CN102125660B - Traditional Chinese medicine sustained-release micro granules stomach and intestine partner for protecting and strengthening functions of stomach and intestine - Google Patents
Traditional Chinese medicine sustained-release micro granules stomach and intestine partner for protecting and strengthening functions of stomach and intestine Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine sustained-release micro granules stomach and intestine partner for protecting and strengthening functions of the stomach and intestine, which consists of a stomach treating compound and an intestine treating compound, wherein the stomach treating compound is prepared by mixing 2 to 4 weight parts of liriope spicata, 2 to 4 weight parts of dendrobium, 2 to 4 weight parts of hawthorn, 2 to 4 weight parts of lizard, 3 to 5 weight parts of medicated leaven, 3 to 5 weight parts of pearl, 3 to 5 weight parts of raw oyster, 2 to 4 weight parts of barbed skullcap herb, 2 to 4 weight parts of felwort, 2 to 4 weight parts of pseudo-ginseng root, 2 to 4 weight parts of pangolin scales, and 1 to 3 weight parts of ruddle; and the intestine treating compound is prepared from 2 to 4 weight parts of Codonopsis pilosula, 2 to 4 weight parts of astragalus, 2 to 4 weight parts of large head atractylodes rhizome, 2 to 4 weight parts of rhizoma corydalis, 3 to 5 weight parts of yam, 3 to 5 weight parts of dark plum fruit, 3 to 5 weight parts of pinellia tuber, 1 to 2 weight parts of bitter orange, 1 to 2 weight parts of amomum fruit, 1 to 2 weight parts of inula flower, 1 to 2 weight parts of white paeony root and 1 to 2 weight parts of bergarmot. The stomach and intestine partner disclosed by the invention has special affinity for stomach and intestine tracts and has the treatment characteristics of high efficiency and quick and long-lasting effect. The gastrointestinal disease treatment effective rate of the stomach and intestine partner reaches over 90 percent, and the cure rate reaches over 60 percent. In addition, when the stomach and intestine partner is used, the relapse rate is low, and even if relapse occurs, the symptoms are much relieved than the symptoms before treatment and can be quickly relieved after the stomach and intestine partner is taken.
Description
Technical field
The Chinese medicine sustained-release microparticle gastrointestinal companion who the present invention relates to a kind of protection, improves gastrointestinal function.
Background technology
World Health Organization (WHO) investigated discovery in the world in 2004, and the number that gastrointestinal disease is died from the whole world every year is more than 1,000 ten thousand, in state-owned 4/5 people suffer from gastrointestinal disease, occupy first place in the world.Because acute gastrointestinal disease Therapeutic Method is improper, and is transformed into chronic gastrointestinal disease.Secular chronic disease is again because a large amount of toxin of harmful bacterium secretion, and causes that corrupt substance increases and cause that gastrointestinal mucosa is rotten to the corn, ulcer gastrointestinal tract in, even bores a hole, and more fearful is to cause cancer easily.So gastrointestinal disease is common clinical, frequently-occurring disease, directly influences human health situation and quality of life, has caused world medicine man's attention, but lack effective method and the specific medicament prevented and treated at present.
Theory of Chinese medical science is thought: taste are hinges of human five internal organs's six internal organs ascending or descending movement of vital Qi, also are energy and blood of human body the source of vital function and " reservoir of food and drink " of depending on for existence.The saying that " The spleen and stomach provide the material basis of the acquired " always arranged, the spleen and stomach being located in the middle of the body soil is the center of internal organs, ill other internal organs that very easily influence of taste.Therefore " Treatise on the spleen and stomach " said: " all kinds of diseases and ailments are all declined by taste and give birth to ", " control taste promptly can settling five organs ".The spleen-stomach disease is that the traditional Chinese medical science is faced card commonly encountered diseases, frequently-occurring disease, can cause other disease again, and this is that physiological and pathological feature by spleen and stomach determines.In the five elements, spleen pertaining to the earth, and soil occupies central authorities, and the four directions is taken into account, and soil can be grown to nourish all things on earth.Spleen and stomach, a dirty internal organs, one rise and one drop, monoyin and monoyang, the exterior and the interior each other, the digesting and assimilating of spleen and stomach fellowship diet.Huangdi's Internal Classics is thought: " the taste person, here barn organs, the five tastes go out." " element is asked contraindication of needling opinion " say: " the spleen transporting the essence to all viscera, the stomach containing and passing the foodstuff like a fair ".The spleen transporting and transforming nutrients from foodstuff is precise and tiny the making of meaning all over the body of supplementing nutrition, stomach are received the city of digesting food five tastes meaning, are reservoir of food and drink, Jiao during taste belong to; The spleen is in charge of sending up essential substances, and stomach is advocated peace and fallen, and is the pivot of rising and falling of QI, source of generating QI and blood; Taste be disease, abnormal ascending-descending of QI then, biochemical weary source, essence, gas, refreshing mistake are filled; Internal organs lose supports, and all kinds of diseases and ailments beginning gives birth to, and the importance of taste in human body has some idea of.
