CN107714794A - Russia's color extract tablet and preparation method thereof - Google Patents
Russia's color extract tablet and preparation method thereof Download PDFInfo
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- CN107714794A CN107714794A CN201710844272.3A CN201710844272A CN107714794A CN 107714794 A CN107714794 A CN 107714794A CN 201710844272 A CN201710844272 A CN 201710844272A CN 107714794 A CN107714794 A CN 107714794A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of Russia's color extract tablet and preparation method thereof, it is related to field of pharmaceutical preparations.Russia's color extract tablet provided by the invention is prepared using Russia's color extract, sustained release agent, filler and binder as raw material, its Sino-Russian color extract is prepared in the method for microbial fermentation, Russia's color extract tablet has slow release, with the effect for reducing blood sugar concentration, the tablet of shaping is made, has on the one hand expanded the application approach of Russia's color；Other hand, make its quality that there is controllability, improve the security of its application；Sustained release agent includes erodible and hydrophilic gel sustained-release matrix material, and the two is used cooperatively, and reaches suitable drug release rate.It is Russia's color extract method for preparing tablet thereof this method rational technology provided by the invention, simple and easy to do.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, especially a kind of Russia's color extract tablet and preparation method thereof.
Background technology
" three high diseases " refer to hypertension, hyperglycaemia (diabetes) and hyperlipidemia, are " the richnesses that modern society is derived from
Your disease ", possible individualism, it is also possible to interrelated.With the improvement of living standards with the change of rhythm of life, " three high diseases "
Such as " old times king thanks to swallow before hall, flies into common people house ", the common disease of particularly more than 50 years old the elderly's health, and closely
With obvious rejuvenation trend.The number that cardiovascular and cerebrovascular disease is died from the whole world every year is up to 15,000,000 people, occupies the various causes of the death
It is the first.Cardiovascular and cerebrovascular disease turns into human death's cause of disease highest " number one killer ", and " the noiseless demon " of health of people！
In terms for the treatment of " three high diseases ", Western medicine has rapid-action, the advantages such as effect is obvious, but its side effect is big.With traditional Chinese medical science pharmacology
That discusses is gradual perfect, it has been found that, there is Chinese medicine Mutiple Targets, multipath, multi-level, individual to be directed in terms for the treatment of " three high diseases "
The strong, effect of property steadily relaxes and the features such as Small side effects, so more fully curative effect can be obtained.
Chinese medicine Russia color（Tibetan language）It is rose family Malus Malus toringoides HughesMalus toringoides(Rehd.)
Hughes or tibetan crabappleMalus transitoria(Batal.) Schneid. leaf.Research shows, contains in Russia's color medicinal material
There are abundant flavonoids, saponins and polysaccharide nutriment, its extract has hypoglycemic, blood fat, blood pressure, anti-diabetic simultaneously
A variety of physiologically actives and the pharmacological actions such as disease are sent out, the treatment, auxiliary treatment and prevention to three high disease of the mankind are significant.
In the prior art to the health products that are particularly true in of Russia's color, such as tealeaves, to its application study in pharmaceutical preparation
Seldom, and application form is single, and quality is uncontrollable, seriously limits the development and application of Russia's color.
The content of the invention
For above-mentioned problem, goal of the invention of the invention is：A kind of Russia's color extract tablet is provided, expanded
The application approach of Russia's color；Russia's color extract is prepared into the preparation of shaping, makes it have quality controllability, improves its clinical practice
Security.Russia's color extract tablet has slow release, has the effect for reducing blood sugar concentration.
It is a second object of the invention to provide the preparation method of above-mentioned Russia's color extract tablet, this method rational technology,
Simple and easy to do, obtained tablet has merged sustained-release matrix and film coating, solves the problems, such as burst drug release, and release science is closed
Reason.
The technical solution adopted by the present invention is as follows：
A kind of Russia's color extract tablet, it is 4-5 that it, which includes mass ratio,:2-3:1-2:1 Russia's color extract, sustained release agent, filler
And binder；The sustained release agent is sodium cellulose glycolate and stearic mixture, and the filler is microcrystalline cellulose, institute
It is hydroxypropyl methylcellulose to state binder.
