CN1127136A - Broad-spectrum antibiotic and bateriostatic and preparing method - Google Patents
Broad-spectrum antibiotic and bateriostatic and preparing method Download PDFInfo
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- CN1127136A CN1127136A CN 95114231 CN95114231A CN1127136A CN 1127136 A CN1127136 A CN 1127136A CN 95114231 CN95114231 CN 95114231 CN 95114231 A CN95114231 A CN 95114231A CN 1127136 A CN1127136 A CN 1127136A
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Abstract
The drug is the oral preparation made from 11 traditional Chinese medicinal herbs of bark of official magnolia and giant knot-weed rhizome etc.. The preparation method divides the medicines into four groups, after water extracting and alcohll precipitating for each, they are mixed and concentrated and further made into various preparations with normal method. Said drug is a broad sprectum anti-biotic and bacteriostatic and can kill gram-positive bacterium, gram-negative bacterium, fungi, microbe and parasite. The preparation method is simple.
Description
The present invention relates to a kind of broad-spectrum antiseptic bacteriostatic and preparation method thereof.
Morbific microorganism has antibacterial, fungus, virus or the like, and antibacterial comprises gram positive bacteria and gram negative bacteria.Up to now, be not the extensive pedigree antibiotic that discovery can have above antibiotic (antibacterial) spectrum simultaneously.But some patient's physical weakness, immunologic hypofunction is not to be merely bacterial infection, often is associated with mixed infections such as virus and fungus.And its diagnosis is also very difficult.Simultaneously because repeatedly medication repeatedly causes the appearance of drug resistance strain, even make and have to add that dosage is at a loss what to do.
Purpose of the present invention just is to provide a kind of broad-spectrum antiseptic antibacterial medicines of killing simultaneously or suppressing gram positive bacteria, gram negative bacteria, fungus, virus and preparation method thereof that has.
The present invention realizes like this.
Product of the present invention is that plurality of Chinese is the Chinese medicine preparation that raw material is processed into, and its preparation adopts peroral dosage form, as Chinese medicine oral liquid, cream, sweet cream, electuary, capsule, tablet, sugar coated tablet.Its Chinese medicine is Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus ten Herba indigoferae Pseudotinctoriae, the ratio of each medicine for wherein arbitrarily Herba indigoferae Pseudotinctoriae be benchmark, other medicine is 1/3～3 times of its weight.
The optimal proportion of each medicine is among the present invention: the weight ratio of Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus is: 2: 1: 1.5: 1: 1.5: 1: 1: 1: 2: 1.5: 2.
Production technology of the present invention is to take by weighing various medicines according to quantity, is divided into four groups: (1) Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei; (2) Radix Pulsatillae, Radix Scutellariae; (3) Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis; (4) Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus, secondary water is carried respectively, and through ethanol precipitation, mixed ethanol supernatant, concentrating under reduced pressure become the thick paste shape, add water or honey one-tenth oral liquid or sweet cream; Or through 60 ℃ of further dryings, granulate, further be processed into electuary, capsule; Or the interpolation adjuvant, be processed into tablet.
Antibacterial bacteriostatic medicine of the present invention combines the antibacterial bacteriostatic medicine of the various pharmacological actions of tool, cell wall toxicant, cell membrane toxicant are arranged, hinder the material of pathogen DNA, the synthetic material of RNA and direct human body immunity improving power, from multi-angle, many-sided (killing) pathogen that suppresses continuously, thereby its has a broad antifungal spectrum, can kill gram positive bacteria, gram negative bacteria, fungus, virus, parasites such as chlamydia, spirillum, infusorian, ameba, imago of blood fluke also have killing action.Its preparation method is simple.
Narrate embodiment below.
Embodiment 1, and the weight ratio of Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus is: 2: 1: 1.5: 1: 1.5: 1: 1: 1: 2: 1.5: 2.
Embodiment 2, each medicine five equilibrium of the weight of Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus.
Embodiment 3, and the weight ratio of Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus is: 3: 1: 1/3: 1: 1/2: 1: 1: 3: 1: 1: 1.
Embodiment 4, and the weight ratio of Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus is: 1: 3: 1: 1: 2: 3: 3: 2: 1: 2: 3.