Stomach and spleen constitute the exterior and the interior relation through belonging to through venation.The stomach master receives food, The spleen has the function to transport and transform nutrients food.Food gets into after the stomach, is become thoroughly decomposed by the stomach mill, and preliminary digest food becomes it into chyme, is digested, is absorbed by spleen then, changes to give birth to be precise and tiny nutrient substance.To accomplish this program well, must spleen and the normal physiological function of stomach coordinate
each other.Spleen is cloudy soil, and it is wet to like dry evil; Stomach is a sun soil, preferring moisture to dryness; The fortuneization of spleen depends on the power of stomach sun, and being received of stomach depends on the cloudy subsidy of spleen, and not dry not wet, and neither very warm nor cold, both complement each other, and could accomplish the fortune process of receiving.On pathology, the many damp syndrome of the spleen being adverse to dampness event, stomach is disliked dry so the up-down imbalance appears in many dryness syndrome easily, and cold and heat are not normal, are prone to cards such as empty Yi Shi, and spleen (intestinal) is though the treatment of gastropathy is prone to onset, and difficult consolidation more is prone to recurrence, and this is the difficult point in the treatment.Therefore, how to improve curative effect of medication, the enhance gastrointestinal function must be according to the gastrointestinal physiological and pathological feature, administration rationally, and thoroughly the treatment gastrointestinal disease improves whole nation's body constitution.And sum up at all times the spleen-stomach disease treatment, it is interdependent often to have ignored this physiology of taste, and the synergism that pathology passes mutually causes that the treatment of the spleen-stomach disease is overstepping the bounds of propriety opens more, controls spleen (intestinal) and does not control stomach, controls stomach and pays no attention to spleen, and therapeutic effect is not good, and relapse rate is higher.
Summary of the invention
The Chinese medicine sustained-release microparticle gastrointestinal companion who the object of the present invention is to provide a kind of protection, improves gastrointestinal function.
Research shows: the spleen-stomach disease is many to be declined by internal organs physiological function void, every because of imapirment of the spleen and stomach more such as diet, feelings will, cold-damp, or to have deficiency of vital energy fortuneization unable etc. because of taste, so that eating accumulation, and turbid damp is stranded spleen, the card of formation deficiency in origin and excess in superficiality or deficiency complicated with excess.Its void is this at spleen, is mark at stomach in fact.Conform to the opinion of Zhong Jing " void is the sun then, excessive disease located in Yangming ".Taste are the foundation of acquired constitution with placed in the middle burnt.The spleen has the function to transport and transform nutrients, and stomach receiving food and drink, spleen rise then strong, stomach fall then with.The taste degree of having that goes up and down, receiving often has, and accomplish being received of diet jointly, digest, absorb, the fortuneization function, be source of generating QI and blood, also be first the dominator of QI.If spleen and stomach function is not normal, then dysfunction of the spleen in transportation can appear, the pathological change of stomach-QI being unable to descend normally.Thereby what recover receiving of taste and up-downs on the clinical treatment can be its key, to the characteristics of the spleen-stomach disease, must be according to the gastrointestinal physiological and pathological feature, with dialectical be main, card is sick to be combined, gastrointestinal disease could be thoroughly treated in administration rationally.The present invention is just from gastrointestinal globality, harmony, complementarity and balance, and medication is paid attention to combining with replenishing QI to invigorate the spleen, stomach function regulating the turbid descending, spleen reinforcing nourishing the stomach, the logical benefit, and simultaneously using both cold and hot drugs, hot sweetness and bitterness are share, gone up and down to go together; Dryness and dampness coordinating each other, with flat degree of being, gastrointestinal is ruled together, the gastrointestinal people having the same aspiration and interest; And the quaternity therapy " is controlled, repaiies, protects, is supported " in utilization; Thoroughly remove the gastrointestinal tract harmful substance, the restoration and protection gastrointestinal mucosa improves comprehensively and recovers to improve gastrointestinal function; Thereby the raising human body constitution fundamentally solves the puzzlement that gastrointestinal tract inflammation shows effect repeatedly.