By adopting the above-described technical solution, Russia's color extract to be prepared into the tablet of shaping, Russia's color has on the one hand been expanded
Application approach；Other hand, make its quality that there is controllability, improve the security of its application.Sodium cellulose glycolate and hard
The equal sustained-release matrix material of resin acid, make Russia's color extract that there is the characteristics of sustained release, avoid its prominent releases from causing blood glucose to reduce suddenly.Hydroxyl first
Base sodium cellulosate and stearic acid are respectively erodible and hydrophilic gel sustained-release matrix material, and the two is used cooperatively, stearic acid energy
Avoid sodium cellulose glycolate meet water when formed gel volume speed it is too fast, so as to avoid its retardance to insoluble drug release, reach conjunction
Suitable drug release rate.
A kind of Russia's color extract tablet of the present invention, the sodium cellulose glycolate and stearic mass ratio are 1-2：
4。
A kind of Russia's color extract tablet of the present invention, Russia's color extract by the method for microbial fermentation prepare and
Into.
A kind of Russia's color extract tablet of the present invention, the preparation method of Russia's color extract are as follows：
（1）It is 1 according to mass ratio:0.5-0.8 takes fresh E Seye and Russia color fruit, cleans respectively, is respectively 1 according to solid-liquid ratio:1
Drinking water is added, heating boils 30min, pulls out and drain, after being cooled to room temperature, the two is mixed, and is 1 according to solid-liquid ratio:1 adds
Sterilized water, broken slurrying obtain slurries；
（2）Zymocyte liquid is accessed into slurries and carries out aerobic fermentation；
（3）Classified filtering takes bacteria-free filtrate to obtain Russia's color extract solution, and Russia's color extract solution is freeze-dried to obtain Russia's color extract.
By adopting the above-described technical solution, in fermentation process, the active principle of macromolecular can be resolved into appearance
The small-molecule substance being easily absorbed by the body, while produce some beneficial metabolites.Aerobic fermentation process can be effectively prevented from
Fermentation process produces alcohol.
A kind of Russia's color extract tablet of the present invention, step（2）In, zymocyte liquid is 1 by concentration ratio:0.6-0.8:0.2-
0.3:0.1 Streptomyces roseolus, red saccharopolyspora, cellulomonas cartae, methanolic acid monad composition, Streptomyces roseolus
Concentration is（5-8）×108CFU/mL；The addition volume of zymocyte liquid is the 1%-5% of slurry volume.
By adopting the above-described technical solution, rose streptomycete, red saccharopolyspora are fermented using flavone glycoside, will
Its complete hydrolysis is glycosides million, and free glucoside member is than glucosides with more extensive biological activity and Geng Gao absorption efficiency.
Cellulomonas cartae, methanolic acid monad assisted fermentation, it is mainly used in decomposing the cellulose and pectin for hooking old cell membrane, is intracellular
Active ingredient be easier dissolution, and methanolic acid monad can also be fermented using alcohol as energy source, further be kept away
Exempt from the accumulation of alcohol in product.That is rose streptomycete, red saccharopolyspora, cellulomonas cartae, methanolic acid monad synergy,
Fermentation process is collectively promoted, fermentation efficiency is improved, obtains the color extract of higher quality.
A kind of Russia's color extract tablet of the present invention, aerobic fermentation process keeping temperature are 25-35 DEG C, duration 7-15
My god, and aseptic oxygen is passed through with 1 ‰ vvm ventilation ratio.
A kind of Russia's color extract tablet of the present invention, the skimmed milk power of grind slurries quality 3% is added before aerobic fermentation into slurries
With 0.5% glucose.
By adopting the above-described technical solution, skimmed milk power and glucose supplement the nutrients for the own metabolism of thalline, improve
Its fermentation activity, so as to improve its fermentation efficiency.
A kind of Russia's color extract tablet of the present invention, step（3）In, classified filtering includes by-pass filtration and secondary filtration；
By-pass filtration uses three layers of filtered through gauze, and secondary filtration is using 0.22 μm of filter filtering.
By adopting the above-described technical solution, by-pass filtration main filtration removes fermentation residue, secondary filtration main purpose
It is filtration sterilization.
