CN102100292A - Functional confectionary with scutellaria baicalensis sugar and preparation technology thereof - Google Patents
Functional confectionary with scutellaria baicalensis sugar and preparation technology thereof Download PDFInfo
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Abstract
The invention relates to functional confectionary with scutellaria baicalensis sugar and a preparation technology thereof. The functional confectionary comprises the following active ingredients in parts by weight: 9 parts of scutellaria baicalensis, 9 parts of paeonia lactiflora, 6 parts of liquorice and 4 parts of Chinese dates. The preparation process comprises the steps of raw material grinding, extraction in aqueous alcohol, supersonic spray drying, nanoscale grinding, high-pressure homogenizing, freeze drying and the like. The functional confectionary has the functions of adjusting the immunity, relieving spasm and pain, protecting the liver and reducing the enzyme level, resisting carcinogenic substances, resisting viruses, bringing down fever, calming the mind, resisting influenza, inflammation and diarrhea, etc. The functional confectionary can be selectively prepared into different varieties of confectionary according to the requirements of the preparation process of the confectionary.
Description
Technical field
The present invention relates to the functional candy of a kind of root of large-flowered skullcap sugar, the invention still further relates to this root of large-flowered skullcap functional candy of sugar and technology of preparing thereof.
Background technology
Functional candy has the third-largest function of regulating human physiological functions, and it can play an important role at aspects such as promoting health, break through inferior health, prevent disease.Functional candy can promote health, have certain regulates the specific physiological function of human body, can not produce bad reaction to human body.
This product is to carry out formula combination under instruction of Chinese Medicine theory, and root of large-flowered skullcap soup comes from the treatise on Febrile Diseases of Han dynasty Zhang Zhongjing.The side is made up of the root of large-flowered skullcap, Chinese herbaceous peony, Radix Glycyrrhizae, date.The root of large-flowered skullcap is monarch in the side, with the interior heat of Xie Shaoyang, and root of large-flowered skullcap bitter cold, clearing away heat to stop diarrhea; Chinese herbaceous peony is a minister, the field headquarters gas with the exterior heat of separating the sun, and sour flavor having the property of astringing is also; The acid of Chinese herbaceous peony flavor, the astringe yin relieving pain by regulating nutrient QI; Radix Glycyrrhizae is assistant, and date is for making, with the weak of auxilliary stomach in delaying also.Radix Glycyrrhizae, date and middle emergency.All medicines share, and play clearing away heat to stop diarrhea altogether, the merit of relieving pain by regulating middle-JIAO.Bitter with heavily fortified point also.Cure mainly and have loose bowels or dysentery, body heat is aversion to cold not, stomachache, bitter taste in the mouth and dry throat, tongue fur Huang, wiry and frequent pulse.Modern clinical be usually used in treating dysentery, acute gastritis, enteritis, baby diarrhea, alimentary canal type virus flu etc.
Each family is discussed: " Treatise on Febrile Disease with Notes ": empty and unreal person, and bitter with heavily fortified point, sour flavor having the property of astringing, the root of large-flowered skullcap, the picric acid of Chinese herbaceous peony are held back the gas of stomach with heavily fortified point; Weak and not enough person, sweet mending it, Radix Glycyrrhizae, date sweet with a little less than mending solid stomach." collection of prescriptions with notes ": the root of large-flowered skullcap is with eliminating heat pathogen, and lunar with sweet, Chinese herbaceous peony, date and its, gas and then outer card are explained by oneself in making." typhoid fever string of pearls collection ": excessive in the hot gas, the hardship of the root of large-flowered skullcap, can be clearly it; Stomach gets hot and solid, the acid of Chinese herbaceous peony, and Radix Glycyrrhizae sweet can be consolidated it." medical center bun want ": the sun is hot and suffocating, then go up bright lung and lose large intestine down, so with the root of large-flowered skullcap with heat except that the lung intestines; Few sun is hot and suffocating, wood subjugates earth then, so with Chinese herbaceous peony with reducing the minister-fire with lunar; Cold excessive in interior, control with sweet heat, thus cold with Radix Glycyrrhizae, date to control, and control oneself profit with the angry blood of thick taste.
