CN102641339B - Traditional Chinese medicine compound preparation for increasing body immunity and resisting fatigue - Google Patents
Traditional Chinese medicine compound preparation for increasing body immunity and resisting fatigue Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine compound preparation for increasing body immunity and promoting body fatigue recovery. Rhodiola, cordyceps militaris, polygala, dragon bone, rhizoma chuanxiong and rhizoma atractylodis macrocephalae are used as raw materials and are decocted via water or ethanol, supernatant is taken, concentrated and dried in a spraying manner to obtain dry powder, and after being added with medically receivable auxiliary materials, the dry powder can be prepared into oral preparations including powder, granules, capsules, tablets, suspensions, oral liquid and the like. The Chinese herbal medicine compound preparation is scientific in compatibility of medicines and reasonable in preparation process, does not damage active ingredients in the various traditional Chinese medicine raw materials, is free of toxic and side effects, can nourish the kidney-yin and strengthen tendons and bones, can prolong swinging time of rats with loads, reduces accumulation of lactic acid in blood serum and skeletal muscles, and accordingly achieves a fatigue resisting effect. In addition, the six Chinese herbal medicines have a high synergistic effect, so that the Chinese herbal medicine compound preparation has a good market prospect.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation that improves immunity of organisms, resisting fatigue degree, have nourishing kidney yin, the effect of bone and muscle strengthening, the present invention relates to Chinese medicine natural medicinal formulations field.
Background technology
Tired (fatigue) is a comprehensive physiological process that relates to many Physiology and biochemistry factors, it is a kind of normal physiological phenomenon that the mental or physical work of human body must occur during to certain phase, in modern society, being important paathogenic factor, is a kind of stress performance.Along with social development, high efficiency work, allegro life, and the enhancing of competitive spirit, people's muscle power, mental in tension for a long time, the sickness rate of chronic fatigue syndrome (CFS) is also the trend rising year by year, and this causes the patient who is chief complaint with fatigue clinically increasingly to increase.So promote the recovery of organism fatigue, the development that improves the endurance compound Chinese medicinal preparation of body fatigue resistance is expected to become a kind of effective health means that helps people to break away from sub-health state.
Chinese medicine carries out integral body conditioning because being good to human body, comprehensively adjusts human immunologic function, and environment in balance body yang blood and qi promotes human body yin-yang balancing, QI and blood to be in harmonious proportion, and aspect treatment chronic fatigue syndrome, is having its unique advantage.And along with the raising of people's living standard, people are not only satisfied with the passive medical insurance target of " ill curing the disease ", but pursue, take active prevention disease as the higher level medical insurance target that principal character, the daily health caring of take are Main Means, pursue high-quality life.Promote the recovery of organism fatigue, the development that improves the endurance compound Chinese medicinal preparation of body fatigue resistance is expected to become a kind of science selection of people's health care.
Based on Traditional Chinese medical theory, adopt Chinese medicine with health role: Radix Rhodiolae, Cordyceps militaris (L.) Link., Radix Polygalae, Os Draconis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, a few taste medicine combinations are made after the compound Chinese medicinal preparation of molding above, there is significant resisting fatigue and promote the effect of antisecosis, and carry, taking convenience, more can increase work efficiency and keep vigorous energy.
summary of the invention:
The invention provides a kind of compound Chinese medicinal preparation and preparation method thereof, can make faster fatigue recovery, energetic, improve self immunity and memory.
The present invention is achieved through the following technical solutions.
Promotion organism fatigue disclosed by the invention recovers, and improves the compound Chinese medicinal preparation of body fatigue resistance endurance, raising immunity of organisms, it is characterized in that said preparation is to be made by the raw material of following weight portion proportioning:
Radix Rhodiolae 5-30 part, Cordyceps militaris (L.) Link. 5-25 part, Radix Polygalae 5-25 part, Os Draconis 5-20 part, Rhizoma Chuanxiong 5-40 part, Rhizoma Atractylodis Macrocephalae 5-40 part.