A kind of preparation method of Russia's color extract tablet, it includes：
Russia's color extract, sodium cellulose glycolate, stearic acid, microcrystalline cellulose and hydroxypropyl methylcellulose are weighed by recipe quantity, is made
Crushed respectively with preceding, and cross 100 mesh sieves；By Russia's color extract, sodium cellulose glycolate, stearic acid, the crystallite after sieving
Cellulose, which is placed in High Speed Stirring Machine, stirs 3-10min；Hydroxypropyl methylcellulose is dissolved in 75% ethanol solution, formed
Saturated solution, under stirring, by the saturated solution dropwise latex granulator, softwood is made；Softwood crosses 20 mesh sieves and obtains particle,
Grain forced air drying under the conditions of 50-60 DEG C, crosses 20 mesh sieves again, and tabletting produces.
A kind of preparation method of Russia's color extract tablet of the present invention, is coated to obtained tablet, is coated to tablet
Weightening 3%.
By adopting the above-described technical solution, after being coated to tablet, its crack resistance and stability can be strengthened.It is coated material
Material generally includes coating membrane, plasticizer and flavouring.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1. Russia's color extract to be prepared into the tablet of shaping, the application approach of Russia's color has on the one hand been expanded；Other hand, make its matter
Measurer has controllability, improves the security of its application.
2. adding sustained release agent in tablets, make Russia's color extract that there is the characteristics of sustained release, avoid its prominent releases from causing blood glucose to be dashed forward
So reduce.
3. sustained release agent includes erodible and hydrophilic gel sustained-release matrix material, the two is used cooperatively, and reaches suitable medicine
Thing rate of release.
Brief description of the drawings
Examples of the present invention will be described by way of reference to the accompanying drawings, wherein：
Fig. 1 is the drug accumulation release curve map of Russia's color extract tablet provided by the invention.
Embodiment
All features disclosed in this specification, or disclosed all methods or during the step of, except mutually exclusive
Feature and/or step beyond, can combine in any way.
This specification（Including any accessory claim, summary）Disclosed in any feature, unless specifically stated otherwise,
Replaced by other equivalent or with similar purpose alternative features.I.e., unless specifically stated otherwise, each feature is a series of
An example in equivalent or similar characteristics.
Embodiment 1
The present embodiment provides a kind of Russia's color extract and preparation method thereof, and this method is simultaneously raw material using E Se and E Se fruits,
Active ingredient therein is extracted by the way of microbial fermentation, while extraction, microorganism utilizes shallow lake therein
The macromolecular substances such as powder, polysaccharide, decomposed and be easy to absorbed small molecule, and produce new active ingredient, i.e., carried by this
The Russia's color extract extraction efficiency for taking method to obtain is high, and excellent.Specifically, Russia's color extract that the present embodiment provides
Preparation method comprise the following steps：
Step 1：It is 1 according to mass ratio:0.5 takes fresh E Seye and Russia color fruit, cleans respectively, is then according to solid-liquid ratio
1:1 is separately added into drinking water, and heating boils 30min, pulls out and room temperature is cooled to after draining, then mix the two, according to feed liquid
Than for 1:1 adds sterilized water, and broken slurrying obtains slurries.
Step 2：Zymocyte liquid is added into slurries and carries out aerobic fermentation.Zymocyte liquid is 1 by concentration ratio:0.6:0.2:
0.1 Streptomyces roseolus, red saccharopolyspora, cellulomonas cartae, methanolic acid monad composition, the concentration of Streptomyces roseolus
For 8 × 108CFU/mL；The addition volume of zymocyte liquid is the 1% of slurry volume.Aerobic fermentation process keeping temperature is 25 DEG C, is held
The continuous 15 days time, and aseptic oxygen is passed through with 1 ‰ vvm ventilation ratio.
Step 3：After the completion of fermentation, tunning is filtered by the way of classified filtering.One-level mistake is carried out first
Filter, by-pass filtration are filtered using three layers of gauze, remove residue；Secondary filtration is degerming using 0.22 μm of filter, takes sterile
Filtrate obtains Russia's color extract solution, and Russia's color extract solution is freeze-dried to obtain Russia's color extract.