Technical scheme of the present invention is:
A kind of protection, the Chinese medicine sustained-release microparticle gastrointestinal companion who improves gastrointestinal function; It is characterized in that forming by controlling the stomach compound recipe and controlling the intestinal compound recipe; The wherein said stomach compound recipe of controlling is to be mixed by Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis and the Haematitum weight ratio by 2～4:2～4:2～4:2～4:3～5:3～5:3～5:2～4:2～4:2～4:2～4:1～3, and controlling the intestinal compound recipe is to be mixed by Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and the Fructus Citri Sarcodactylis weight ratio by 2～4:2～4:2～4:2～4:3～5:3～5:3～5:1～2:1～2:1～2:1～2:1～2.
The present invention is dry at low temperatures with above-mentioned raw materials; Process the different microgranule of 65～100 orders behind the levigation, be mixed into sustained-release microparticle gastrointestinal companion, this process will guarantee will have at least among the gastrointestinal companion 3 kinds of varigrained microgranules to exist; Shine (or oven dry) for a long time through steaming (about dry blowing 2 hours) for a long time then; Alleviate toxic and side effects, the enhance gastrointestinal affinity, subsequent use with cobalt 60 sterilization backs; To different gastrointestinal disease, patients with gastric disease is with everyone each oral stomach medicine 4g, companion 2g (children's is cut down according to the circumstance) in clinical; The each oral intestinal medicine 4g of enteropathy patient, companion 2g (children's is cut down according to the circumstance); Every day 3 times, furnishing medicated porridge appearance or in milk pot, be heated into medicated porridge and take (cooking method is promptly boiled to getting away with very hot oven earlier, uses little fire again instead medicated porridge soup is slowly received to dense thick) after meal, make medicine can rapid persistent performance pain relieving, effects such as antacid, antiinflammatory, reparation.
The present invention has following technical characterstic:
1, treatment characteristics:
From the gastrointestinal physiological and pathological, replenishing QI to invigorate the spleen, stomach function regulating the turbid descending, spleen reinforcing nourishing the stomach, the logical benefit combine, and simultaneously using both cold and hot drugs, hot sweetness and bitterness are share, gone up and down to go together; Dryness and dampness coordinating each other; With flat degree of being, gastrointestinal is ruled together, the gastrointestinal people having the same aspiration and interest, and the quaternity therapy " is controlled, repaiies, protects, supported " in utilization.Thoroughly remove the gastrointestinal tract harmful substance, the restoration and protection gastrointestinal mucosa improves comprehensively and recovers to improve gastrointestinal function, thereby improves human body constitution, fundamentally solves the puzzlement that gastrointestinal tract inflammation shows effect repeatedly.
Then rise 1.1 spleen is strong, stomach fall then with
Syndrome of deficiency of spleen qi and stomach qi is clinical a lot ofly to be seen, is characterized in that disease is of a specified duration and empty.Temper is lost empty and the vital essence of not loosing, and then blood is capable unable, and pathogen usually intruding into collateral in protracted disease becomes the stasis of blood.The clinical diseases such as peptic ulcer, chronic gastritis, chronic dysentery, ulcerative colitis, chronic hepatitis, early stage liver cirrhosis of being more common in.Part patient does endoscopy, the pathological change of visible gastrointestinal mucosa, and ulcer or inflammatory activity be one of the pathologic basis of blood stasis just.Say in the Difficult Classic: " can not control its void, peace is to all the other." void is this, at spleen; The stasis of blood is a mark at gastrointestinal.Li Dongyuan more spells out: " Gan Wen wherein rises its sun to mend." clinical practice and modern pharmacological research all be enough to confirm, uses the medicine of sweet temperature QI invigorating, can recover the function of the biochemical QI and blood transporting and transforming nutrients from foodstuff of taste, can cell activity enhancing, raise immunity is improved gastrointestinal motility, promotes drug absorption, improves the whole body situation.We use sweet temperature QI invigorating, spleen invigorating such as Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae to be principal agent; Assistant is an accessory drugs with the article of removing food stagnancy stomach function regulating blood stasis dispellings such as the Rhizoma Pinelliae, Fructus Crataegi, the Radix Paeoniae Alba, Fructus Aurantii.Not only can receive spleen reinforcing and do not stagnate, removing food stagnancy stomach function regulating and do not hinder merit just, and very be in step with the theoretical of " spleen is strong then to be risen, stomach fall then with ".That tests is clinical, and its effect is distinguished.
