CN101731226A - Bactericidal composition containing ethirimol and penconazole - Google Patents
Bactericidal composition containing ethirimol and penconazole Download PDFInfo
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- CN101731226A CN101731226A CN201010003089A CN201010003089A CN101731226A CN 101731226 A CN101731226 A CN 101731226A CN 201010003089 A CN201010003089 A CN 201010003089A CN 201010003089 A CN201010003089 A CN 201010003089A CN 101731226 A CN101731226 A CN 101731226A
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- China
- Prior art keywords
- penconazole
- phonetic phenol
- phonetic
- phenol
- bactericidal composition
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- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 title claims abstract description 114
- 239000005813 Penconazole Substances 0.000 title claims abstract description 114
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 18
- BBXXLROWFHWFQY-UHFFFAOYSA-N ethirimol Chemical compound CCCCC1=C(C)NC(NCC)=NC1=O BBXXLROWFHWFQY-UHFFFAOYSA-N 0.000 title abstract description 5
- 239000000375 suspending agent Substances 0.000 claims abstract description 25
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 17
- 241000221785 Erysiphales Species 0.000 claims abstract description 12
- 235000013311 vegetables Nutrition 0.000 claims abstract description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 110
- 239000000843 powder Substances 0.000 claims description 23
- 238000009736 wetting Methods 0.000 claims description 19
- 206010039509 Scab Diseases 0.000 claims description 7
- 230000003641 microbiacidal effect Effects 0.000 claims 2
- 229940124561 microbicide Drugs 0.000 claims 2
- 239000002855 microbicide agent Substances 0.000 claims 2
- 235000013339 cereals Nutrition 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 241000395107 Cladosporium cucumerinum Species 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000004563 wettable powder Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 44
- 230000003449 preventive effect Effects 0.000 description 22
- 238000012360 testing method Methods 0.000 description 19
- 239000002131 composite material Substances 0.000 description 17
- 240000008067 Cucumis sativus Species 0.000 description 13
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 13
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 239000000575 pesticide Substances 0.000 description 9
- 239000002270 dispersing agent Substances 0.000 description 7
- -1 polyoxyethylene Polymers 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 239000000080 wetting agent Substances 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229920005646 polycarboxylate Polymers 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 240000003377 Shepherdia canadensis Species 0.000 description 5
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 238000012271 agricultural production Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 235000014443 Pyrus communis Nutrition 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 150000004996 alkyl benzenes Chemical class 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 4
- 239000000440 bentonite Substances 0.000 description 4
- 229910000278 bentonite Inorganic materials 0.000 description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 4
- 229940077388 benzenesulfonate Drugs 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000007859 condensation product Substances 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 229920001732 Lignosulfonate Polymers 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 230000002528 anti-freeze Effects 0.000 description 3
- 150000007942 carboxylates Chemical class 0.000 description 3
- 239000013530 defoamer Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical compound N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 241000233679 Peronosporaceae Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002487 adenosine deaminase inhibitor Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bactericidal composition with synergy, which contains ethirimol and penconazole serving as effective active components, wherein the weight ratio of ethirimol to penconazole is 5-80:40-1. The effective active components are added with additives and excipients and prepared into wettable powder, water dispersible granules or suspending agents which are mainly used to prevent and control powdery mildew, cladosporium cucumerinum or anthracnose of vegetables and fruit trees.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on crop pest that contains phonetic phenol of second and penconazole.
Technical background
The phonetic phenol of second (ethirimol) is the miazines bactericide of Syngenta Co.,Ltd's exploitation.Molecular formula is C
11H
19N
3O, chemical name: 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine.
The phonetic phenol of second belongs to adenosine deaminase inhibitors.Be a kind of systemic fungicide, have prevention and therapeutic action.Can be absorbed rapidly by plant roots, stem, leaf, and in plant corpus, run to each position.
Penconazole (penconazole) molecular formula: C
13H
15Cl
2N
3, chemical name: 1-[2-(2,4 dichloro benzene base)-4-propyl group-1,3-dioxolanes-2-methyl]-1-hydrogen-1,2, the 4-triazole.
Penconazole belongs to three nitrogen heterocycles bactericide, is sterol demethylation inhibitor, destroys and stop the biosynthesis of the cell membrane important composition composition ergosterol of germ, causes cell membrane not form, and is germ death.Root, stem, leaf isoreactivity tissue by crop absorb, and can upwards conduct with body fluid in the plant body soon.
