CN102100288A - Liujunzi functional confectionary and preparation technology thereof - Google Patents
Liujunzi functional confectionary and preparation technology thereof Download PDFInfo
- Publication number
- CN102100288A CN102100288A CN2009102631534A CN200910263153A CN102100288A CN 102100288 A CN102100288 A CN 102100288A CN 2009102631534 A CN2009102631534 A CN 2009102631534A CN 200910263153 A CN200910263153 A CN 200910263153A CN 102100288 A CN102100288 A CN 102100288A
- Authority
- CN
- China
- Prior art keywords
- candy
- nano
- preparing
- technology
- functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to Liujunzi functional confectionary and a preparation technology thereof. The functional confectionary comprises the following active ingredients in parts by weight: 15 parts of ginseng, 12 parts of atractylodes macrocephala koidz, 12 parts of pinellia tuber, 9 parts of poria, 9 parts of dried orange peel and 6 parts of liquorice. The preparation process comprises the steps of raw material grinding, extraction in aqueous alcohol, supersonic spray drying, nanoscale grinding, high-pressure homogenizing, freeze drying and the like. The functional confectionary has the function of adjusting the immunity. The functional confectionary can be selectively prepared into different varieties of confectionary according to the requirements of the preparation process of the confectionary.
Description
Technical field
The present invention relates to the functional candy of a kind of six gentleman, the invention still further relates to functional candy of this six gentleman and technology of preparing thereof.
Background technology
Functional candy has the third-largest function of regulating human physiological functions, and it can play an important role at aspects such as promoting health, break through inferior health, prevent disease.Functional candy can promote health, have certain regulates the specific physiological function of human body, can not produce bad reaction to human body.
This product is to carry out formula combination under instruction of Chinese Medicine theory, and Liujunzi Tang comes from Song's " married woman's good recipe is annotated in the school ".It is also on the books that " medical science main story " volume three draws " office side ".Genseng reinforces vital energy and is monarch in the side, bighead atractylodes rhizome strengthening the spleen and replenishing qi, and tuber of pinellia invigorating the spleen to dry is ministerial drug altogether, and assistant is with Poria cocos, dried orange peel invigorating spleen to remove dampness, and the Radix Glycyrrhizae coordinating the drug actions of a prescription is for making.All medicines match, monarch play altogether reinforce vital energy, the effect of beneficial gas bowl spares, strengthening spleen and nourishing stomach, promoting qi circulation, resolving food retention, eliminating dampness eliminating phlegm, regulating QI and lowering the adverseness, unobstructed enteron aisle.Prescription cures mainly weakness of the spleen and the stomach, and circulation of vital energy in the wrong direction phlegm stagnates.Anorexia and loose stool brings up phlegm when one coughs, and look rare is clearly in vain, and the ruffian of losing heart is full, the evil of vomitting hiccup, acid regurgitation, sallow complexion, four limbs burnout; And insufficiency of the spleen expansion, outer ulcer is burst for a long time, the few stomach weak person of food; Anal fistula with the passing of time, the arteries and veins number is and puckery, diet day subtracts, limbs are more tired, the card of all deficiencies; Asthenia gastropyrexia, aphthae; Middle gas discord, band down constantly.
Liujunzi Tang mainly contains the adjusting gastrointestinal motility, anti-gastric-ulcer, and anti-gastric mucosa injure is regulated effects such as immunity.Drink Liujunzi Tang and all can significantly suppress pathologies such as gastric mucosa oedema, hyperemia and hemostasis, reduce inflammation cellular infiltration and glandular hyperplasia sexually revise, and can also obviously reduce the generation example number of intestinal metaplasia.Clinical research shows that Liujunzi Tang has the effect of regulating immunologic function.Crossing the virtuous govern-education in limit awards, " Liujunzi Tang " of being praised highly in Japan derives from TCM Document, they cross comparative study to this specialize, chosen 68 examples and accepted to take after the chemotherapy patient of " Liujunzi Tang " and be the treatment group, with 68 examples of not taking is control group, comparing result finds, treatment group generation constipation 7 examples, incidence 10.29% arranged, control group generation constipation has 18 examples, incidence 26.47%, obviously, Liujunzi Tang has the effect of constipation after the prevention chemotherapy really.