1.2 up-down is also transferred, it is interdependent to go up and down
Taste are the hinge of mechanism of qi all over the body, spleen be good for the stomach with, receiving often has, it is orderly to go up and down, and accomplishes biochemical QI and blood transporting and transforming nutrients from foodstuff jointly, it is precise and tiny in whole body to fail cloth.If spleen and stomach function is not normal, then the machine of up-downs is disorderly, and the gas of clear sun can not be failed cloth, and being difficult of essence of water and grain received, and be general on the turbid pathogen, sinking of QI of middle-JIAO, QI and blood is contrary random, key is not normal clearly, on can reach the mountain peak and push up the vertigo, feeling of stuffiness in chest abdominal distention, nausea singultus.Diseases such as down visible lientery, constipation, abdominal distention, gas bob, proctoptosis, uterine prolapse.To this clear QI in the lower part of the body, turbid QI failing to descend, Qing Chuju is turbid, and turbid place conceals clear time, no matter rises with that which side falls is not normal, all can influence the recovery of gastrointestinal function, so Flos Inulae share with Haematitum, goes up and down and also transfers, and residence rises in falling, and resides and falls in liter, and coordination of potent and mild therapies can not be biased.
1.3 invigorating spleen and reinforcing stomach, coordination of potent and mild therapies
Ye Tianshi says: " lunar spleen soil, positive beginning fortune, the bright dry soil of sun, cloudy from peace, just dry with the spleen happiness, the stomach happiness is also soft and moist." this viewpoint of Ye Tianshi replenished Li Dongyuan and known clearly in controlling spleen, slightly in the deficiency of controlling stomach.Spleen happiness is dry and dislike wetly, and stomach happiness profit and dislike dryly if moisturize the mistake degree pathological change takes place then.Because of stomach-Yin hinder also can consume and spleen cloudy, spleen has wet then expectorant to give birth in turbid, so lunar wet soil, the bright dry soil of sun is whenever seen the turbid disease of phlegm-damp dirt.The clinical deficiency of both QI and YIN of being more common in, disease is seen vague epigastralgia, burns if any fire, noisyly feel sick, hunger but having no desire to eat, polydipsia not yearningly, dry laryngopharynx, dysphoria with feverish sensation in the chest palms and soles is hard and dry, red tongue with a little fluid, tongue is few or see crackle, thready and rapid pulse.With Radix Ophiopogonis, Herba Dendrobii, the Radix Paeoniae Alba etc. with nourishing stomach-YIN; The taste stagnation of phlegm-damp in middle-JIAO adds with the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Fructus Citri Sarcodactylis circulation of qi promoting reason spleen.So nourishing stomach and spleen is taken into account, stomach reinforcing should not be crossed taste, and spleen invigorating should not be dry excessively, estimate and moisturize, and coordination of potent and mild therapies, side's card is in step with, and taste two help, and regenerate Central Region.
1.4. cold and heat and asthenia and sthenia plans as a whole to attack benefit
Spleen is the dirty of Zhiyin, and stomach is the internal organs of sun heat, the how empty much cold of the splenopathy, the how real frequent fever of gastropathy.Taste are the exterior and the interior each other, and receiving is interdependent, interacts, or spleen-heat and cold syndrome of the stomach, and spleen and stomach function is not normal, can present the resembling of pathology of cold and heat, also with cold relevant with the hot cause of disease.As eat raw food, and cross with cold and cool, locate cold-damp for a long time, can cause taste and cut down, hypoactivity of spleen-YANG, spleen loses fortuneization, also can cause the cold Middle Palace of meeting, and middle-jiao yang, function of the spleen and stomach is stranded, stomach-QI being unable to descend normally, this is cold syndrome, deficiency syndrome.If YANG pathogen is gone into internal organs, damp and hot friendship resistance, hot and suffocating in the stomach, accumulate in the fire-toxin, QI of the spleen and stomach loses in accent and reaches, and this is cold syndrome, excess syndrome.Treating cold syndrome with drugs of hot nature is with the supporing yang cold expelling of warming middle-JIAO such as Radix Codonopsis, the Radix Astragali.Treating heat syndrome with drugs of cold nature, clearing away heat-fires such as Herba Scutellariae Barbatae commonly used, Radix Gentianae, in addition, and the empty patient of prolonged illness or old body, every disease of seeing cold and heat and asthenia and sthenia, treatment should be trembled with fear warm and transferred, cold and cool mutual association, deficiency and excess is taken into account, and plans as a whole to attack benefit.
2. medication characteristics:
Control: Herba Scutellariae Barbatae, Radix Gentianae etc. has antibacterial, antiinflammatory, improves gastrointestinal function, repairs the gastrointestinal tract mucosa damage, and the healing ulcer surface improves symptoms such as stomachache, diarrhoea fast.