Compound Chinese medicinal preparation of the present invention, its preferred prescription is as follows:
20 parts of Radix Rhodiolaes, 15 parts of Cordyceps militaris (L.) Link., 15 parts of Radix Polygalaes, 10 parts of Os Draconis, 25 parts of Rhizoma Chuanxiongs, 10 parts of the Rhizoma Atractylodis Macrocephalaes.
The preparation technology of Chinese medicinal compound extract of the present invention is as follows,
Get Radix Rhodiolae, Cordyceps militaris (L.) Link., Radix Polygalae, Os Draconis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, add 6-10 times of water or ethanol and decoct extraction 1 ~ 3 time, extraction time is each 1 ~ 3 hour; Merge extractive liquid,, filters, and is concentrated into 5% ~ 20% of original volume, and spraying is dried to obtain extract dry powder.
Chinese medicinal compound extract of the present invention can add the adjuvant of medically accepting to make required dosage form, as oral formulations such as powder, granule, capsule, tablet, suspensoid, oral liquids.
Good effect of the present invention is: compound Chinese medicinal preparation belongs to pure oral medicinal herb preparation, between Six-element Chinese herbal medicine, there is stronger synergism, can promote the recovery of organism fatigue, improve immunity of organisms, particularly improve the endurance of body fatigue resistance, make energetic, improve memory, have no side effect, without addiction, effect is remarkable.The preparation technology of this preparation is reasonable, and method is convenient, easy operating.
Compatibility science of the present invention, preparation technology is reasonable, does not destroy the effective ingredient of each raw material of Chinese medicine, have no side effect, can nourishing kidney yin, bone and muscle strengthening, can extend the heavy burden rats'swimming time, reduce the accumulation of lactic acid in serum and skeletal muscle, thereby reach the effect of resisting fatigue.There is good market prospect.
the specific embodiment:
For the ease of understanding the present invention, especially exemplified by following examples.Its effect is understood to be to explaination of the present invention but not to any type of restriction of the present invention.
embodiment 1
After taking Radix Rhodiolae 20g, Cordyceps militaris (L.) Link. 15g, Radix Polygalae 15g, Os Draconis 10g, Rhizoma Chuanxiong 25g, Rhizoma Atractylodis Macrocephalae 10g and being pulverized and mixed, add 6 times of volume water boiling and extraction 1 ~ 3 time, extraction time is each 1 ~ 3 hour; Merge extractive liquid,, filters, and is concentrated into 10% of original volume, and spraying is dried to obtain extract dry powder.
embodiment 2
After taking Radix Rhodiolae 30g, Cordyceps militaris (L.) Link. 25g, Radix Polygalae 25g, Os Draconis 20g, Rhizoma Chuanxiong 40g, Rhizoma Atractylodis Macrocephalae 40g and being pulverized and mixed, add 10 times of 70% ethanol and decoct and extract 1 ~ 3 time, extraction time is each 1 ~ 3 hour; Merge extractive liquid,, filters, and is concentrated into 20% of original volume, and spraying is dried to obtain extract dry powder.
embodiment 3
After taking Radix Rhodiolae 30g, Cordyceps militaris (L.) Link. 15g, Radix Polygalae 15g, Os Draconis 10g, Rhizoma Chuanxiong 20g, Rhizoma Atractylodis Macrocephalae 20g and being pulverized and mixed, add 8 times of water or 70% ethanol and decoct and extract 3 times, extraction time is each 1.5 hours.Merge extractive liquid,, filters, and is concentrated into 10% of original volume, and spraying is dried to obtain extract dry powder.
embodiment 4
The present embodiment is Chinese medicine compound oral tablet:
Radix Rhodiolae, Cordyceps militaris (L.) Link., Radix Polygalae, Os Draconis, Rhizoma Chuanxiong and Rhizoma Atractylodis Macrocephalae extract dry powder: 1 weight portion
Starch, dextrin mixture: 2 weight portions
Get Chinese medicinal compound extract dry powder, add the adjuvant of qdx as excipient, mix homogeneously, adds starch slurry soft material processed, 14 mesh sieve extrusion granulators, and in 50 ~ 70 ℃ of dry 1h, 12 mesh sieve granulate, add Pulvis Talci, magnesium stearate tabletting and get final product.Sundry item all should meet 2010 editions tablet project relevant requirements of Pharmacopoeia of People's Republic of China.
