CN102100294A - Middle-warmer-adjusting sugar functional candies and preparation technology thereof - Google Patents
Middle-warmer-adjusting sugar functional candies and preparation technology thereof Download PDFInfo
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Abstract
The invention relates to middle-warmer-adjusting sugar functional candies and a preparation technology thereof. The middle-warmer-adjusting sugar functional candies comprise the following active ingredients in part by weight: 9 parts of ginseng, 9 parts of rhizoma atractylodis macrocephalae, 9 parts of roasted liquorice and 9 parts of rhizoma zingiberis. The preparation process comprises the following steps of: crushing the raw materials; extracting by using alcohol water; spray-drying at a supersonic speed; performing nano-scale crushing; homogenizing at high temperature; and freeze-drying and the like. The middle-warmer-adjusting sugar functional candies have effects of adjusting spleen and stomach deficiency, resisting fatigue and adjusting immunologic function. According to requirements of the candy preparation technology, different varieties of candies can be prepared selectively.
Description
Technical field
The present invention relates to sugared functional candy in a kind of reason, the invention still further relates to sugared functional candy and technology of preparing thereof in this reason.
Background technology
Functional candy has the third-largest function of regulating human physiological functions, and it can play an important role at aspects such as promoting health, break through inferior health, prevent disease.Functional candy can promote health, have certain regulates the specific physiological function of human body, can not produce bad reaction to human body.
This product is to carry out formula combination under instruction of Chinese Medicine theory, and lizhong decoction comes from the treatise on Febrile Diseases of Han dynasty Zhang Zhongjing, is made up of genseng, rhizoma zingiberis, the bighead atractylodes rhizome, honey-fried licorice root.Be monarch with hot rhizoma zingiberis in the side, warm the middle warmer taste and the interior cold of dispelling; Genseng reinforces vital energy, and helps fortuneization and positive lifting, is ministerial drug, tonifying Qi benefit spleen; Assistant, makes with honey-fried licorice root benefit gas and the native coordinating the drug actions of a prescription of middle benefit to promote the strong fortune of spleen sun with bighead atractylodes rhizome invigorating the spleen to dry.All medicines share, the burnt regeneration in making, and the strong fortune of taste, the ascending the clear and descending the turbid function is recovered, and the stomachache of then vomiting and diarrhoea can heal." distinguishing after the Treatise on Fevrile Diseases ": sun is moving, starts from temperature, and wet gets and Gu Jingyun, and essence derived from food rises and middle gas is supported, so say in the reason.Real merit with mediate reason, Jiao's sun also in giving.If the stomach deficiency of yang, promptly in gas lose and kill, acomia a surname's of Danzhong usefulness, six internal organs do not have the Chen Zhigong of spilling, and lose flame just as the still firewood, so down to Qing Gu, on lose flavour, the five internal organs icepro is taken by force, all diseases institute origin also.Ginseng, art.Process grass, so solid Central Region, the rhizoma zingiberis suffering is with in keeping, and must vacation rise yang-energy with flame still firewood.Be to go into Yu Yin with paddy, long gas is in sun, and upward defeated canopy is taken the photograph the state all down, and the vital organs of the human body are all to be bullied.Purport in this reason also." the warm disease bar is distinguished ": the lizhong decoction warming spleen and stomach for dispelling cold, genseng, Radix Glycyrrhizae, stomach keep medicine; The bighead atractylodes rhizome, Radix Glycyrrhizae; Spleen keep medicine; Rhizoma zingiberis can be led to and can be kept, and two persons of letting out up and down are so taste two are kept it; And have logically in keeping, keep in logical, do generally, keep usefulness with logical medicine to keep medicine." typhoid fever is sought the source ": person in the lid reason, regulating the function of middle-JIAO cold also.Tremble with fear on the Weishang, it is slow to get pill, hangs out in, and it is cold to loose with warm stomach; If the cholera of cold prevailing over heat is sharp in anxious temperature, then unsuitable ball and suitable soup.Slow suitable ball, anxious suitable soup, this is sage's established law earlier, can not be also disorderly.The deficiency of yang during we cure mainly due to the burnt deficiency-cold in spleen and stomach card of losing blood, diarrhea without thirst, vomiting stomachache, abdomen is not completely eaten and the syncope due to pathogenic cold cholera, and the deficiency of yang is lost blood, as spitting blood, have blood in stool or uterine bleeding, feeling of stuffiness in chest asthenic symptoms, chest pain radiating to the back, the burnout weak breath, four limbs are not warm.
