CN102131801B - 1,2-二取代的杂环化合物 - Google Patents

1,2-二取代的杂环化合物 Download PDF

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Publication number
CN102131801B
CN102131801B CN200980133288.7A CN200980133288A CN102131801B CN 102131801 B CN102131801 B CN 102131801B CN 200980133288 A CN200980133288 A CN 200980133288A CN 102131801 B CN102131801 B CN 102131801B
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phenyl
mmol
water
ylmethoxy
reaction mixture
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Chinese (zh)
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CN102131801A (zh
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埃米·里普卡
吉迪恩·夏皮罗
理查德·切兹沃思
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Forum Pharmaceuticals Inc
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Forum Pharmaceuticals Inc
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980133288.7A 2008-06-25 2009-06-24 1,2-二取代的杂环化合物 Expired - Fee Related CN102131801B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US7559408P 2008-06-25 2008-06-25
US61/075,594 2008-06-25
US10916208P 2008-10-28 2008-10-28
US61/109,162 2008-10-28
US13886608P 2008-12-18 2008-12-18
US61/138,866 2008-12-18
US17641309P 2009-05-07 2009-05-07
US61/176,413 2009-05-07
PCT/US2009/048426 WO2009158393A1 (en) 2008-06-25 2009-06-24 1, 2 disubstituted heterocyclic compounds

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Publication Number Publication Date
CN102131801A CN102131801A (zh) 2011-07-20
CN102131801B true CN102131801B (zh) 2015-04-08

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CN200980133288.7A Expired - Fee Related CN102131801B (zh) 2008-06-25 2009-06-24 1,2-二取代的杂环化合物
CN2009801332730A Pending CN102131800A (zh) 2008-06-25 2009-06-25 5元和6元杂环化合物

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CN2009801332730A Pending CN102131800A (zh) 2008-06-25 2009-06-25 5元和6元杂环化合物

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US (7) US8071595B2 (enExample)
EP (2) EP2297133B1 (enExample)
JP (4) JP5658664B2 (enExample)
KR (2) KR20110031355A (enExample)
CN (2) CN102131801B (enExample)
AU (2) AU2009262241B2 (enExample)
BR (2) BRPI0914772A2 (enExample)
CA (2) CA2729259A1 (enExample)
MX (2) MX2011000175A (enExample)
TW (2) TWI458723B (enExample)
WO (2) WO2009158393A1 (enExample)

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JP5627574B2 (ja) * 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
BRPI0914772A2 (pt) 2008-06-25 2015-10-20 Envivo Pharmaceuticals Inc compostos heterocíclicos 1,2-dissubstituídos
CA2761032A1 (en) 2009-05-07 2010-11-11 Envivo Pharmaceuticals, Inc. Phenoxymethyl heterocyclic compounds
MA33451B1 (fr) 2009-06-26 2012-07-03 Novartis Ag Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17
EP2601192B1 (en) * 2010-08-04 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
US8883788B2 (en) 2010-08-04 2014-11-11 Takeda Pharmaceutical Company Limited Fused heterocyclic ring compound
AU2011305568B2 (en) 2010-09-20 2015-12-10 Ironwood Pharmaceuticals, Inc. Imidazotriazinone compounds
CN107141309A (zh) 2011-01-11 2017-09-08 桑诺维恩药品公司 杂芳基化合物及其使用方法
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