CN102008556B - Qiqing Baidu effervescent granule and preparation method thereof - Google Patents
Qiqing Baidu effervescent granule and preparation method thereof Download PDFInfo
- Publication number
- CN102008556B CN102008556B CN2009100660829A CN200910066082A CN102008556B CN 102008556 B CN102008556 B CN 102008556B CN 2009100660829 A CN2009100660829 A CN 2009100660829A CN 200910066082 A CN200910066082 A CN 200910066082A CN 102008556 B CN102008556 B CN 102008556B
- Authority
- CN
- China
- Prior art keywords
- parts
- effervescent
- radix
- internal heat
- clearly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a Qiqing Baidu effervescent granule, belonging to the pharmaceutical field of traditional Chinese medicines. The Qiqing Baidu effervescent granule is prepared from the following raw materials and auxiliary materials in part by weight: raw materials: 100 parts of baical skullcap root, 100 parts of giant knotweed rhizome, 80 parts of pulsatilla chinensis, 80 parts of lightyellow sophora root, 100 parts of isatis root, 60 parts of male fern rhizome and 40 parts of indigowoad leaves; and auxiliary materials: 72-88 parts of sodium bicarbonate, 60-74 parts of fumaric acid, 387-417 parts of thinning agents and 11-15 parts of flavoring agents. The effervescent granule is prepared by utilizing a method for separately granulating with acid-alkali. In the invention, the Qiqing Baidu effervescent granule is prepared by taking the sodium bicarbonate as an alkaline agent and fumaric acid as an acidic agent and adding other auxiliary materials; the use level of the auxiliary materials can be reduced; and the effervescent granule has the advantages of simple preparation process, high effervescent speed, favorable effervescent effect, dissolubility and liquid medicine clarity after being effervesced, is easily formed and does not absorb moisture easily.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, be specifically related to a kind of seven effervescent granules and preparation method thereof that relieve internal heat clearly.
Background technology
Seven granules that relieve internal heat clearly are processed into seven by Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Folium Isatidis seven flavor Chinese medicines through extraction and relieve internal heat clearly behind the extractum; With sugar, the granule that is mixed and made into according to a certain percentage of dextrin; Has heat-clearing and toxic substances removing; The function of dampness removing and diarrhea-relieving, the clinical treatment that is mainly used in the diarrhea due to damp-heat and the white scour of chicken.Because of its definite curative effect and good reputation, included in 2005 editions 2 P of People's Republic of China's veterinary drug allusion quotation
401But seven when relieving internal heat the clinical use of granule clearly, dissolving slowly, palatability is poor.
Effervescent granule is to be the novel immediate-release granules agent of disintegrating agent with the effervescent, compares with granule, need not during dissolving to stir; Use cold water can process clear and bright Liquid drug preparation at short notice; Shortened dissolution time, easy to use, good absorbing; Onset is rapid, bioavailability is high, and good palatability.
Owing to the ratio that Chinese medicine effervescent granule Chinese medicine extractum is shared is great, having difficulties aspect the selection of drug extract and pharmaceutic adjuvant kind and ratio, there are common problems such as disintegration time is slow, poor stability, palatability difference mostly in existing Chinese medicine effervescent granule; Because of the acid-base reaction of disintegrating agent itself, the influence of ambient moisture in the storage process in addition very easily produces gas to effervescent granule in the preservation process simultaneously, makes the product that makes the unfavorable conditions such as bag, air-blowing that expand occur.
Summary of the invention
The objective of the invention is to be to solve the problems of the technologies described above, a kind of principal agent, supplementary product kind reasonable mixture ratio are provided, seven good effervescent granules and preparation method thereof that relieve internal heat clearly of clarity after good stability, the disintegrate.
The objective of the invention is to realize through following technical scheme:
Of the present invention seven effervescent granules that relieve internal heat clearly, it is prepared from the raw material and the adjuvant of following weight parts:
Raw material: Radix Scutellariae 100, Rhizoma Polygoni Cuspidati 100, the Radix Pulsatillae 80, Radix Sophorae Flavescentis 80, Radix Isatidis 100, Rhizoma Dryopteris Crassirhizomatis 60, Folium Isatidis 40.
Adjuvant: sodium bicarbonate 72～88, fumaric acid 60～74, diluent 387～417, correctives 11～15.
Described diluent is at least a in glucose, sucrose, lactose, soluble starch, microcrystalline Cellulose, dextrin, mannitol, the sorbitol, is preferably the mixture of glucose and dextrin.
Described correctives is at least a in steviosin, vanillin, Aspartane, xylitol, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid sodium, agedoite, dihydrochalcone, glycyrrhizin, alcohol sugar or the radix asparagi sweet extract, is preferably steviosin.
