CN102100846A - Chinese medicinal composition with function of relieving physical fatigue and preparation method thereof - Google Patents
Chinese medicinal composition with function of relieving physical fatigue and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition with a function of relieving physical fatigue, which comprises the following components in percentage by weight: 1 to 50 percent of glossy ganoderma, 1 to 50 percent of medicinal indianmulberry root,1 to 50 percent of medlar, 1 to 50 percent of siberian solomonseal rhizome, 1 to 50 percent of prepared polygonum multiflorum thunb., 1 to 50 percent of notoginseng root and 0.1 to 50 percent of auxiliary materials. On the basis of the theory of traditional Chinese medical science, traditional Chinese medicines capable of relieving the physical fatigue effectively are screened, and are subjected to scientific compatibility to achieve the mutually-synergistic effect, so that a Chinese medicinal formula which has the function of relieving the physical fatigue is obtained.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, belong to the field of Chinese medicines with alleviating physical fatigue function.
Background technology
Fatigue is a kind of signal, reminds your body to surpass normal duty.When feeling of fatigue occurring, just should adjust and have a rest, " suit the remedy to the case " according to the reason that causes fatigue.If be in fatigue state for a long time, not only can reduce work efficiency, and can induce an illness.Accumulate because of overworked and professional stress and to bring out the state of an illness and worsen suddenly deadly, be called " overworking death ".
The present invention is on the basis of existing theory of Chinese medical science, filters out the effectively Chinese medicine of alleviating physical fatigue, carries out the science compatibility, brings into play its mutual synergism, thereby obtains a kind of Chinese medicine preparation with alleviating physical fatigue function.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition and preparation method thereof with alleviating physical fatigue function.
The objective of the invention is to be achieved through the following technical solutions:
A kind of Chinese medicine composition with alleviating physical fatigue function, count by weight percentage and comprise following component:
Ganoderma 1%～50%, Radix Morindae Officinalis 1%～50%,
Fructus Lycii 1%～50%, Rhizoma Polygonati 1%～50%,
Radix Polygoni Multiflori Preparata 1%～50%, Radix Notoginseng 1%～50%,
Adjuvant 0.1%～50%.
Preferably, Chinese medicine composition of the present invention, count by weight percentage and comprise following component:
Ganoderma 1%～30%, Radix Morindae Officinalis 1%～30%,
Fructus Lycii 1%～30%, Rhizoma Polygonati 1%～30%,
Radix Polygoni Multiflori Preparata 1%～25%, Radix Notoginseng 1%～20%,
Adjuvant 0.1%～50%.
Chinese medicine composition of the present invention includes acceptable auxiliary on the bromatology, thereby can be made into various peroral dosage forms, as powder, granule, tablet, hard capsule, soft capsule and oral liquid etc.
In the present invention, described adjuvant is selected from one or more the combination in Fruit powder, edible essence, sweeting agent, acidic flavoring agent, filler, lubricant, antiseptic, suspending agent, food coloring, diluent and the plasticizer etc.
Wherein, described Fruit powder comprises orange powder, Fructus Citri Limoniae powder, cherry powder, Fructus Mali pumilae powder and coconut palm powder etc.; Described edible essence comprises orange essence, Fructus Citri Limoniae essence, cherry essence, apple essence and cocoanut flavour etc.; Described sweeting agent comprises sucralose, acesulfame potassium, aspartame, mogroside and neotame etc.; Described acidic flavoring agent comprises citric acid, malic acid, lactic acid and citric acid etc.; Described filler comprises fructose, sugar alcohols, sucrose, starch and dextrin etc.; Described lubricant comprises Pulvis Talci, magnesium stearate, silicon dioxide and stearic acid etc.; Described antiseptic comprises sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben and P-hydroxybenzoic acid phenyl ester etc.; Described suspending agent comprises sodium carboxymethyl cellulose, sodium alginate and Cera Flava etc.; Described food coloring comprises burnt sugar coloring, Gardenia Yellow, curcumin and chlorophyll etc.; Described diluent comprises that edible vegetable oil, propylene glycol and molecular weight are 400～2000 Polyethylene Glycol etc.; Described plasticizer comprises glycerol, sodium carboxymethyl cellulose, sorbitol and oleamide sodium sulfonate etc.
Chinese medicine composition of the present invention can be made other products by acceptable composition on bromatology.
The preparation method of Chinese medicine composition of the present invention is: Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and panax mixed are fed intake, and water decocts, and is condensed into extractum then, and drying promptly makes described Chinese medicine composition after handling.
The preparation method of Chinese medicine composition of the present invention can also be: directly adopt the extract of Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng to allocate.
