the biscuit formulation, and the biscuit monolithic is pale brown look, and color and luster is even, the sandwich yellow green that is, 10g/ piece.Both outward appearances, taste are basic identical, and normal temperature is preserved, and is for experiment.
Each 6 of human oral, every day 2 times, amounting to oral RD is 12/people/sky.
1.2 study subject: the experimenter is selected from Changsha Yuelu District, male or female.Simple obesity person through health check-up, does not have dysfunctions such as the obvious heart, liver, courage, kidney.
1.2.1 experimenter's choice criteria: adult BMI 〉=30, or total fatty percentage reaches man＞25%, the volunteer of woman＞30%.
1.2.2 exclusion standard:
1.2.2.1 merge to have the inclination, serious primary diseases such as liver, kidney and hemopoietic system the mental patient.
1.2.2.2 take the article relevant in a short time, have influence on judgement person to the result with being tried function.
1.2.2.3 eat in accordance with regulations and tried thing, can't judge effect or data not umbra sound effect or security judgement person.
1.3 experimental design and grouping: adopt two kinds of control design between self and group.Be divided into biscuit sample test-meal group and placebo group at random by experimenter's body weight, body fat weight level, test-meal group 50 examples, control group 50 examples.Carry out the test-meal test by blind method.
1.4 test-meal method: the experimenter began test on 04 28th, 2004, take biscuit every day 2 times, each 2, took continuously 45 days.Duration of test does not change original eating habit, normal diet.
1.5 key instrument: cortical thickness meter, bioelectrical impedance analysis instrument (OMRON-HBF-306), cycle ergometer
2. observation index: test-meal 45 days, every index begin and finish each in the test-meal experiment and test once.
2.1 ordinary circumstance: sleep, spirit, stool and urine.
2.2 security is observed:
2.2.1 blood routine inspection: red blood cell count(RBC), hemoglobin, white blood cell count(WBC)
2.2.2 routine urinalysis (comprising the urine ketoboidies) and stool routine examination:
2.2.3 biochemical indicator is measured: albumin (ALB), total protein (TP), glutamic-oxalacetic transaminease (AST), glutamic-pyruvic transaminase (ALT), urea (UREA), creatinine (CRE), blood uric acid (UA), blood sugar (GLU),
Triglycerides (TG), T-CHOL (CHOL).
2.2.4 Abdominal B type ultrasonography, electrocardiogram, the fluoroscopy of chest of X line.
2.3 body weight and height: emptying stool and urine before measuring, to take off one's shoes, the test-meal forebody-afterbody is resurveyed and is regularly all worn same clothes in unified doctor's type scale mensuration.
2.4 bioelectrical impedance analysis: measure the human body body fat rate.
2.5 measurements of the chest, waist and hips are measured:
2.5.1 waistline: the abdomen girth of flat navel.
2.5.2 hip circumference: with the girth of both sides greater trochanter of femur level.
2.6 sebum thickness measurement: measure the position
2.6.1 right deltoid muscle lower edge arm outside mid-point.
2.6.2 right angulus inferior scapulae
2.6.3 the other 3cm of right navel
2.6.4 right anterior superior spine
2.7 maximal oxygen uptake test: the experimenter uses cycle ergometer to measure exercise tolerance (50 watts of power, 5 minutes time) before and after fat-reducing.The record exercise heart rate is inferred experimenter's maximal oxygen uptake.
2.8 test data statistics: carry out statistical analysis with INSTA software.
3 results
3.1 ordinary circumstance: after the test-meal test, experimenter's mental status, sleep quality, stool and urine situation no abnormality seen.The test-meal group: man/woman is 18/32, and the age is 33.00 ± 7.88; Control group: man/woman is 19/31, and the age is 33.52 ± 9.74.
3.2 the security observation index detects
3.2.1 before and after the test-meal, it is all negative that the experimenter urinates the ketoboidies result.
3.2.2 blood routine and biochemical indicator are measured:
Table 1 blood routine and biochemical indicator detect
Every index before and after the test-meal all in normal range (NR).