Of the present invention seven relieve internal heat effervescent granule clearly method for preparing, carry out according to the following steps:
(1) takes by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, the Folium Isatidis of recipe quantity, decoct, decoct 2 times by the water heating of 8 times of medical material weight; Each 2 hours, collecting decoction filtered; Filtrating merges; Leave standstill, relative density is 1.30～1.35 when getting supernatant and being evaporated to 20 ℃, clear paste;
(2) preparation of acid particles: get the clear paste of half amount, the diluent of half amount and the fumaric acid of recipe quantity, mix homogeneously adds an amount of adhesive and processes soft material, and 16 mesh sieves are granulated, and is dry under 70～80 ℃ of conditions, and granulate is subsequent use;
(3) preparation of alkali grain: get the clear paste of half amount, the diluent of half amount and the sodium bicarbonate mix homogeneously of recipe quantity, add an amount of adhesive and process soft material, 16 mesh sieves are granulated, and are dry under 70～80 ℃ of conditions, and granulate is subsequent use;
(4), add correctives, drying, packing with qualified soda acid granule mix homogeneously.
Used adhesive can be a present technique field adhesive commonly used among the present invention, such as being a kind of in water or alcoholic solution, the polyvinyl alcohol water solution of water or alcoholic solution, the polyethylene glycol 6000 of water or alcoholic solution, sodium carboxymethyl cellulose solution, the Macrogol 4000 of water or alcoholic solution, methylated cellulose aqueous solution, ethyl cellulose alcoholic solution, the hydroxypropyl emthylcellulose of starch slurry, pregelatinized Starch aqueous solution, aqueous gelatin solution, aqueous sucrose solution, alcoholic solution, polyvidone or the mixture of any two kinds or any two or more materials in the middle of them.
In order to increase the stability of effervescent granule, the applicant carries out the strictness screening to disintegrating agent in the prescription, particularly acid source is screened, and the method that adopts soda acid separately to granulate simultaneously reduces the probability that disintegrating agent is in contact with one another; And its stability investigated, the effervescent granule of guaranteeing to make store with use in, when ensureing effervescent granule good effervescent effect and melting, can not produce unfavorable conditions such as bloated bag, air-blowing.
The present invention adopts sodium bicarbonate as alkaline agent, adopts fumaric acid as acidizer, and adds other adjuvant preparation seven effervescent granule that relieves internal heat clearly and can reduce supplementary product consumption; Preparation technology is simple, and easy-formation is difficult for moisture absorption; Effervescent speed is fast; Effervescent is effective, and melting is good, good, no breeze foreign body of medicinal liquid clarity etc. behind the effervescent.
The specific embodiment
One, the seven clear paste Study on extraction process that relieve internal heat clearly:
2005 editions 2 P of People's Republic of China's veterinary drug allusion quotation
401In seven relieve internal heat the clearly clear and definite amount of the medical material of respectively distinguishing the flavor of, the number of times of extracting in water, the density of clear paste and the amounts that make in particulate prescription and the method for making.Former technology is: Radix Scutellariae 100g, Rhizoma Polygoni Cuspidati 100g, Radix Pulsatillae 80g, Radix Sophorae Flavescentis 80g, Radix Isatidis 100g, Rhizoma Dryopteris Crassirhizomatis 60g, Folium Isatidis 40g be totally 7 flavor medical materials; Extracting in water 2 times, merging filtrate, being concentrated into relative density is 1.30～1.35 (20 ℃); Get clear paste 160g; Clear paste, sugar, dextrin are processed granule in 1: 2.5: 1 ratio, and drying promptly gets.
In former technology, clearly do not soak the water yield and the extraction time of medical material; In order to guarantee seven relieve internal heat clearly effervescent granule quality of stability and controllabilitys; And make make seven relieve internal heat effervescent granule clearly medicament contg can be consistent with the seven particulate medicament contgs that relieve internal heat clearly; The applicant to seven relieve internal heat clear paste clearly extraction process study, mainly from amount of water and extraction time two aspects start with, be that leading indicator adopts single factor investigation method to investigate with the yield of extract:
The mensuration of yield of extract: take by weighing the recipe quantity medical material, soak by the setting scheme, heating decocts, and filters, and filtrating merges, and leaves standstill, and relative density is 1.30～1.35 clear paste when getting supernatant and being evaporated to 20 ℃.Accurate draw in right amount, put in the evaporating dish that is dried to constant weight, water bath method in 105 ℃ of dryings 3 hours, was put in the drying basin cooling 0.5 hour, weighed rapidly, was calculated as follows yield of extract:
Yield of extract (%)=W/W
0* 100%
W: the weight of extractum;
W
0: the weight of medical material.
1. amount of water: according to seven relieve internal heat effervescent granule clearly prescription and technology, select a recipe quantity, parallel test three times; By decocting 2 times, each 2 hours, 6,8,10,12 times of water gagings that add medical material weight made an experiment respectively; With the yield of extract is to investigate index, and the result sees table 1.