The present invention is by " utilization nano-carrier GC-MS research and development functional food " the functional candy of this original creation theoretical research and development six gentleman.Do not see open report at home in the document, its theoretical and technology of preparing has the novelty of essence and breakthrough.The present invention has integrated each about industry advantage and up-to-date nanometer technology of preparing, be to be the overall strategy tactical thinking with the organic conception of theory of traditional Chinese medical science and the collaborative idea of paying attention to medicinal and edible Chinese medicine, in conjunction with modern western pharmacology scheduling theory, pay attention to the effect of certified effective ingredient in Chinese, monomer, pay attention to using different nano-carriers to prepare new effect and the high added value that functional candy brings supplemental treatment.Society and remarkable in economical benefits.
Preparation of product technology of the present invention is the set of multiple technology of preparing, has adopted pure water extractive technique, nano powder preparation technology, supersonic speed spray drying technology, Freeze Drying Technique, high pressure homogenization technique, beta-cyclodextrin inclusion compound technology etc. respectively.Product of the present invention and technology of preparing have significant substantial innovation and novelty.
Further, the present invention pays attention to medicinal and edible Chinese medicine raw material active component, active principle group to booster action that health played.Pay attention to the contained trace element of medicine and food raw materials to the treatment booster action that disease played.Its particle diameter of this product is distributed in 10 nanometers--and between 10 microns, bioavilability can be greatly improved.The present invention has substantive technological break-through in confectionery industry.
Summary of the invention:
Purpose of the present invention is exactly in order to solve the above-mentioned problems in the prior art, and functional candy of a kind of six gentleman and technology of preparing thereof are provided.
Purpose of the present invention is achieved through the following technical solutions:
Functional candy of a kind of six gentleman and technology of preparing thereof, wherein: this functional candy raw materials of effective components and weight proportion---
15 parts of gensengs, 12 parts of the bighead atractylodes rhizomes, 12 parts of the tuber of pinellia, 9 parts in Poria cocos, 9 parts of dried orange peels, 6 parts in Radix Glycyrrhizae.
Functional candy of a kind of six gentleman and technology of preparing thereof, wherein: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
Above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof wherein, contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
Above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof, wherein: described end product is: used sweetener is that Abbas is sweet, in the maltose, xylitol, D-sorbite, mannitol, galactitol, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
Further, above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof, wherein: described end product is: hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugar.
Further, above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof, wherein: used auxiliary material is an emulsifying agent, blowing agent, activating agent, cosurfactant, antioxidant, help emulsion, dispersant, spices and essence, hardening agent, condensed milk, milk powder, chocolate powder, cream, hydrogenated oil and fat, cocoa butter, menthol, albumin and starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three palmitic acids, three laurate, in three oleic acid etc., the glyceride of LCFA), glyceride is (as glycerin monostearate, contain list, two, the synthetic glyceride of triglyceride), steroidal class (cholesterol etc.), polyethylene glycol, wax class (microcrystalline wax, whale ester type waxes), red blood cell, in the montmorillonite etc. one or more.
Again further, above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof, wherein: used colloid is one or more in agar, carragheen, gelatin, starch, pectin, konjac glucomannan, algin, gellan gum, xanthans, locust bean gum, hydroxypropul starch, Sodium Polyacrylate, the tamarind seed polysaccharide glue etc.
Functional candy of a kind of six gentleman and technology of preparing thereof is characterized in that may further comprise the steps:
Step 1: get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.
Step 2: get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.
Step 4: get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.
Step 5: get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.