3.2.3 Abdominal B type ultrasonography, electrocardiogram, the fluoroscopy of chest of X line detect: all in normal range (NR).
3.2.4 the variation of maximal oxygen uptake and feed
The variation of maximal oxygen uptake and food-intake before and after table 2 test-meal
Experimenter's maximal oxygen uptake and food-intake do not seen significant change before and after the test, and the endurance (aerobic capacity) that the experimenter is described does not descend and appetite does not descend.
3.3 effect observation index
3.3.1 body weight, body fat total amount and fatty percentage measurement result
Table 3 body weight, body fat total amount and fatty percentage measurement result
Annotate: compare relatively P＜0.01 of P＜0.01# and control group before * and the test-meal
Control group and test-meal group body weight, body fat total amount, the percentage comparisons of body fat before the test, the P value is pointed out between two groups to have comparativity all greater than 0.05.Test back test-meal group experimenter is the weight average different conspicuousness (P＜0.01) that has that descends before the test.Test back test-meal group experimenter's system total amount and body fat percentage and control group comparing difference have conspicuousness (P＜0.01).
3.3.2 subcutaneous fat thickness measuring
Table 4 subcutaneous fat thickness measuring result
Annotate: compare relatively P＜0.01 of P＜0.01# and control group before * and the test-meal
Subcutaneous fat thickness all descended before test back test-meal group experimenter tested, and wherein the deltoid muscle place reduces 2.73mm, and omoplate is place's minimizing 2.21mm down, and the other place of navel reduces 4.28mm, and minimizing 2.09mm in ilium sour jujube place has conspicuousness (P＜0.01) with comparing difference before the test.
Test back test-meal group experimenter subcutaneous fat thickness (deltoid muscle place, omoplate place, other place of navel and ilium sour jujube place) has conspicuousness (P＜0.01) with the control group comparing difference.
3.3 girth diameter measurement result
Table 5 girth diameter measurement result
Annotate: compare relatively P＜0.01 of P＜0.01# and control group before * and the test-meal
The test back test-meal group experimenter preceding waistline of test reduces 3.24cm, and hip circumference reduces 4.49cm, with comparing difference before the test conspicuousness (P＜0.01) is arranged.Test back test-meal group experimenter's waistline and hip circumference and control group comparing difference have conspicuousness (P＜0.01).
4 brief summaries
The edible continuously biscuit sample of experimenter is after 45 days, test-meal group weight average decline 2.89kg, and the body fat total amount 2.10kg that on average descends, body fat percentage on average descends 1.51%; Subcutaneous fat thickness all descends, and wherein the deltoid muscle place reduces 2.73mm, and omoplate reduces 2.21mm in the place down, and the other place of navel reduces 4.28mm, and ilium sour jujube place reduces 2.09mm; Waistline reduces 3.24cm, and hip circumference reduces 4.49cm, with comparing difference before the test conspicuousness (P＜0.01) is arranged all.Test back test-meal group body weight, body fat total amount, body fat percentage, subcutaneous fat thickness (deltoid muscle place, omoplate place, the other place of navel, ilium sour jujube place), waistline and hip circumference and control group comparing difference have conspicuousness (P＜0.01).All in normal range (NR), exercise tolerance and appetite are not fallen as follows for test-meal group and the every clinical indices of control group experimenter before and after the experiment.This shows that the biscuit sample has antiobesity action to human body, and to the healthy no obvious damage of human body.
The blood sugar decreasing effect experiment of this example:
Embodiment one:
This biscuit is cooked the postprandial blood sugar test through normal healthy people, wherein 20 normal healthy peoples are taken this biscuit and other 20 normal healthy people control groups comparisons of taking common biscuit, postprandial blood sugar does not have obvious rising, otherness highly significant (P＜0.01), illustrate take this biscuit after, postprandial blood sugar can significantly not raise, and is suitable for the diabetic and takes.
