CN101999380B - Difenoconazole- and propineb-containing pesticidal composition - Google Patents
Difenoconazole- and propineb-containing pesticidal composition Download PDFInfo
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- CN101999380B CN101999380B CN 201010572253 CN201010572253A CN101999380B CN 101999380 B CN101999380 B CN 101999380B CN 201010572253 CN201010572253 CN 201010572253 CN 201010572253 A CN201010572253 A CN 201010572253A CN 101999380 B CN101999380 B CN 101999380B
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- difenoconazole
- bactericidal composition
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- 239000005823 Propineb Substances 0.000 title claims abstract description 81
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 title claims abstract description 81
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 230000000361 pesticidal effect Effects 0.000 title 1
- 239000005760 Difenoconazole Substances 0.000 claims abstract description 79
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 claims abstract description 79
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 9
- 235000009566 rice Nutrition 0.000 claims abstract description 9
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 5
- 241001530056 Athelia rolfsii Species 0.000 claims abstract description 4
- 235000013311 vegetables Nutrition 0.000 claims abstract description 4
- 241000221785 Erysiphales Species 0.000 claims abstract description 3
- 235000013339 cereals Nutrition 0.000 claims abstract description 3
- 240000007594 Oryza sativa Species 0.000 claims abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 17
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- 230000035613 defoliation Effects 0.000 claims description 3
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- 229930182558 Sterol Natural products 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
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- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- PNWSHHILERSSLF-UHFFFAOYSA-N 4-methylbenzene-1,3-dicarboxylic acid Chemical compound CC1=CC=C(C(O)=O)C=C1C(O)=O PNWSHHILERSSLF-UHFFFAOYSA-N 0.000 description 1
- 241000222195 Ascochyta Species 0.000 description 1
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
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- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 241000317942 Venturia <ichneumonid wasp> Species 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
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- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
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- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
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- 159000000000 sodium salts Chemical class 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
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Abstract
The invention relates to a germicide composition with synergistic effect. The active ingredients comprise difenoconazole and propineb in a weight ratio of 4:1-1:64. The active ingredients are added with aids and excipients to be prepared into wettable powder and water dispersible granules. The germicide composition is mainly used for powdery mildew, anthracnose, alternaria leaf spot, downy mildewand epidemic diseases of vegetables and fruit trees, and banded sclerotial blight, rice blast and the like of grains.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains Difenoconazole and Propineb.
Technical background
Difenoconazole (difenoconazole) molecular formula: C
19H
17Cl
2N
3O
3, chemical name: 1-(2-[4-(4-chlorobenzene oxygen)-2-chlorphenyl]-the 4-methyl isophthalic acid, 3-dioxin-pentane-2-ylmethyl)-H-1,2,4-triazole.
Difenoconazole has protection, treatment and systemic activity, is sterol demethylation inhibitor, suppresses the biosynthesis of cell wall sterol, stops fungi growth.Fungicidal spectrum is wide, and leaf surface treatment or seed treatment can improve output and the guaranteed quality of crop.Fungicidal spectrum is wide; to Ascomycetes, Basidiomycetes and comprise Alternaria, Ascochyta, the mould genus of tail spore, Colletotrichum, ball Cuo Pseudomonas, Phoma, Ramularia, Septoria, Venturia partly know disease, Erysiphaceae, Uredinales and some are planted and are passed pathogen lasting protection and therapeutic action are arranged.
Propineb (propineb), molecular formula are (C5H8N2S4Zn) x, chemical name: acrylic bisdithiocarbamic zinc.
Propineb acts on the synthetic of fungal cell wall and protein, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death.And this medicine contains and is easy to the zinc element that absorbed by crop, the quality that is conducive to promote plant growth and improves fruit.
No matter be Difenoconazole, Propineb or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.Difenoconazole is different with the Propineb mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about Difenoconazole and Propineb do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains Difenoconazole and Propineb.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Difenoconazole and Propineb, wherein Difenoconazole and Propineb weight ratio are 4: 1～1: 64.
The described bactericidal composition that contains Difenoconazole and Propineb, wherein the weight ratio of Difenoconazole and Propineb be preferably 1: 1～1: 32.
The described bactericidal composition that contains Difenoconazole and Propineb, wherein the weight ratio of Difenoconazole and Propineb is more preferably 1: 2～1: 16.