Step 6: get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
Above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof, wherein: above-mentioned employed extraction, technology of preparing and method, be not only described technology of preparing and method, as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
Further, above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof, wherein: key point of the present invention is: 1, the effect requirement that will reach according to traditional Chinese medical science global theory and functional candy, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with sweetener, in colloid and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional candy.2, be that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
The outstanding substantive distinguishing features and the obvious improvement of technical solution of the present invention is mainly reflected in: the present invention is by " utilization nano-carrier GC-MS research and development functional food " the functional candy of this original creation theoretical research and development six gentleman.Do not see open report at home in the document, have one-level novelty assessment report and patent data library searching to show substantive progressive and novelty and novelty of the present invention.
Further, the present invention pays attention to monomer, active component and active principle group to booster action that health played.Pay attention to the contained trace element of raw material to the treatment booster action that disease played.Its particle diameter of the raw material of this preparation of product is distributed between 10 microns of 10 nanometers----, can promote the human body fast Absorption, and product has target wide, the slow strong characteristics of controlled release properties that distribute.The present invention has found out the key point that traditional Chinese and western medicine theory and functional candy combine, the present invention is theoretical and that adopt, and technology of preparing very just is harmonious, both embodied compatibility preparation, embodied the importance of nanometer technology again at aspects such as enhanced feature candy added values with traditional Chinese medical science organic conception and doctor trained in Western medicine pharmacology guiding function candy.
Product preparation process route of the present invention is: at first, get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.Get 30%-90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.Get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
Purpose of the present invention, advantage and characteristics will make an explanation by the non-limitative illustration of following preferred embodiment.These embodiment only are the prominent examples of using technical solution of the present invention, and all technical schemes of taking to be equal to replacement or equivalent transformation and forming all drop within the scope of protection of present invention.
The specific embodiment
Functional candy of a kind of six gentleman and technology of preparing thereof, its special feature is: this functional candy raw materials of effective components and weight proportion---
15 parts of gensengs, 12 parts of the bighead atractylodes rhizomes, 12 parts of the tuber of pinellia, 9 parts in Poria cocos, 9 parts of dried orange peels, 6 parts in Radix Glycyrrhizae.
Functional candy of a kind of six gentleman and technology of preparing thereof, wherein: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
See that further above-mentioned functional candy of a kind of six gentleman and technology of preparing thereof wherein, contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
Production method of the present invention may further comprise the steps: at first, get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.Get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.Get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.Get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.Get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
" embodiment one "
Press the following raw material of preceding method preparation:
Medicinal extract, solid lipid nano granule, nano-emulsion.
It makes the raw materials of effective components composition---
15 parts of gensengs, 12 parts of the bighead atractylodes rhizomes, 12 parts of the tuber of pinellia, 9 parts in Poria cocos, 9 parts of dried orange peels, 6 parts in Radix Glycyrrhizae.
Its manufacture process is as follows:
In the toilet that meets the GMP standard, medicinal extract, solid lipid nano granule, nano-emulsion are mixed in 4: 3: 3 ratios, get that 35% above-mentioned raw materials that mixes, 30% pure water, 2% glycyrrhizin, 5% Abbas are sweet, 2% stevioside fully mixes 140 ℃ of temperature infusions, add 4% hydroxyl isomaltulose, 4% maltitol, 2% gelatin, 15% starch, 1% essence and flavoring agent again, fully stir miscible even, press the conventional preparation technology of pan work, prepare six gentleman's functional sugar-free candies.
" embodiment two "
Press the following raw material of preceding method preparation:
Water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid.
It makes the raw materials of effective components composition---
15 parts of gensengs, 12 parts of the bighead atractylodes rhizomes, 12 parts of the tuber of pinellia, 9 parts in Poria cocos, 9 parts of dried orange peels, 6 parts in Radix Glycyrrhizae.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid was in 5: 1: 1: ratio was mixed in 2: 1, get 30% pure water, 1% glycyrrhizin, 5% Abbas is sweet, 2% stevioside fully mixes 80-140 ℃ of temperature infusion, add 2% gelatin again, 20% starch, fully stir miscible even, when being cooled to 40-60 ℃ again with 39% above-mentioned raw materials that mixes, 1% essence and flavoring agent adds, stir, press the conventional preparation technology of pan work, prepare the functional hard candy of six gentleman.