embodiment 5
After getting Radix Rhodiolae 200g, Cordyceps militaris (L.) Link. 200g, Radix Polygalae 150g, Os Draconis 100g, Rhizoma Chuanxiong 200g, Rhizoma Atractylodis Macrocephalae 100g and being pulverized and mixed, with 8 times, measure 70% alcohol reflux 2 times, each 1 hour, merge extractive liquid,, reclaims ethanol, is concentrated into thick paste, merge extractive liquid,, filter, be concentrated into 10% of original volume, spraying is dried to obtain extract dry powder.Powder adds magnesium stearate by weight 100:1, and screen cloth is that 14 object preparation technologies carry out dry granulation, after granulation, incapsulates, and obtains.Sundry item all should meet 2010 editions capsule project relevant requirements of Pharmacopoeia of People's Republic of China.
experimental example 1
1. experiment material and method
1.1 experiment materials:
Laboratory animal, adopt kunming mice in 4 week age, body weight 20 ± 2g, purchased from Jilin University's medical board Experimental Animal Center, raise under the environment of 12h alternate cycles at daytime/night 20 ± 1 ℃ of temperature, humidity 55 ± 10%, in rate of ventilation 20 ± 2 times/time, the pellet of feeding standard, freely ingests and drinks water.The extract powder of getting preparation in embodiment 3 carries out following zoopery.
1.2 experimental techniques:
1.2.1 grouping: mice male and female half and half, are all divided into 6 groups at random by different experiments, 10 every group.The 1st group is physiology saline control group, gavage normal saline 10mLkg
-1.The 2nd group ~ 4 groups is experimental group: the administration 0.5,1.0 respectively of the basic, normal, high dosage group of Chinese medicine extract powder formulation, the 3.0gkg that are respectively the embodiment of the present invention 1 ~ 3 preparation
-1.5th, 6 groups of positive matched groups, give respectively Radix Rhodiolae extract and Cordyceps militaris (L.) Link. extract 3gkg
-1.Medication group gavage gives medicinal liquid, and 1 time/d, totally 2 weeks.
1.2.2 the swimming time of loading is measured: last gives after tested material 30min, put mice in swimming trunk, depth of water 35cm, water temperature (25 ± 0.5) ℃, the load sheet lead of 5% body weight of mouse tail root, records mice swimming and starts to the dead time as mice swimming time.
1.2.3 the mensuration of serum urea nitrogen content: last gavage gives after tested material 30min, in temperature, be not swimming with a load attached to the body 90min in the water of 30 ℃, pluck eyeball blood sampling, the centrifugal 15min of 2000r/min, gets serum and measures urea nitrogen content with Hitachi's 7020 full automatic biochemical apparatus.
1.2.4 the mensuration of hepatic glycogen content: last gavage gives after tested material 30min, in temperature, be the water went swimming 90min of 30 ℃, put to death immediately, get liver blots with filter paper after normal saline rinsing, accurately take liver 200mg, add 4mL trichloroacetic acid, every pipe homogenate 1min, pour homogenate into centrifuge tube, with the centrifugal 15min of 3000r/min, supernatant is transferred to another in vitro, in precipitation, add again 4mL trichloroacetic acid homogenate 1min, recentrifuge 15min, get supernatant, and merge with the 1st centrifugal supernatant, fully mix, anthrone method is measured hepatic glycogen content.
1.2.5 Serum lactic acid content is measured: last gavage gives after tested material 30min, with the glass capillary eyeball angular vein 20 μ L that take a blood sample, add in 5mL test tube and (add in advance 0.48mL 1%NaF solution), add again 1.5mL protein precipitant to mix, with the centrifugal 15min of 3000r/min, stay supernatant, use full blood lactic (LD) test kit to measure lactic acid content.After animal blood taking, not bearing a heavy burden, is to stop after the water went swimming 10min of 30 ℃ in temperature, the 20 μ L that take a blood sample immediately, and the 20 μ L that take a blood sample again after rest 20min, are measured in the same method lactic acid content.
