CN101991807A

CN101991807A - Chinese herbal compound for treating liver cancer

Info

Publication number: CN101991807A
Application number: CN2009100420702A
Authority: CN
Inventors: 陈泽雄; 孙保国
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-08-24
Filing date: 2009-08-24
Publication date: 2011-03-30

Abstract

The invention relates to a Chinese herbal compound for treating liver cancer, comprising a main prescription and two auxiliary prescriptions, wherein the main prescription comprises 2-18 parts of herba scutellariae barbatae, 1-9 parts of rhizoma zedoariae, 1-4 parts of radix bupleuri, 2-18 parts of radix codonopsitis; the two auxiliary prescriptions comprise 1-9 parts of herba lobeliae chinensis, 1-6 parts of woodlouse, 1-4 parts of raw liquorice, 1-9 parts of atractylodes macrocephaia, 1-9 parts of Tuckahoe and 1-4 parts of honey-fried licorice root. The invention is characterized in that corresponding treatment medicines are applised according to different kinds of pathogenesis emphasis (depression of the liver, insufficiency of the spleen and stagnating stasis in the body) in a developing process of the liver cancer. The traditional research prompts that the two auxiliary prescriptions which use the main prescription as a base can obviously improve the life quality and the liver function of liver cancer patients, can obviously prolong the life time of the tumor-burdened rat, can obviously confront the generation and the development of the dyscrasia of the tumor-burdened rat, which are resulted from the transplanted tumor and can prolong the survive time of the rat with tumors; and an animal acute toxicity test proves that no animal death occurs. The Chinese herbal compound for treating the liver cancer is safe and convenient to use and has determined curative effect.

Description

A kind of Chinese medicine compound for the treatment of hepatocarcinoma

Technical field

The present invention relates to a kind of herbal mixture for the treatment of hepatocarcinoma, particularly a kind of herbal mixture combination for the treatment of primary hepatocarcinoma.

Background technology

Hepatocarcinoma has the advantages that discovery is late, development is fast, treat difficulty, poor prognosis, and sickness rate is ascendant trend year by year, is a kind of disease of serious harm human health.Hepatocarcinoma is one of 10 kinds of tumors that sickness rate is the highest in the world, and China's hepatocarcinoma case load accounts for 43.7% of the total routine number of whole world hepatocarcinoma.Its mortality rate second of row in malignant tumor.Because the pathogenesis of hepatocarcinoma is indeterminate, lack at this sick specific treatment at present, the general curative effect of hepatocarcinoma is pessimistic.So explore effective method for treatment, improving survival time of patients and quality of life is a problem demanding prompt solution.In recent years, Chinese medicine is definite with its clinical efficacy, the advantage that toxic and side effects is few, can to a certain degree suppress hepatocarcinoma growth, prolong patient's life span and obviously improved patient's life quality greatly, cause people's attention day by day.Through nearly 20 years clinical and experimental exploring, I find out effective prescription combination of treatment by Chinese herbs hepatocarcinoma gradually.Do not see the research that duplicates with the present invention by literature search.

Summary of the invention

The object of the present invention is to provide the Chinese medicinal formulae combination of a kind of determined curative effect, safe in utilization, taking convenience, treatment hepatocarcinoma that expense is cheap.

Knot in the basic pathogenesis that the present invention takes place according to hepatocarcinoma---stagnation of liver-QI with deficiency of the spleen, the stasis of blood poison, and scientific composition such as clinical experience and basic research in early stage result form.

2 prescription agent of the present invention have strict compatibility and dose ratio.

Occur becoming in the stasis of blood poison when main for liver cancer patient, can adopt the described auxiliary side one of described main formula of claim 1 and claim 2 to be used in combination:

1～9 part of 2～18 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

2～18 parts of 1～4 part of Radix Codonopsis of Radix Bupleuri

1～6 part of 1～9 part of Eupolyphaga Seu Steleophaga of Herba Lobeliae Chinensis

1～4 part of Radix Glycyrrhizae;

When insufficiency of the spleen mistake fortune to occur be main for liver cancer patient, described main formula of claim 1 and claim 3 described auxiliary side two be used in combination:

1～9 part of 2～18 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

2～18 parts of 1～4 part of Radix Codonopsis of Radix Bupleuri

1～9 part in 1～9 part of Poria of the Rhizoma Atractylodis Macrocephalae

1～4 part of Radix Glycyrrhizae Preparata

Clinical practice finds that above-mentioned 2 prescriptions can obviously improve the life quality and the liver function of liver cancer patient; It can obviously prolong the life span of tumor bearing nude mice experimental research suggested, and has dyscrasic generation of mice with tumor and progress that tangible antagonism transplanted tumor causes, prolongs mice with tumor band tumor life span.2 prescriptions are irritated 6 week of stomach kunming mice in age (male and female half and half) 20 with 120 times of adult's one daily doses respectively, once irritate stomach in 4 hours, and animal dead is not observed in administration 6 times, the prompting safety of medicine.