No matter be the phonetic phenol of second, penconazole or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.The phonetic phenol of second is different with the penconazole mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about phonetic phenol of second and penconazole do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains phonetic phenol of second and penconazole.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains phonetic phenol of second and penconazole, wherein phonetic phenol of second and penconazole weight ratio are 5～80: 40～1.
The described bactericidal composition that contains phonetic phenol of second and penconazole, wherein the weight ratio of phonetic phenol of second and penconazole is 10～70: 30～1.
The described bactericidal composition that contains phonetic phenol of second and penconazole, wherein the weight ratio of phonetic phenol of second and penconazole is 20～60: 20～1.
The described bactericidal composition that contains phonetic phenol of second and penconazole is made wetting powder, water dispersible granules or suspending agent.
When making wetting powder, composition comprises following constituent content: the phonetic phenol 5～80% of second, penconazole 1～40%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
The phonetic phenol of second, penconazole, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into the phonetic phenol penconazole of second wetting powder product.
When making water dispersible granules, composition comprises following constituent content: the phonetic phenol 5～80% of second, penconazole 1～40%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, filler 10～90%.
The phonetic phenol of second, penconazole, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes the phonetic phenol penconazole of second water dispersible granules product.
Comprise following constituent content when composition is made suspending agent: the phonetic phenol 5～50% of second, penconazole 1～20%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add the phonetic phenol of second, penconazole, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes the phonetic phenol penconazole of second suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, scab, the anthracnose of control vegetables and fruit tree.
Beneficial effect of the present invention: the phonetic phenol of (1) present composition effective active composition second and penconazole belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single agent, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, scab, anthracnose.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one the implementation of Formulation Example
The phonetic phenol penconazole of embodiment 1 80% second wetting powder
The phonetic phenol 60% of second, penconazole 20%, polycarboxylate 5%, lauryl sodium sulfate 3%, spaonin powder 2%, kaolin 10%, mixture carries out comminution by gas stream, makes the phonetic phenol penconazole of 80% second wetting powder.
The phonetic phenol penconazole of embodiment 2 65% second wetting powder
The phonetic phenol 35% of second, penconazole 30%, lignosulfonates 4%, tea are withered 4%, white carbon 8%, kaolin 19%, and mixture carries out comminution by gas stream, makes the phonetic phenol penconazole of 65% second wetting powder.
The phonetic phenol penconazole of embodiment 3 55% second wetting powder
The phonetic phenol 45% of second, penconazole 10%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F3%, white carbon 8%, bentonite 29%, mixture carries out comminution by gas stream, makes the phonetic phenol penconazole of 55% second wetting powder.
The phonetic phenol penconazole of embodiment 4 15% second wetting powder
The phonetic phenol 10% of second, penconazole 5%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F3%, white carbon 8%, bentonite 36%, mixture carries out comminution by gas stream, makes the phonetic phenol penconazole of 15% second wetting powder.
The phonetic phenol penconazole of embodiment 5 80% second water dispersible granules
The phonetic phenol 70% of second, penconazole 10%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 8%, the mixed phonetic phenol penconazole of the 80% second water dispersible granules that gets.
The phonetic phenol penconazole of embodiment 6 70% second water dispersible granules
The phonetic phenol 50% of second, penconazole 20%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 17%,, mixed the phonetic phenol penconazole of 70% second water dispersible granules.
The phonetic phenol penconazole of embodiment 7 50% second water dispersible granules
The phonetic phenol 38% of second, penconazole 12%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 37%,, mixed the phonetic phenol penconazole of 50% second water dispersible granules.
The phonetic phenol penconazole of embodiment 8 40% second water dispersible granules
The phonetic phenol 36% of second, penconazole 4%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, starch 20%, diatomite 33%, mixed the phonetic phenol penconazole of 40% second water dispersible granules.
The phonetic phenol penconazole of embodiment 9 43% second suspending agent
The phonetic phenol 35% of second, penconazole 8%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, the mixed phonetic phenol penconazole of the 43% second suspending agent that gets.
The phonetic phenol penconazole of embodiment 10 30% second suspending agent
The phonetic phenol 24% of second, penconazole 6%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed phonetic phenol penconazole of the 30% second suspending agent that gets.
