CN103751762B - A kind ofly skin cell is promoted to recombinate and can the product of slow down aging - Google Patents

Abstract

The invention belongs to technical field of Chinese medicines, relate to and a kind ofly promote skin cell to recombinate and can the product of slow down aging.This product is made up of the raw material of following weight: Radix Ginseng 6 ~ 12 parts, tremella polysaccharide 1 ~ 5 part, oat peptide 2 ~ 6 parts, Radix Puerariae isoflavone 2 ~ 9 parts and soybean isoflavone 1 ~ 8 part, sweeting agent 0.5 ~ 2 part.Experiment proves, herbal compositions of the present invention can obviously promote and improve skin metabolism, and make it tender smooth, more flexible and gloss, serves slow down aging, effect of whitening and speckle dispelling.

Description

A kind ofly skin cell is promoted to recombinate and can the product of slow down aging

Technical field

The present invention relates to a kind of Chinese medicine preparation, relate to a kind of promotion skin cell being prepared by raw material with Chinese herbal medicine specifically and recombinate and the product of energy slow down aging.

Background technology

The traditional Chinese medical science think human body composition outside have skin, arteries and veins, meat, muscle, bone, inside have the vital organs of the human body, and meridians, QI and blood contact in length and breadth, define an organic whole.Therefore skin and internal organs have close relationship.Especially very close with the relation of lung.The traditional Chinese medical science has very strong advantage in promoting blood circulation to remove obstruction in the collateral, benefiting vital QI and blood and transfer healthy energy, has and promotes QI-blood circulation, clean blood vessel access, regulates blood hemal ring to reduce blood fat and blood viscosity, regulates blood circulation, enhances metabolism and effect of catharsis and toxin expelling.

The traditional Chinese medical science is thought " lung governing skin and hair ".Human body is sent out by a surname of lung qi and is fallen with respectful, makes qi-blood-body fluid be able to spreading whole body.If with the passing of time pulmonary function not normal, then scaly dry skin, with a haggard face and pale.The people of the deficiency of the lung, xerosis cutis and lackluster, with a haggard face.Lung and spleen kidney interrelated, taste the foundation of acquired constitution, source of generating QI and blood.The spleen has the function to transport and transform nutrients, main muscle, and with the lung is concerned with QI of the whole body, kidney is congenital, but must the nourishing of the angry blood of spleenization, only has lung spleen normal renal function, will QI and blood to fill skin ruddy, make skin Lightening skin healthy.

Summary of the invention

The object of the invention is to overcome prior art deficiency, and provide that a kind of curative effect is fast, expense is low, having no side effect effectively promotes skin cell restructuring and can the product of slow down aging.

For realizing object of the present invention, existing according to following technical scheme.This product is made up of the raw material of following weight: Radix Ginseng 6 ~ 12 parts, tremella polysaccharide 1 ~ 5 part, oat peptide 2 ~ 6 parts, Radix Puerariae isoflavone 2 ~ 9 parts and soybean isoflavone 1 ~ 8 part, sweeting agent 0.5 ~ 2 part.

Radix Ginseng (PanaxginsengC.A.Mey.) is Araliaceae.As traditional medicinal herbs most in use, there is the history of thousands of years, in countries in the world extensive use.Radix Ginseng strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.Radix Ginseng herbaceos perennial, the weather that happiness is shady and cool, moistening, in the theropencedrymion being grown on the little height above sea level of day and night temperature gentle slope, 500 ~ 1100 meters of mountain regions or slope land or shaw more.Because root is loose, if shape spindle, often have bifurcated, overall picture quite like the head of people, hands, foot and extremity, so be called Radix Ginseng.Ancient times Radix Ginseng be refinedly called Rhizoma Polygonati, Herba Stellariae Saxatilis, SHENCAO.Radix Ginseng is called " king of BAICAO " by people, is one of well-known " northeast three essentials-essence " (Radix Ginseng, fur, Cornu Cervi Pantotrichum), be have won fame both at home and abroad, rare medicinal herbs that old children all knows.This is most important, one of the famousst and precious qi-invigorating herb, sweet in the mouth, micro-hardship, and slightly warm in nature, has invigorating QI to relieve exhaustion, spleen invigorating lung benefiting, mind calming Fructus Alpiniae Oxyphyllae, effect of nourishing blood to promote the production of body fluid.Function strongly invigorating primordial QI, intelligent promoting and the mind tranquilizing is the good merchantable brand of tonification health care.Research confirms, Radix Ginseng has promotion human body cell to grow, increase the effect of frequency dividing cell, and American scholar is taught Fu Like and is thought, human body cell approximately divides 50 times and just stops fourth, cell divides at every turn once needs 2.4 years, if division can be reached 50 times, just can live 120 years old, due to Radix Ginseng strongly invigorating primordial QI, shallow breathing can be usually used in, extreme cold of the limbs, faint and weak pulse, the diseases such as the shock that blood pressure is low. in addition, because Radix Ginseng has the strong effect of tonification, can defying age, be applicable to weakness due to chronic disease, cardiopalmus severe palpitation, spontaneous perspiration and cold extremities, breathe hard, collapse, heart failure, the diseases such as neurasthenia.Modern study confirms, Radix Ginseng contains multiple Saponin and volatile oil, polysaccharide, the compositions such as vitamin B I, B2, C; There is good regulating action to nervous system, have short gonadotropic Effect, also have cardiotonic; Can blood glucose be reduced, strengthen hematopoietic function, adrenal cortex reinforcing function, improve the adaptive capacity of body environment to external world, improve immunologic function.In addition, Radix Ginseng also can promote the synthesis of protein, suppresses the generation of hypercholesterolemia, has facilitation to the rehabilitation of chronic disease.