The impact of table 1. medicine on mice swimming time and serum urea nitrogen, hepatic glycogen
Compare * P<0.05, * * P<0.01 with normal saline matched group; N=10
The impact of table 2. medicine on Mouse Blood lactate level before and after motion
Compare * P<0.05, * * P<0.01 with normal saline matched group; N=10
2. result: from table 1, each dosage group mice swimming time of Chinese medicinal compound extract powder is all apparently higher than Normal group (P < 0.05, P < 0.01), serum urea nitrogen content is all starkly lower than Normal group (P < 0.05, P < 0.01), illustrate that medicine has the effect of the serum urea nitrogen content that reduces the rear mice of motion.Mouse Liver glycogen content increases with the increase of dosage, high dose group and middle dosage group and Normal group comparison, there is highly significant difference (P < 0.01), illustrate that medicine has the effect that increases Glycogen deposit or reduce glycogen use.From table 2, the Serum lactic acid content of each dosage group mice of Chinese medicinal compound extract powder of the present invention is all lower than Normal group (P < 0.05, P < 0.01), illustrate that this medicine raises and has inhibitory action the blood lactic acid of mice after moving, and the effect of middle and high dosage group is more obvious.The impact of comprehensive compound Chinese medicinal preparation on the every biochemical indicator of mice after moving, shows that it can increase aerobic metabolism, accelerates tired elimination and antisecosis, thereby improves the motor capacity to the adaptability of sports load and body.
Claims (1)
1. improve a compound Chinese medicinal preparation for immunity of organisms, resisting fatigue degree, it is characterized in that said preparation is to be made by the raw material of following weight portion proportioning:
Radix Rhodiolae 5-30 part, Cordyceps militaris (L.) Link. 5-25 part, Radix Polygalae 5-25 part, Os Draconis 5-20 part, Rhizoma Chuanxiong 5-40 part, Rhizoma Atractylodis Macrocephalae 5-40 part;
The preparation method of the compound Chinese medicinal preparation of described raising immunity of organisms, resisting fatigue degree, comprises following processing step:
Get Radix Rhodiolae, Cordyceps militaris (L.) Link., Radix Polygalae, Os Draconis, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae and add 6-10 times of water or ethanol and decoct and extract 1 ~ 3 time, extraction time is each 1 ~ 3 hour; Merge extractive liquid,, filters, and is concentrated into 5% ~ 20% of original volume, and spraying is dried to obtain extract dry powder.
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| CN103202891A (en) * | 2013-04-15 | 2013-07-17 | 褚小红 | Weishuning tablet Chinese medicinal composition and preparation method thereof |
| CN104587151A (en) * | 2015-01-08 | 2015-05-06 | 中国药科大学 | Traditional Chinese medicine composite used for releasing fatigue as well as preparation method and application of traditional Chinese medicine composite |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009072688A1 (en) * | 2007-12-07 | 2009-06-11 | Hankook Pharm. Co., Inc. | Composition for inhibition of trasplant rejection containing the cordyceps mycellia extract as an active ingredient |
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| CN1085788A (en) * | 1993-06-26 | 1994-04-27 | 长春市白山药物开发研究所 | Oral liquid |
| KR100871399B1 (en) * | 2007-02-20 | 2008-12-02 | 원광대학교산학협력단 | Endo-polymer and exo-polymer obtained from submerged mycelial culture of Cordyceps militaris increasing immuno-modulating activities and optimum culture conditions for producing the same |
| CN101579455B (en) * | 2009-06-16 | 2011-05-25 | 李军 | Traditional Chinese medicine preparation for treating consumptive disease |
| KR20110047585A (en) * | 2009-10-30 | 2011-05-09 | 주식회사 백옥생 | Anti-obesity composition comprising Cordyceps militaris extracts |
| CN101850030A (en) * | 2010-06-02 | 2010-10-06 | 烟台大洋制药有限公司 | Anti-fatigue medicament or health food |
| CN102319351B (en) * | 2011-09-22 | 2013-01-09 | 王璐 | Blood enriching and qi replenishing health-care product |
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| WO2009072688A1 (en) * | 2007-12-07 | 2009-06-11 | Hankook Pharm. Co., Inc. | Composition for inhibition of trasplant rejection containing the cordyceps mycellia extract as an active ingredient |
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