Embodiment 2
The present embodiment provides a kind of Russia's color extract and preparation method thereof, and this method is simultaneously raw material using E Se and E Se fruits,
Active ingredient therein is extracted by the way of microbial fermentation, while extraction, microorganism utilizes shallow lake therein
The macromolecular substances such as powder, polysaccharide, decomposed and be easy to absorbed small molecule, and produce new active ingredient, i.e., carried by this
The Russia's color extract extraction efficiency for taking method to obtain is high, and excellent.Specifically, Russia's color extract that the present embodiment provides
Preparation method comprise the following steps：
Step 1：It is 1 according to mass ratio:0.8 takes fresh E Seye and Russia color fruit, cleans respectively, is then according to solid-liquid ratio
1:1 is separately added into drinking water, and heating boils 30min, pulls out and room temperature is cooled to after draining, then mix the two, according to feed liquid
Than for 1:1 adds sterilized water, and broken slurrying obtains slurries.
Step 2：Zymocyte liquid is added into slurries and carries out aerobic fermentation.Zymocyte liquid is 1 by concentration ratio:0.8:0.3:
0.1 Streptomyces roseolus, red saccharopolyspora, cellulomonas cartae, methanolic acid monad composition, the concentration of Streptomyces roseolus
For 5 × 108CFU/mL；The addition volume of zymocyte liquid is the 5% of slurry volume, and slurries matter is added into slurries before aerobic fermentation
The skimmed milk power and 0.5% glucose of amount 3%.Aerobic fermentation process keeping temperature is 35 DEG C, 15 days duration, and with 1 ‰
Vvm ventilation ratio is passed through aseptic oxygen.
Step 3：After the completion of fermentation, tunning is filtered by the way of classified filtering.One-level mistake is carried out first
Filter, by-pass filtration are filtered using three layers of gauze, remove residue；Secondary filtration is degerming using 0.22 μm of filter, takes sterile
Filtrate obtains Russia's color extract solution, and Russia's color extract solution is freeze-dried to obtain Russia's color extract.
Embodiment 3
The present embodiment provides a kind of Russia's color extract tablet and preparation method thereof.Russia's color extract is prepared into shaping by this method
Tablet, quality controllability is made it have, improve the security of its clinical practice；Rational technology, simple and easy to do, obtained tablet tool
There is slow-release function, solve the problems, such as burst drug release, release is scientific and reasonable..Specifically, Russia's color extract that the present embodiment provides
The preparation method of tablet comprises the following steps：
Step 1：It is 4 in mass ratio:2:1:1 weighs Russia's color extract, sustained release agent, microcrystalline cellulose and hydroxypropyl methylcellulose, so
Crushed respectively afterwards, and it is standby to cross 100 mesh sieves.Wherein, it is 1 that sustained release agent, which has mass ratio,:2 stearic acid and hydroxymethyl cellulose
Sodium.
Step 2：Russia's color extract, sodium cellulose glycolate, stearic acid, microcrystalline cellulose after sieving is placed at a high speed
3min is stirred in mixer granulator.Hydroxypropyl methylcellulose is dissolved in 75% ethanol solution, forms saturated solution, will under stirring
In latex granulator, softwood is made dropwise in the saturated solution.
Step 3：Softwood crosses 20 mesh sieves and obtains particle, particle in 50 DEG C of blast drier forced air drying to water content
For 3%, 20 mesh sieves are crossed again, and tabletting produces Russia's color extract tablet.
Step 4：Russia's color extract tablet is put into coating pan, is coated, is coated to tablet weightening 3%.
Embodiment 4
The present embodiment provides a kind of Russia's color extract tablet and preparation method thereof.Russia's color extract is prepared into shaping by this method
Tablet, quality controllability is made it have, improve the security of its clinical practice；Rational technology, simple and easy to do, obtained tablet tool
There is slow-release function, solve the problems, such as burst drug release, release is scientific and reasonable..Specifically, Russia's color extract that the present embodiment provides
The preparation method of tablet comprises the following steps：
Step 1：It is 5 in mass ratio:3:2:1 weighs Russia's color extract, sustained release agent, microcrystalline cellulose and hydroxypropyl methylcellulose, so
Crushed respectively afterwards, and it is standby to cross 100 mesh sieves.Wherein, it is 1 that sustained release agent, which has mass ratio,:4 stearic acid and hydroxymethyl cellulose
Sodium.