Containing ginsenoside and ginseng polysaccharide in Radix Ginseng.Especially ginsenoside Rb2 has obvious hypoglycemic activity, and ginseng polysaccharide's (or glycopeptide class) is another kind of blood sugar reducing component in Radix Ginseng in addition.Radix Ginseng is containing multiple Saponin and polysaccharide composition, the leachate of Radix Ginseng slowly can be absorbed by skin, to skin without any pessimal stimulation, energy skin expansion blood capillary, promote cutaneous circulation, increase skin-nourishing, the water oil balance of regulation of skin, prevent skin dehydration, sclerosis, wrinkling, adhere to for a long time using the product containing Radix Ginseng, can skin elasticity be strengthened, cell is obtained newborn.Radix Ginseng active substance also has the reducing property of check melanin simultaneously, makes skin pure white smooth.Its beauty treatment effectiveness is innumerable, is the superfine product of improving looks.

Herba bromi japonici is the ancient cereal crops originating from China, belongs to grass family Avena in plant classification.According to Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene to the content of the analysis result oat egg white matter of composition of food and fat in cereal crops all containing the first, contain 18 seed amino acids in oat egg white matter, wherein 8 kinds is the aminoacid of needed by human.Research shows that micromolecular bioactive peptide can be absorbed by the body better than macromolecular protein free amino acid, has immunity moderation power, and regulate hormone, antioxidation, the effects such as resisting fatigue, may be used in health food.In addition, the biologically active polypeptide that research finds adds in cosmetics and skincare product, plays defying age, moisturizing, the effects such as Whitening, speckle removing, acne removing.Herba bromi japonici, except having natural health care, also has very high its cosmetic values.People have understood very early and utilize Herba bromi japonici to itch to treat xerosis cutis and fullying recover from an illness.Investigate according to archeologist, ancient egypt queens and princesses just have the custom of Herba bromi japonici water washing bath.Containing avenin, oat peptide, Herba bromi japonici wet goods composition in Herba bromi japonici.There is anti-oxidation efficacy, increase skin activity, delaying skin aging, whitening skin and preserving moisture, minimizing wrinkle mottle, antiallergic, etc. effect.Herba bromi japonici is claimed to be " family doctor ", " plant gold ", " natural cosmetologist " in countries such as the U.S., Japan, Canada, France.Herba bromi japonici delicate fragrance free from extraneous odour.Utilize modern biotechnology enzyme engineering, protein dissociation in bran of Fagopyrum esculentum Moench is become small-molecular peptides, closely similar with epithelical cell growth factor (EGF), be easy to skin absorb, can cell proliferation be accelerated, promote skin metabolism, Cucumber Extract, reduce skin coarseness, make skin shine delicate and charming elegance.Other protein hydrolysates relatively, Herba bromi japonici small-molecular peptides has characteristic that is pure, abnormal smells from the patient delicate fragrance, is also the green succedaneum of good animal polypeptide.Small-molecular peptides enters skin inside, plays the effect of Moisture factor, can soften skin, pins moisture of skin, gives skin and moistens.There is reduce wrinkle, accelerate cell proliferation and metabolism.Reduce skin coarseness, Cucumber Extract.The function of scavenging free radicals, makes skin keep younger state.Moisturizing, crease-resistant, whitening and speckle dispelling slow down aging.Can use as dosage forms such as cream frost, emulsion, essence, gel, astringent, facial films.