" embodiment three "
Press the following raw material of preceding method preparation:
Medicinal extract nano powder, nano liposomes, freeze-dried powder, dry powder.
It makes the raw materials of effective components composition---
15 parts of gensengs, 12 parts of the bighead atractylodes rhizomes, 12 parts of the tuber of pinellia, 9 parts in Poria cocos, 9 parts of dried orange peels, 6 parts in Radix Glycyrrhizae.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with medicinal extract nano powder, nano liposomes, freeze-dried powder, dry powder in 4: 2: 2: 2 ratios are mixed, get that 40% above-mentioned raw materials that mixes, 10% sucrose, 20% xylitol, 2% glycyrrhizin, 5% Abbas are sweet, 2% stevioside, 20% milk powder, 1% essence and flavoring agent, fully mix, press the conventional preparation technology of pulverized sugar goods, prepare the functional pulverized sugar of six gentleman.
" embodiment four "
Press the following raw material of preceding method preparation:
Water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid.
It makes the raw materials of effective components composition---
15 parts of gensengs, 12 parts of the bighead atractylodes rhizomes, 12 parts of the tuber of pinellia, 9 parts in Poria cocos, 9 parts of dried orange peels, 6 parts in Radix Glycyrrhizae.
Its manufacture process is as follows:
In the toilet that meets the GMP standard with water drug-decocting concentrating liquid, nano liposomes, nano-emulsion, micro emulsion, nanometer suspension liquid in 5: 1: 1: ratio was mixed in 2: 1, get that 39% above-mentioned raw materials that mixes, 1% essence and flavoring agent, 7% agar, 3% carragheen, 5% gelatin, 5% pectin, 10% konjac glucomannan, 1% glycyrrhizin, 5% Abbas are sweet, 2% stevioside, 2% xylitol, 20% maltitol, press the conventional preparation technology of jelly goods, prepare the functional jelly of six gentleman.
Claims (10)
1. functional candy of gentleman and technology of preparing thereof is characterized in that: this functional candy raw materials of effective components and weight proportion---
15 parts of gensengs, 12 parts of the bighead atractylodes rhizomes, 12 parts of the tuber of pinellia, 9 parts in Poria cocos, 9 parts of dried orange peels, 6 parts in Radix Glycyrrhizae.
2. functional candy of a kind of six gentleman according to claim 1 and technology of preparing thereof, it is characterized in that: this functional candy is according to traditional Chinese medical science global theory, compatibility theory adopts the nano-powder of medicinal and edible Chinese medicine raw material, micro-powder, monomer, active ingredient, active component, the active principle group, Chinese medical concrete, water drug-decocting concentrating liquid is united use and is prepared into nanoparticle with different pharmaceutical carrier and auxiliary material, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, one or more combinations in the microcapsules etc., and can one or more be mixed according to different needs.
3. according to claim 1,2 described functional candy of a kind of six gentleman and technologies of preparing thereof, it is characterized in that: contain in the trace elements such as organic selenium, organic zinc, calcium, phosphorus, iron one or more in the raw material.
4. according to claim 1 or 2 or 3 any described functional candy of a kind of six gentleman and technologies of preparing thereof, it is characterized in that: used sweetener is that Abbas is sweet, in the maltose, xylitol, D-sorbite, mannitol, galactitol, maltitol, lactitol, isomalt, FOS, xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose, stachyose, lactulose, milk ketose, low shitosan, stevioside, sucrose, white granulated sugar, glycyrrhizin etc. one or more.
5. according to claim 1 or 2 or 3 or 4 any described functional candy of a kind of six gentleman and technologies of preparing thereof, it is characterized in that: described end product is: hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugar.