The effect of root of large-flowered skullcap decoction of medicinal ingredients reason: root of large-flowered skullcap soup has antibacterial, anti-inflammatory and immunological regulation, relieving spasm and pain, protecting liver, lowering enzymes, anti-promoting, and antiviral, bring down a fever and calm pharmacodynamic action.That baicalein in the root of large-flowered skullcap has is anti-oxidant, antibiotic, antiviral, the effect of antiallergy, step-down, diuresis, cholagogic.Root of large-flowered skullcap soup and the single root of large-flowered skullcap, Chinese herbaceous peony, Radix Glycyrrhizae and date all have the obvious anti-inflammatory and anti effect.Root of large-flowered skullcap soup and simple thereof also have certain inhibitory action to rat assist agent arthritis.The external metabolism through gut flora of root of large-flowered skullcap soup main component studies show that, main component scutelloside (BG) in the root of large-flowered skullcap soup, wogonoside (WG), qroxylin A glycosides (OG) (deriving from the root of large-flowered skullcap), Paeoniflorin (PF) (deriving from Chinese herbaceous peony) and liquiritin (LG), glycyrrhizic acid (GL), isoliquiritin (ILG) (deriving from Radix Glycyrrhizae) in external metabolism, is separately converted to corresponding metabolite baicalein (B) through gut flora, wogonin (W), qroxylin A (O), the plain I (PM-I) of Paeoniflorin metabolism, glycyrrhizin (L), enoxolone (GA) and isoliquiritigenin (IL) etc.Scutellaria decoction for treating ulcer colitis (damp-heat type) clinical cure rate is 50%.Total effective rate is 86.67%.Control group clinical cure rate 33.33%, total effective rate are 76.67%.Root of large-flowered skullcap soup has significant analgesia role.Histopathology shows: root of large-flowered skullcap soup has antiinflammatory action, can repair pathological tissues, can protect intestinal mucosa.Antibacterial tests studies confirm that, root of large-flowered skullcap soup and enteron aisle bacterium metabolite thereof all have external bacteriostasis to the 50 strain pathogenic entero becterias of being tested, but root of large-flowered skullcap soup enteron aisle bacterium metabolite obviously is better than root of large-flowered skullcap soup to the vitro antibacterial activity of salmonella, shigella dysenteriae and proteus, staphylococcus aureus, Pseudomonas aeruginosa and colibacillary bacteriostasis is had the trend of enhancing.Root of large-flowered skullcap soup, the root of large-flowered skullcap have synergy to pentobarbital sodium sub-threshold lull dosage, can obviously improve the sleep number of animals, the effect of behaving with composure.
Acute toxicity: root of large-flowered skullcap soup maximal tolerance dose is 102g/kg.102 times of quite clinical recommended drug amount.Subacute toxicity: with 80,40g/kg root of large-flowered skullcap soup gavaged rat 30 continuously, to body weight, routine blood test.Liver, renal function, main organs exponential sum pathological tissue etc. there is no obvious influence.
The present invention is by " utilization nano-carrier GC-MS research and development functional food " the functional candy of the theoretical research and development of this original creation root of large-flowered skullcap sugar.Do not see open report at home in the document, its theoretical and technology of preparing has the novelty of essence and breakthrough.The present invention has integrated each about industry advantage and up-to-date nanometer technology of preparing, be to be the overall strategy tactical thinking with the organic conception of theory of traditional Chinese medical science and the collaborative idea of paying attention to medicinal and edible Chinese medicine, in conjunction with modern western pharmacology scheduling theory, pay attention to the effect of certified effective ingredient in Chinese, monomer, pay attention to using different nano-carriers to prepare new effect and the high added value that functional candy brings supplemental treatment.Society and remarkable in economical benefits.
Preparation of product technology of the present invention is the set of multiple technology of preparing, has adopted pure water extractive technique, nano powder preparation technology, supersonic speed spray drying technology, Freeze Drying Technique, high pressure homogenization technique, beta-cyclodextrin inclusion compound technology etc. respectively.Product of the present invention and technology of preparing have significant substantial innovation and novelty.
Further, the present invention pays attention to medicinal and edible Chinese medicine raw material active component, active principle group to booster action that health played.Pay attention to the contained trace element of medicine and food raw materials to the treatment booster action that disease played.Its particle diameter of this product is distributed between 10 nanometers-10 micron, and bioavilability can be greatly improved.The present invention has substantive technological break-through in confectionery industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof are provided.