Table 1 adds water and doubly measures the investigation result
| The test batch | Adding water doubly measures | Yield of extract (%) |
| 1 | 6 | 14.6 |
| 2 | 8 | 15.2 |
| 3 | 10 | 16.5 |
| 4 | 12 | 16.7 |
The result shows, adds water and doubly measures when being 6,8,10,12 times, and yield of extract is not had obvious influence.In conjunction with these article practical situation, selecting amount of water is 8 times of amounts.
2. extraction time
According to seven relieve internal heat effervescent granule clearly prescription and technology, select a recipe quantity, parallel test three times by decocting 2 times, adds 8 times of water gagings of medical material weight respectively at every turn, make an experiment according to the extraction time in the table 2, be to investigate index with the yield of extract, the result sees table 2.
Table 2 extraction time investigation result
| The test batch | 1 | 2 | 3 | 4 |
| The 1st extraction time (h) | 1 | 2 | 3 | 4 |
| The 2nd extraction time (h) | 1 | 2 | 3 | 4 |
| Yield of extract (%) | 14.8 | 15.8 | 15.1 | 16.2 |
The result shows, according to seven relieve internal heat effervescent granule clearly prescription and technology, decoct 2 times, each 2 hours, when adding 8 times of water gagings of medical material weight at every turn and extracting clear paste, yield of extract was higher.Actual according to producing, select to decoct 2 times, each 2 hours extraction process carry out seven relieve internal heat clear paste clearly extraction.
3. seven clear paste determination of water that relieve internal heat clearly
Adopt the People's Republic of China's 2005 editions 2 (appendix 57) aquametry first methods of veterinary drug allusion quotation (oven drying method) that seven moisture that relieve internal heat clearly in the clear paste are measured.
Get relative density and be seven relieve internal heat clearly 3 batches of the clear paste of 1.30～1.35 (20 ℃), every crowd of 2～5g is tiled in the flat bottle that is dried to constant weight, and thickness is no more than 5mm; Accurate claim surely, open bottle cap, bottle cap is built, in the dry exsiccator of dislocation 100～105 ℃ of dryings 5 hours; Cooled off 30 minutes, accurate claim fixed, again dry 1 hour of said temperature; Cooling is weighed, and extremely double difference of weighing is no more than till the 5mg.According to the weight that subtracts mistake, calculate seven relieve internal heat clear paste clearly water content (%), ask its meansigma methods, finally record seven relieve internal heat clear paste clearly water content be 28.6% ± 1.4%.
Conclusion: Radix Scutellariae 100g, Rhizoma Polygoni Cuspidati 100g, Radix Pulsatillae 80g, Radix Sophorae Flavescentis 80g, Radix Isatidis 100g, Rhizoma Dryopteris Crassirhizomatis 60g, Folium Isatidis 40g be totally 7 flavor medical materials; Adding 8 times of water gagings extracts 2 times; Each 2 hours, merging filtrate, being concentrated into relative density is 1.30～1.35 (20 ℃); Get clear paste 160g, can get extract powder 110g～118g.
Therefore, seven relieve internal heat effervescent granule clearly prescription and technology be decided to be: take by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, the Folium Isatidis of recipe quantity, decoct, decoct 2 times by the heating of the water of 8 times of medical material weight; Each 2 hours, collecting decoction filtered, and filtrating merges; Leave standstill, relative density is 1.30～1.35 when getting supernatant and being evaporated to 20 ℃, clear paste 160g; Clear paste, adjuvant are processed granule in 1: 3.5 ratio, and drying promptly gets.
Two, seven relieve internal heat the effervescent granule formulation and technology clearly screening
1. the screening of acidizer and alkaline agent
In the selection of effervescent, sodium bicarbonate is as carbon source, and consumption is few, and gas production is big, and the present invention adopts sodium bicarbonate as carbon source.Because Chinese medical concrete is prone to the moisture absorption, viscosity is big, so the selection of acid source is very important.Take by weighing a certain amount of extractum respectively with the bronsted lowry acids and bases bronsted lowry mix homogeneously, granulate the screening of filling a prescription respectively with ethanol.The result sees table 3.