In addition, 20 type ii diabetes patients are observed, the all inactive antidiabetic drug of patient, take this biscuit 120g every day, after 4 weeks of logotype, wherein 7 patient's blood sugar significantly reduce, 3 no significant changes, show that this product has certain function of health care to the diabetic, the part patient is stopped using or the minimizing dose, have the function of keeping blood glucose value simultaneously again.
Embodiment two:
1 materials and methods
1.1 sample: biscuit sample and placebo are provided by Zhang Lifen, are the biscuit formulation, and the biscuit monolithic is pale brown look, and color and luster is even, the sandwich yellow green that is, 10g/ piece.Both outward appearances, taste are basic identical, and normal temperature is preserved, and is for experiment.
Oral each 2, every day 2 times, amounting to oral RD is 120g/ people/sky.
1.2 study subject:
1.2.1 experimenter's choice criteria: the state of an illness was more stable after the experimenter selected diet control or OHA treatment, do not need to change types of drugs and dosage, only take the adult type ii diabetes patient of maintenance dose, fasting blood-glucose 〉=7.8mmol/L (140mg/dl) or 2h blood sugar 〉=11.1mm0l/L (200mg/dl) after the meal; Also can select the hyperglycemia population of 2h blood sugar 〉=7.8mmol/L of 7.8mmol/L 〉=fasting blood-glucose 〉=6.7mmol/L (120mg/dl) or 11.1mm0l/L 〉=after the meal.
1.2.2 exclusion standard:
1.2.2.1I type diabetes patient.
1.2.2.2 the age, gestation or women breast-feeding their children were to the given the test agent allergy sufferers under-18s or the above person of 65 wind.
1.2.2.3 have the inclination, main organs complication such as liver, kidney, or be associated with other serious disease, the mental patient takes glucocorticoid or other influences blood sugar medicine person.
Diet control influences observed result person 1.2.2.4 can not be cooperated.
1.2.2.5 in nearly 3 months diabetes ketosis, acid poisoning and the infected are arranged.
1.2.2.6 take the article relevant with being tried function in a short time, influence is to result's judgement person.
1.2.2.7 all standards of including in that do not meet are not taken given the test agent in accordance with regulations, or data not umbra ring observed result person.
1.3 experimental design and grouping: adopt two kinds of control design between self and group.Require 120 routine experimenters according to the random-blind method, by blood sugar level, sex, age, the course of disease, the kind of taking medicine (sulfonylureas, biguanides) etc. at random equilibrium be divided into two groups (test-meal group and control groups), every group 60 example.Each experimenter is stipulated corresponding diet by sex, age, different labor intensity, ideal body weight with reference to original habits and customs before the test-meal, adhere to diet control during the test-meal, former medicament categories and the dosage of taking the treatment diabetes is constant.The test-meal group adds food biscuit sample, every day 2 times, each 6, takes 45 days.Control group is taken placebo.
1.4 test-meal method: the experimenter began test on 04 28th, 2010, take biscuit every day 2 times, each 2, took continuously 45 days.
1.5 key instrument: F-820 type blood counting instrument, ten analyzers of MIDIRON urine (Germany produces), Olympus is complete in a Biochemical Analyzer (Japan produces), and the biochemical reagents box is provided by middle living company.
2. observation index:
2.1 effect index: test-meal 45 days, every index begins and finishes each test once in the test-meal experiment.
2.1.1 symptom is observed: detailed medical history-taking, understand patient's diet situation, medicining condition, activity is observed main clinic symptoms: thirsty many drinks, polyorexia, lassitude hypodynamia, diuresis etc.By symptom shape weight integration (severe 3 minutes, middle disease 2 minutes, light disease 1 minute, asymptomatic 0 minute), before and after test-meal, add up integrated value, and improve (each doing well,improving 1 is divided into effectively), observation of clinical signs improvement rate with regard to its cardinal symptom.
2.1.2 fasting blood-glucose: the percentage that fasting blood sugar and blood sugar descend before and after the observation degree food.
2.1.3 2h blood sugar after the meal: observe before and after the test-meal after the smart powder steamed bun of edible 100g the percentage that 2 hours blood glucose values and blood sugar descend.