In the Chinese medicine composition of the present invention, Rhizoma Polygonati, Ganoderma and the invigorating the liver and kidney of Fructus Lycii QI invigorating are monarch drug, and the Shennong's Herbal meaning " Ganoderma, QI invigorating tonify deficiency, nourishing the liver are calmed the nerves, clothes are made light of one's life by commiting suicide and are prolonged life for a long time "; Compendium of Material Medica meaning " Fructus Lycii, for nourishing the liver and kidney, nourish blood and mend good medicine smart, that skin care makes eye bright "; " Mingyi Bielu " meaning " settling five organs is obeyed fat reducing and long life for a long time for Rhizoma Polygonati, main invigorating the spleen and replenishing QI ".Modern pharmacological research proves, Ganoderma, and Fructus Lycii and Rhizoma Polygonati three medicines all resist myocardial ischemia, resisting fatigue, antioxidation and function in delaying senility.The Radix Polygoni Multiflori Preparata nourishing the liver and kidney that nourishes blood, Radix Morindae Officinalis kidney-replenishing, benefiting essence-blood, two medicines are all ministerial drug.Modern study shows that Radix Polygoni Multiflori Preparata is rich in lecithin, has the newborn and effects such as growth, increase liver glycogen of the hemocyte of promotion, and can improve the superoxide dismutase vigor, has antioxidation and antifatigue effect preferably; Radix Morindae Officinalis contains multiple oligosaccharide and anthraquinone component, and its decoct has free radical resisting and antifatigue effectiveness.The sweet little bitter temperature of Radix Notoginseng, kind and battalion stops blooding, blood circulation and channel invigorating, is that assistant makes it product in the prescription, modern study shows, Radix Notoginseng mainly contains arasaponin, Radix Notoginseng propylhomoserin etc., and arasaponin has facilitation to the propagation of hematopoietic stem cell, and has antioxidation, reduction myocardial oxygen consumption and fatigue-resisting function.In the Chinese medicine composition of the present invention, all medicines share, and full side has the health-care effect of alleviating physical fatigue.
Chinese medicine composition of the present invention proves through toxicological test, has no side effect; Prove to have the health care of alleviating physical fatigue through the animal function test.
Description of drawings
Fig. 1 is preparation technology's flow chart of the oral liquid of Chinese medicine composition of the present invention;
Fig. 2 is preparation technology's flow chart of the granule of Chinese medicine composition of the present invention;
Fig. 3 is preparation technology's flow chart of the hard capsule of Chinese medicine composition of the present invention;
Fig. 4 is preparation technology's flow chart of the tablet of Chinese medicine composition of the present invention;
Fig. 5 is preparation technology's flow chart of the powder of Chinese medicine composition of the present invention;
Fig. 6 is preparation technology's flow chart of the soft capsule of Chinese medicine composition of the present invention.
The specific embodiment
Embodiment one: the preparation of the oral liquid of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Ganoderma 10.0%, Radix Morindae Officinalis 10.0%,
Fructus Lycii 20.0%, Rhizoma Polygonati 15.0%,
Radix Polygoni Multiflori Preparata 15.0%, Radix Notoginseng 8.00%,
Cherry powder 21.8%, citric acid 0.10%,
Sodium benzoate 0.05%, mogroside 0.03%,
Fructus Citri Limoniae essence 0.02%.
Get Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng and extract, concentrate, obtain concentrated solution; Add Fructus Citri Limoniae essence, mogroside, cherry powder, citric acid, sodium benzoate and an amount of purified water mix homogeneously, behind instantaneous sterilizing, carry out fill, promptly make the oral liquid of Chinese medicine composition of the present invention after the sterilization in filling machine.
Embodiment two: the preparation of the granule of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Ganoderma 10.0%, Radix Morindae Officinalis 10.0%,
Fructus Lycii 10.0%, Rhizoma Polygonati 10.0%,
Radix Polygoni Multiflori Preparata 8.00%, Radix Notoginseng 2.00%,
Erythritol 29.98%, dextrin 15.0%,
Fructus Mali pumilae powder 5.00%, aspartame 0.02%.
Get Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng and extract, concentrate, obtain concentrated solution; Add dextrin, erythritol, Fructus Mali pumilae powder and aspartame mix homogeneously, in granulator, granulate, promptly make the granule of Chinese medicine composition of the present invention behind the granulate.
Embodiment three: the preparation of the hard capsule of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Ganoderma 5.00%, Radix Morindae Officinalis 10.0%,
Fructus Lycii 10.0%, Rhizoma Polygonati 5.00%,
Radix Polygoni Multiflori Preparata 10.0%, Radix Notoginseng 10.0%,
Dextrin 50.0%.