The The selection result of table 3 acidizer and alkaline agent
| Prescription | Extractum (in dried cream) (g) | Acid kind (g) | Alkali kind (g) | The result |
| 1 | 11 | Tartaric acid 10 | Sodium bicarbonate 12 | Granulate, effervescent is all good, dissolving back clarity is bad |
| 2 | 11 | Adipic acid 10 | Sodium bicarbonate 12 | The grain that makes is lump, and effervescent is slow, and dissolving back clarity is bad |
| 3 | 11 | Succinic acid 10 | Sodium bicarbonate 12 | The moisture absorption can't be granulated |
| 4 | 11 | Malic acid 10 | Sodium bicarbonate 12 | The moisture absorption can't be granulated |
| 5 | 11 | Fumaric acid 10 | Sodium bicarbonate 12 | Granulate, effervescent is better, and dissolving back clarity is good |
| 6 | 11 | Citric acid 10 | Sodium bicarbonate 12 | Caking can't be granulated |
Tartaric acid is during as acid source, because the calcium, the magnesium ion that exist in tartaric acid and the ordinary water combine, generates white flocculent deposit, and dissolving back clarity is bad, influence sense organ, in prescription 1, is confirmed, so selection writes out a prescription 5, the employing fumaric acid is as the acid source of effervescent.
2. prescription screening EXPERIMENTAL DESIGN
Owing to contain Chinese medicine extraction extractum, viscosity is big in this preparation, so select for use the ratio of soda acid must be moderate; Just can reach the requirement of effervescent disintegrate; General soda acid ratio is 0.8: 1, but also has report to think that the consumption of acid surpasses theoretical consumption, and the effervescent granule that makes could be stablized with agreeable to the taste.Therefore, according to the characteristics and the performance of various adjuvants, as investigating index, the consumption of the soda acid ratio in the prescription and other adjuvants is screened with the difficulty of the disintegration time of effervescent granule, granulation, outward appearance, melting etc.
Table 4 prescription screening EXPERIMENTAL DESIGN and result
| Prescription | 1 | 2 | 3 | ?4 | 5 | 6 |
| Extractum (in dried cream) (g) | 11 | 11 | 11 | ?11 | 11 | 11 |
| Sodium bicarbonate (g) | 8 | 8 | 10 | ?10 | 12 | 15 |
| Fumaric acid (g) | 10 | 8 | 8 | ?10 | 10 | 10 |
| Glucose (g) | 30 | 30 | 64 | ?35 | 55 | 35 |
| Soluble starch (g) | 28 | 28 | —— | ?22 | —— | 24 |
| Dextrin (g) | 6 | 6 | —— | ?6 | 5 | |
| Correctives (g) | Steviosin 2 | Vanillin 4 | Xylitol 3 | Aspartame 1 | Steviosin 2 | --- |
| The granulation difficulty or ease | Be prone to | Be prone to | Be prone to | Be prone to | Be prone to | The alkali grain is loose |
| Outward appearance | Generally | Generally | Good | Generally | Good | Generally |
| Disintegration time (min) | 6 | 5 | 3 | ?4 | 2 | 1.9 |
| Palatability | Good | Good | Good | Good | Good | Bad |
| Melting | Dissolving is incomplete, and a small amount of insoluble matter is arranged at the bottom | Foreign bodies such as dissolving is complete, no breeze, the solution clarification is bright, not wall built-up | Foreign bodies such as dissolving is complete, no breeze, the solution clarification is bright, not wall built-up | Dissolving is incomplete, and a small amount of insoluble matter is arranged at the bottom | Foreign bodies such as dissolving is complete, no breeze, the solution clarification is bright, not wall built-up | Foreign bodies such as dissolving is complete, no breeze, the solution clarification is bright, not wall built-up |
Can find out that from result of the test the disintegration time of prescription 5 is minimum, and outward appearance, palatability and melting are all good, so confirm that prescription 5 is a technical scheme of the present invention.
Three, granulating process is confirmed
This preparation adopts extractum to prepare effervescent granule, contains in the extractum than juicy, for avoiding acid-base reaction in the pelletization, so adopt soda acid separately to granulate.
Recipe quantity takes by weighing extractum and adjuvant respectively, and fully mixing is processed acidity, alkaline soft material respectively, and 16 mesh sieves are granulated respectively, 70～80 ℃ of dryings, and granulate with acid grain, alkali grain mix homogeneously, adds correctives, drying, packing promptly gets.
Embodiment 1
1. seven effervescent granules that relieve internal heat clearly, it is to be prepared from by following materials of weight proportions and adjuvant:
Raw material is: Radix Scutellariae 100g, Rhizoma Polygoni Cuspidati 100g, Radix Pulsatillae 80g, Radix Sophorae Flavescentis 80g, Radix Isatidis 100g, Rhizoma Dryopteris Crassirhizomatis 60g, Folium Isatidis 40g;
Adjuvant is: sodium bicarbonate 80g, fumaric acid 67g, diluent: glucose 367g, dextrin 33g, correctives: steviosin 13g.
