CN102105163B - 氯霉素乙酰转移酶(cat)-缺陷型促生长素抑制素融合蛋白及其用途 - Google Patents

氯霉素乙酰转移酶(cat)-缺陷型促生长素抑制素融合蛋白及其用途 Download PDF

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Publication number
CN102105163B
CN102105163B CN200880130533.4A CN200880130533A CN102105163B CN 102105163 B CN102105163 B CN 102105163B CN 200880130533 A CN200880130533 A CN 200880130533A CN 102105163 B CN102105163 B CN 102105163B
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somatostatin
seq
cat
chimeric
cow
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Chinese (zh)
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CN102105163A (zh
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A·R·门德尔松
K·N·哈费尔
J·拉里克
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Braasch Biotech LLC
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Braasch Biotech LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12N9/1033—Chloramphenicol O-acetyltransferase (2.3.1.28)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01028—Chloramphenicol O-acetyltransferase (2.3.1.28)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Birds (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880130533.4A 2008-06-25 2008-06-25 氯霉素乙酰转移酶(cat)-缺陷型促生长素抑制素融合蛋白及其用途 Expired - Fee Related CN102105163B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/068195 WO2009157926A1 (en) 2008-06-25 2008-06-25 Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof

Publications (2)

Publication Number Publication Date
CN102105163A CN102105163A (zh) 2011-06-22
CN102105163B true CN102105163B (zh) 2014-12-10

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CN200880130533.4A Expired - Fee Related CN102105163B (zh) 2008-06-25 2008-06-25 氯霉素乙酰转移酶(cat)-缺陷型促生长素抑制素融合蛋白及其用途

Country Status (15)

Country Link
US (3) US7722881B2 (enExample)
EP (1) EP2303314B1 (enExample)
JP (1) JP5506792B2 (enExample)
KR (1) KR101555731B1 (enExample)
CN (1) CN102105163B (enExample)
AU (1) AU2008358353B2 (enExample)
CA (1) CA2728734A1 (enExample)
DK (1) DK2303314T3 (enExample)
ES (1) ES2445403T3 (enExample)
IL (1) IL209792A (enExample)
MX (1) MX2010014082A (enExample)
NZ (1) NZ590011A (enExample)
RU (1) RU2501565C2 (enExample)
WO (1) WO2009157926A1 (enExample)
ZA (1) ZA201009125B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ590011A (en) 2008-06-25 2012-09-28 Braasch Biotech Llc Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof
NZ590010A (en) 2008-06-25 2013-01-25 Braasch Biotech Llc Compositions and methods treating growth hormone deficiency and/or an insulin-like growth factor 1 deficiency with somatostatin and an adjuvant
CN104812241A (zh) * 2012-06-26 2015-07-29 生物原子价有限公司 快速的无特定病原动物
BR112015010375B1 (pt) 2012-11-08 2023-03-28 Phi Pharma Sa Molécula ou composto, conjugado de bam, composição farmacêutica, e, uso de uma molécula ou composto
RU2526571C1 (ru) * 2013-04-08 2014-08-27 Сергей Михайлович Юдин Инъекционный препарат для повышения спермопродукции человека и способ его применения
US10441652B2 (en) * 2014-08-21 2019-10-15 Braasch Biotech Llc Methods for improving immunological response in vaccinated animals
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
JP7727389B2 (ja) * 2020-02-11 2025-08-21 ブラッシュ・バイオテック・エルエルシー 乳房炎の処置及び／又は予防のための組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0645454A2 (en) * 1993-06-22 1995-03-29 Vladimir Glebovich Lunin Chimeric somatostatin containing protein and coding DNA, immunogenic compositions and method for increasing farm animal productivity
WO2005066344A2 (en) * 2004-01-09 2005-07-21 Instytut Biotechnologii I Antybiotykow New plasmids, their derivatives and fragments, their methods of manufacture and application