Step 2：Russia's color extract, sodium cellulose glycolate, stearic acid, microcrystalline cellulose after sieving is placed at a high speed
10min is stirred in mixer granulator.Hydroxypropyl methylcellulose is dissolved in 75% ethanol solution, forms saturated solution, will under stirring
In latex granulator, softwood is made dropwise in the saturated solution.
Step 3：Softwood crosses 20 mesh sieves and obtains particle, particle in 60 DEG C of blast drier forced air drying to water content
For 3%, 20 mesh sieves are crossed again, and tabletting produces Russia's color extract tablet.
Embodiment 5
The present embodiment provides the checking to the slow release and pharmacological activity of Russia's color extract tablet, provided by the invention to prove
Russia's color extract tablet formulation is reasonable, has pharmacological activity, and scientific basis is provided for its application.
Experiment material：The Russia's color extract tablet provided in embodiment 4；Reference substance is：Formula is 5 by mass ratio:5:1
Russia's color extract, microcrystalline cellulose, hydroxypropyl methylcellulose, contrast tablet prepared by the preparation method provided according to embodiment；SD
Rat 40,220 ± 5g of body weight, male and female half and half.
Experiment 1
Experimental method：With to the release of the flavones in Russia's color extract, for evaluation index, main flavones of investigating is in 12h
Accumulation dissolution.
Experimental result：Russia's color extract tablet and the release for compareing tablet 12h are as shown in Figure 1.In Fig. 1, curve a is pair
The release curve of photo agent, medicine accumulative releasing degree is more than 90% in 2h, without slow release effect.Curve b is Russia's color extract
The Accumulation dissolution of tablet, medicine slowly discharge in 8h, and rate of release is suitable, show Russia's color extraction provided by the invention
The formula of thing tablet is reasonable.
Experiment 2
Experimental method：SD rats are taken, stochastic averagina is divided into 3 groups：Normal group, model group, experimental group and control group.Normal group, mould
Type group and control group give microcrystalline cellulose and hydroxypropyl methylcellulose according to 10:Tablet made of 1, experimental group are given Russia's color and carried
Take thing tablet, by daily single, a piece of, successive administration 7 days is administered in each animal every time, before last dose fasting can't help water
12h, remaining each group in addition to normal group is administered after 1h and, by 0.15mg/kg intraperitoneal injection adrenalin hydrochlorides, blood is measured after 2h is administered
Sugared concentration.
Experimental result：Different pharmaceutical causes the influence result of hyperglycemic rat as shown in table 1 in adrenaline.
The different pharmaceutical of table 1 causes the influence result of hyperglycemic rat to adrenaline
As shown in Table 1, the blood glucose of model group substantially increases compared with normal group, and the blood sugar concentration five of control group and model group is substantially poor
Not, experimental group substantially reduces compared with the blood sugar concentration of model group, and showing that Russia's color extract tablet provided by the invention has reduces blood
The pharmacological activity of sugared concentration.
The invention is not limited in foregoing embodiment.The present invention, which expands to, any in this manual to be disclosed
New feature or any new combination, and disclose any new method or process the step of or any new combination.
Claims (10)
1. a kind of Russia's color extract tablet, it is characterised in that it is 4-5 that it, which includes mass ratio,:2-3:1-2:1 Russia's color extract,
Sustained release agent, filler and binder；The sustained release agent is sodium cellulose glycolate and stearic mixture, and the filler is
Microcrystalline cellulose, the binder are hydroxypropyl methylcellulose.
2. Russia's color extract tablet according to claim 1, it is characterised in that the stearic acid and sodium cellulose glycolate
Mass ratio be 1-2：4.
3. Russia's color extract tablet according to claim 1 or 2, it is characterised in that Russia's color extract passes through micro- life
The method of thing fermentation is prepared.
