CN102186973B - 细菌的[2Fe‑2S]二羟酸脱水酶的鉴定和用途 - Google Patents
细菌的[2Fe‑2S]二羟酸脱水酶的鉴定和用途 Download PDFInfo
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- CN102186973B CN102186973B CN200980138542.2A CN200980138542A CN102186973B CN 102186973 B CN102186973 B CN 102186973B CN 200980138542 A CN200980138542 A CN 200980138542A CN 102186973 B CN102186973 B CN 102186973B
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01009—Dihydroxy-acid dehydratase (4.2.1.9), i.e. acetohydroxyacid dehydratase
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Theoretical Computer Science (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10079208P | 2008-09-29 | 2008-09-29 | |
| US61/100792 | 2008-09-29 | ||
| PCT/US2009/058827 WO2010037112A1 (en) | 2008-09-29 | 2009-09-29 | IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102186973A CN102186973A (zh) | 2011-09-14 |
| CN102186973B true CN102186973B (zh) | 2017-08-15 |
Family
ID=41402186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980138542.2A Expired - Fee Related CN102186973B (zh) | 2008-09-29 | 2009-09-29 | 细菌的[2Fe‑2S]二羟酸脱水酶的鉴定和用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20100081154A1 (https=) |
| EP (2) | EP2821484B1 (https=) |
| JP (1) | JP5846912B2 (https=) |
| KR (1) | KR101659101B1 (https=) |
| CN (1) | CN102186973B (https=) |
| AU (1) | AU2009296225B2 (https=) |
| BR (1) | BRPI0913682A2 (https=) |
| CA (1) | CA2735690A1 (https=) |
| ES (1) | ES2521675T3 (https=) |
| MX (1) | MX2011003238A (https=) |
| NZ (1) | NZ591244A (https=) |
| WO (1) | WO2010037112A1 (https=) |
| ZA (2) | ZA201101367B (https=) |
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| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| EP2134849B1 (en) | 2007-04-18 | 2013-07-10 | Butamax (TM) Advanced Biofuels LLC | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| US20160222370A1 (en) * | 2008-09-29 | 2016-08-04 | Butamax Advanced Biofuels Llc | Recombinant Yeast Host Cell With Fe-S Cluster Proteins And Methods Of Using Thereof |
| CA2736420A1 (en) * | 2008-09-29 | 2010-04-01 | Butamaxtm Advanced Biofuels Llc | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| US9206447B2 (en) | 2008-09-29 | 2015-12-08 | Butamax Advanced Biofuels Llc | Recombinant yeast host cells comprising FE-S cluster proteins |
| AU2009296227A1 (en) * | 2008-09-29 | 2010-04-01 | Butamax(Tm) Advanced Biofuels Llc | Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria |
| MX2011003238A (es) | 2008-09-29 | 2011-04-28 | Butamax Tm Advanced Biofuels | Identificacion y uso de dihidroxiacido deshidratasas [2fe-2s] bacterianas. |
| US8465964B2 (en) | 2008-11-13 | 2013-06-18 | Butamax (TM) Advanced Biofules LLC | Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis |
| US8614085B2 (en) * | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| BRPI1006492A2 (pt) | 2009-04-13 | 2019-09-24 | Butamax Advanced Biofuels Llc | método para a recuperação de butanol a partir de um meio de fermentação, método para a produção de butanol e mistura de duas fases |
| BR112012003241A2 (pt) * | 2009-08-12 | 2015-09-01 | Gevo Inc | Localização de via de isobutanol citosólico para a produção de isobutanol |
| EP2483401B1 (en) | 2009-09-29 | 2017-06-21 | Butamax (TM) Advanced Biofuels LLC | Improved yeast production host cells |
| AU2010300642B2 (en) | 2009-09-29 | 2015-05-14 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes |
| US20110195505A1 (en) * | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| BR112012012211A2 (pt) | 2009-11-23 | 2017-05-09 | Butamax (Tm) Advanced Biofuels Llc | método para a recuperação de butanol e método para a produção de butanol |
| CA2779884A1 (en) | 2009-11-23 | 2011-05-26 | Butamax(Tm) Advanced Biofuels Llc | Method for producing butanol using extractive fermentation with electrolyte addition |
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| US8765425B2 (en) | 2011-03-23 | 2014-07-01 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| US8759044B2 (en) | 2011-03-23 | 2014-06-24 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
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| CA2862450A1 (en) | 2011-12-30 | 2013-07-04 | Butamax Advanced Biofuels Llc | Genetic switches for butanol production |