Semen sojae atricolor originates in the crops of China, is the leguminous plant that its seed a kind of contains rich in protein and oils and fats.It is one of primary raw material of some traditional foods.But also containing the various bioactivators such as oligosaccharide, isoflavone.Soybean isoflavone wherein, has more weak estrogen activity, and it receives the common concern of people to the health benefit of human body.Soybean isoflavone is polyphenol compound, mainly comprises daiazi, Dai, genistin, genistein, Glycitein, daidzin.Research shows: genistein (isoflavone) contained in Semen sojae atricolor can suppress a kind of enzyme stimulating tumor growth, stops the growth of tumor, anti-curing cancers, especially breast carcinoma, carcinoma of prostate, colon cancer.Soybean isoflavone has the different physiological roles such as antitumor, angiocardiopathy preventing, osteoporosis, radioprotective, antioxidation.The obvious benefit of Semen sojae atricolor to male can help to overcome prostatosis.

Tremella is that China's economic worth is high, and a kind of edible fungi of preciousness and medicinal fungus, is traditional edible and medicinal fungi.Polysaccharide is most important constituent, accounts for 60% ~ 70% of its dry weight, and meanwhile, tremella polysaccharide is a kind of important bioactive substance.Numerous achievement in research shows, tremella polysaccharide obviously can reduce the content of free cholesterol, cholesteryl ester in hyperlipidemia, serum, the immunologic function of obvious enhancing body, promotes Hepatocyte Glycogen synthesis and antitumor, mutation, radioprotective and leukocyte increasing.Long-term taking tremella polysaccharide can reduce blood pressure, blood fat, prevents arteriosclerosis, Tumor suppression, enhancing human body immunity function.Experiment extracts tremella polysaccharide with water extraction from Tremella, and by orthogonal experiment Optimized Extraction Process, and study its beauty and skin care effect, tremella polysaccharide has the ability of certain removing hydroxyl radical free radical, can be used as aging ingredient and is applied in cosmetics.Performance of keeping humidity research also proves that the moistening effect of tremella polysaccharide is better than glycerol and trehalose.So as functional component, in external many cosmetics of super quality, with the addition of tremella polysaccharide.List of references: the progress of Yang Shihai, the red tremella polysaccharide of Yin Chunmei, Miao Shuan and pharmacological action thereof.

Radix Puerariae is the dry root of leguminous plant Puerarialobata (Willd.) Ohwi.Practise and claim Herba Gelsemii Elegantis.Sweet in the mouth, property is pungent, cool, returns spleen, stomach warp.Be good at expelling pathogenic factors from muscles for reducing heat, rash of promoting the production of body fluid, yang invigorating antidiarrheal.Be mainly used in the headache for the treatment of fever caused by exogenous pathogens, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.The effective site of kudzuvine root for treating cardiovascular and cerebrovascular disease is Radix Puerariae total flavones, and effective ingredient mainly contains puerarin, daidzein, daidzin, seven material lignin etc.The pharmacological action of Radix Puerariae has antipyretic, blood sugar lowering, Fructus Alpiniae Oxyphyllae, improve cerebral circulation, arrhythmia, resist myocardial ischemia, reduce myocardial oxygen consumption and without obvious negative inotropic action, also there is antithrombotic, improve the effects such as high density lipoprotein, vasospasm and reduction platelet aggregation.

Described sweeting agent is that oligosaccharides is as oligomeric isomaltose, oligomeric galactose, Oligomeric maltose, oligofructose etc.; Sugar alcohols is as maltose alcohol, Sorbitol, dew sugar alcohol, xylitol, erythritol etc.; Natural sweetener is as sweet protein, stevioside, glycyrrhizin etc.

The said goods can also add pharmaceutically acceptable excipient and make the regular dosage form pharmaceutically such as tablet, capsule, granule or oral liquid, or makes the common beverage such as beverage, teabag.

Another object of the present invention is to provide the preparation method of this product, and Radix Ginseng obtains Radix Ginseng extract dry powder after adopting suitable solvent extraction, then with tremella polysaccharide, oat peptide, Radix Puerariae isoflavone, soybean isoflavone, sweeting agent is mixed to get active component, then it is obtained to press preparation interpolation adjuvant.

Described solvent preferred water, ethanol or its mixture.

