CN102066350A - 获得西那特林c3和c1的方法 - Google Patents

获得西那特林c3和c1的方法 Download PDF

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Publication number
CN102066350A
CN102066350A CN2009801240480A CN200980124048A CN102066350A CN 102066350 A CN102066350 A CN 102066350A CN 2009801240480 A CN2009801240480 A CN 2009801240480A CN 200980124048 A CN200980124048 A CN 200980124048A CN 102066350 A CN102066350 A CN 102066350A
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formula
compound
alkyl
mixtures
stereoisomers
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CN2009801240480A
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Chinese (zh)
Inventor
佩德罗·诺埃达马林
路易斯·米格尔·洛萨诺戈蒂洛
塞尔吉奥·马罗托金塔纳
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Consejo Superior de Investigaciones Cientificas CSIC
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Consejo Superior de Investigaciones Cientificas CSIC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40—Succinic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
CN2009801240480A 2008-05-06 2009-05-05 获得西那特林c3和c1的方法 Pending CN102066350A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200801305 2008-05-06
ES200801305A ES2328214B1 (es) 2008-05-06 2008-05-06 Procedimiento de obtencion de las cinatrinas c3 y c1.
PCT/ES2009/070139 WO2009135978A1 (es) 2008-05-06 2009-05-05 Procedimiento de obtención de las cinatrinas c3 y c1

Publications (1)

Publication Number Publication Date
CN102066350A true CN102066350A (zh) 2011-05-18

Family

ID=41226503

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801240480A Pending CN102066350A (zh) 2008-05-06 2009-05-05 获得西那特林c3和c1的方法

Country Status (7)

Country Link
US (1) US20110275838A1 (https=)
EP (1) EP2287157A4 (https=)
JP (1) JP2011523631A (https=)
CN (1) CN102066350A (https=)
AU (1) AU2009245668A1 (https=)
ES (1) ES2328214B1 (https=)
WO (1) WO2009135978A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102503825A (zh) * 2011-11-11 2012-06-20 上海华谊（集团）公司 药物中间体丁酮二酸二酯类化合物的制备方法
CN115141199A (zh) * 2022-06-28 2022-10-04 江西师范大学 一种合成吴茱萸次碱的新方法
CN116354907A (zh) * 2023-04-12 2023-06-30 智仑超纯环氧树脂(西安)有限公司 一种含氟环氧树脂及其制备方法、应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03108490A (ja) 1989-06-30 1991-05-08 Shionogi & Co Ltd フォスフォリパーゼａ↓２阻害物質

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANTHONY N. CUZZUPE,等: "Enantiospecific synthesis of the phospholipase A2 inhibitors (-)-cinatrin C1 and (+)-cinatrin C3", 《ORGANIC BIOMOLECULAR CHEMISTRY》 *
DAVID A.EVANS,等: "Aldol reactions of ketal-protected tartrate ester enolates.Asymmetric syntheses and absolute stereochemical assignments of phospholipase A2 Inhibitors Cinatrin C1 and C3", 《TETRAHEDRON》 *
SCHREIBER, JEAN: "Preparation of β-alkyloxalacetic esters", 《CA》 *
SCHREIBER.J，等: "Contribution a the prèparation des esters α-alcoyloxalacétiques", 《BULLETIN OF THE SOCIETE CHIMIQUE OF FRANCE》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102503825A (zh) * 2011-11-11 2012-06-20 上海华谊（集团）公司 药物中间体丁酮二酸二酯类化合物的制备方法
CN115141199A (zh) * 2022-06-28 2022-10-04 江西师范大学 一种合成吴茱萸次碱的新方法
CN115141199B (zh) * 2022-06-28 2023-04-07 江西师范大学 一种合成吴茱萸次碱的新方法
CN116354907A (zh) * 2023-04-12 2023-06-30 智仑超纯环氧树脂(西安)有限公司 一种含氟环氧树脂及其制备方法、应用

Also Published As

Publication number Publication date
EP2287157A1 (en) 2011-02-23
ES2328214B1 (es) 2010-07-23
JP2011523631A (ja) 2011-08-18
AU2009245668A1 (en) 2009-11-12
US20110275838A1 (en) 2011-11-10
ES2328214A1 (es) 2009-11-10
EP2287157A4 (en) 2011-08-31
WO2009135978A1 (es) 2009-11-12

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Application publication date: 20110518