The described bactericidal composition that contains Difenoconazole and Propineb, wherein the weight ratio of Difenoconazole and Propineb is more preferably 1: 4～1: 16.
The described bactericidal composition that contains Difenoconazole and Propineb, wherein the effective active component content accounts for 1～85% of gross weight, is preferably 10～80%.
The described bactericidal composition of Difenoconazole and Propineb that contains is by method well-known in the art, add conventional auxiliary agent and excipient, be processed into acceptable forms on any agricultural chemicals, wherein the excellent formulation of selecting is wetting powder, water dispersible granules, seed treatment etc.
When making wetting powder, composition comprises following constituent content: Difenoconazole 1～50%, Propineb 1～80%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
Difenoconazole, Propineb, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, namely can be made into Difenoconazole Wettable propineb powder product.
When making water dispersible granules, composition comprises following constituent content: Difenoconazole 1～50%, Propineb 1～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, filler 10～90%.
Difenoconazole, Propineb, dispersant, wetting agent, disintegrant, filler etc. are pulverized the particle diameter that obtains needs through air-flow together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes Difenoconazole Propineb water dispersible granules product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, anthracnose, spot defoliation, downy mildew, eqpidemic disease and cereal banded sclerotial blight, rice blast of vegetables and fruit tree etc.
Beneficial effect of the present invention:
(1) present composition effective active composition Difenoconazole and Propineb belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict;
(2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single agent, and dosage is little;
(3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage;
(4) present composition has special efficacy to eqpidemic disease, downy mildew, spot defoliation and rice blast, the banded sclerotial blight of vegetables and fruit tree.
Embodiment
Below in conjunction with the further instruction of the present invention of embodiment, the percentage among the embodiment all is weight percentage, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one: Difenoconazole and Propineb are composite to be provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation cucumber downy mildew Toxicity Determination test medicine.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of cucumber downy mildew.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively Difenoconazole and Propineb shared ratio in combination
A is Difenoconazole
B is Propineb
Result of the test is as shown in table 1:
Table 1 Difenoconazole, Propineb and composite toxicity test analysis of results table to cucumber downy mildew thereof
As shown in Table 1, Difenoconazole, Propineb are to the EC of cucumber downy mildew
50Be respectively 0.18mg/L and 57.51mg/L.The virulence of Difenoconazole is higher than the virulence of Propineb.Difenoconazole and Propineb were mixed in the scope at 4: 1～1: 64 and all show obvious synergistic effect.Wherein Difenoconazole and Propineb mixed synergies in 1: 1～1: 32 scope is comparatively desirable, and the effect that was mixed in the scope at 1: 2～1: 16 is particularly outstanding.
Implementation of an application example two the implementation of Formulation Example
Embodiment 180% Difenoconazole Propineb water dispersible granules
Difenoconazole 8%, Propineb 72%, lauryl sodium sulfate 4%, lignosulfonates 3%, alkylphenol-polyethenoxy are phonetic 3%, starch adds to 100%, mixed 80% Difenoconazole Propineb water dispersible granules.
Embodiment 266% Difenoconazole Propineb water dispersible granules
Difenoconazole 6%, Propineb 60%, polycarboxylate 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, starch 10%, bentonite add to 100%, the mixed 66% Difenoconazole Propineb water dispersible granules that gets.
Embodiment 345% Difenoconazole Propineb water dispersible granules
Difenoconazole 5%, Propineb 40%, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, gelatin 2%, starch 5%, bentonite add to 100%, mixed 45% Difenoconazole Propineb water dispersible granules.
Embodiment 430% Difenoconazole Propineb water dispersible granules
Difenoconazole 15%, Propineb 15%, alkylphenol-polyethenoxy are phonetic 4%, DBSA 4%, starch 8%, urea 5%, diatomite add to 100%, mixed 30% Difenoconazole Propineb water dispersible granules.
Embodiment 580% Difenoconazole Wettable propineb powder
Difenoconazole 10%, Propineb 70%, polycarboxylate 5%, neopelex 3%, soapberry powder 2%, bentonite add to 100%, and mixture carries out air-flow to be pulverized, and makes 80% Difenoconazole Wettable propineb powder.
Embodiment 666% Difenoconazole Wettable propineb powder
Difenoconazole 2%, Propineb 64%, lignosulfonates 5%, spaonin powder 3%, starch 7%, diatomite add to 100%, and mixture carries out air-flow to be pulverized, and makes 66% Difenoconazole Wettable propineb powder.