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US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4446235A (en) * 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
JP2602968B2 (ja) * 1987-11-04 1997-04-23 カリフォルニア バイオテクノロジー インコーポレイテッド 肺胞の界面活性タンパク類
RU2034457C1 (ru) * 1993-06-22 1995-05-10 Товарищество с ограниченной ответственностью "Ветек" Способ повышения продуктивности сельскохозяйственных животных и препарат для его осуществления
US6025368A (en) * 1997-02-25 2000-02-15 Celtrix Pharmaceuticals, Inc. Method for treating the symptoms of chronic stress-related disorders using IGF
US20070048860A1 (en) * 1997-10-10 2007-03-01 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Carcinoembryonic antigen (CEA) peptides
US7998930B2 (en) * 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
NZ561375A (en) * 2005-06-27 2011-06-30 Biovail Lab Int Srl Bupropion hydrobromide, and crystalline forms, compositions, and uses of this compound
NZ590011A (en) 2008-06-25 2012-09-28 Braasch Biotech Llc Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof
NZ590010A (en) 2008-06-25 2013-01-25 Braasch Biotech Llc Compositions and methods treating growth hormone deficiency and/or an insulin-like growth factor 1 deficiency with somatostatin and an adjuvant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0645454A2 (en) * 1993-06-22 1995-03-29 Vladimir Glebovich Lunin Chimeric somatostatin containing protein and coding DNA, immunogenic compositions and method for increasing farm animal productivity
US6316004B1 (en) * 1993-06-22 2001-11-13 T. Tikhonenko Chimeric somatostatin containing protein and encoding DNA, plasmids of expression, method for preparing chimeric protein, strain-producers, immunogenic composition, method for increasing the productivity of farm animals
WO2005066344A2 (en) * 2004-01-09 2005-07-21 Instytut Biotechnologii I Antybiotykow New plasmids, their derivatives and fragments, their methods of manufacture and application

Non-Patent Citations (4)

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Title
Ann LEWENDON and William V. SHAW.The PKa of the catalytic histidine residue of chloramphenicol acetyltransferase.《Biochem. J》.1993,第290卷第15-19页. *
Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59;Gary Ott et al.;《Vaccine》;19951231;第13卷(第16期);摘要 *
Gary Ott et al..Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59.《Vaccine》.1995,第13卷(第16期),第1557-1562页. *
The PKa of the catalytic histidine residue of chloramphenicol acetyltransferase;Ann LEWENDON and William V. SHAW;《Biochem. J》;19930215;第290卷;摘要，图1-2 *

Also Published As

Publication number Publication date
AU2008358353B2 (en) 2013-11-07
KR20110039517A (ko) 2011-04-19
NZ590011A (en) 2012-09-28
ES2445403T3 (es) 2014-03-03
US20120076806A1 (en) 2012-03-29
JP2011525914A (ja) 2011-09-29
EP2303314A1 (en) 2011-04-06
US7722881B2 (en) 2010-05-25
CN102105163A (zh) 2011-06-22
BRPI0822826A2 (pt) 2015-07-07
RU2501565C2 (ru) 2013-12-20
IL209792A (en) 2012-12-31
EP2303314B1 (en) 2013-12-11
US8367073B2 (en) 2013-02-05
US7943143B2 (en) 2011-05-17
EP2303314A4 (en) 2012-07-18
MX2010014082A (es) 2011-04-07
KR101555731B1 (ko) 2015-09-25
IL209792A0 (en) 2011-02-28
DK2303314T3 (da) 2014-01-13
US20100136037A1 (en) 2010-06-03
WO2009157926A1 (en) 2009-12-30
CA2728734A1 (en) 2009-12-30
JP5506792B2 (ja) 2014-05-28
RU2011100104A (ru) 2012-07-20
US20090324629A1 (en) 2009-12-31
ZA201009125B (en) 2012-06-27
AU2008358353A1 (en) 2009-12-30

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Granted publication date: 20141210