2.1.4 glucose in urine: with urina sanguinis is qualitative on an empty stomach, by-, ± ,+, ++, +++, ++ ++ long-pending respectively is 0,0.5,1,2,3,4 minute, statistics integrated value before and after test-meal.
2.1.5 blood fat: observe test-meal front and back serum total cholesterol (TC), serum levels of triglyceride (TG), HDL-C (HDL-C) level.
2.2 security is observed:
2.2.1 general situation sign: comprise spirit, sleep, diet, stool and urine, blood pressure etc.
2.2.2 blood urine is routine inspection just: red blood cell count(RBC), hemoglobin, white blood cell count(WBC), urine ketoboidies, stool routine examination
2.2.3 hepatic and renal function inspection:
2.2.4X the line fluoroscopy of chest, electrocardiogram, Abdominal B type ultrasonography (only pretest inspection is once).
3. effect criterion
3.1 fasting blood-glucose result judges: 1) self compare before and after the fasting blood-glucose test, difference has conspicuousness, and test back average blood sugar descends 〉=10%, 2) test back test-meal group blood glucose value or blood sugar decline percentage and control group are relatively, difference has conspicuousness, satisfy above-mentioned two conditions, decidable is this given the test agent sugared index positive as a result of being engaged on an empty stomach.
3.2 the 2h blood sugar effects is judged after the meal: 1) self compare before and after the 2h blood sugar test after the meal, difference has conspicuousness, and test back average blood sugar descends 〉=10%, 2) test back test-meal group blood glucose value or blood sugar decline percentage and control group are relatively, difference has conspicuousness. and satisfy above-mentioned two conditions, this given the test agent of decidable is the 2h blood glucose target positive as a result after the meal.
3.3 fasting blood-glucose, matter is index positive in two indexs of 2h blood sugar after the meal, this given the test agent of decidable has auxiliary hyperglycemic function.
4. result:
The observed result double blinding is made known: take I person and be biscuit sample (test-meal group), take II person and be placebo (control group).
4.1 physical data:
Observe 120 examples altogether, wherein effective case 104 examples. experimenter's blood, urine, just routine inspection before the test-meal, hepatic and renal function is checked, Abdominal B type ultrasonography, electrocardiogram, X line fluoroscopies of chest etc. are all substantially in normal range (NR), after the random packet test-meal group and control group test-meal last as situation relatively see Table 1,2, two group of subject age, sex, the course of disease, blood sugar, the former equal no significant difference of hypoglycemic medicine situation of taking, have comparativity.
Situation comparison as table 1 observation is last (X ± SD)
Every index before and after the test-meal all in normal range (NR).
The former hypoglycemic medicine situation of taking of table 2 examination trencherman
4.2 effect index observing:
4.2.1 symptom is observed:
By table 3,4 as seen, take and tried thing one month, aspect each cardinal symptom improved, the test-meal group all was better than control group.Relatively there were significant differences (P＜0.01) for two groups of clinical symptoms integrations self before and after the test-meal, and the clinical symptoms of test-meal group and control group all has improvement.Compare between group, the preceding two groups of clinical symptoms integration no significant differences of test-meal (P＞0.05), there were significant differences (P＜0.01) for two groups of clinical symptoms integrations after the test-meal, illustrates that the improvement of test-meal group cardinal symptom is significantly better than control group.
Experimenter's maximal oxygen uptake and food-intake do not seen significant change before and after the test, and the endurance (aerobic capacity) that the experimenter is described does not descend and appetite does not descend.
Table 3 cardinal symptom is improved situation
Table 4 clinical symptoms integration statistics (X ± SD)
4.2.2 fasting blood-glucose
By table 5 as seen, self compare before and after two groups of tests, test-meal group fasting blood-glucose descends self relatively, test-meal group fasting blood-glucose decline 1.35 ± 0.28mmol/L, rate of descent is 13.78 ± 2.56%, difference has conspicuousness (P＜0.01), control group fasting blood-glucose decline 0.25 ± 0.48mmol/L, rate of descent is 2.41 ± 4.73%, and no significant difference (P＞0.05) compares before and after two groups of tests, test preceding two groups of fasting blood-glucose no significant differences (P＞0.05), test back test-meal group fasting blood-glucose obviously descends, and compares with control group, and difference has conspicuousness (P＜0.01).