6. according to claim 1 or 2 or 3 or 4 or 5 any described functional candy of a kind of six gentleman and technologies of preparing thereof, it is characterized in that: used auxiliary material is an emulsifying agent, blowing agent, activating agent, cosurfactant, antioxidant, help emulsion, dispersant, spices and essence, hardening agent, condensed milk, milk powder, chocolate powder, cream, hydrogenated oil and fat, cocoa butter, menthol, albumin and starch and derivative thereof, alginate, beta-schardinger dextrin-, protein, shitosan and derivative thereof, lactose, hydroxypropyl methylcellulose, ethyl cellulose, cellulose acetate phthalate, the metering system acetate, PLA and cyanoacrylate, the semisolid poe, triglyceride is (as three stearic acid, three palmitic acids, three laurate, in three oleic acid etc., the glyceride of LCFA), glyceride is (as glycerin monostearate, contain list, two, the synthetic glyceride of triglyceride), steroidal class (cholesterol etc.), polyethylene glycol, wax class (microcrystalline wax, whale ester type waxes), red blood cell, in the montmorillonite etc. one or more.
7. according to claim 1 or 2 or 3 or 4 or 5 or 6 described functional candy of a kind of six gentleman and technologies of preparing thereof, it is characterized in that: used colloid is one or more in agar, carragheen, gelatin, starch, pectin, konjac glucomannan, algin, gellan gum, xanthans, locust bean gum, hydroxypropul starch, Sodium Polyacrylate, the tamarind seed polysaccharide glue etc.
8. functional candy of gentleman and technology of preparing thereof is characterized in that may further comprise the steps:
Step 1: get each medicinal and edible Chinese medicine preliminary treatment, insert pulverizer after the weighing and be crushed to the 20-200 order, obtain each raw material meal with standby.Get each Chinese medicine meal of 10-60% and mix, boiled 3 times with the traditional Chinese medicine extracting machine decocting after being soaked in water two hours, decocting liquid merges filtration, and filtrate concentrates, and gets raw material medicinal extract or water drug-decocting concentrating liquid with standby.Concentrate is fried in shallow oil in water intaking, adopting supersonic speed (temperature 10-60 degree, pressure 0.01-0.65Mpa, supersonic jet speed are 350 meters-980 meter per seconds) is carrier with the beta-schardinger dextrin-, spray-drying obtains the nano-micro level dry powder raw material of 10 nanometers-10 micron grain size, and is standby.
Step 2: get 30%--90% alcohol solution that 10-60% raw material meal doubly measures with 6-12 and mix and soak after 1-10 days, extracts 3 times, extract effective ingredients such as water-soluble, pure dissolubility, ester dissolubility simultaneously, recovered alcohol must the different material extract, and is standby.
Step 3: get above-mentioned each extract of 10-30%, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.Get above-mentioned raw materials medicinal extract, the nano ball grinding equipment of packing into according to the difference of extract, adds dispersant and mill pearl and ground 4-16 hour, obtains the nano powder that particle diameter is distributed as the 10-1000 nanometer, and is standby.
Step 4: get above-mentioned each extract of 10-40%, according to the contained material difference of each Chinese medicine material, adopt technology such as leafing, macroporous absorption, gel molecular screening, mould separation, ultracentrifugation to carry out the separation and purification preparation respectively, get medicine materials such as different pharmaceutical monomer, active component, active principle.Then, get the above-mentioned gained ester of 10-60% dissolubility traditional Chinese medicine monomer, active component and stearic acid, in 2: 3: 1 ratios, heating and melting was to oil phase under 40-90 ℃ of water-bath.Get lecithin, poloxamer 188 and Tween-80 in 3: 4: 3 ratios, be dissolved in an amount of pure water, it is identical with the oil phase temperature that water-bath is heated to, and is water.Oil phase is slowly dripped in aqueous phase, 2 * 10
2-4Under the rmin stirring condition, high-speed stirred 1-2h gets colostrum, temperature is controlled at the 40-85 degree, under 80-200Pa pressure, and the even circulation of high pressure breast 3-6 time, be chilled to room temperature rapidly, get the solid lipid nano granule SLN suspension that particle diameter is distributed as the 10-1000 nanometer, add an amount of essence and flavoring agent, stir in 38--40 degree temperature, 2-10 ℃ of preservation, standby.Get above-mentioned an amount of SLN suspension, add an amount of sweet mellow wine freeze drying protectant, under-30 ℃ to-80 ℃ vacuum, frozen drying 12h-72h gets freeze-dried powder.