Purpose of the present invention is achieved through the following technical solutions:
A kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: this functional candy raw materials of effective components and weight proportion---
9 parts of the roots of large-flowered skullcap, 9 parts of Chinese herbaceous peonies, 6 parts in Radix Glycyrrhizae, 4 parts in date.
A kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
The above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof wherein, contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
The above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: described end product is: used sweetener is that Abbas is sweet, in the maltose, xylitol, D-sorbite, mannitol, galactitol, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
Further, the above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: described end product is: hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugar.
Further, the above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: used auxiliary material is an emulsifying agent, blowing agent, activating agent, cosurfactant, antioxidant, help emulsion, dispersant, spices and essence, hardening agent, condensed milk, milk powder, chocolate powder, cream, hydrogenated oil and fat, cocoa butter, menthol, albumin and starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three palmitic acids, three laurate, in three oleic acid etc., the glyceride of LCFA), glyceride is (as glycerin monostearate, contain list, two, the synthetic glyceride of triglyceride), steroidal class (cholesterol etc.), polyethylene glycol, wax class (microcrystalline wax, whale ester type waxes), red blood cell, in the montmorillonite etc. one or more.
Again further, the above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: used colloid is one or more in agar, carragheen, gelatin, starch, pectin, konjac glucomannan, algin, gellan gum, xanthans, locust bean gum, hydroxypropul starch, Sodium Polyacrylate, the tamarind seed polysaccharide glue etc.
A kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof is characterized in that may further comprise the steps:
Step 1: get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.
Step 2: get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.
Step 4: get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.
Step 5: get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.
Step 6: get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
The above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: above-mentioned employed extraction, technology of preparing and method, be not only described technology of preparing and method, as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
Further, the above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: key point of the present invention is: 1, the effect requirement that will reach according to traditional Chinese medical science global theory and functional candy, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with sweetener, in colloid and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional candy.2, be that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in: the present invention is by " utilization nano-carrier GC-MS research and development functional food " the functional candy of the theoretical research and development of this original creation root of large-flowered skullcap sugar.Do not see open report at home in the document, have one-level novelty assessment report and patent data library searching to show substantive progressive and novelty and novelty of the present invention.
Further, the present invention pays attention to monomer, active component and active principle group to booster action that health played.Pay attention to the contained trace element of raw material to the treatment booster action that disease played.Its particle diameter of the raw material of this preparation of product is distributed in 10 nanometers--and between 10 microns, can promote the human body fast Absorption, product has target and distributes extensively, delays the strong characteristics of controlled release properties.The present invention has found out the key point that traditional Chinese and western medicine theory and functional candy combine, the present invention is theoretical and that adopt, and technology of preparing very just is harmonious, both embodied compatibility preparation, embodied the importance of nanometer technology again at aspects such as enhanced feature candy added values with traditional Chinese medical science organic conception and doctor trained in Western medicine pharmacology guiding function candy.
Product preparation process route of the present invention is: at first, get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.Get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38-40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.Get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
A kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, its special feature is: this functional candy raw materials of effective components and weight proportion---
9 parts of the roots of large-flowered skullcap, 9 parts of Chinese herbaceous peonies, 6 parts in Radix Glycyrrhizae, 4 parts in date.
A kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof, wherein: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
See that further the above-mentioned a kind of root of large-flowered skullcap functional candy of sugar and technology of preparing thereof wherein, contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
Production method of the present invention may further comprise the steps: at first, get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.Get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10--1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.Get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
" embodiment one "
Press the following raw material of preceding method preparation:
Medicinal extract, solid lipid nano granule, nano-emulsion.
It makes the raw materials of effective components composition---
9 parts of the roots of large-flowered skullcap, 9 parts of Chinese herbaceous peonies, 6 parts in Radix Glycyrrhizae, 4 parts in date.
Its manufacture process is as follows:
In the toilet that meets the GMP standard, medicinal extract, solid lipid nano granule, nano-emulsion are mixed in 4: 3: 3 ratios, get that 35% above-mentioned raw materials that mixes, 30% pure water, 2% glycyrrhizin, 5% Abbas are sweet, 2% stevioside fully mixes 140 ℃ of temperature infusions, add 4% hydroxyl isomaltulose, 4% maltitol, 2% gelatin, 15% starch, 1% essence and flavoring agent again, fully stir miscible even, press the conventional preparation technology of pan work, prepare root of large-flowered skullcap sugar functional sugar-free candy.
