CN102112487B - 制备卡泊芬净及其中间体的方法 - Google Patents

制备卡泊芬净及其中间体的方法 Download PDF

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Publication number
CN102112487B
CN102112487B CN200980121924.4A CN200980121924A CN102112487B CN 102112487 B CN102112487 B CN 102112487B CN 200980121924 A CN200980121924 A CN 200980121924A CN 102112487 B CN102112487 B CN 102112487B
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CN
China
Prior art keywords
compound
molecular formula
acid salt
caspofungin
group
Prior art date
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Expired - Fee Related
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CN200980121924.4A
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English (en)
Chinese (zh)
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CN102112487A (zh
Inventor
澳顿·海格路德
欧尔·海内·科佛内内斯
维达尔·乔尼斯塔德
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Xellia Pharmaceuticals ApS
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Xellia Pharmaceuticals ApS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CN200980121924.4A 2008-06-13 2009-06-11 制备卡泊芬净及其中间体的方法 Expired - Fee Related CN102112487B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/138,488 2008-06-13
US12/138,488 US8048853B2 (en) 2008-06-13 2008-06-13 Process for preparing pharmaceutical compound and intermediates thereof
PCT/NO2009/000218 WO2009151341A1 (en) 2008-06-13 2009-06-11 Process for preparing caspofungin and intermediates thereof

Publications (2)

Publication Number Publication Date
CN102112487A CN102112487A (zh) 2011-06-29
CN102112487B true CN102112487B (zh) 2014-05-07

Family

ID=41011915

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980121924.4A Expired - Fee Related CN102112487B (zh) 2008-06-13 2009-06-11 制备卡泊芬净及其中间体的方法

Country Status (15)

Country Link
US (1) US8048853B2 (enExample)
EP (1) EP2307445B1 (enExample)
JP (1) JP5604423B2 (enExample)
CN (1) CN102112487B (enExample)
AU (1) AU2009258343B2 (enExample)
BR (1) BRPI0915036A2 (enExample)
CA (1) CA2727567C (enExample)
DK (1) DK2307445T3 (enExample)
ES (1) ES2394059T3 (enExample)
HR (1) HRP20121026T1 (enExample)
IL (1) IL209919A (enExample)
PL (1) PL2307445T3 (enExample)
RU (1) RU2489442C2 (enExample)
SI (1) SI2307445T1 (enExample)
WO (1) WO2009151341A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010064219A1 (en) * 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
CN103180336B (zh) * 2010-09-28 2016-06-15 中化帝斯曼制药有限公司荷兰公司 用于分离环六肽的方法
KR101331984B1 (ko) * 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
CN102746384B (zh) * 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
CN103483426A (zh) * 2012-06-14 2014-01-01 博瑞生物医药技术(苏州)有限公司 一种氮杂环己肽的制备方法
CN112110991A (zh) * 2014-12-24 2020-12-22 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
CN105440109B (zh) * 2015-11-26 2019-03-05 成都摩尔生物医药有限公司 一种卡泊芬净的制备方法
EP3620462A1 (en) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Process for the preparation of caspofungin
CN111808172B (zh) * 2019-04-12 2023-05-12 上海森辉医药有限公司 肺念菌素b0衍生物及其制备方法和用途
CN111233981A (zh) * 2020-03-17 2020-06-05 湖南欧亚药业有限公司 一种卡泊芬净的制备方法
CN113801237A (zh) * 2020-06-15 2021-12-17 杭州中美华东制药有限公司 一种醋酸卡泊芬净杂质e的制备方法
CN113801202B (zh) * 2020-06-15 2024-11-05 杭州中美华东制药有限公司 一种醋酸卡泊芬净杂质g的制备方法
CN113801201A (zh) * 2020-06-15 2021-12-17 杭州中美华东制药有限公司 一种醋酸卡泊芬净杂质b的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336756A (en) 1991-05-01 1994-08-09 Merck & Co., Inc. Process for crystalline cyclic lipopeptides
US6030944A (en) 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
US5348940A (en) 1991-10-01 1994-09-20 Merck & Co., Inc. Cyclohexapeptidyl hydroxypropionitrile compounds
US5939384A (en) 1991-10-01 1999-08-17 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
US5378804A (en) 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
WO1996008266A1 (en) 1994-09-16 1996-03-21 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5552521A (en) 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AR006598A1 (es) 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
US5952300A (en) 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US5936062A (en) 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
CA2380176A1 (en) 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
US7214768B2 (en) 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
WO2007027141A1 (en) 2005-08-30 2007-03-08 Abb Research Ltd Wind mill power flow control with dump load and power converter
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.

Also Published As

Publication number Publication date
US20090312541A1 (en) 2009-12-17
ES2394059T3 (es) 2013-01-16
IL209919A (en) 2015-01-29
SI2307445T1 (sl) 2013-01-31
RU2489442C2 (ru) 2013-08-10
DK2307445T3 (da) 2013-01-14
AU2009258343B2 (en) 2012-09-13
WO2009151341A1 (en) 2009-12-17
HRP20121026T1 (hr) 2013-01-31
JP5604423B2 (ja) 2014-10-08
CN102112487A (zh) 2011-06-29
RU2011100815A (ru) 2012-07-20
JP2011524871A (ja) 2011-09-08
CA2727567A1 (en) 2009-12-17
BRPI0915036A2 (pt) 2015-10-27
PL2307445T3 (pl) 2013-03-29
EP2307445B1 (en) 2012-09-26
AU2009258343A1 (en) 2009-12-17
IL209919A0 (en) 2011-02-28
EP2307445A1 (en) 2011-04-13
CA2727567C (en) 2014-08-05
US8048853B2 (en) 2011-11-01

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Granted publication date: 20140507

Termination date: 20170611

CF01 Termination of patent right due to non-payment of annual fee