Step 5: get the above-mentioned gained traditional Chinese medicine monomer of 10-40%, active component, active ingredient adopts the even method of high pressure breast respectively according to contained material difference, inclusion technique, solid state technology, polishing, solvent-fusion method, the double helix extrusion, complex coacervation, emulsion-crosslinking method, the polymerization dispersion method, fusion method, technology such as freeze-drying are prepared into nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer polymer micelle, pharmacome, nano-emulsion, lipid microsphere, micro-capsule, micro emulsion, lipid liquid, nanometer film, nanometer suspension liquid, nano raw materials such as microcapsules.The nano raw material particle diameter of preparing is distributed between 10 nanometers-10 micron.
Step 6: get above-mentioned gained nano-micro level dry powder, nano powder, freeze-dried powder, nano raw material etc., mix by difference requirements such as hard candy, jelly work, comfit, chewing gum, penuche, butterscotch, butterfat candy, pressed candy, crisp candy, gel candy, aerated candy, matrix candy, polishing candy, jelly, sugar-free candy, pulverized sugar, loaf sugars, press the conventional preparation technology of above-mentioned functions pan work again, in adding sweetener, auxiliary material, the colloid one or more, mix, prepare described pan work.
9. functional candy of a kind of six gentleman according to claim 8 and technology of preparing thereof; it is characterized in that: above-mentioned employed extraction, technology of preparing and method; the described protection domain of this claim is not only described technology of preparing and method; as required, be also included within its basis go up to add or change use other preparation better effects if, more economical, upgrade, more advanced extraction, technology of preparing and method.
10. functional candy of a kind of six gentleman according to claim 9 and technology of preparing thereof, it is characterized in that: key point of the present invention is: 1, the effect requirement that will reach according to traditional Chinese medical science global theory and functional candy, get above-mentioned gained medicinal extract, water drug-decocting concentrating liquid, nano powder, nano-emulsion, nanoparticle, milimicron particle, the micron liposome, nano liposomes, solid lipid nano granule, nanometer suspension liquid, dry powder, in the raw materials such as freeze-dried powder one or more, with sweetener, in colloid and other auxiliary materials one or more, after fully mixing again routinely preparation technology make above-mentioned each functional candy.2, be that basis is prepared the nanometer particle size difference and the medicinal and edible Chinese medicine raw material effect of raw material and used the different of carrier, can produce the gentle controlled capability of different targets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102631534A CN102100288A (en) | 2009-12-17 | 2009-12-17 | Liujunzi functional confectionary and preparation technology thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102631534A CN102100288A (en) | 2009-12-17 | 2009-12-17 | Liujunzi functional confectionary and preparation technology thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102100288A true CN102100288A (en) | 2011-06-22 |
Family
ID=44153527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102631534A Pending CN102100288A (en) | 2009-12-17 | 2009-12-17 | Liujunzi functional confectionary and preparation technology thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102100288A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212039A (en) * | 2013-03-19 | 2013-07-24 | 赵霞 | Traditional Chinese medicine composition for treating infantile cough caused by qi deficiency |
| CN103875876A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Butter peanut pieces capable of invigorating spleen, tonifying Qi and resisting cancers and preparation method thereof |
| CN103875875A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Puffed cakes capable of invigorating spleen, tonifying Qi and resisting cancers and preparation method thereof |
| CN103875877A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Anti-cancer hard candy capable of strengthening spleen and replenishing qi and preparation method thereof |