Fasting blood-glucose comparison before and after the table 5 liang group test-meal (mmol/L, X ± SD)
4.2.3 two hours after the meal blood sugar:
By table 6 as seen, self compare before and after two groups of tests, 2 hours after the meal blood sugar 1.95 ± 0.52mmol/L of test-meal group, rate of descent is that 14.59 ± 3.43%. difference has conspicuousness (P＜0.01), control group blood sugar decline in 2 hours after the meal 0.31 ± 0.84mmol/L, rate of descent is 2.01 ± 6.09%, no significant difference (P＞0.05), compare before and after two groups of tests, test preceding two groups of 2 hours after the meal blood sugar no significant differences (P＞0.05), 2 hours after the meal blood sugar of test back test-meal group obviously descends, and compares with control group, and difference has conspicuousness (P＜0.01).
Fasting blood-glucose comparison before and after the table 6 liang group test-meal (mmol/L, X ± SD)
4.2.4 glucose in urine:
By table 7 as seen, self compare before and after two groups of tests, test-meal group glucose in urine integrated value reduces, and difference has conspicuousness (P＜0.01); Control group glucose in urine integrated value no significant difference (P＞0.05).Compare between group before and after two groups of tests, test preceding two groups of glucose in urine integrated values ground notable difference (P＞0.05); Test back test-meal group glucose in urine integrated value obviously reduces, and compares with control group, and difference has conspicuousness (P＜0.01).
Glucoses in urine (integrated value) comparison before and after the table 7. liang group test-meal (X ± SD)
4.2.5 blood fat:
By table 8,9,10 as seen, self compare before and after two groups of tests, serum total cholesterol (TC), serum levels of triglyceride (TG), HDL-C (HDL-C) levels do not have significant change before and after two groups of test-meals.
Serum total cholesterols (TC) variation comparison before and after the table 8. liang group test-meal (mmol/L, X ± SD)
Serum levels of triglyceride (TG) variation comparison before and after the table 9. liang group test-meal (mmol/L, X ± SD)
Serum levels of triglyceride (TG) variation comparison before and after the table 10. liang group test-meal (mmol/L, X ± SD)
4.3 safety indexes is observed: by table 11 as seen, before and after two groups of test-meals, detect every index all in normal range (NR).
Safety index variation comparison before and after the table 11. liang group test-meal (X ± SD)
4.4X the line fluoroscopy of chest, electrocardiogram, Abdominal B type ultrasonography inspection and heart rate, blood pressure: substantially in normal range (NR).
4.5 case is taken off the mistake rate: test-meal group and control group MethodsThe cases enrolled respectively are 60 examples, have 3 examples not take in accordance with regulations during wherein test-meal group test-meal end and are tried thing, and 5 examples are check on time at the appointed time, and control group has the check on time at the appointed time of 7 examples, and 1 example is dropped by the wayside.It is 13.3% that case is taken off the mistake rate.
5. sum up:
5.1 this biscuit sample has the tangible reduction effect of 2h blood sugar on an empty stomach and after the meal.Self compares before and after the test, biscuit sample sets fasting blood-glucose decline 1.35 ± 0.28mmol/L, and rate of descent is 13.78 ± 2.56%; 2 hours after the meal blood sugar decline 1.95 ± 0.52mmol/L, rate of descent is 14.59 ± 3.43%; Difference all has conspicuousness (P＜0.01).
The control group fasting blood-glucose, blood descends not obvious after the meal.Test back biscuit sampling test group fasting blood-glucose, 2 hours after the meal blood glucose values and control group comparison have conspicuousness (P＜0.01).Test between front and back self and group for two groups and compare, serum total cholesterol (TC), serum levels of triglyceride (TG), HDL-C (HDL-C) levels do not have significant change before and after two groups of test-meals.Illustrate that this biscuit sample has auxiliary hyperglycemic function.