The preparation method of embodiment 1 is:
Medicine is divided into four groups, (1) Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, (2) Radix Pulsatillae, Radix Scutellariae, (3) Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, (4) Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus.
The step of group (1):
(1) Radix Et Rhizoma Rhei of getting once chopping with cold water express developed is put in the pressure cooker, the cold water that adds qdx under High Temperature High Pressure, heat (121 ℃, 12 pounds/cur
2Pressure heating 0.1～1 hour), cool.Again Radix Et Rhizoma Rhei medicinal liquid and medicinal residues are all poured in the decoction device.
(2) get Cortex Magnoliae Officinalis and the Rhizoma Polygoni Cuspidati that once shreds express developed with cold water, add to decoct in the device and mix with Radix Et Rhizoma Rhei medicinal liquid and medicinal residues, add cold water and soaked powder, ebuillition of heated is 40～50 minutes under the normal pressure, pours out medicinal liquid.In medicinal residues, add water again and cross powder and under normal pressure, heat, seethed with excitement 40～50 minutes, pour out medicinal liquid.The secondary medicinal liquid is mixed, filter, blended medicinal liquid is put in the decompression evaporator, decompression (vacuum) concentrates (or in decocting device under the normal pressure heating evaporation concentrate), to 1/8～1/10 of admixing medical solutions, leave standstill 2～24 hours (or using centrifuge centrifugation), the last clear liquid medicine on the taking precipitate face.
(3) in last clear liquid medicine, add isopyknic 95% ethanol, shake up, stir, leave standstill.
(4) leave standstill 24 hours, get supernatant ethanol medicinal liquid.
The step of group (2):
To get the Radix Pulsatillae and the Radix Scutellariae that shred for 1～2 time express developed with cold water and put in the decoction device, and add water, then, method is with step (two), (three) and (four) of prescription 1.
The step of compositing formula 3:
To wash 1 time chopping Rhizoma Coptidis, Cortex Phellodendri and Radix Sophorae Flavescentis fast with cold water and put and decoct in the device, and add water, then, method is with step (two), (three) and (four) of prescription 1.
The step of compositing formula 4:
To get Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba and the Polyporus of 1～2 chopping with cold water express developed, and put in the decoction device, and add water, then, method is equally operated with the step (two) of prescription 1.
The last clear liquid medicine of compositing formula 1,2,3,4 is mixed, put in the decompression evaporator, decompression (vacuum) concentrates admixing medical solutions, is thick paste shape (the thick paste shape ointment of this moment also contains a spot of moisture content) up to admixing medical solutions.
The mixing ointment of thick paste shape is taken out from decompression evaporator, put in 60 ℃ the calorstat further dry, dry 24 hours, (annotate: dry ointment is the soft viscosity semifluid of the thick paste sample shape thing of grey black under 60 ℃ of conditions to turn 4～7 times in dry run, and after cold at normal temperatures, just become atrous such as the rigid thing of Colla Corii Asini shape, this dry ointment is the soft chill reversibility medicine of heat).
Exsiccant 60 ℃ of ointment are put the middle spray of airless injection (mist) device (tower) for vaporific, become fine particulate or powdery, add an amount of compound (as starch, medicated powder etc.), stir, become the capsule oral agent with automatic capsule filler, or exsiccant 60 ℃ of ointment are added an amount of compound, stir, be pressed into tablet with automatic tableting press, or become coated tablet after going up sweet tablet.At last, packing is dispatched from the factory.
All the other embodiment are identical with embodiment 1 preparation method as the preparation capsule.Preparing its processing method after extracting of other preparation also is conventional method.
Antibacterial bacteriostatic medicine oral dose of the present invention is 10 grams～50 grams that each dosage is equivalent to former Chinese medicine, day 3～4 times.Embodiment 1 shows that through acute toxicity test in mice its toxicity is very low.The patient's of the pathogenic bacteria strain of mice through inoculating anti-ampicillin, pioneer No. four, ciprofloxacin, ofloxacin suppurative secretions, cure rate reaches 100% in three days.Get in advance oral at random or injection penicillins, cephalosporins, ciprofloxacin, the husky star therapeutic effect of fluorine oxygen unconspicuous 87 routine clinical cases, take the product of the embodiment of the invention 1 separately, and do not drink, do not drink strong tea during advising its medication, observe and find, took medicine first back about 2 hours, most of patient infection's symptom goes down and sign is obviously improved, and after three days, all cures.Each patient infection system is respectively: respiratory system 42 examples, urinary system 25 examples, digestive system 16 examples, joint 1 example, skin 1 example.