| CN112369490A (en) * | 2020-11-17 | 2021-02-19 | 王安琪 | Formula and preparation method of traditional Chinese medicine functional soft sweets with effects of invigorating spleen and replenishing qi |
-
2009
- 2009-12-17 CN CN2009102631534A patent/CN102100288A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212039A (en) * | 2013-03-19 | 2013-07-24 | 赵霞 | Traditional Chinese medicine composition for treating infantile cough caused by qi deficiency |
| CN103212039B (en) * | 2013-03-19 | 2015-02-11 | 赵霞 | Traditional Chinese medicine composition for treating infantile cough caused by qi deficiency |
| CN103875876A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Butter peanut pieces capable of invigorating spleen, tonifying Qi and resisting cancers and preparation method thereof |
| CN103875875A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Puffed cakes capable of invigorating spleen, tonifying Qi and resisting cancers and preparation method thereof |
| CN103875877A (en) * | 2014-04-02 | 2014-06-25 | 陈迎霞 | Anti-cancer hard candy capable of strengthening spleen and replenishing qi and preparation method thereof |
| CN103875876B (en) * | 2014-04-02 | 2016-04-06 | 陈迎霞 | Butter peanut slice that a kind of invigorating the spleen tonifying Qi is anticancer and preparation method thereof |
| CN112369490A (en) * | 2020-11-17 | 2021-02-19 | 王安琪 | Formula and preparation method of traditional Chinese medicine functional soft sweets with effects of invigorating spleen and replenishing qi |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102100294A (en) | Middle-warmer-adjusting sugar functional candies and preparation technology thereof | |
| CN102100286A (en) | Functional confectionary with functions of strengthening middle jiao and benefiting qi and preparation technology thereof | |
| CN102100295A (en) | 'Xiaoyao' sugar functional candies and preparation technology thereof | |
| CN101444273B (en) | Health product oral fast-release preparation and production method thereof | |
| CN104623670A (en) | Compositions Containing Enriched Natural Crocin and/or Crocetin, and Their Therapeutic or Nutraceutical Uses | |
| CN104799146A (en) | Functional nutritional good composition for improving sub-health and preparation method thereof | |
| CN102100292A (en) | Functional confectionary with scutellaria baicalensis sugar and preparation technology thereof | |
| CN102100288A (en) | Liujunzi functional confectionary and preparation technology thereof | |
| CN102100287A (en) | Guipi syrup functional confectionary and preparation technology thereof | |
| CN102100391A (en) | Preparation technology for four-material soup functional beverage | |
| WO2007133054A1 (en) | A novel process for preparing black ginseng and the composition comprising the same | |
| US5128131A (en) | Process for preparing a watersoluble composition containing ginkgo leaf extracts | |
| Abdulqahar et al. | In vitro digestibility of Aucklandia costus-loaded nanophytosomes and their use in yoghurt as a food model | |
| WO2008075866A1 (en) | A composition comprising the processed extract of panax quinquefolium l. for the prevention and treatment of cancer | |
| CN105707876B (en) | It is a kind of that there is the dietary composition and its preparation method and application stablized and dissolve patch | |
| CN102100392A (en) | Preparation technology of functional beverage for invigorating qi and blood | |
| JP4516958B2 (en) | Anti-diabetic composition | |
| KR102043433B1 (en) | Method for Making Extract of Red Ginseng | |
| CN103230486A (en) | Traditional Chinese medicine composition, preparation method thereof, and application thereof in preparing medicines used for treating fatty liver | |
| CN102100290A (en) | Technology for preparing four-material sugar functional candies | |
| CN108578556A (en) | A kind of health products of reducing blood sugar and blood fat and preparation method thereof | |
| CN101856389A (en) | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases and application thereof | |
| KR101818500B1 (en) | Composition for preventing, improviong or treating disease caused by side effect of anticancer agent comprising Phragmites communis Trin extract as effective component | |
| CN102100289A (en) | Jade screen functional candy and preparation technique thereof | |
| CN103751762A (en) | Product for promoting skin cell reconstruction and delaying senescence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110622 |