Seven relieve internal heat effervescent granule clearly method for preparing, carry out according to the following steps:
(1) takes by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, the Folium Isatidis of recipe quantity, decoct, decoct 2 times by the water heating of 8 times of medical material weight; Each 2 hours, collecting decoction filtered; Filtrating merges; Leave standstill, relative density is 1.30～1.35 when getting supernatant and being evaporated to 20 ℃, clear paste;
(2) preparation of acid particles: get the clear paste of half amount, the diluent of half amount and the fumaric acid of recipe quantity, mix homogeneously adds an amount of adhesive and processes soft material, and 16 mesh sieves are granulated, and is dry under 70～80 ℃ of conditions, and granulate is subsequent use;
(3) preparation of alkali grain: get the clear paste of half amount, the diluent of half amount and the sodium bicarbonate mix homogeneously of recipe quantity, add an amount of adhesive and process soft material, 16 mesh sieves are granulated, and are dry under 70～80 ℃ of conditions, and granulate is subsequent use;
(4), add correctives, drying, packing with qualified soda acid granule mix homogeneously.
Embodiment 2
1. seven effervescent granules that relieve internal heat clearly, it is to be prepared from by following materials of weight proportions and adjuvant:
Raw material is: Radix Scutellariae 100g, Rhizoma Polygoni Cuspidati 100g, Radix Pulsatillae 80g, Radix Sophorae Flavescentis 80g, Radix Isatidis 100g, Rhizoma Dryopteris Crassirhizomatis 60g, Folium Isatidis 40g.
Adjuvant is: sodium bicarbonate 72g, fumaric acid 60g, diluent: mannitol 387g, correctives: Aspartane 11g.
Seven relieve internal heat effervescent granule clearly method for preparing: repeat method for preparing among the embodiment 1 and obtain of the present invention seven effervescent granules that relieve internal heat clearly.
Embodiment 3
1. seven effervescent granules that relieve internal heat clearly, it is to be prepared from by following materials of weight proportions and adjuvant:
Raw material is: Radix Scutellariae 100g, Rhizoma Polygoni Cuspidati 100g, Radix Pulsatillae 80g, Radix Sophorae Flavescentis 80g, Radix Isatidis 100g, Rhizoma Dryopteris Crassirhizomatis 60g, Folium Isatidis 40g.
Adjuvant is: sodium bicarbonate 76g, fumaric acid 62g, diluent: soluble starch 200g, microcrystalline Cellulose 100g, dextrin 90g, correctives: saccharin sodium 4g, Calcium o-benzolsulfimide 4g, cyclohexane sulfamic acid sodium 4g.
Seven relieve internal heat effervescent granule clearly method for preparing: repeat method for preparing among the embodiment 1 and obtain of the present invention seven effervescent granules that relieve internal heat clearly.
Embodiment 4
1. seven effervescent granules that relieve internal heat clearly, it is to be prepared from by following materials of weight proportions and adjuvant:
Raw material is: Radix Scutellariae 100g, Rhizoma Polygoni Cuspidati 100g, Radix Pulsatillae 80g, Radix Sophorae Flavescentis 80g, Radix Isatidis 100g, Rhizoma Dryopteris Crassirhizomatis 60g, Folium Isatidis 40g.
Adjuvant is: sodium bicarbonate 85g, fumaric acid 70g, diluent: lactose 300g, dextrin 117g, correctives: radix asparagi sweet extract 14g.
Seven relieve internal heat effervescent granule clearly method for preparing: repeat method for preparing among the embodiment 1 and obtain of the present invention seven effervescent granules that relieve internal heat clearly.
Embodiment 5
1. seven effervescent granules that relieve internal heat clearly, it is to be prepared from by following materials of weight proportions and adjuvant:
Raw material is: Radix Scutellariae 100g, Rhizoma Polygoni Cuspidati 100g, Radix Pulsatillae 80g, Radix Sophorae Flavescentis 80g, Radix Isatidis 100g, Rhizoma Dryopteris Crassirhizomatis 60g, Folium Isatidis 40g.
Adjuvant is: sodium bicarbonate 88g, fumaric acid 72g, diluent: glucose 415g, correctives: Aspartane 15g.
Seven relieve internal heat effervescent granule clearly method for preparing: repeat method for preparing among the embodiment 1 and obtain of the present invention seven effervescent granules that relieve internal heat clearly.
Diluent in the embodiments of the invention can be any one or two kinds or the combination in any of any two kinds of materials in glucose, sucrose, lactose, soluble starch, microcrystalline Cellulose, dextrin, mannitol, the sorbitol.
Correctives can be the combination in any of any one or two or more material in steviosin, vanillin, Aspartane, xylitol, sugar, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid sodium, agedoite, dihydrochalcone, glycyrrhizin, pure sugar or the radix asparagi sweet extract.
The seven effervescent granule stability tests that relieve internal heat clearly
Get effervescent granule of the present invention, the simulation commercially available back, 25 ± 2 ℃ of temperature, relative humidity 60% ± 10% condition held is respectively at 0,3,6,9,12 ... Moon sampling is investigated, and investigates the result and sees table 5.
1. moisture: according to 2005 editions 2 aquametries of Chinese veterinary drug allusion quotation (57 pages of appendix).