The phonetic phenol penconazole of embodiment 11 22% second suspending agent
The phonetic phenol 20% of second, penconazole 2%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed phonetic phenol penconazole of the 20% second suspending agent that gets.
The phonetic phenol penconazole of embodiment 12 10% second suspending agent
The phonetic phenol 5% of second, penconazole 5%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, the mixed phonetic phenol penconazole of the 10% second suspending agent that gets.
Implementation of an application example two: phonetic phenol of second and penconazole are composite to the powdery mildew of cucumber Toxicity Determination
Test medicine provides by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament powdery mildew of cucumber.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively the phonetic phenol of second and penconazole shared ratio in combination
A is the phonetic phenol of second
B is a penconazole
Result of the test is as shown in table 1:
The phonetic phenol of table 1 second, penconazole and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 1, the phonetic phenol of second, penconazole are to the EC of powdery mildew of cucumber
50Be respectively 43.68mg/ and 0.18mg/L.The virulence of the phonetic phenol of second is lower than the virulence of penconazole.1: 1,5: 1,10: 1,15: 1,20: 1 synergy ratio of phonetic phenol of second and penconazole proportioning is respectively 1.56,1.96,2.24,1.83,1.52, illustrating that phonetic phenol of second and penconazole were mixed in the scope at 1: 1 to 20: 1 all shows obvious synergistic effect, synergy ratio SR maximum when the phonetic phenol of second and penconazole weight ratio are 10: 1 wherein, synergistic effect is the most obvious.
Embodiment uses the phonetic phenol of three second and the penconazole and the composite control cucumber anthracnose test of pesticide effectiveness thereof
This experimental establishment is at the Xian City, Shanxi Province Changan District, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 10% penconazole missible oil (commercial).
The preceding investigation of medicine cucumber anthracnose disease index, in the their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 15 days after the dispenser for the second time and calculates preventive effect.Experimental result is as follows:
The phonetic phenol of table 2 second, penconazole and the composite control cucumber anthracnose test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the second time | 15 days preventive effects (%) behind the medicine for the second time |
| The phonetic phenol penconazole of 80% second wetting powder | 7 gram/mus | ??88.35 | ??95.12 |
| The phonetic phenol penconazole of 70% second water dispersible granules | 8 gram/mus | ??89.64 | ??95.62 |
| The phonetic phenol penconazole of 43% second suspending agent | 15 gram/mus | ??92.76 | ??96.32 |
| The phonetic phenol suspending agent of 25% second | 60 gram/mus | ??68.13 | ??75.14 |
| 10% penconazole missible oil | 15 gram/mus | ??73.51 | ??80.12 |
As can be seen from Table 2, can effectively prevent and treat cucumber anthracnose after phonetic phenol of second and penconazole are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects, and cucumber downy mildew is had preventive effect preferably.
The phonetic phenol of implementation of an application example tetrem, penconazole and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is at Luochuan, Shaanxi Province suburban area, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 10% penconazole missible oil (commercial).
Investigation apple mildew state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
The phonetic phenol of table 3 second, penconazole and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| The phonetic phenol penconazole of 65% second wetting powder | 9000 times | ??88.68 | ??94.12 | ??93.24 |
| The phonetic phenol penconazole of 50% second water dispersible granules | 6000 times | ??86.89 | ??93.74 | ??93.49 |
| The phonetic phenol penconazole of 30% second suspending agent | 3500 times | ??87.47 | ??93.24 | ??92.14 |
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| The phonetic phenol suspending agent of 25% second | 800 times | ??69.86 | ??76.65 | ??72.38 |
| 10% penconazole missible oil | 2500 times | ??75.27 | ??80.42 | ??79.42 |
As can be seen from Table 3, can effectively prevent and treat apple mildew after phonetic phenol of second and penconazole are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and apple fallen leaves spot disease is had preventive effect preferably.
Phonetic phenol of implementation of an application example five second and penconazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 10% penconazole missible oil (commercial).