The modern pharmacology experiment shows: rhizoma zingiberis methyl alcohol or ether extract have calmness, analgesia, anti-inflammatory, the effect of preventing or arresting vomiting and of short duration rising blood pressure; Water extract or volatile oil is prolong rats experimental thrombosis formation time obviously; Rhizoma zingiberis alcohol extract and contained gingerol thereof and the peppery ketenes of ginger have significantly go out spiral shell and anti-schistosome function.The rhizoma zingiberis alcohol extract can obviously increase the rat liver choleresis.Genseng has the effect of antibody gram, and excited hypophysis one interrenal system of energy improves the stress reaction ability, excitement and process of inhibition to higher nervous activity all have humidification, can strengthen the flexibility of nervous activity process, antifatigue is arranged, promote synthesizing of protein, RNA, DNA, promote the hemopoietic system function, regulate effects such as cholesterol metabolic, can strengthen body's immunity, can strengthen gonad function, the effect of promoting sexual gland hormone sample is arranged, can reduce blood sugar.In addition, anti-inflammatory, antiallergy, antidiuresis and multiple effect such as antitumor are still arranged.Activity has dual regulation to the bighead atractylodes rhizome to intestinal tube, when the intestinal tube excitation time is inhibitory action, then is excitation during the intestinal tube inhibition, and the effect of the experimental gastric ulcer of control is arranged.Can obviously promote the synthetic of small intestine protein, can promote cellular immune function, the effect of certain lifting leucocyte is arranged, can also protect the liver, cholagogic, diuresis, hypoglycemic, anticoagulant, antibiotic, antitumor.Licorice mono-ammonium glycyrrhizinate, diammonium glycyrrhizinate etc. have antiviral significantly, antitumor and antiinflammatory action.Can be widely used in multiple treatment of cancer and viral therapy etc.Lizhong decoction can reduce free concentration of hydrochloric acid in the gastric juice, thereby the etch and the minimizing pepsin that alleviate film activate, and ulcer has been played protective effect; Lizhong decoction can also promote the acetic acid type gastric ulcer healing, illustrates that it can impel the mucomembranous cell Regeneration and Repair.Therefore, lizhong decoction can suppress attack factor, can strengthen defense factor again, brings into play its antiulcer action by two aspect comprehensive functions.
The present invention is by sugared functional candy in " utilization nano-carrier GC-MS research and development functional food " theoretical research and development reason of this original creation.Do not see open report at home in the document, its theoretical and technology of preparing has the novelty of essence and breakthrough.The present invention has integrated each about industry advantage and up-to-date nanometer technology of preparing, be to be the overall strategy tactical thinking with the organic conception of theory of traditional Chinese medical science and the collaborative idea of paying attention to medicinal and edible Chinese medicine, in conjunction with modern western pharmacology scheduling theory, pay attention to the effect of certified effective ingredient in Chinese, monomer, pay attention to using different nano-carriers to prepare new effect and the high added value that functional candy brings supplemental treatment.Society and remarkable in economical benefits.
Preparation of product technology of the present invention is the set of multiple technology of preparing, has adopted pure water extractive technique, nano powder preparation technology, supersonic speed spray drying technology, Freeze Drying Technique, high pressure homogenization technique, beta-cyclodextrin inclusion compound technology etc. respectively.Product of the present invention and technology of preparing have significant substantial innovation and novelty.
Further, the present invention pays attention to medicinal and edible Chinese medicine raw material active component, active principle group to booster action that health played.Pay attention to the contained trace element of medicine and food raw materials to the treatment booster action that disease played.Its particle diameter of this product is distributed in 10 nanometers--and between 10 microns, bioavilability can be greatly improved.The present invention has substantive technological break-through in confectionery industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and sugared functional candy and technology of preparing thereof in a kind of reason are provided.
Purpose of the present invention is achieved through the following technical solutions:
Sugared functional candy and technology of preparing thereof in a kind of reason, wherein: this functional candy raw materials of effective components and weight proportion---
9 parts of gensengs, 9 parts of the bighead atractylodes rhizomes, 9 parts of honey-fried licorice roots, 9 parts of rhizoma zingiberis.
Sugared functional candy and technology of preparing thereof in a kind of reason, wherein: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
Sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason wherein, contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
Sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason, wherein: described end product is: used sweetener is that Abbas is sweet, in the maltose, xylitol, D-sorbite, mannitol, galactitol, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
Further, sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason, wherein: described end product is: hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugar.