Repair: Eremiatis argi is the genuine animal drugs in Ningxia, and its tail has disconnected regenerated function, is used to treat injury of gastrointestinal tract property disease, can obviously repair the gastrointestinal mucosa of damage, improves symptom of digestive tract.
Protect: Margarita is processed powder and is used to treat digestive tract disease, and the gastrointestinal mucosa that can go directly has the function that skin ulcer is held back in antacid, also can protect gastrointestinal mucosa to avoid damaging again.
Support: have in the prescription be medicine be again the Fructus Crataegi, Fructus Mume, Rhizoma Dioscoreae etc. of food, the lasting efficacy of a drug can be to weakness of the spleen and stomach with receive medicine irritation gastrointestinal function to occur for a long time to descend, nourish comprehensively and improve, the raising digestive tract power.Have the gastrointestinal absorption of improvement function simultaneously, make the histiocyte Regeneration and Repair of atrophy, improve gastrointestinal tract immunity rapidly, the resistance against diseases in enhance gastrointestinal road.
3. formulation characteristic
The present invention adopts the separately novel pattern of packing of stomach medicine and intestinal medicine, takes into full account the complexity and the multiformity of gastrointestinal disease, and the gastrointestinal physiological and pathological feature; And consider the physical behavior of medicine, promptly quality is different according to the medicine quality; Pulverizing back granule has different, and is loose, frangible like quality such as Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Fructus Crataegi, Fructus Mume, Massa Medicata Fermentata, the easy superfine powder that forms in processing back; So directly be attached to gastric mucosa after going into stomach, can bring into play curative effect rapidly.And quality such as Margarita, Rhizoma Corydalis, Radix Notoginseng, Concha Ostreae are harder, and thick, thin different microgranule is arranged after the processing, go into stomach and are difficult for adhering to, and can get into intestinal, and at intestinal segmentation slow release, segmentation plays a role.Margarita also has extremely strong characterization of adsorption simultaneously, adsorbable gastrointestinal tract harmful substance, and excrete.The medicated porridge agent is simple for production in addition, and plus-minus flexibly adapts to widely, is easy to digest and assimilate.
4. cure mainly characteristics:
The big multiaction of medicine of modern clinical treatment gastroenteropathy is single, controls stomach and does not control intestinal, and control intestinal and do not control stomach, but in secular clinical practice, find, gastrointestinal disease patient, therefore most gastrointestinals answer gastrointestinal to rule together with sick, just can obtain satisfactory effect.Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) pure natural gastrointestinal companion's segmentation slow releasing function can reach the purpose that gastrointestinal is ruled together.
5. clinical characters:
1) the present invention can obviously improve the therapeutic effect of Chinese medicine, improves bioavailability, reduces dose, practices thrift natural resources of Chinese medicinal materials, reduces the toxic and side effects of Chinese medicine.
2) the present invention be medicine be again food, be the good merchantable brand that helps digestion like Fructus Crataegi, Fructus Mume.
3) the present invention has guaranteed that Chinese medicine is genuine, and no any additives has no side effect.
4) the present invention is applicable to various crowds, carries, taking convenience.
5) the present invention obviously increases its dissolubility in gastrointestinal through the micronize to Chinese medicine, absorbs and strengthen, and extremely strong targeting is arranged.
6) the present invention all has good curing and repair to the various inflammation and the damage of oral cavity, esophagus, stomach, intestinal, has formed the new product of comprehensive raising gastrointestinal function.
7) the present invention has ten effects greatly, antiinflammatory: like Herba Scutellariae Barbatae, Radix Gentianae; Pain relieving: like Rhizoma Corydalis; Antacid: like Margarita; Hold back skin ulcer: like Concha Ostreae; Promote the mucosa reparation: like Eremiatis argi; Improve digestive tract power: like Radix Codonopsis, the Radix Astragali, Squama Manis; Appetite strengthening: like Fructus Crataegi (parched to brown), Massa Medicata Fermentata; Absorption intestinal bacterium and metabolite: like Margarita, Concha Ostreae; Antifatigue anti senility: synergism; Build up resistance: synergism.
8) contain trace element such as necessary multivitamin of human body and calcium, magnesium, ferrum, zinc among the present invention, and necessary for human body 17 seed amino acids.
6. modern study
Eremiatis argi: we discover, Eremiatis argi loose in the large, medium and small dose groups serum TNF-alpha content significantly low with model group (P < 0.01), the Eremiatis argi significantly low and Vitamycin group of TNF-alpha content (P < 0.05) of loosing in the big or middle dose groups serum; Show that Eremiatis argi has desensitization, the blood circulation promoting and blood stasis dispelling function can be improved the blood capillary intravascular coagulation that the TNF-alpha levels raises and causes; Thereby improve the bad situation of mucosa nutritive; Suppress the release of TNF-α simultaneously, and stop it to activate the multiple inflammatory mediator of neutral grain generation, reduce the damage and the inflammation of tissue; Gastric mucosa to atrophy has good repair, the protection of gastric mucosa tissue is had have positive meaning.