Claims (3)
1. broad-spectrum antiseptic bacteriostatic, for plurality of Chinese is the Chinese medicine preparation that raw material processes, be peroral dosage form, its Chinese medicine is Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus ten Herba indigoferae Pseudotinctoriae, the ratio of each medicine for wherein arbitrarily Herba indigoferae Pseudotinctoriae be benchmark, other medicine is 1/3～3 times of its weight.
2. according to the described broad-spectrum antiseptic bacteriostatic of claim, it is characterized in that the optimal proportion of each Chinese medicine is: the weight ratio of Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus is: 2: 1: 1.5: 1: 1.5: 1: 1: 1: 2: 1.5: 2.
3. the preparation method of a broad-spectrum antiseptic bacteriostatic as claimed in claim 1 comprises the steps:
A. medicine is divided into four groups, (1) Cortex Magnoliae Officinalis, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, (2) Radix Pulsatillae, Radix Scutellariae, (3) Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, (4) Radix Et Caulis Acanthopanacis Senticosi, the Radix Paeoniae Alba, Polyporus;
B. each medicine is distinguished water extraction ethanol precipitation;
C. merge the ethanol supernatant, be condensed into the thick paste shape;
D. conventional method is processed into each peroral dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95114231 CN1055627C (en) | 1995-10-25 | 1995-10-25 | Broad-spectrum antibiotic and bateriostatic and preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95114231 CN1055627C (en) | 1995-10-25 | 1995-10-25 | Broad-spectrum antibiotic and bateriostatic and preparing method |
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| Publication Number | Publication Date |
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| CN1127136A true CN1127136A (en) | 1996-07-24 |
| CN1055627C CN1055627C (en) | 2000-08-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95114231 Expired - Fee Related CN1055627C (en) | 1995-10-25 | 1995-10-25 | Broad-spectrum antibiotic and bateriostatic and preparing method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| CN102397383A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis pure Chinese medicinal composition for treating avian spirochaetosis and preparation method thereof |
| CN102008556B (en) * | 2009-09-08 | 2012-06-06 | 河南惠通天下动物药业有限公司 | Qiqing Baidu effervescent granule and preparation method thereof |
| CN103301142A (en) * | 2013-06-03 | 2013-09-18 | 南京正亮医药科技有限公司 | Application of polyflavanostilbene A in preparation of anti-human fungus medicine |
| CN105233144A (en) * | 2015-09-10 | 2016-01-13 | 山东宝来利来生物工程股份有限公司 | Traditional Chinese medicine preparation for treating dermatomycoses of animals and preparation method of traditional Chinese medicine preparation |
-
1995
- 1995-10-25 CN CN 95114231 patent/CN1055627C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
| US8163304B2 (en) | 2002-06-25 | 2012-04-24 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| CN102008556B (en) * | 2009-09-08 | 2012-06-06 | 河南惠通天下动物药业有限公司 | Qiqing Baidu effervescent granule and preparation method thereof |
| CN102397383A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis pure Chinese medicinal composition for treating avian spirochaetosis and preparation method thereof |
| CN103301142A (en) * | 2013-06-03 | 2013-09-18 | 南京正亮医药科技有限公司 | Application of polyflavanostilbene A in preparation of anti-human fungus medicine |
| CN105233144A (en) * | 2015-09-10 | 2016-01-13 | 山东宝来利来生物工程股份有限公司 | Traditional Chinese medicine preparation for treating dermatomycoses of animals and preparation method of traditional Chinese medicine preparation |
| CN105233144B (en) * | 2015-09-10 | 2018-12-25 | 山东宝来利来生物工程股份有限公司 | A kind of Chinese materia medica preparation and preparation method thereof for treating animal fungal dermatoses |
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| Publication number | Publication date |
|---|---|
| CN1055627C (en) | 2000-08-23 |
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