" embodiment two "
Press the following raw material of preceding method preparation:
Water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid.
It makes the raw materials of effective components composition---
9 parts of the roots of large-flowered skullcap, 9 parts of Chinese herbaceous peonies, 6 parts in Radix Glycyrrhizae, 4 parts in date.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid was in 5: 1: 1: ratio was mixed in 2: 1, get 30% pure water, 1% glycyrrhizin, 5% Abbas is sweet, 2% stevioside fully mixes 80-140 ℃ of temperature infusion, add 2% gelatin again, 20% starch, fully stir miscible even, when being cooled to 40-60 ℃ again with 39% above-mentioned raw materials that mixes, 1% essence and flavoring agent adds, stir, press the conventional preparation technology of pan work, prepare the functional hard candy of root of large-flowered skullcap sugar.
" embodiment three "
Press the following raw material of preceding method preparation:
Medicinal extract nano powder, nano liposomes, freeze-dried powder, dry powder.
It makes the raw materials of effective components composition---
9 parts of the roots of large-flowered skullcap, 9 parts of Chinese herbaceous peonies, 6 parts in Radix Glycyrrhizae, 4 parts in date.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with medicinal extract nano powder, nano liposomes, freeze-dried powder, dry powder in 4: 2: 2: 2 ratios are mixed, get that 40% above-mentioned raw materials that mixes, 10% sucrose, 20% xylitol, 2% glycyrrhizin, 5% Abbas are sweet, 2% stevioside, 20% milk powder, 1% essence and flavoring agent, fully mix, press the conventional preparation technology of pulverized sugar goods, prepare the functional pulverized sugar of root of large-flowered skullcap sugar.
" embodiment four "
Press the following raw material of preceding method preparation:
Water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid.
It makes the raw materials of effective components composition---
9 parts of the roots of large-flowered skullcap, 9 parts of Chinese herbaceous peonies, 6 parts in Radix Glycyrrhizae, 4 parts in date.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid in 5: 1: 1: ratio was mixed in 2: 1, get that 39% above-mentioned raw materials that mixes, 1% essence and flavoring agent, 7% agar, 3% carragheen, 5% gelatin, 5% pectin, 10% konjac glucomannan, 1% glycyrrhizin, 5% Abbas are sweet, 2% stevioside, 2% xylitol, 20% maltitol, press the conventional preparation technology of jelly goods, prepare the functional jelly of root of large-flowered skullcap sugar.
Claims (10)
1. the root of large-flowered skullcap functional candy of sugar and technology of preparing thereof is characterized in that: this functional candy raw materials of effective components and weight proportion---
9 parts of the roots of large-flowered skullcap, 9 parts of Chinese herbaceous peonies, 6 parts in Radix Glycyrrhizae, 4 parts in date.
2. a kind of root of large-flowered skullcap functional candy of sugar according to claim 1 and technology of preparing thereof, it is characterized in that: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
3. according to claim 1, the 2 described a kind of roots of large-flowered skullcap functional candy of sugar and technologies of preparing thereof, it is characterized in that: contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
4. according to claim 1 or the 2 or 3 any described a kind of root of large-flowered skullcap functional candy of sugar and technologies of preparing thereof, it is characterized in that: used sweetener is that Abbas is sweet, in the maltose, xylitol, D-sorbite, mannitol, galactitol, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
5. according to claim 1 or 2 or the 3 or 4 any described a kind of root of large-flowered skullcap functional candy of sugar and technologies of preparing thereof, it is characterized in that: described end product is: hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugar.
6. according to claim 1 or 2 or 3 or the 4 or 5 any described a kind of root of large-flowered skullcap functional candy of sugar and technologies of preparing thereof, it is characterized in that: used auxiliary material is an emulsifying agent, blowing agent, activating agent, cosurfactant, antioxidant, help emulsion, dispersant, spices and essence, hardening agent, condensed milk, milk powder, chocolate powder, cream, hydrogenated oil and fat, cocoa butter, menthol, albumin and starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three palmitic acids, three laurate, in three oleic acid etc., the glyceride of LCFA), glyceride is (as glycerin monostearate, contain list, two, the synthetic glyceride of triglyceride), steroidal class (cholesterol etc.), polyethylene glycol, wax class (microcrystalline wax, whale ester type waxes), red blood cell, in the montmorillonite etc. one or more.