Rhizoma Dioscoreae: spleen reinforcing lung kidney qi, strengthening spleen and lung kidney yin.These article contain diosgenin, phlegmatic temperament, choline, starch, glycoprotein, free amino acid, vitamin C, amylase etc.Be used for syndrome of spleen-deficiency.These article are the invigorating the spleen and replenishing QI medicine of tool Nutrition, doublely can nourish spleen the moon.Be used for deficiency-weakness of spleen-QI, becoming thin of malnutrition is weak more, lack of appetite, loose stool; Because of it contains nutritional labeling, advantages of easy digesting again, side effect is little, can make food and take for a long time, to chronic prolonged illness or weak after being ill weakness and emaciation, need nutrition to transfer and mend and the strong person of spleen fortune, these article really simply nutrition transfer the benefit good merchantable brand.Rhizoma Dioscoreae has prevention and therapeutical effect to the experimental rat model of spleen deficiency; Motion has dual regulation to intestine in vitro; Digestion-aid effect is arranged; Mouse cell immunologic function and humoral immunization there is stronger facilitation; Effects such as antioxidation are arranged.
Fructus Crataegi: promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis.These article ability promoting digestion and removing stagnation can be used for various eating accumulations cards, and the outstanding kind greasy meat digestion that promotes is for controlling the key medicine of greasy meat stagnation.In addition, these article also slightly promoting the circulation of QI to relieve pain with control the merit of dysentery, still can be used for dysentery stomachache or hernia etc.These article contain multiple organic acid, like Crataegolic acid, oleanolic acid, ursolic acid etc., and contain aminoacid, protein, vitamin C, and Semen Crataegi contains liposoluble constituent.Improving immunology, can increase rabbit anteserum lysozyme content and T lymhocyte transformation rate etc.; Dysentery bacterium and escherichia coli etc. all there is a stronger inhibitory action external; Fructus Crataegi can increase the secretion of digestive enzyme in the stomach, facilitating digestion, and contained lipase can promote steatolysis, contained multiple organic acid can improve protease activities, makes meat be prone to digested.
Fructus Mume: antidiarrheal dysentery, promote the production of body fluid.Be used for chronic diarrhea, chronic dysentery.The effect of these article relieving diarrhea with astringents dysentery is stronger.Chronic dysentery chronic diarrhea and damp and hot evil poison be person to the greatest extent, should with the article compatibility of clearing away heat-damp and expelling toxic material.Be the relieving colic caused by ascaris key medicine, can kill helicobacter pylori in the stomach.The Fructus Mume decoct has inhibitory action to the isolated rabbit intestinal.In vitro tests proves that Fructus Mume has inhibitory action to multiple pathomycetes such as various bacteria such as sonne bacillus and trichophyton mentagrophyteses, and its antimicrobial spectrum is wider; Desensitization is arranged; Ability enhancing human body immunity function; Can increase biliary secretion, and make bile be tending towards acid.
Radix Gentianae: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.These article can also rush down stomach-fire clearly, also can be used for treating that stomach-fire is stopped up aphtha and haematemesis due to containing, card such as have blood in stool.Should use with corresponding eliminating fire and detoxication medicine or blood-cooling hemostatic compatibility.These article still have certain heat-clearing toxin-expelling functions, can also be used for the pyretic toxicity carbuncle.Can promote gastric secretion, free acid is increased, can also obviously promote bile secretion; And antiinflammatory is arranged, suppress effects such as antibody generation.
Herba Scutellariae Barbatae: heat-clearing and toxic substances removing dissipating blood stasis analgesic therapy.Herb contains compositions such as multivitamin, trace element and aminoacid.Removing pathogenic heat from blood and toxic substance from the body is arranged, eliminating stasis to stop pain, the effect of detumescence and clearing away heat-damp and promoting diuresis.
Radix Notoginseng: blood-activating analgetic.Hot loosing and kind blood-activating analgetic, drug effect is distinguished, has hemostasis not stay the stasis of blood, blood stasis dispelling and do not hinder positive characteristics, to have the stasis of blood person of swelling and ache that stagnates concurrently particularly suitable to hemorrhage.