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| BR112015005439A8 (pt) | 2012-09-12 | 2022-01-11 | Butamax Advanced Biofuels Llc | Método para recuperar um produto alcoólico de um caldo de fermentação e sistema |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
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| CA2736420A1 (en) | 2008-09-29 | 2010-04-01 | Butamaxtm Advanced Biofuels Llc | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| MX2011003238A (es) | 2008-09-29 | 2011-04-28 | Butamax Tm Advanced Biofuels | Identificacion y uso de dihidroxiacido deshidratasas [2fe-2s] bacterianas. |
| US9206447B2 (en) * | 2008-09-29 | 2015-12-08 | Butamax Advanced Biofuels Llc | Recombinant yeast host cells comprising FE-S cluster proteins |
| WO2010037119A1 (en) | 2008-09-29 | 2010-04-01 | Butamax™ Advanced Biofuels LLC | Enhanced iron-sulfur cluster formation for increased dihydroxy-acid dehydratase activity in lactic acid bacteria |
| AU2009296227A1 (en) | 2008-09-29 | 2010-04-01 | Butamax(Tm) Advanced Biofuels Llc | Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria |
| US8828694B2 (en) * | 2008-11-13 | 2014-09-09 | Butamax Advanced Biofuels Llc | Production of isobutanol in yeast mitochondria |
| BR112012003241A2 (pt) * | 2009-08-12 | 2015-09-01 | Gevo Inc | Localização de via de isobutanol citosólico para a produção de isobutanol |
| AU2010300642B2 (en) * | 2009-09-29 | 2015-05-14 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes |
| EP2483401B1 (en) * | 2009-09-29 | 2017-06-21 | Butamax (TM) Advanced Biofuels LLC | Improved yeast production host cells |
| CA2779884A1 (en) * | 2009-11-23 | 2011-05-26 | Butamax(Tm) Advanced Biofuels Llc | Method for producing butanol using extractive fermentation with electrolyte addition |
| BR112012012211A2 (pt) * | 2009-11-23 | 2017-05-09 | Butamax (Tm) Advanced Biofuels Llc | método para a recuperação de butanol e método para a produção de butanol |
-
2009
- 2009-09-29 MX MX2011003238A patent/MX2011003238A/es not_active Application Discontinuation
- 2009-09-29 CN CN200980138542.2A patent/CN102186973B/zh not_active Expired - Fee Related
- 2009-09-29 JP JP2011529364A patent/JP5846912B2/ja active Active
- 2009-09-29 KR KR1020117009692A patent/KR101659101B1/ko not_active Expired - Fee Related
- 2009-09-29 EP EP14180626.5A patent/EP2821484B1/en active Active
- 2009-09-29 US US12/569,636 patent/US20100081154A1/en not_active Abandoned
- 2009-09-29 BR BRPI0913682-7A patent/BRPI0913682A2/pt not_active Application Discontinuation
- 2009-09-29 WO PCT/US2009/058827 patent/WO2010037112A1/en not_active Ceased
- 2009-09-29 CA CA2735690A patent/CA2735690A1/en not_active Abandoned
- 2009-09-29 AU AU2009296225A patent/AU2009296225B2/en active Active
- 2009-09-29 NZ NZ591244A patent/NZ591244A/xx not_active IP Right Cessation
- 2009-09-29 ES ES09793126.5T patent/ES2521675T3/es active Active
- 2009-09-29 EP EP09793126.5A patent/EP2337851B1/en active Active
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2011
- 2011-02-21 ZA ZA2011/01367A patent/ZA201101367B/en unknown
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2013
- 2013-03-15 US US13/838,508 patent/US8951937B2/en active Active
- 2013-03-15 US US13/838,570 patent/US20140051137A1/en not_active Abandoned
- 2013-12-20 ZA ZA2013/09658A patent/ZA201309658B/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| ZA201309658B (en) | 2016-06-29 |
| NZ591244A (en) | 2013-03-28 |
| ES2521675T3 (es) | 2014-11-13 |
| US20140030776A1 (en) | 2014-01-30 |
| BRPI0913682A2 (pt) | 2020-08-11 |
| US20140051137A1 (en) | 2014-02-20 |
| KR20110063575A (ko) | 2011-06-10 |
| EP2821484A1 (en) | 2015-01-07 |
| ZA201101367B (en) | 2014-03-26 |
| EP2337851A1 (en) | 2011-06-29 |
| EP2821484B1 (en) | 2016-06-29 |
| MX2011003238A (es) | 2011-04-28 |
| WO2010037112A1 (en) | 2010-04-01 |
| US20100081154A1 (en) | 2010-04-01 |
| AU2009296225B2 (en) | 2015-09-17 |
| CN102186973A (zh) | 2011-09-14 |
| JP5846912B2 (ja) | 2016-01-20 |
| CA2735690A1 (en) | 2010-04-01 |
| EP2337851B1 (en) | 2014-08-13 |
| AU2009296225A1 (en) | 2010-04-01 |
| KR101659101B1 (ko) | 2016-09-22 |
| JP2012503993A (ja) | 2012-02-16 |
| US8951937B2 (en) | 2015-02-10 |
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