KR20050036665A - 면역 거세용 재조합 폴리펩타이드 및 이를 포함하는 백신 - Google Patents
면역 거세용 재조합 폴리펩타이드 및 이를 포함하는 백신 Download PDFInfo
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- KR20050036665A KR20050036665A KR1020030072378A KR20030072378A KR20050036665A KR 20050036665 A KR20050036665 A KR 20050036665A KR 1020030072378 A KR1020030072378 A KR 1020030072378A KR 20030072378 A KR20030072378 A KR 20030072378A KR 20050036665 A KR20050036665 A KR 20050036665A
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- seq
- peptide
- gnrh
- recombinant polypeptide
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract
Description
Claims (12)
- (a) gonadotropin releasing hormone (GnRH)으로부터 유래된 펩타이드 또는 상기 펩타이드의 멀티머; 및 (b) GRV의 VP6 단백질 또는 CDV의 P35를 포함하며, 동물에서 GnRH에 대한 면역 반응을 유도할 수 있는 재조합 폴리펩타이드.
- 제 1 항에 있어서, 상기 펩타이드는 SEQ ID NO:1에 표시된 아미노산 서열을 갖거나, 또는 SEQ ID NO:1에 표시된 아미노산 서열 중 1-3개의 아미노산 서열이 점 돌연변이된 서열을 갖으며, 상기 점 돌연변이는 SEQ ID NO:1의 펩타이드 보다 GnRH에 대하여 높은 immunogenicity를 유발하도록 하는 것을 특징으로 하는 재조합 폴리펩타이드.
- 제 2 항에 있어서, 상기 점 돌연변이가 발생된 펩타이드는 SEQ ID NO:2, SEQ ID NO:3 및 SEQ ID NO:4로 구성된 군으로부터 선택되는 아미노산 서열을 갖는 펩타이드인 것을 특징으로 하는 재조합 폴리펩타이드.
- 제 1 항에 있어서, 상기 펩타이드의 멀티머는 상기 제 2 항에 기재된 펩타이드 중 1 종 이상의 펩타이드를 포함하는 것을 특징으로 하는 재조합 폴리펩타이드.
- 제 4 항에 있어서, 상기 펩타이드의 멀티머는 SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 및 SEQ ID NO:4로 구성된 군으로부터 선택되는 1종 이상의 펩타이드를 포함하는 것을 특징으로 하는 재조합 폴리펩타이드.
- 제 4 항에 있어서, 상기 펩타이드의 멀티머는 SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 및 SEQ ID NO:4로 구성된 군으로부터 선택되는 2종 이상의 펩타이드를 포함하는 것을 특징으로 하는 재조합 폴리펩타이드.
- 제 5 항에 있어서, 상기 펩타이드의 멀티머는 SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 및 SEQ ID NO:4로 구성된 군으로부터 선택되는 2종 이상의 펩타이드를 포함하는 것을 특징으로 하는 재조합 폴리펩타이드.
- 제 7 항에 있어서, 상기 펩타이드의 멀티머는 SEQ ID NO:6으로 표시되는 아미노산 서열을 포함하는 것을 특징으로 하는 재조합 폴리펩타이드.
- 다음을 포함하는 면역거세 용 백신 조성물:(a) 상기 제 1 항 내지 제 8 항 중 어느 한 항의 재조합 폴리펩타이드; 및(b) 약제학적 허용 가능한 담체.
- 제 9 항에 있어서, 상기 백신 조성물은 아쥬번트를 추가적으로 포함하는 것을 특징으로 하는 백신 조성물.
- 상기 제 9 항의 백신 조성물을 포유동물에게 투여하는 단계를 포함하는 면역 거세 방법.
- 제 11 항에 있어서, 상기 포유동물은 소, 돼지, 개, 고양이, 염소, 양, 말, 토끼 또는 쥐인 것을 특징으로 하는 면역 거세 방법.
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KR101080015B1 (ko) * | 2008-02-14 | 2011-11-04 | 주식회사 고려비엔피 | CTLA-4-GnRH 또는 GM-CSF-GnRH 재조합 단백질을 유효성분으로 함유하는 동물의 면역거세용 백신 |
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US5837268A (en) | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
US6541011B2 (en) | 1998-02-11 | 2003-04-01 | Maxygen, Inc. | Antigen library immunization |
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