Radix Ginseng extract dry powder, tremella polysaccharide, oat peptide, Radix Puerariae isoflavone, soybean isoflavone and sweeting agent also can directly mix to incapsulate to be taken, or the solvent of the Radix Ginseng used suitable in above-mentioned composition respectively or mixed extraction processing obtain its extract, total extract makes preparation with pharmaceutical excipient hybrid process again.Described solvent refers to pharmaceutically conventional solvent, and preferred water, ethanol or its combination, extracting method can extract, as decocting method, percolation, reflux extraction, continuous extraction etc. by pharmaceutically conventional method.

During for oral administration, conventional solid preparation can be made into, comprise capsule, tablet, granule, pill and oral solution etc.Tablet means the solid preparation of the disc-shaped that medicine and suitable auxiliary materials and mixing are suppressed or special-shaped lamellar; Tablet, based on oral ordinary tablet, separately has Sublingual tablet, buccal tablet, mouth paster, chewable tablet, dispersible tablet, effervescent tablet, fuse, enteric coatel tablets, controlled release tablet and slow releasing tablet etc.Capsule means medicine or is added with adjuvant and is filled in Capsules or is sealed in the solid preparation in soft capsule material; Capsule dissolves and release characteristics according to it, can be divided into hard capsule (being commonly referred to as capsule), soft capsule (soft gelatin capsule), slow releasing capsule, controlled release capsule and enteric coated capsule.Granule means that medicine makes the dried particles shape preparation with certain particle size with suitable adjuvant; Granule can be divided into soluble particles (being commonly referred to as granule), mix suspension grain, effervescent granule, enteric coated particles, slow-releasing granules and controlled release granule etc.Pill means medicine and suitable adjuvant Homogeneous phase mixing, the spherical or near-spherical solid preparation made with proper method; Pill comprises drop pill, sugar pill, piller etc.Oral solution means that medicine dissolution is made for oral liquid clarification preparation in suitable solvent.

The preparation of herbal compositions of the present invention can adopt the conventional method in existing pharmaceutical field to produce, and can add various pharmaceutically acceptable carrier when needs.Described carrier comprises the osmotic pressure regulator, antioxidant, pH value regulator, emulsifying agent, solubilizing agent, antibacterial, filler, suspending agent, lubricant, disintegrating agent, binding agent etc. of pharmaceutical field routine.

Herbal compositions of the present invention, when making oral formulations, can add suitable binding agent, filler, lubricant, disintegrating agent etc.Filler comprises Icing Sugar, starch, calcium phosphate, calcium sulfate two water thing, dextrin, microcrystalline Cellulose, mannitol, lactose, pregelatinized Starch etc.; Binding agent comprises sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Disintegrating agent comprises dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Sodium lauryl sulphate, micropowder silica gel, lubricant comprise magnesium stearate, Pulvis Talci etc.

Its active component of the present invention is by Radix Ginseng extract, tremella polysaccharide, oat peptide, Radix Puerariae isoflavone, soybean isoflavone forms, and experiment proves, herbal compositions of the present invention can obviously promote and improve skin metabolism, make it tender smooth, more flexible and gloss, serves slow down aging, effect of whitening and speckle dispelling.

Detailed description of the invention

The operation of the herbaceous plant active component water extract carried out in specific embodiment and the concrete content of excipient added, are all ordinary skill in the art, are that those skilled in the art easily realizes, there is not the problem of insufficient disclosure.The object of embodiment illustrates that compositions of the present invention can make regular dosage form, instead of for limiting its protection domain or affecting it openly fully.

Raw material: Radix Ginseng, tremella polysaccharide, oat peptide, Radix Puerariae isoflavone, soybean isoflavone, sweeting agent and adjuvant are commercially available prod.Radix Ginseng is extracted the Radix Ginseng extract obtained by water, ethanol or its mixture, what this technique adopted is extracting method conventional on Chinese materia medica.

Embodiment 1

Get Radix Ginseng 900g through alcohol reflux, concentrated after spraying dry, obtain Radix Ginseng extract dry powder, add tremella polysaccharide 150g, oat peptide 150g Radix Puerariae isoflavone 200g, soybean isoflavone 300g and xylitol 70g, mixing, pulverizing, directly filled hard capsules.

Embodiment 2

Get Radix Ginseng 800g extract through decocting in water, concentrated after spraying dry, obtain Radix Ginseng extract dry powder, add tremella polysaccharide 100g, oat peptide 200g, Radix Puerariae isoflavone 200g and soybean isoflavone 200g, mixing, granulation, oven dry, granulate, add magnesium stearate, tabletting.