5.2 the biscuit sample has a better role to cardinal symptoms such as the thirsty many drinks of hyperglycaemia examination trencherman, polyorexia, lassitude hypodynamia, diuresis.
After 5.3 the examination trencherman takes this biscuit sample, hemoglobin, red blood cell, leucocyte, total serum protein, albumin, paddy third changes ammonia undergraduate course, glutamic-oxalacetic transaminease, creatinine, urea and urinates just every inspection index such as routine all in normal range (NR), and this product be described, and the trencherman is healthy to have no adverse effects to trying.
5.4 the biscuit sample is not observed allergy and other bad reaction in the test-meal process.
Therefore, can be the health food of this biscuit as obese people and diabetes B crowd.
Claims (3)
1. one kind has the fat-reducing and the sandwich biscuits and the method for making thereof of function of blood sugar reduction, it is characterized in that containing auricularia auriculajudae, konjaku flour, dehydration celery powder in its prescription.Specifically form: wholemeal, buckwheat, oatmeal, palm oil, dehydration auricularia auriculajudae powder, dehydration celery powder, konjaku flour, FOS, hippophae rhamnoides, Rhizoma Polygonati Odorati extract by following raw material proportioning is refining.
2. described according to claim 1, it is characterized in that it is to be formed by following component raw material proportioning.
5～14 parts of wholemeals, 5～20 parts of buckwheats, 5～15 parts of oatmeals, 2～20 parts of konjaku flours, 1～3 part of palm oil, 2～20 parts in dehydration auricularia auriculajudae powder, 1～3 part in dehydration celery powder, 1～2 part of FOS, 1～3 part of hippophae rhamnoides, 1～3 part of Rhizoma Polygonati Odorati extract, water are an amount of.
3. the sandwich biscuits manufacture craft with fat-reducing and function of blood sugar reduction is as follows:
(1) preparation of dehydration auricularia auriculajudae powder
Get high-quality black fungus, behind emerge in worm water, pull out and wash bubble with clear water and send out, selected, through ultrasonic extraction, dehydrate, pulverize the back, crosses 100 mesh sieves, and the auricularia auriculajudae powder that must dewater is standby.
(2) preparation of dehydration celery powder
Get fresh celery, use the clear water cleaning, drying, pulverize, cross 100 mesh sieves, the celery powder that must dewater, standby.
(3) preparation of konjaku flour
Get slice food made from Amorphophallus rivieri and process through the edible alcohol wet method, granulate, cross 150 mesh sieves, get konjaku micropowder through physical dry or fresh Amorphophallus rivieri, standby.
(4) preparation of biscuit
A. will wholemeal, oatmeal, buckwheat add in the dough mixing machine and stir, and becomes dough, after fermentation, adds palm oil and water again, stirs in the time of as far as possible lacking, and leaves standstill 10-20min.
B. dough enters the forming machine shaping through roll-in.After roll marks is shaped, directly send into 220-250 ℃ of baking oven baking, till ripe (5-6min).
C. core material modulation: earlier palm oil is heated, make it be in molten condition, put into a mixing bowl, it is evenly mixed to add dehydration auricularia auriculajudae powder, dehydration celery powder, konjaku flour, FOS, hippophae rhamnoides, Rhizoma Polygonati Odorati extract while stirring, and general mixing time is 5～10 minutes.Insulation is placed.
D. biscuit sandwich: can be sandwich after the core material modulation, turn cold and solidify with grease-proof.
E. pack: after core material clips, pack, promptly.
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Application publication date: 20110921 Assignee: Heilongjiang Beiqishen Pharmaceutical Co., Ltd. Assignor: Zhang Lifen Contract record no.: 2013230001794 Denomination of invention: Sandwich biscuit with functions of losing weight and regulating blood sugar and production method thereof Granted publication date: 20130327 License type: Exclusive License Record date: 20130916 |
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