Get Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng and extract, concentrate, obtain concentrated solution; After adding the dextrin mix homogeneously, granulate in granulator, drying is carried out granulate after handling again, adopts Autocapsulefillingmachine to fill then, promptly makes the hard capsule of Chinese medicine composition of the present invention after polishing.
Get the hard capsule that present embodiment makes, pertinent regulations according to Ministry of Public Health " health food check and assessment technique standard " (version in 2003) are carried out the test of safety toxicological evaluation, the result is as follows: 1, acute oral toxicity test: sample greater than 20000mg/kgbw, belongs to avirulence to the maximum tolerated dose (MTD) of female, male Kunming mouse; 2, genetic toxicity test: the result is all negative for three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test and mouse sperm deformity test); 3,30 days feeding trials: the capsule 's content with 1.267g/kgbw, 1.900g/kgbw, 2.533g/kgbw dosage (be equivalent to respectively human body recommended amounts 50,75,100 times) is given rat oral gavage 30 days, each treated animal growth promoter of experimental session is good, and each dosage of sample is to rat body weight, body weight gain, average food-intake and food utilization do not make significant difference (P＞0.05); The experiment end, each dosage group hematological indices (hemoglobin, erythrocyte sum, packed cell volume, total number of blood platelet, total white blood cells and classification), blood biochemistry index (serum glutamic pyruvic transminase, glutamic oxaloacetic transaminase, GOT, total protein, albumin, cholesterol, triglyceride, blood urea nitrogen, creatinine, blood glucose), dirty body ratio (testis/body weight ratio of liver/body, spleen/body, kidney/body ratio and male Mus) compare there was no significant difference (P＞0.05) with corresponding matched group; Gross anatomy is not seen the abnormal change relevant with sample with tissue pathology checking; Point out to feed in 30 days rat is not had obvious toxic-side effects.
The hard capsule of per os filling stomach mice 0.127g/kgbw, 0.253g/kgbw, 0.760g/kgbw dosage 30 days, compare with matched group, 0.760g/kgbw the swimming with a load attached to the body time of dosage energy significant prolongation mice, significantly reducing tired mice serum carbamide produces, significantly reduce mice blood lactic acid area under curve, significantly increase the hepatic glycogen storage level.Each dosage does not have obvious influence to the body weight gain of mice.According to " health food check and the middle criterion of assessment technique standard (2003 editions) think that animal is had the alleviating physical fatigue function.
Embodiment four: the preparation of the tablet of Chinese medicine composition of the present invention
Take by weighing each component according to following percentage by weight:
Ganoderma 10.0%, Radix Morindae Officinalis 10.0%,
Fructus Lycii 10.0%, Rhizoma Polygonati 5.00%,
Radix Polygoni Multiflori Preparata 10.0%, Radix Notoginseng 5.00%,
Dextrin 13.0%, hydroxyl isomaltulose 36.9%,
Fructus Citri Limoniae essence 0.01%, mogroside 0.02%,
Silicon dioxide 0.04%, magnesium stearate 0.03%.
Get Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng and extract, concentrate, obtain concentrated solution; In granulator, granulate after adding dextrin, the pure and mild mogroside mix homogeneously of isomaltulose; add Fructus Citri Limoniae essence, silicon dioxide and magnesium stearate behind the granulate again; in tablet machine, carry out tabletting then, promptly make the tablet of Chinese medicine composition of the present invention.
Embodiment five: the preparation of the powder of Chinese medicine composition of the present invention
Ganoderma 10.0%, Radix Morindae Officinalis 10.0%,
Fructus Lycii 10.0%, Rhizoma Polygonati 5.00%,
Radix Polygoni Multiflori Preparata 10.0%, Radix Notoginseng 5.00%,
Dextrin 14.5%, cherry powder 5.00%,
Erythritol 20.5%, fructose 10.0%.
Get Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng and extract, concentrate, obtain concentrated solution; After the adding dextrin carries out drying, add cherry powder, erythritol and fructose again, promptly make the powder of Chinese medicine composition of the present invention after total the mixing.
Embodiment six: the preparation of the soft capsule of Chinese medicine composition of the present invention
Feed liquid: Ganoderma 5.00%, Radix Morindae Officinalis 10.0%,
Fructus Lycii 10.0%, Rhizoma Polygonati 10.0%,
Radix Polygoni Multiflori Preparata 10.0%, Radix Notoginseng 10.0%,
Dextrin 25.0%, soybean oil 19.4%,
Cera Flava 0.60%.
Glue: gelatin 46.0%, glycerol 16.0%,
Purified water 37.0%, burnt sugar coloring 0.80%,
Ethylparaben 0.20%.