2. melting: get 3 crowdes of each 10g of effervescent granule respectively, add hot water 200ml and produce gas rapidly and be the effervescent shape, the 5min endoparticle disperses fully and is dissolved in the water, and the solution clarification is bright, foreign bodies such as no breeze.
3. disintegration: effervescent granule in the inspection time limit all disintegrates dissolve and loose or become particle and be dissolved in the required time in the water.
The table 5 seven effervescent granule stability test that relieves internal heat clearly
Can find out that by last table adopt the effervescent granule of the present invention's preparation to meet the pharmacopeia requirement: through 12 months stability tests, the product character did not have significant change; Moisture＜6%, melting is better, and the effervescent granule effervescent of preparation is rapid; The solution clarification does not have deposition, foreign bodies such as no breeze; Outward appearance is good, thereby the effervescent granule stable in properties of explanation the present invention preparation is quality controllable.
Clinical trial one
On March 15th, 2008; Henan Zhumadian 2500 the 165 blue brown laying hens in ages in days sea that raise at the family of raising chickens; Chicken crowd lethargy, slow-witted upright, inappetence, feather pine are disorderly, two wings are sagging, hat is blue, arrange yellowish green loose stool, slight respiratory symptom is arranged; Indivedual chicken calculus ash water sample feces, arthroncus, dead chicken is many because of the depleted death of dehydration.Found dead 5 before 4 days, be diagnosed as colibacillosis through near veterinary, medication is after 4 days, and the state of an illness does not have controlled, and mortality rate increases on the contrary.
Pathological change: cut open 8 chickens that die of illness of inspection, its pathological change is roughly the same, in the chicken abdominal cavity of dying of illness disruptive egg yolk liquid is arranged, and severe patient forms yolk peritonitis, intestinal wall attenuation, blackout, air bag muddiness; The heart, liver, mesentery cover the urate of one deck white, limy appearance; Kidney enlargement, color shoal, and the ureter chap contains a large amount of white urates; The glandular stomach papilledema has slight bleeding, muscular stomach not to have significant change individually; Colic lymph nodes swelling, hyporrhea; Arthroncus, in the urate of Calx appearance is arranged.
According to clinical symptoms, pathological change and laboratory inspection, be diagnosed as atypical newcastle disease secondary colibacillosis, and with the gout symptom.
Treatment: select for use effervescent granule of the present invention to add drinking-water, every 100g converts water 200Kg, logotype 3～5 days; Reduce protein level in the feedstuff simultaneously, replenish multivitamin, ORS.Medication 3 days, the dead basic controlling of chicken crowd, mental status is clearly better; After 5 days, feed intake is normal, and chicken the crowd gradually recover one's health.
Clinical trial two
Henan Zhang raises 200 bull pigs, and wherein piglets is introduced existing 1 wheat harvesting period about 100 2 monthly ages.On JIUYUE 10th, 2008, the piglets sudden onset, 15 of sick pigs, wherein dead 5, sick afterwards pig is increased gradually, and feeds through to big pig.Local veterinary is diagnosed as cold pig, presses common cold treatment, intramuscular injection antondin, penicillin and sulfadiazine, and logotype 3 days, DeGrain, it is dead to still have indivedual sick pigs to take place.
Clinical symptoms: spirit is depressed, subtracts to eat or do not eat, and is erect by hair, and fear of cold trembles, and is reluctant to move, and happiness crowded pushes away, and is afraid of cold, and calls hoarse; Fervescence to 40 ℃～41.5 ℃, ear, extremity, subcutaneous abdomen have the petechia; Draw the argol ball and have mucus, eye secretion is many; It is yellow that skin and visual mucosal pallor, jaundice, urine are, last depleted dead.
Cuing open inspection changes: cut open 5 pigs that die of illness of inspection altogether, pathological changes is similar basically, and whole body serous coat, mucosa and organa parenchymatosum have the petechia; Gastric mucosa, mucous membrane of urinary bladder are hemorrhage, and renomegaly is khaki, and there is needle point massive hemorrhage point on the surface, and splenomegaly has much the hemorrhage hemorrhage infarction with Semen phaseoli radiati size mulberry of mound shape point; Heart hat fat, endocardium have the petechia, and the muscle color and luster is thin out, fatty xanthochromia; Lymph nodes of body as a whole enlargement, edema, thoracic cavity and seroperitoneum; Whole skin, visual mucosal pallor; Blood is thin in water, solidifies badly, and liver is swollen slightly to be khaki, and gallbladder expands, and bile is dense thick; Pericardial effusion, cardiac muscle is loose.
According to incidence, clinical symptoms, pathological change and laboratory inspection, be diagnosed as swine fever and swine eperythrozoonosis mixed infection.