Further, sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason, wherein: used auxiliary material is an emulsifying agent, blowing agent, activating agent, cosurfactant, antioxidant, help emulsion, dispersant, spices and essence, hardening agent, condensed milk, milk powder, chocolate powder, cream, hydrogenated oil and fat, cocoa butter, menthol, albumin and starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three palmitic acids, three laurate, in three oleic acid etc., the glyceride of LCFA), glyceride is (as glycerin monostearate, contain list, two, the synthetic glyceride of triglyceride), steroidal class (cholesterol etc.), polyethylene glycol, wax class (microcrystalline wax, whale ester type waxes), red blood cell, in the montmorillonite etc. one or more.
Again further, sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason, wherein: used colloid is one or more in agar, carragheen, gelatin, starch, pectin, konjac glucomannan, algin, gellan gum, xanthans, locust bean gum, hydroxypropul starch, Sodium Polyacrylate, the tamarind seed polysaccharide glue etc.
Sugared functional candy and technology of preparing thereof in a kind of reason is characterized in that may further comprise the steps:
Step 1: get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.
Step 2: get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.
Step 4: get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.
Step 5: get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.
Step 6: get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
Sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason, wherein: above-mentioned employed extraction, technology of preparing and method, be not only described technology of preparing and method, as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
Further, sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason, wherein: key point of the present invention is: 1, the effect requirement that will reach according to traditional Chinese medical science global theory and functional candy, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with sweetener, in colloid and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional candy.2, be that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in: the present invention is by sugared functional candy in " utilization nano-carrier GC-MS research and development functional food " theoretical research and development reason of this original creation.Do not see open report at home in the document, have one-level novelty assessment report and patent data library searching to show substantive progressive and novelty and novelty of the present invention.
Further, the present invention pays attention to monomer, active component and active principle group to booster action that health played.Pay attention to the contained trace element of raw material to the treatment booster action that disease played.Its particle diameter of the raw material of this preparation of product is distributed in 10 nanometers--and between-10 microns, can promote the human body fast Absorption, product has target and distributes extensively, delays the strong characteristics of controlled release properties.The present invention has found out the key point that traditional Chinese and western medicine theory and functional candy combine, the present invention is theoretical and that adopt, and technology of preparing very just is harmonious, both embodied compatibility preparation, embodied the importance of nanometer technology again at aspects such as enhanced feature candy added values with traditional Chinese medical science organic conception and doctor trained in Western medicine pharmacology guiding function candy.
Product preparation process route of the present invention is: at first, get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.Get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.Get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
Sugared functional candy and technology of preparing thereof in a kind of reason, its special feature is: this functional candy raw materials of effective components and weight proportion---
9 parts of gensengs, 9 parts of the bighead atractylodes rhizomes, 9 parts of honey-fried licorice roots, 9 parts of rhizoma zingiberis.
Sugared functional candy and technology of preparing thereof in a kind of reason, wherein: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
See that further sugared functional candy and technology of preparing thereof in above-mentioned a kind of reason wherein, contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
Production method of the present invention may further comprise the steps: at first, get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.Get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.Get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
" embodiment one "
Press the following raw material of preceding method preparation:
Medicinal extract, solid lipid nano granule, nano-emulsion.
It makes the raw materials of effective components composition---
9 parts of gensengs, 9 parts of the bighead atractylodes rhizomes, 9 parts of honey-fried licorice roots, 9 parts of rhizoma zingiberis.
Its manufacture process is as follows:
In the toilet that meets the GMP standard, medicinal extract, solid lipid nano granule, nano-emulsion are mixed in 4: 3: 3 ratios, get that 35% above-mentioned raw materials that mixes, 30% pure water, 2% glycyrrhizin, 5% Abbas are sweet, 2% stevioside fully mixes 140 ℃ of temperature infusions, add 4% hydroxyl isomaltulose, 4% maltitol, 2% gelatin, 15% starch, 1% essence and flavoring agent again, fully stir miscible even, press the conventional preparation technology of pan work, prepare sugared functional sugar-free candy in the reason.
" embodiment two "
Press the following raw material of preceding method preparation:
Water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid.
It makes the raw materials of effective components composition---
9 parts of gensengs, 9 parts of the bighead atractylodes rhizomes, 9 parts of honey-fried licorice roots, 9 parts of rhizoma zingiberis.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid was in 5: 1: 1: ratio was mixed in 2: 1, get 30% pure water, 1% glycyrrhizin, 5% Abbas is sweet, 2% stevioside fully mixes 80-140 ℃ of temperature infusion, add 2% gelatin again, 20% starch, fully stir miscible even, when being cooled to 40-60 ℃ again with 39% above-mentioned raw materials that mixes, 1% essence and flavoring agent adds, stir, press the conventional preparation technology of pan work, prepare sugared functional hard candy in the reason.
