CA2728734A1 - Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof - Google Patents

Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof Download PDF

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Publication number
CA2728734A1
CA2728734A1 CA2728734A CA2728734A CA2728734A1 CA 2728734 A1 CA2728734 A1 CA 2728734A1 CA 2728734 A CA2728734 A CA 2728734A CA 2728734 A CA2728734 A CA 2728734A CA 2728734 A1 CA2728734 A1 CA 2728734A1
Authority
CA
Canada
Prior art keywords
somatostatin
seq
amino acid
cat
chimeric polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2728734A
Other languages
English (en)
French (fr)
Inventor
Andrew R. Mendelsohn
Keith N. Haffer
James Larrick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Braasch Biotech LLC
Original Assignee
Braasch Biotech LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Braasch Biotech LLC filed Critical Braasch Biotech LLC
Publication of CA2728734A1 publication Critical patent/CA2728734A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/60Feeding-stuffs specially adapted for particular animals for weanlings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12N9/1033Chloramphenicol O-acetyltransferase (2.3.1.28)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01028Chloramphenicol O-acetyltransferase (2.3.1.28)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2728734A 2008-06-25 2008-06-25 Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof Abandoned CA2728734A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/068195 WO2009157926A1 (en) 2008-06-25 2008-06-25 Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof

Publications (1)

Publication Number Publication Date
CA2728734A1 true CA2728734A1 (en) 2009-12-30

Family

ID=41444809

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2728734A Abandoned CA2728734A1 (en) 2008-06-25 2008-06-25 Chloramphenicol acetyl transferase (cat)-defective somatostatin fusion protein and uses thereof

Country Status (15)

Country Link
US (3) US7722881B2 (enExample)
EP (1) EP2303314B1 (enExample)
JP (1) JP5506792B2 (enExample)
KR (1) KR101555731B1 (enExample)
CN (1) CN102105163B (enExample)
AU (1) AU2008358353B2 (enExample)
CA (1) CA2728734A1 (enExample)
DK (1) DK2303314T3 (enExample)
ES (1) ES2445403T3 (enExample)
IL (1) IL209792A (enExample)
MX (1) MX2010014082A (enExample)
NZ (1) NZ590011A (enExample)
RU (1) RU2501565C2 (enExample)
WO (1) WO2009157926A1 (enExample)
ZA (1) ZA201009125B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2728735A1 (en) 2008-06-25 2009-12-30 Braasch Biotech Llc Compositions and methods for enhanced somatostatin immunogenicity
RU2501565C2 (ru) 2008-06-25 2013-12-20 Брааш Биотех Ллк Слитый белок дефектная хлорамфеникол ацетилтрансфераза (сат)-соматостатин и его применения
WO2014003538A1 (en) * 2012-06-26 2014-01-03 Biovalence Sdn. Bhd. Rapid specific pathogen free animal
JP6595340B2 (ja) 2012-11-08 2019-10-23 ペアシュイ ファルマ ソシエテ アノニム C4sプロテオグリカン特異的トランスポーター分子
RU2526571C1 (ru) * 2013-04-08 2014-08-27 Сергей Михайлович Юдин Инъекционный препарат для повышения спермопродукции человека и способ его применения
WO2016029013A2 (en) 2014-08-21 2016-02-25 Braasch Biotech Llc Methods for improving immunological response in vaccinated animals
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
JP7727389B2 (ja) * 2020-02-11 2025-08-21 ブラッシュ・バイオテック・エルエルシー 乳房炎の処置及び/又は予防のための組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4446235A (en) 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
WO1989004326A1 (en) * 1987-11-04 1989-05-18 California Biotechnology Inc. Alveolar surfactant proteins
US6316004B1 (en) * 1993-06-22 2001-11-13 T. Tikhonenko Chimeric somatostatin containing protein and encoding DNA, plasmids of expression, method for preparing chimeric protein, strain-producers, immunogenic composition, method for increasing the productivity of farm animals
RU2034457C1 (ru) * 1993-06-22 1995-05-10 Товарищество с ограниченной ответственностью "Ветек" Способ повышения продуктивности сельскохозяйственных животных и препарат для его осуществления
US6025368A (en) 1997-02-25 2000-02-15 Celtrix Pharmaceuticals, Inc. Method for treating the symptoms of chronic stress-related disorders using IGF
US20070048860A1 (en) 1997-10-10 2007-03-01 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Carcinoembryonic antigen (CEA) peptides
PL213561B1 (pl) * 2004-01-09 2013-03-29 Inst Biotechnologii I Antybiotykow Sposób otrzymywania plazmidu, plazmid oraz zastosowania
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
EP1896002A4 (en) 2005-06-27 2009-11-25 Biovail Lab Int Srl BUPROPIONAL SALT FORMULATIONS WITH MODIFIED RELEASE
CA2728735A1 (en) 2008-06-25 2009-12-30 Braasch Biotech Llc Compositions and methods for enhanced somatostatin immunogenicity
RU2501565C2 (ru) 2008-06-25 2013-12-20 Брааш Биотех Ллк Слитый белок дефектная хлорамфеникол ацетилтрансфераза (сат)-соматостатин и его применения

Also Published As

Publication number Publication date
NZ590011A (en) 2012-09-28
DK2303314T3 (da) 2014-01-13
US8367073B2 (en) 2013-02-05
US20120076806A1 (en) 2012-03-29
BRPI0822826A2 (pt) 2015-07-07
US20100136037A1 (en) 2010-06-03
JP2011525914A (ja) 2011-09-29
US7722881B2 (en) 2010-05-25
EP2303314A4 (en) 2012-07-18
MX2010014082A (es) 2011-04-07
EP2303314A1 (en) 2011-04-06
ES2445403T3 (es) 2014-03-03
WO2009157926A1 (en) 2009-12-30
AU2008358353B2 (en) 2013-11-07
CN102105163A (zh) 2011-06-22
KR20110039517A (ko) 2011-04-19
JP5506792B2 (ja) 2014-05-28
AU2008358353A1 (en) 2009-12-30
US7943143B2 (en) 2011-05-17
IL209792A0 (en) 2011-02-28
KR101555731B1 (ko) 2015-09-25
EP2303314B1 (en) 2013-12-11
RU2501565C2 (ru) 2013-12-20
RU2011100104A (ru) 2012-07-20
US20090324629A1 (en) 2009-12-31
IL209792A (en) 2012-12-31
ZA201009125B (en) 2012-06-27
CN102105163B (zh) 2014-12-10

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130625

FZDE Discontinued

Effective date: 20180627