Treatment: select for use effervescent granule of the present invention to add drinking-water, every 100g converts water 200Kg, logotype 3～5 days; Promptly inoculate with the swine fever hyper-immune serum simultaneously.Simultaneously, strengthen feeding and management, adopt the mixed feed of comprehensive nutrition, improve pig body premunition.Pig to ill is isolated for treatment, and seriously ill pig and dead pig are taked buried harmless treatment, and pig farm, apparatus, colony house and surrounding are carried out thorough disinfection.Medication 3 days, the dead basic controlling of swinery, mental status is clearly better; After 5 days, feed intake is normal, and swinery gradually recovers one's health.
Claims (6)
1. the effervescent granule that relieves internal heat clearly is characterized in that, it is prepared from the raw material and the adjuvant of following weight parts:
Raw material: Radix Scutellariae 100, Rhizoma Polygoni Cuspidati 100, the Radix Pulsatillae 80, Radix Sophorae Flavescentis 80, Radix Isatidis 100, Rhizoma Dryopteris Crassirhizomatis 60, Folium Isatidis 40;
Adjuvant: sodium bicarbonate 72～88, fumaric acid 60～74, diluent 387～417, correctives 11～15.
2. according to claim 1 seven effervescent granules that relieve internal heat clearly is characterized in that: described diluent is at least a in glucose, sucrose, lactose, soluble starch, microcrystalline Cellulose, dextrin, mannitol, the sorbitol.
3. according to claim 2 seven effervescent granules that relieve internal heat clearly, it is characterized in that: described diluent is the mixture of glucose and dextrin.
4. according to claim 1 and 2 seven effervescent granules that relieve internal heat clearly is characterized in that: described correctives is at least a in steviosin, vanillin, Aspartane, xylitol, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid sodium, agedoite, dihydrochalcone, glycyrrhizin, pure sugar or the radix asparagi sweet extract.
5. according to claim 4 seven effervescent granules that relieve internal heat clearly, it is characterized in that: described correctives is a steviosin.
6. as claimed in claim 1 seven relieve internal heat effervescent granule clearly method for preparing, it is characterized in that it carries out according to the following steps:
(1) takes by weighing Radix Scutellariae, Rhizoma Polygoni Cuspidati, the Radix Pulsatillae, Radix Sophorae Flavescentis, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, the Folium Isatidis of recipe quantity, decoct, decoct 2 times by the water heating of 8 times of medical material weight; Each 2 hours, collecting decoction filtered; Filtrating merges; Leave standstill, relative density is 1.30～1.35 when getting supernatant and being evaporated to 20 ℃, clear paste;
(2) preparation of acid particles: get the clear paste of half amount, the diluent of half amount and the fumaric acid of recipe quantity, mix homogeneously adds an amount of adhesive and processes soft material, and 16 mesh sieves are granulated, and is dry under 70～80 ℃ of conditions, and granulate is subsequent use;
(3) preparation of alkali grain: get the clear paste of half amount, the diluent of half amount and the sodium bicarbonate mix homogeneously of recipe quantity, add an amount of adhesive and process soft material, 16 mesh sieves are granulated, and are dry under 70～80 ℃ of conditions, and granulate is subsequent use;
(4), add correctives, drying, packing with qualified soda acid granule mix homogeneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100660829A CN102008556B (en) | 2009-09-08 | 2009-09-08 | Qiqing Baidu effervescent granule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100660829A CN102008556B (en) | 2009-09-08 | 2009-09-08 | Qiqing Baidu effervescent granule and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102008556A CN102008556A (en) | 2011-04-13 |
| CN102008556B true CN102008556B (en) | 2012-06-06 |
Family
ID=43839017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100660829A Active CN102008556B (en) | 2009-09-08 | 2009-09-08 | Qiqing Baidu effervescent granule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102008556B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638268A (en) * | 2013-12-03 | 2014-03-19 | 镇江天和生物技术有限公司 | Qiqing baidu drink and preparation method thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214862B (en) * | 2016-08-18 | 2019-10-25 | 山东省农业科学院家禽研究所 | A kind of Traditional Chinese veterinary medicine oral solution and preparation method thereof preventing and treating the atypical newcastle disease of chicken |
| CN106236713B (en) * | 2016-08-30 | 2018-11-09 | 林州中农颖泰生物肽有限公司 | Seven clear Toxin-Vanquishing effervescence granulars of one kind and preparation method thereof |
| CN107361281B (en) * | 2017-07-13 | 2021-04-20 | 江苏中邦制药有限公司 | Momordica grosvenori effervescent tablet and preparation method thereof |