Embodiment 3

Get Radix Ginseng 850g through water-ethanol (4: 6) reflux, extract, concentrated after spraying dry, obtain Radix Ginseng extract dry powder, add tremella polysaccharide 150g, oat peptide 200g Radix Puerariae isoflavone 200g, soybean isoflavone 200g and glycyrrhizin 100g, mixing, granulate, dry, add magnesium stearate and Pulvis Talci, filled hard capsules.

Embodiment 4

Get Radix Ginseng 900g and extract to obtain Radix Ginseng extract aqueous solution through decocting in water, then add tremella polysaccharide 200g, oat peptide 300g Radix Puerariae isoflavone 300g, soybean isoflavone 300g and glycyrrhizin 150g, concentrate to obtain concentrated solution, fill, sterilizing, makes oral liquid.

Embodiment 5

Get Radix Ginseng 1000g through water-ethanol (10: 1) reflux, extract, concentrated after spraying dry, obtain Radix Ginseng extract dry powder, add tremella polysaccharide 200g, oat peptide 200g, Radix Puerariae isoflavone 300g and soybean isoflavone 300g again, stevioside 50g, more appropriate microcrystalline Cellulose, pregelatinized Starch, CMS-Na are added mixing in active component, granulation, granulate, finally add magnesium stearate, tabletting.

concrete enforcement statistical analysis

Select by skin problem, all ages and classes level patient 360 people carry out the test of this product function in various degree.Wherein women 256 people, male 104 people.According to the person's of taking one's test different situations, after taking different modes (for oral administration or external) to use this product course for the treatment of (30 days) respectively, the skin problems such as wherein 326 application on human skin are dry, dark yellow, lax are obviously changed, effective percentage 90.5%.By adjustment using method, after using this product two courses for the treatment of (60 days), the skin of 356 people has clear improvement, effective percentage 98,9%.It is little that 4 people feel that skin improves, but the readme mental status makes moderate progress.

be below model case:

case 1:

×××, man, 46 years old, long-term work was busy, had alcohol drinking patterns, caused skin dry especially, even played bits decortication.Take this product capsule every day for three times after 30 days, skin peeling plays bits phenomenon and disappears, and skin obviously becomes smooth.

case 2:

×××, female, 26 years old, professional model, due to life-time service cosmetics, facial pimpling and have cutis laxa phenomenon.Every daily facial mask cloth soaks this product oral liquid and spreads on face 30 minutes, and after 30 days, pimple disappears and skin becomes smooth flexible.

case 3:

×××, female, 38 years old, skin have chloasma and, matt, in test every day this product oral of per os hora somni liquid, every daily facial mask cloth soaks this product oral liquid and spreads on face 30 minutes simultaneously, and after 30 days, chloasma disappears and facial skin is tender smooth.

case 4:

×××, female, 21 years old, student, the black and xerosis cutis of face, due to the long pox of the large facial large area of learning pressure.Take this product capsule every day orally three times and soak this product oral liquid with facial mask cloth and spread on face 30 minutes, after 30 days, skin obviously bleaches and smooth moistening, and small pox disappears.

case 5:

×××, female: 34 years old, teacher.Skin of face relaxes too early, canthus wrinkle weight, and every daily facial mask cloth soaks this product oral liquid and spreads on face 30 minutes, and after 30 days, wrinkle obviously attenuates and shoals, and skin becomes flexible glossy.

case 6:

×××, female, 24 years old, after treating facial large area pustule-type acne, skin left spot and becomes abnormal dry.Every daily facial mask cloth soak this product oral liquid spread on face 30 minutes, after 30 days, spot disappear, and skin of face become compact glossy.

The present invention has the restructuring of promotion Skin Cell, skin nutrition cell, promotes and improves skin cell metabolism process, the function of anti aging effect, can be used for preparing antidotal skin Caring and uses.

Claims (1)

1. promote skin cell to recombinate and a product for energy slow down aging, it is characterized in that it is made up of the raw material of Chinese medicine of following weight proportion:

Radix Ginseng 6 ~ 12 parts, tremella polysaccharide 1 ~ 5 part, oat peptide 2 ~ 6 parts, Radix Puerariae isoflavone 2 ~ 9 parts and soybean isoflavone 1 ~ 8 part, sweeting agent 0.5 ~ 2 part.