Embodiment 750% Difenoconazole Wettable propineb powder
Difenoconazole 10%, Propineb 40%, alkylphenol-polyethenoxy are phonetic 4%, neopelex 3%, white carbon 5%, kaolin add to 100%, and mixture carries out air-flow to be pulverized, and makes 50% Difenoconazole Wettable propineb powder.
Embodiment 834% Difenoconazole Wettable propineb powder
Difenoconazole 2%, Propineb 32%, lignosulfonates 5%, wetting and penetrating agent F3%, white carbon 7%, bentonite add to 100%, and mixture carries out air-flow to be pulverized, and makes 34% Difenoconazole Wettable propineb powder.
Embodiment uses triphenylmethyl ether methyl cyclic-azole and Propineb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This experimental establishment is in the Liquan County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% Difenoconazole missible oil (commercial).
The investigation alternaria leaf spot of apple state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated alternaria leaf spot of apple feelings index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the third time.Experimental result is as follows:
Table 2 Difenoconazole, Propineb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
As can be seen from Table 2, can effectively prevent and treat alternaria leaf spot of apple after Difenoconazole and Propineb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects.
Implementation of an application example four: Difenoconazole and Propineb and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This experimental establishment is in the Qian County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% Difenoconazole missible oil (commercial).
The investigation cucumber downy mildew state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated the cucumber downy mildew disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 3 Difenoconazole, Propineb and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 3, energy effectively preventing cucumber downy mildew after Difenoconazole and Propineb are composite, control efficiency all is better than contrasting medicament, and dosage is little, and the lasting period is long.In the test scope of medication, the target crop there is not harm.
Implementation of an application example five: Difenoconazole, Propineb and the composite early blight of tomato test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in the Jinta County, Gansu Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% Difenoconazole missible oil (commercial).
Investigation early blight of tomato state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 4 Difenoconazole, Propineb and the composite early blight of tomato test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 4, can effectively prevent and treat early blight of tomato after Difenoconazole and Propineb are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.
Implementation of an application example six: Difenoconazole, Propineb and the composite control rice blast test of pesticide effectiveness thereof
This experimental establishment is in the Yongde County, Yunnan Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% Difenoconazole missible oil (commercial).
Investigation rice blast state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
The sick test of pesticide effectiveness of table 5 Difenoconazole, Propineb and composite control rice blast thereof
As can be seen from Table 5, can effectively prevent and treat rice blast after Difenoconazole and Propineb are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.And rice sheath blight disease had good preventive effect, preventive effect all reaches more than 90%.
Claims (4)
1. bactericidal composition that contains Difenoconazole and Propineb, the weight ratio that it is characterized in that bactericidal composition effective active composition Difenoconazole and Propineb is 4:1 ~ 1:4 or 1:8 or 1:16 ~ 1:64.
2. the bactericidal composition that contains Difenoconazole and Propineb according to claim 1, it is characterized in that: wherein the effective active component content accounts for 1～85% of gross weight.
3. the bactericidal composition that contains Difenoconazole and Propineb according to claim 2, it is characterized in that: wherein the effective active component content accounts for 10～80% of gross weight.
4. the bactericidal composition that contains Difenoconazole and Propineb according to claim 1 is characterized in that: bactericidal composition is used for powdery mildew, anthracnose, spot defoliation, downy mildew, eqpidemic disease and the cereal banded sclerotial blight of vegetables and fruit tree, the control of rice blast is used.
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| CN101171921A (en) * | 2007-10-15 | 2008-05-07 | 张少武 | Bactericide agent composition containing active ingredient of metiram |
| CN101416636A (en) * | 2008-11-06 | 2009-04-29 | 张少武 | Composition containing difenoconazole and zineb with bactericidal action |
| CN101940216A (en) * | 2010-08-31 | 2011-01-12 | 周保东 | Water dispersible granule compounded by difenoconazole and propineb |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101171921A (en) * | 2007-10-15 | 2008-05-07 | 张少武 | Bactericide agent composition containing active ingredient of metiram |
| CN101416636A (en) * | 2008-11-06 | 2009-04-29 | 张少武 | Composition containing difenoconazole and zineb with bactericidal action |
| CN101940216A (en) * | 2010-08-31 | 2011-01-12 | 周保东 | Water dispersible granule compounded by difenoconazole and propineb |
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