4. Russia's color extract tablet according to claim 1, it is characterised in that the preparation method of Russia's color extract is such as
Under：
（1）It is 1 according to mass ratio:0.5-0.8 takes fresh E Seye and Russia color fruit, cleans respectively, is respectively 1 according to solid-liquid ratio:1
Drinking water is added, heating boils 30min, pulls out and drain, after being cooled to room temperature, the two is mixed, and is 1 according to solid-liquid ratio:1 adds
Sterilized water, broken slurrying obtain slurries；
（2）Zymocyte liquid is accessed into slurries and carries out aerobic fermentation；
（3）Classified filtering takes bacteria-free filtrate to obtain Russia's color extract solution, and Russia's color extract solution is freeze-dried to obtain Russia's color extract.
5. Russia's color extract tablet according to claim 4, it is characterised in that step（2）In, zymocyte liquid is by concentration ratio
For 1:0.6-0.8:0.2-0.3:0.1 Streptomyces roseolus, red saccharopolyspora, cellulomonas cartae, methanolic acid monad group
Into the concentration of Streptomyces roseolus is（5-8）×108CFU/mL；The addition volume of zymocyte liquid is the 1%-5% of slurry volume.
6. Russia's color extract tablet according to claim 5, it is characterised in that aerobic fermentation process keeping temperature is 25-
35 DEG C, 7-15 days duration, and aseptic oxygen is passed through with 1 ‰ vvm ventilation ratio.
7. Russia's color extract tablet according to claim 6, it is characterised in that add slurries before aerobic fermentation into slurries
The skimmed milk power of quality 3% and 0.5% glucose.
8. Russia's color extract tablet according to claim 7, it is characterised in that step（3）In, classified filtering includes one-level
Filtering and secondary filtration；By-pass filtration uses three layers of filtered through gauze, and secondary filtration is filtered using 0.22 μm of filter.
9. the preparation method of Russia's color extract tablet any one of claim 1-8, it is characterised in that it includes：
Russia's color extract, sodium cellulose glycolate, stearic acid, microcrystalline cellulose and hydroxypropyl methylcellulose are weighed by recipe quantity, is made
Crushed respectively with preceding, and cross 100 mesh sieves；By Russia's color extract, sodium cellulose glycolate, stearic acid, the crystallite after sieving
Cellulose, which is placed in High Speed Stirring Machine, stirs 3-10min；Hydroxypropyl methylcellulose is dissolved in 75% ethanol solution, formed
Saturated solution, under stirring, by the saturated solution dropwise latex granulator, softwood is made；Softwood crosses 20 mesh sieves and obtains particle,
Grain forced air drying under the conditions of 50-60 DEG C, crosses 20 mesh sieves again, and tabletting produces.
10. the preparation method of Russia's color extract tablet according to claim 9, it is characterised in that enter to obtained tablet
Row coating, it is coated to tablet weightening 3%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815251A (en) * | 2018-07-30 | 2018-11-16 | 四川智佳成生物科技有限公司 | Russia color fruit and its extract are preparing the purposes in blood lipid-lowering medicine |
| CN108888665A (en) * | 2018-07-30 | 2018-11-27 | 四川智佳成生物科技有限公司 | E Seye and its extract are preparing the purposes in blood lipid-lowering medicine |
| CN109060985A (en) * | 2018-08-24 | 2018-12-21 | 成都中医药大学 | A kind of Russia's color berry extract and its quality determining method |
| CN112089761A (en) * | 2019-11-07 | 2020-12-18 | 四川智佳成生物科技有限公司 | Mixed extract of russian fruits and russian leaves and application of mixed extract in preparation of blood fat reducing medicines |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815251A (en) * | 2018-07-30 | 2018-11-16 | 四川智佳成生物科技有限公司 | Russia color fruit and its extract are preparing the purposes in blood lipid-lowering medicine |
| CN108888665A (en) * | 2018-07-30 | 2018-11-27 | 四川智佳成生物科技有限公司 | E Seye and its extract are preparing the purposes in blood lipid-lowering medicine |
| CN109060985A (en) * | 2018-08-24 | 2018-12-21 | 成都中医药大学 | A kind of Russia's color berry extract and its quality determining method |
| CN109060985B (en) * | 2018-08-24 | 2021-08-13 | 成都中医药大学 | Russian fruit extract and quality detection method thereof |
| CN112089761A (en) * | 2019-11-07 | 2020-12-18 | 四川智佳成生物科技有限公司 | Mixed extract of russian fruits and russian leaves and application of mixed extract in preparation of blood fat reducing medicines |
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