CN102112191B - 用于离子交换色谱的接枝共聚物 - Google Patents

用于离子交换色谱的接枝共聚物 Download PDF

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Publication number
CN102112191B
CN102112191B CN200980129665.XA CN200980129665A CN102112191B CN 102112191 B CN102112191 B CN 102112191B CN 200980129665 A CN200980129665 A CN 200980129665A CN 102112191 B CN102112191 B CN 102112191B
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CN
China
Prior art keywords
copolymer
monomeric unit
acrylamide
methyl
group
Prior art date
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CN200980129665.XA
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English (en)
Chinese (zh)
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CN102112191A (zh
Inventor
H·格拉尔夫斯
L·布里奇
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Merck Patent GmbH
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Merck Patent GmbH
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Publication date
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Publication of CN102112191A publication Critical patent/CN102112191A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B01J39/17—Organic material containing also inorganic materials, e.g. inert material coated with an ion-exchange resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B01J39/18—Macromolecular compounds
    • B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B01J41/14—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Graft Or Block Polymers (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN200980129665.XA 2008-07-30 2009-07-08 用于离子交换色谱的接枝共聚物 Active CN102112191B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08013674A EP2153877A1 (de) 2008-07-30 2008-07-30 Mischpfropfpolymere für die Ionenaustauschchromatographie
EP08013674.0 2008-07-30
PCT/EP2009/004952 WO2010012358A1 (de) 2008-07-30 2009-07-08 Mischpfropfpolymere für die ionenaustauschchromatographie

Publications (2)

Publication Number Publication Date
CN102112191A CN102112191A (zh) 2011-06-29
CN102112191B true CN102112191B (zh) 2014-07-30

Family

ID=39876773

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980129665.XA Active CN102112191B (zh) 2008-07-30 2009-07-08 用于离子交换色谱的接枝共聚物

Country Status (7)

Country Link
US (1) US8673988B2 (ja)
EP (2) EP2153877A1 (ja)
JP (2) JP6043062B2 (ja)
KR (1) KR101673631B1 (ja)
CN (1) CN102112191B (ja)
CA (1) CA2732398C (ja)
WO (1) WO2010012358A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2153877A1 (de) * 2008-07-30 2010-02-17 MERCK PATENT GmbH Mischpfropfpolymere für die Ionenaustauschchromatographie
IN2012DN02539A (ja) * 2009-10-12 2015-08-28 Ge Healthcare Bio Sciences Ab
SG185590A1 (en) * 2010-07-29 2012-12-28 Emd Millipore Corp Grafting method to improve chromatography media performance
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
US11628381B2 (en) 2012-09-17 2023-04-18 W.R. Grace & Co. Conn. Chromatography media and devices
US20150266919A1 (en) * 2012-10-18 2015-09-24 Jnc Corporation Cation exchange chromatography carrier for refining of antibodies, and method for separation of antibody monomers from polymers thereof produced in antibody drug manufacturing process
WO2014084790A1 (en) * 2012-11-29 2014-06-05 Jerker Porath Superhydroxylated adsorbents and uses thereof
WO2015088677A1 (en) 2013-12-12 2015-06-18 Emd Millipore Corporation Protein separations using an acrylamide containing filter
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
CN105732916B (zh) * 2014-12-09 2018-04-03 中国科学院大连化学物理研究所 一种有机无机杂化微球颗粒及其制备和应用
JP2018517559A (ja) 2015-06-05 2018-07-05 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法
US10641751B2 (en) * 2015-06-19 2020-05-05 Dionex Corporation Ion exchange chromatography column, method, and system thereof
DE102015011884A1 (de) 2015-09-10 2017-03-16 Sartorius Stedim Biotech Gmbh Adsorptionsmedium, Verfahren zu dessen Herstellung, sowie Verwendung desselben zur Aufreinigung von Biomolekülen
JP7005515B2 (ja) * 2016-04-24 2022-02-10 ウオーターズ・テクノロジーズ・コーポレイシヨン 荷電表面逆相クロマトグラフィ材料による両親媒性強塩基性部分で修飾されたグリカンの分析方法
JP7024509B2 (ja) * 2017-03-17 2022-02-24 三菱ケミカル株式会社 分離剤、並びに当該分離剤を用いた標的分子の分離方法及びクロマトグラフィー用カラム
JP2021519339A (ja) * 2018-04-03 2021-08-10 メルク パテント ゲーエムベーハー Ｃｅｘクロマトグラフィー媒体及び生物製剤供給原料からの標的タンパク質の低塩溶出
US10737259B2 (en) 2018-08-31 2020-08-11 Pall Corporation Salt tolerant anion exchange medium
US11045773B2 (en) * 2018-08-31 2021-06-29 Pall Corporation Salt tolerant porous medium
JP2022539240A (ja) * 2019-07-03 2022-09-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗体薬物コンジュゲートの精製

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1413300A (zh) * 1999-12-23 2003-04-23 蒂特根博士生物技术公司 层析材料以及使用该材料的方法
EP1473075A2 (en) * 1999-02-25 2004-11-03 Pall Corporation Negatively charged membrane

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3811042A1 (de) 1988-03-31 1989-10-19 Merck Patent Gmbh Ionenaustauscher
JPH01262468A (ja) * 1988-04-13 1989-10-19 Showa Denko Kk クロマトグラフィー用担体
JP3139410B2 (ja) * 1997-04-15 2001-02-26 富士ゼロックス株式会社 グラフト重合方法
US6783937B1 (en) * 1999-02-25 2004-08-31 Pall Corporation Negatively charged membrane
JP2001322972A (ja) * 2000-05-17 2001-11-20 Mitsubishi Chemicals Corp エチレンジアミン−ｎ，ｎ’−ジコハク酸又はその塩の製造方法
DE10149256A1 (de) * 2001-10-05 2003-04-17 Merck Patent Gmbh Alkalistabile hydrophile Sorbentien für die Ionenaustauschchromatographie
EP2143482A1 (en) * 2003-02-19 2010-01-13 Natrix Separations Inc. Composite materials comprising supported porous gels
JP2006304666A (ja) * 2005-04-27 2006-11-09 Hokkaido Univ トリプシン阻害活性を有する新規ポリペプチド
EP2153877A1 (de) * 2008-07-30 2010-02-17 MERCK PATENT GmbH Mischpfropfpolymere für die Ionenaustauschchromatographie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1473075A2 (en) * 1999-02-25 2004-11-03 Pall Corporation Negatively charged membrane
CN1413300A (zh) * 1999-12-23 2003-04-23 蒂特根博士生物技术公司 层析材料以及使用该材料的方法

Also Published As

Publication number Publication date
JP6043062B2 (ja) 2016-12-14
JP2017036445A (ja) 2017-02-16
KR101673631B1 (ko) 2016-11-22
WO2010012358A1 (de) 2010-02-04
CA2732398C (en) 2016-09-13
EP2310104A1 (de) 2011-04-20
JP2011529508A (ja) 2011-12-08
CN102112191A (zh) 2011-06-29
KR20110044882A (ko) 2011-05-02
US8673988B2 (en) 2014-03-18
EP2153877A1 (de) 2010-02-17
EP2310104B1 (de) 2017-10-18
CA2732398A1 (en) 2010-02-04
US20110136925A1 (en) 2011-06-09

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