" embodiment three "
Press the following raw material of preceding method preparation:
Medicinal extract nano powder, nano liposomes, freeze-dried powder, dry powder.
It makes the raw materials of effective components composition---
9 parts of gensengs, 9 parts of the bighead atractylodes rhizomes, 9 parts of honey-fried licorice roots, 9 parts of rhizoma zingiberis.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with medicinal extract nano powder, nano liposomes, freeze-dried powder, dry powder in 4: 2: 2: 2 ratios are mixed, get that 40% above-mentioned raw materials that mixes, 10% sucrose, 20% xylitol, 2% glycyrrhizin, 5% Abbas are sweet, 2% stevioside, 20% milk powder, 1% essence and flavoring agent, fully mix, press the conventional preparation technology of pulverized sugar goods, prepare sugared functional pulverized sugar in the reason.
" embodiment four "
Press the following raw material of preceding method preparation:
Water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid.
It makes the raw materials of effective components composition---
9 parts of gensengs, 9 parts of the bighead atractylodes rhizomes, 9 parts of honey-fried licorice roots, 9 parts of rhizoma zingiberis.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid in 5: 1: 1: ratio was mixed in 2: 1, get that 39% above-mentioned raw materials that mixes, 1% essence and flavoring agent, 7% agar, 3% carragheen, 5% gelatin, 5% pectin, 10% konjac glucomannan, 1% glycyrrhizin, 5% Abbas are sweet, 2% stevioside, 2% xylitol, 20% maltitol, press the conventional preparation technology of jelly goods, prepare sugared functional jelly in the reason.
Claims (10)
1. sugared functional candy and technology of preparing thereof in the reason is characterized in that: this functional candy raw materials of effective components and weight proportion---
9 parts of gensengs, 9 parts of the bighead atractylodes rhizomes, 9 parts of honey-fried licorice roots, 9 parts of rhizoma zingiberis.
2. sugared functional candy and technology of preparing thereof in a kind of reason according to claim 1, it is characterized in that: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
3. according to sugared functional candy and technology of preparing thereof in claim 1, the 2 described a kind of reasons, it is characterized in that: contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
4. according to sugared functional candy and technology of preparing thereof in claim 1 or the 2 or 3 any described a kind of reasons, it is characterized in that: used sweetener is that Abbas is sweet, in the maltose, xylitol, D-sorbite, mannitol, galactitol, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
5. according to sugared functional candy and technology of preparing thereof in claim 1 or 2 or the 3 or 4 any described a kind of reasons, it is characterized in that: described end product is: hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugar.
6. according to sugared functional candy and technology of preparing thereof in claim 1 or 2 or 3 or the 4 or 5 any described a kind of reasons, it is characterized in that: used auxiliary material is an emulsifying agent, blowing agent, activating agent, cosurfactant, antioxidant, help emulsion, dispersant, spices and essence, hardening agent, condensed milk, milk powder, chocolate powder, cream, hydrogenated oil and fat, cocoa butter, menthol, albumin and starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three palmitic acids, three laurate, in three oleic acid etc., the glyceride of LCFA), glyceride is (as glycerin monostearate, contain list, two, the synthetic glyceride of triglyceride), steroidal class (cholesterol etc.), polyethylene glycol, wax class (microcrystalline wax, whale ester type waxes), red blood cell, in the montmorillonite etc. one or more.
7. according to sugared functional candy and technology of preparing thereof in claim 1 or 2 or 3 or 4 or the 5 or 6 described a kind of reasons, it is characterized in that: used colloid is one or more in agar, carragheen, gelatin, starch, pectin, konjac glucomannan, algin, gellan gum, xanthans, locust bean gum, hydroxypropul starch, Sodium Polyacrylate, the tamarind seed polysaccharide glue etc.
8. sugared functional candy and technology of preparing thereof in the reason is characterized in that may further comprise the steps:
Step 1: get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.
Step 2: get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.
Step 4: get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.
Step 5: get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.
Step 6: get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
9. sugared functional candy and technology of preparing thereof in a kind of reason according to claim 8; it is characterized in that: above-mentioned employed extraction, technology of preparing and method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
10. sugared functional candy and technology of preparing thereof in a kind of reason according to claim 9, it is characterized in that: key point of the present invention is: 1, the effect requirement that will reach according to traditional Chinese medical science global theory and functional candy, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with sweetener, in colloid and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional candy.2, be that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
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