Rhizoma Corydalis: the hot temperature of loosing is logical, action temperature with, be longer than pain relieving especially, Compendium of Material Medica is claimed its " stagnation of QI in can promoting the circulation of blood, stasis in the gas is so specially control all up and down all over the body pains ", is pain relieving good medicine, no matter which kind of is demonstrate,proved bitterly, but all compatibility application.The chemical constituent of these article is main with alkaloid, and contains volatile oil, resin, phlegmatic temperament etc.These article have analgesic activity, and the alcohol extract of Rhizoma Corydalis, particularly dehydrogenation Rhizoma Corydalis first element be antiulcer action obviously.
Squama Manis: blood circulation promoting and blood stasis dispelling, detumescence and apocenosis.These article are good at walking to scurry row and are loose, and the power of promoting blood circulation to remove obstruction in the collateral, eliminating stasis and resolving masses is stronger, reaches the internal organs meridians in the ability, invigorates blood circulation through it and receives the effect of hard masses softening and resolving, dredge the meridian passage.The Zhi lumps in the chest and abdomen can blood circulation promoting and blood stasis dispelling, and kind again detumescence and apocenosis can make the carbuncle sore person's detumescence that do not become pus, and person's speed is burst to have become pus, is the clinical common drug of controlling skin infection.These article contain several amino acids, stearic acid, cholesterol, two tridecanoyl butylamine, keratin, volatile oil, and these article also have the effect of antiinflammatory, human body immunity improving power and anoxia endurance.
Margarita: contain 19 seed amino acids, nearly 20 kinds of mineral and high-activity biological taurine and the pearl protein that enriches and a large amount of trace element; Can improve the activity of flight against senium of human body factor S OD and amino acid carrier GSH-PX, have the effect of the arresting convulsion of calming the nerves, heat-clearing and toxic substances removing, soothing the liver hepatoprotective, the intestines and stomach coordinating, additional calcium system, trace element supplement; While ability delaying skin aging, speckle dispelling, anti-acne, crease-resistant strengthen skin gloss and elasticity; Through regulating human endocrine, enhance metabolism and multiple function such as enhancing human body immunity power.
7. invention effect
7.1 be the test of gastrointestinal companion's of the present invention treatment chronic gastritis (600 example) efficacy analysis below:
This group case is healing basically normally with clinical symptom disappearance, microscopy; Clinical symptoms disappears basically and most of disappearance, microscopy transfer to well effectively; Clinical symptoms do not have be clearly better, the microscopy no change is invalid.
Instructions of taking: everyone is each orally to control stomach compound recipe 4g, control intestinal compound recipe 2g, every day 3 times, furnishing medicated porridge appearance or in the milk pot, be heated into medicated porridge and take after meal.
The result: after 600 examples of controlling, the l that takes medicine～2 dose, it is thinning to defecate, and number of times has in various degree to be increased, and symptom also alleviates thereupon.The shortest 2 courses of treatment (60 days one courses of treatment), the longest 9 courses of treatment, average 3 courses of treatment.Cure 320 examples, account for 53%; Effective 240 examples account for 40%; Invalid 40 examples account for 7%.Total effective rate is 93%.
7.2 gastrointestinal companion of the present invention and motilium treatment functional dyspepsia (FD) 180 routine synopsis
Therapeutic outcome is seen table 1.
The curative effect (example) of table 1 integrative therapy FD
Annotate: * and matched group compare, P＜0.05
7.3 gastrointestinal companion of the present invention and positive intestinal rubber capsule treatment irritable bowel syndrome (IBS) 190 routine synopsis
Therapeutic outcome is seen table 2
In the table 2, the curative effect (example) of western medical treatment IBS
x
2 0.05（2）＝5.99，x
2＝8.08，P＜0.05
In sum, gastrointestinal companion of the present invention has special affinity to gastrointestinal tract, has efficient, quick-acting, long lasting treatment characteristics, and the treatment effective percentage of various gastrointestinal disease is reached more than 90%, and cure rate is more than 60%.And relapse rate is low, even recurrence, its symptom also obviously alleviates than before, can get effect rapidly after taking medicine.It is little to take our effective dose, carries, taking convenience, has no side effect, and has kept the genuineness of Chinese medicine.
The specific embodiment
Embodiment 1
At first with Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis, Haematitum, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis; Dry at low temperatures; Grind to form 60～100 purpose microgranules (guaranteeing to have at least the microgranule of three kinds of particle size diameters); Then Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis and Haematitum are mixed into according to the weight ratio of 4:4:4:4:3:3:3:2:2:2:2:1 and control the stomach compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations; The weight ratio of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis 4:4:4:4:3:3:3:2:2:2:2:1 is mixed into controls the intestinal compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations.