7. according to claim 1 or 2 or 3 or 4 or the 5 or 6 described a kind of root of large-flowered skullcap functional candy of sugar and technologies of preparing thereof, it is characterized in that: used colloid is one or more in agar, carragheen, gelatin, starch, pectin, konjac glucomannan, algin, gellan gum, xanthans, locust bean gum, hydroxypropul starch, Sodium Polyacrylate, the tamarind seed polysaccharide glue etc.
8. the root of large-flowered skullcap functional candy of sugar and technology of preparing thereof is characterized in that may further comprise the steps:
Step 1: get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.
Step 2: get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.
Step 4: get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.
Step 5: get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.
Step 6: get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
9. a kind of root of large-flowered skullcap functional candy of sugar according to claim 8 and technology of preparing thereof; it is characterized in that: above-mentioned employed extraction, technology of preparing and method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
10. a kind of root of large-flowered skullcap functional candy of sugar according to claim 9 and technology of preparing thereof, it is characterized in that: key point of the present invention is: 1, the effect requirement that will reach according to traditional Chinese medical science global theory and functional candy, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with sweetener, in colloid and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional candy.2, be that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356832A (en) * | 2011-09-30 | 2012-02-22 | 芜湖蜂联有限公司 | Honey jelly |
| CN103564129A (en) * | 2013-11-05 | 2014-02-12 | 黎秋萍 | Herbaceous plant lactation-promoting candy |
| CN105613897A (en) * | 2015-12-17 | 2016-06-01 | 安徽金诺食品有限公司 | Liver protecting health-care Switzerland sugar |
| CN108451949A (en) * | 2018-06-20 | 2018-08-28 | 山东省分析测试中心 | Paeoniflorin is metabolized element I and is preparing the application in treating colitis drug |
| CN110122646A (en) * | 2019-06-05 | 2019-08-16 | 江苏师范大学 | A kind of gingko polysaccharide the confectionery industry and preparation method thereof |
| CN111773295A (en) * | 2020-08-26 | 2020-10-16 | 广西中医药大学第一附属医院 | Traditional Chinese medicine composition for treating arthritis, sea salt bag and preparation method and application thereof |
| CN113181252A (en) * | 2021-04-26 | 2021-07-30 | 广东省农业科学院动物卫生研究所 | Application of scutellaria decoction in preparing medicine for treating diarrhea and improving intestinal function |
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2009
- 2009-12-17 CN CN200910263191XA patent/CN102100292A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356832A (en) * | 2011-09-30 | 2012-02-22 | 芜湖蜂联有限公司 | Honey jelly |
| CN103564129A (en) * | 2013-11-05 | 2014-02-12 | 黎秋萍 | Herbaceous plant lactation-promoting candy |
| CN105613897A (en) * | 2015-12-17 | 2016-06-01 | 安徽金诺食品有限公司 | Liver protecting health-care Switzerland sugar |
| CN108451949A (en) * | 2018-06-20 | 2018-08-28 | 山东省分析测试中心 | Paeoniflorin is metabolized element I and is preparing the application in treating colitis drug |
| CN108451949B (en) * | 2018-06-20 | 2021-03-19 | 山东省分析测试中心 | Application of paeoniflorin metabolite I in preparation of colitis treatment drug |
| CN110122646A (en) * | 2019-06-05 | 2019-08-16 | 江苏师范大学 | A kind of gingko polysaccharide the confectionery industry and preparation method thereof |
| CN111773295A (en) * | 2020-08-26 | 2020-10-16 | 广西中医药大学第一附属医院 | Traditional Chinese medicine composition for treating arthritis, sea salt bag and preparation method and application thereof |
| CN113181252A (en) * | 2021-04-26 | 2021-07-30 | 广东省农业科学院动物卫生研究所 | Application of scutellaria decoction in preparing medicine for treating diarrhea and improving intestinal function |
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Application publication date: 20110622 |