The specific embodiment

Specific embodiment is as follows, includes but not limited to the following example.

1, be used for liver cancer patient or animal model and occur becoming in the stasis of blood poison when main, give any dosage form intervention with following prescription:

3 parts of 6 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

6 parts of 2 parts of Radix Codonopsis of Radix Bupleuri

2 parts of 3 parts of Eupolyphaga Seu Steleophagas of Herba Lobeliae Chinensis

1 part of Radix Glycyrrhizae;

2, be used for liver cancer patient or animal model and occur insufficiency of the spleenly when being main, give any dosage form intervention with following prescription:

3 parts of 6 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

6 parts of 2 parts of Radix Codonopsis of Radix Bupleuri

3 parts in 3 parts of Poria of the Rhizoma Atractylodis Macrocephalae

2 parts of Radix Glycyrrhizae Preparatas.

Claims

1. a Chinese medicine compound for the treatment of hepatocarcinoma is characterized in that, it is made of 1 main formula and 2 auxiliary sides, loses empty different pathogenesis according to knot in the stasis of blood poison and temper and selects various combination.The feature of its main formula is that its preparation raw materials of effective components forms and parts by weight are:

1～9 part of 2～18 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

2～18 parts of 1～4 part of Radix Codonopsis of Radix Bupleuri

2. the auxiliary side one of hepatocarcinoma when stasis of blood poison to occur be main pathogenesis feature is that its preparation raw materials of effective components forms and parts by weight are:

1～4 part of Radix Glycyrrhizae;

3. insufficiency of the spleen auxiliary side's two when being main pathogenesis feature to occur be that its preparation raw materials of effective components forms and parts by weight are to hepatocarcinoma:

1～9 part in 1～9 part of Poria of the Rhizoma Atractylodis Macrocephalae

1～4 part of Radix Glycyrrhizae Preparata

4. the prescription of the described treatment hepatocarcinoma of claim 1～3 is that main formula and claim 2 or 3 are combined into 2 compound recipes with claim 1, and feature is that its preparation raw materials of effective components forms and the parts by weight ratio is:

Side one:

1～9 part of 2～18 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

2～18 parts of 1～4 part of Radix Codonopsis of Radix Bupleuri

1～4 part of Radix Glycyrrhizae;

Side two:

1～9 part of 2～18 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

2～18 parts of 1～4 part of Radix Codonopsis of Radix Bupleuri

1～9 part in 1～9 part of Poria of the Rhizoma Atractylodis Macrocephalae

1～4 part of Radix Glycyrrhizae Preparata

5. the feature of described two prescriptions of claim 4 is, its preparation raw materials of effective components forms and the parts by weight ratio is:

Side one:

3 parts of 6 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

6 parts of 2 parts of Radix Codonopsis of Radix Bupleuri

2 parts of 3 parts of Eupolyphaga Seu Steleophagas of Herba Lobeliae Chinensis

1 part of Radix Glycyrrhizae;

Side two:

3 parts of 6 parts of Rhizoma Curcumae of Herba Scutellariae Barbatae

6 parts of 2 parts of Radix Codonopsis of Radix Bupleuri

3 parts in 3 parts of Poria of the Rhizoma Atractylodis Macrocephalae

2 parts of Radix Glycyrrhizae Preparatas.

6. the feature of described two prescriptions of claim 5 is, its preparation raw materials of effective components forms and the parts by weight ratio is:

Side one:

Herba Scutellariae Barbatae 30 gram Rhizoma Curcumae 15 grams

Radix Bupleuri 10 gram Radix Codonopsis 30 grams

Herba Lobeliae Chinensis 15 gram Eupolyphaga Seu Steleophagas 10 grams

Radix Glycyrrhizae 5 grams;

Side two:

Herba Scutellariae Barbatae 30 gram Rhizoma Curcumae 15 grams

Radix Bupleuri 10 gram Radix Codonopsis 30 grams

The Rhizoma Atractylodis Macrocephalae 15 gram Poria 15 grams

Radix Glycyrrhizae Preparata 10 grams.

7. the feature of described side one of claim 4 and side two is that the form of its preparation effective ingredient can be water decoction, concentrating agents, unguentum, granule, oral liquid, powder.