In the dispenser of pear scab their early stage, dispenser in per 7 days once is total to dispenser 2 times, and the investigation disease index was investigated disease index respectively in 7 days, 15 days after the 2nd dispenser before the dispenser, and the calculation correction preventive effect, and result of the test is as follows:
Phonetic phenol of table 4 second and penconazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the medicine for the second time | 15 days preventive effects (%) behind the medicine for the second time |
| The phonetic phenol penconazole of 55% second wetting powder | 5500 times | ??90.38 | ??94.21 |
| The phonetic phenol penconazole of 40% second water dispersible granules | 2800 times | ??91.27 | ??95.64 |
| The phonetic phenol penconazole of 10% second suspending agent | 2000 times | ??89.52 | ??92.50 |
| The phonetic phenol suspending agent of 25% second | 1000 times | ??63.34 | ??72.13 |
| 10% penconazole missible oil | 3000 times | ??73.75 | ??79.06 |
As can be seen from Table 4, the phonetic phenol of second, penconazole energy effectively preventing pear scab, control efficiency all is better than contrasting medicament, in the test scope of medication target crop is not had harm.
Embodiment uses the phonetic phenol of six second and the penconazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is at the Xian City, Shanxi Province Changan District, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 10% penconazole missible oil (commercial).
The preceding investigation of medicine powdery mildew of cucumber disease index, in the their early stage dispenser, dispenser for the second time after 10 days, dispenser is 2 times altogether, investigates disease indexs in 7 days, 15 days after the dispenser for the second time and calculates preventive effect.Experimental result is as follows:
The phonetic phenol of table 5 second, penconazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the second time | 15 days preventive effects (%) behind the medicine for the second time |
| The phonetic phenol penconazole of 15% second wetting powder | 30 gram/mus | ??88.35 | ??95.12 |
| The phonetic phenol penconazole of 80% second water dispersible granules | 5 gram/mus | ??89.89 | ??94.62 |
| The phonetic phenol penconazole of 22% second suspending agent | 45 gram/mus | ??91.96 | ??96.32 |
| The phonetic phenol suspending agent of 25% second | 50 gram/mus | ??66.13 | ??75.44 |
| 10% penconazole missible oil | 10 gram/mus | ??74.28 | ??81.12 |
As can be seen from Table 5, can effectively prevent and treat powdery mildew of cucumber after phonetic phenol of second and penconazole are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects.
Claims (5)
1. bactericidal composition that contains phonetic phenol of second and penconazole, the weight ratio that it is characterized in that phonetic phenol of microbicide compositions effective active composition second and penconazole is 5～80: 40～1.
2. the bactericidal composition that contains phonetic phenol of second and penconazole according to claim 1 is characterized in that: wherein the weight ratio of phonetic phenol of second and penconazole is 10～70: 30～1.
3. the bactericidal composition that contains phonetic phenol of second and penconazole according to claim 2 is characterized in that: wherein the weight ratio of phonetic phenol of second and penconazole is 20～60: 20～1.
4. the bactericidal composition that contains phonetic phenol of second and penconazole according to claim 1, it is characterized in that: microbicide compositions is made wetting powder, water dispersible granules or suspending agent.
5. the bactericidal composition that contains phonetic phenol of second and penconazole according to claim 1 is used to prevent and treat powdery mildew, scab, the anthracnose of vegetables and cereal crop.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999366A (en) * | 2010-12-07 | 2011-04-06 | 陕西韦尔奇作物保护有限公司 | Bactericide composition containing ethirimol |
| CN102204540A (en) * | 2011-04-02 | 2011-10-05 | 陕西汤普森生物科技有限公司 | Sterilization composite containing ethirimol and triazole compound |
| CN104705308A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and ethirimol, and applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101548677B (en) * | 2009-05-12 | 2011-12-07 | 陕西标正作物科学有限公司 | Sterilizing compound of ethirimol and triazole |
| CN101632364B (en) * | 2009-05-27 | 2012-12-12 | 深圳诺普信农化股份有限公司 | Sterilization composition |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999366A (en) * | 2010-12-07 | 2011-04-06 | 陕西韦尔奇作物保护有限公司 | Bactericide composition containing ethirimol |
| CN101999366B (en) * | 2010-12-07 | 2013-11-06 | 陕西韦尔奇作物保护有限公司 | Bactericide composition containing ethirimol |
| CN102204540A (en) * | 2011-04-02 | 2011-10-05 | 陕西汤普森生物科技有限公司 | Sterilization composite containing ethirimol and triazole compound |
| CN102204540B (en) * | 2011-04-02 | 2014-03-05 | 陕西汤普森生物科技有限公司 | Sterilization composite containing ethirimol and triazole compound |
| CN104705308A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and ethirimol, and applications thereof |
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