| CN110464776A (en) * | 2019-08-10 | 2019-11-19 | 江苏禾宝药业有限公司 | A kind of the removing summer-heat mixture and its preparation process of prevention and treatment newcastle disease for animals |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127136A (en) * | 1995-10-25 | 1996-07-24 | 张飞雄 | Broad-spectrum antibiotic and bateriostatic and preparing method |
| CN1456269A (en) * | 2003-02-21 | 2003-11-19 | 毛友昌 | Preparation of effervescent tablets against cold |
| CN1456271A (en) * | 2003-02-21 | 2003-11-19 | 毛友昌 | Preparation of south isatis root effervescent tablets |
-
2009
- 2009-09-08 CN CN2009100660829A patent/CN102008556B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127136A (en) * | 1995-10-25 | 1996-07-24 | 张飞雄 | Broad-spectrum antibiotic and bateriostatic and preparing method |
| CN1456269A (en) * | 2003-02-21 | 2003-11-19 | 毛友昌 | Preparation of effervescent tablets against cold |
| CN1456271A (en) * | 2003-02-21 | 2003-11-19 | 毛友昌 | Preparation of south isatis root effervescent tablets |
Non-Patent Citations (4)
| Title |
|---|
| 中国兽药典委员会编.七清败毒颗粒.《中华人民共和国兽药典》.中国农业出版社,2006,(第2005年版),401. * |
| 傅文栋.中草药及其有效成分体外抗菌抗病毒研究进展.《中兽医医药杂志》.2006,(第5期), * |
| 张国红.按中草药对畜禽疾病病原体作用分类初探.《云南畜牧兽医》.1997,(第3期), * |
| 谢仲权.中草药预防高致病性禽流感.《中国动物保健》.2004,(第4期), * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638268A (en) * | 2013-12-03 | 2014-03-19 | 镇江天和生物技术有限公司 | Qiqing baidu drink and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102008556A (en) | 2011-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101664421B (en) | Traditional Chinese biological preparation for preventing and treating livestock diarrhea and preparation method and feedstuff thereof | |
| CN102835609B (en) | Pig feed capable of preventing piglets from diarrhea and traditional Chinese medicine composition | |
| CN102302634B (en) | Thousand-mesh traditional Chinese medicine preparation used for controlling livestock and poultry diarrhea, and preparation method thereof | |
| CN102008585B (en) | Sihuang anti-dysentery effervescent particle and preparation method thereof | |
| CN101417008B (en) | Biberberine for injection as veterinary herb medicine composite preparation and preparation technique and use thereof | |
| CN102008556B (en) | Qiqing Baidu effervescent granule and preparation method thereof | |
| CN102078522A (en) | Chinese medicine composition for treating enterovirus syndrome in chicken | |
| CN102727569A (en) | Preparation method of licorice particles for livestock and poultry | |
| CN101590139A (en) | A kind of preparation method of preventing and treating the Chinese medicine compound four yellow dysentery stopping preparations of livestock and poultry intestinal canal diseases | |
| CN105166545A (en) | Bovine compound feed and preparation method thereof | |
| CN102988363B (en) | Medicine for treating poultry proventriculitis and necrotic enteritis and preparation method thereof | |
| CN107714794A (en) | Russia's color extract tablet and preparation method thereof | |
| CN104256165A (en) | Functional feed for preventing and treating chronic swine plague and preparation method of functional feed | |
| CN103689748B (en) | One has adjustment intestines and stomach function, the anti-washing drink treated constipation | |
| WO2005074952A1 (en) | Chinese medicine for treatment of irritable bowel sysndrome and the preparation thereof | |
| CN103609893A (en) | Cattle feed for promoting digestion | |
| CN103550354A (en) | Compound stomach-invigorating and intestine-treating granules for fishes and preparation method thereof | |
| CN109999117A (en) | Prevent and treat enteritis, bacillary dysentery, dysentery, intractable diarrhea Chinese medicine composition | |
| CN114886961A (en) | Traditional Chinese medicine composition for treating/preventing avian gout and preparation method and application thereof | |
| CN102379939A (en) | Drug composition for preventing and treating exogenous fever of livestock and poultry | |
| CN103610975A (en) | Preparation method of cattle medicine for promoting digestion | |
| CN1256117C (en) | Medicine for treating chronic ulcerative colitis and its preparation process | |
| CN108853343A (en) | It is a kind of to prevent and treat the Chinese materia medica preparation of chicken mycotoxicosis, preparation method and application | |
| CN114191510B (en) | Chinese herbal compound preparation for preventing and treating diarrhea of piglets and preparation method thereof | |
| CN114073728B (en) | Traditional Chinese medicine composition for preventing and treating salpingitis of laying hens and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150921 Address after: 451162, Henan, Zhengzhou province Xinzheng Xue Zhen Station Front Street Patentee after: Henan Huitong Tianxia Bio-engineering Co., Ltd. Address before: 450008, Henan, Zhengzhou by three road 28, Fung Garden A block, 5 floor, C households Patentee before: Henan Huitong World Animal Pharmaceutical Co., Ltd. |