Get Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng and extract, concentrate, obtain concentrated solution; Adding dextrin carries out obtaining extract powder after the drying; Make suspended matter after getting extract powder and soybean oil, Cera Flava mixing.Make rubber after getting gelatin, glycerol, purified water, burnt sugar coloring and ethylparaben mixing, prepared suspended matter fill is pressed into soft capsule, after washing ball, drying, promptly make the soft capsule of Chinese medicine composition of the present invention.
Claims (8)
1. Chinese medicine composition with alleviating physical fatigue function, count by weight percentage and comprise following component:
Ganoderma 1%～50%, Radix Morindae Officinalis 1%～50%,
Fructus Lycii 1%～50%, Rhizoma Polygonati 1%～50%,
Radix Polygoni Multiflori Preparata 1%～50%, Radix Notoginseng 1%～50%,
Adjuvant 0.1%～50%.
2. Chinese medicine composition according to claim 1 is characterized in that, counts by weight percentage to comprise following component:
Ganoderma 1%～30%, Radix Morindae Officinalis 1%～30%,
Fructus Lycii 1%～30%, Rhizoma Polygonati 1%～30%,
Radix Polygoni Multiflori Preparata 1%～25%, Radix Notoginseng 1%～20%,
Adjuvant 0.1%～50%.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that: described adjuvant is selected from one or more the combination in Fruit powder, edible essence, sweeting agent, acidic flavoring agent, filler, lubricant, antiseptic, suspending agent, food coloring, diluent and the plasticizer.
4. Chinese medicine composition according to claim 3 is characterized in that: described Fruit powder comprises orange powder, Fructus Citri Limoniae powder, cherry powder, Fructus Mali pumilae powder and coconut palm powder; Described edible essence comprises orange essence, Fructus Citri Limoniae essence, cherry essence, apple essence and cocoanut flavour; Described sweeting agent comprises sucralose, acesulfame potassium, aspartame, mogroside and neotame; Described acidic flavoring agent comprises citric acid, malic acid, lactic acid and citric acid; Described filler comprises fructose, sugar alcohols, sucrose, starch and dextrin; Described lubricant comprises Pulvis Talci, magnesium stearate, silicon dioxide and stearic acid; Described antiseptic comprises sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben and P-hydroxybenzoic acid phenyl ester; Described suspending agent comprises sodium carboxymethyl cellulose, sodium alginate and Cera Flava; Described food coloring comprises burnt sugar coloring, Gardenia Yellow, curcumin and chlorophyll; Described diluent comprises that edible vegetable oil, propylene glycol and molecular weight are 400～2000 Polyethylene Glycol; Described plasticizer comprises glycerol, sodium carboxymethyl cellulose, sorbitol and oleamide sodium sulfonate.
5. Chinese medicine composition according to claim 1 and 2 is characterized in that: described Chinese medicine composition is prepared to oral formulations.
6. Chinese medicine composition according to claim 5 is characterized in that: described oral formulations comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
7. the preparation method of claim 1 or 2 described Chinese medicine compositions, may further comprise the steps: Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and panax mixed are fed intake, water decocts, and is condensed into extractum then, and drying promptly makes described Chinese medicine composition after handling.
8. the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that: directly adopt the extract of Ganoderma, Radix Morindae Officinalis, Fructus Lycii, Rhizoma Polygonati, Radix Polygoni Multiflori Preparata and Radix Notoginseng to allocate.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103800672A (en) * | 2014-02-14 | 2014-05-21 | 安徽天马生物科技有限公司 | Health care capsule for relieving physical fatigue and preparation method of health care capsule |
| CN103919003A (en) * | 2014-04-01 | 2014-07-16 | 安徽省怀宁县顶雪食品有限公司 | Pastry with efficacy of resisting fatigue |
| CN104223054A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Anti-fatigue health food composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104223054A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Anti-fatigue health food composition |
| CN103800672A (en) * | 2014-02-14 | 2014-05-21 | 安徽天马生物科技有限公司 | Health care capsule for relieving physical fatigue and preparation method of health care capsule |
| CN103919003A (en) * | 2014-04-01 | 2014-07-16 | 安徽省怀宁县顶雪食品有限公司 | Pastry with efficacy of resisting fatigue |
| CN103919003B (en) * | 2014-04-01 | 2015-08-26 | 安徽省怀宁县顶雪食品有限公司 | A kind of cake with anti-fatigue effect |
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Effective date of registration: 20170123 Address after: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee after: Perfect (China) Co., Ltd. Patentee after: Perfect (Guangdong) Commodity Co., Ltd. Address before: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee before: Perfect (China) Co., Ltd. |