Embodiment 2
At first with Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis, Haematitum, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis; Dry at low temperatures; Grind to form 60～100 purpose microgranules (guaranteeing to have at least the microgranule of three kinds of particle size diameters); Then Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis and Haematitum are mixed into according to the weight ratio of 3:3:3:3:4:4:4:3:3:3:3:2 and control the stomach compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations; The weight ratio of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis 2:2:2:2:3:3:3:1:1:1:1:2 is mixed into controls the intestinal compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations.
Embodiment 3
At first with Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis, Haematitum, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis; Dry at low temperatures; Grind to form 60～100 purpose microgranules (guaranteeing to have at least the microgranule of three kinds of particle size diameters); Then Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis and Haematitum are mixed into according to the weight ratio of 2:2:2:2:5:5:5:4:4:4:4:3 and control the stomach compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations; The weight ratio of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis 3:3:3:3:4:4:4:2:2:2:2:1 is mixed into controls the intestinal compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations.
Embodiment 4
At first with Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis, Haematitum, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis; Dry at low temperatures; Grind to form 60～100 purpose microgranules (guaranteeing to have at least the microgranule of three kinds of particle size diameters); Then Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis and Haematitum are mixed into according to the weight ratio of 4:2:4:2:3:4:3:4:2:2:2:2 and control the stomach compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations; The weight ratio of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and Fructus Citri Sarcodactylis 2:4:2:4:5:5:5:1:1:1:1:2 is mixed into controls the intestinal compound recipe, dry blowing or oven dry back about 2 hours is afterwards subsequent use with cobalt 60 sterilizations.
Claims (3)
1. a protection, the Chinese medicine sustained-release microparticle gastrointestinal companion who improves gastrointestinal function; It is characterized in that forming by controlling the stomach compound recipe and controlling the intestinal compound recipe; The wherein said stomach compound recipe of controlling is to be mixed by Radix Ophiopogonis, Herba Dendrobii, Fructus Crataegi, Eremiatis argi, Massa Medicata Fermentata, Margarita, Concha Ostreae, Herba Scutellariae Barbatae, Radix Gentianae, Radix Notoginseng, Squama Manis and the Haematitum weight ratio by 2～4:2～4:2～4:2～4:3～5:3～5:3～5:2～4:2～4:2～4:2～4:1～3, and controlling the intestinal compound recipe is to be mixed by Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Corydalis, Rhizoma Dioscoreae, Fructus Mume, the Rhizoma Pinelliae, Fructus Aurantii, Fructus Amomi, Flos Inulae, the Radix Paeoniae Alba and the Fructus Citri Sarcodactylis weight ratio by 2～4:2～4:2～4:2～4:3～5:3～5:3～5:1～2:1～2:1～2:1～2:1～2.
2. according to the Chinese medicine sustained-release microparticle gastrointestinal companion of the described protection of claim 1, raising gastrointestinal function, it is characterized in that: above-mentioned all raw materials are microgranular, and its granularity is 60～100 orders.
3. according to the Chinese medicine sustained-release microparticle gastrointestinal companion of the described protection of claim 2, raising gastrointestinal function, it is characterized in that: above-mentioned raw materials has at least the microgranule of three kinds of granularities to exist in the gastrointestinal companion.
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| CN103768190A (en) * | 2014-01-18 | 2014-05-07 | 史克勇 | Prescription for accelerating gastric emptying |
| CN104888096A (en) * | 2015-05-07 | 2015-09-09 | 青岛市市立医院 | Medicine for improving gastric motility |
| CN108126114B (en) * | 2018-01-12 | 2020-11-27 | 宁夏医科大学 | Traditional Chinese medicine sustained-release particle medicated diet for detoxifying and expelling toxins and preparation method thereof |
| CN107929550A (en) * | 2018-01-12 | 2018-04-20 | 宁夏医科大学 | It is a kind of protect, the activity gels of renovating tummy mucous membrane and preparation method thereof |
| CN108096516A (en) * | 2018-01-12 | 2018-06-01 | 宁夏医科大学 | Chinese medicine composition with detoxication and toxicant eliminating function cleaning gastrointestinal tract and preparation method thereof, herbal cuisine |
| CN116059302B (en) * | 2022-12-01 | 2023-11-10 | 大连医科大学附属第一医院 | Traditional Chinese medicine composition for treating gastrointestinal motility diseases and preparation method and application thereof |
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| CN101797347B (en) * | 2010-04-09 | 2012-04-11 | 王志海 | Traditional Chinese medicinal composition for treating gastrointestinal tract and preparation thereof |
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