CN101697720B - Bactericide composition containing ethirimol and kresoxim - Google Patents
Bactericide composition containing ethirimol and kresoxim Download PDFInfo
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- CN101697720B CN101697720B CN 200910218742 CN200910218742A CN101697720B CN 101697720 B CN101697720 B CN 101697720B CN 200910218742 CN200910218742 CN 200910218742 CN 200910218742 A CN200910218742 A CN 200910218742A CN 101697720 B CN101697720 B CN 101697720B
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- methyl
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Abstract
The invention relates to a bactericide composition having synergistic effect, which contains ethirimol and kresoxim as effective active ingredient, wherein the weight ratio of ethirimol to kresoxim is 5-70:60-1, the effective active ingredient is formulated to wettable powder, aqueous dispersion granule and suspension by adding auxiliary agent and excipient therein, and the bactericide composition is mainly used for the prevention and the treatment of scab, downy mildew and powdery mildew of fruit trees.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on fruit diseases that contains the phonetic phenol of second and kresoxim-methyl.
Technical background
The phonetic phenol of second (ethirimol) is the miazines bactericide of Syngenta Co.,Ltd's exploitation.Molecular formula is C
11H
19N
3O, chemical name: 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine.
The phonetic phenol of second belongs to adenosine deaminase inhibitors.Be a kind of systemic fungicide, have preventive and therapeutic action.Can be absorbed rapidly by plant roots, stem, leaf, and in plant corpus, run to each position.
Kresoxim-methyl (kresoxim-methyl) is the methoxy acrylic bactericide of BASF Aktiengesellschaft's exploitation.Molecular formula: C
18H
19NO
4, chemical name: methyl (E)-2-methoxyimino-2-[2-(0-toloxyl) phenyl] and acetate.
Kresoxim-methyl belongs to the mitochondrial respiratory inhibitor; it is a kind of wide-spectrum bactericide; and the lasting period is long; most of diseases that the pathomycetes such as Ascomycetes, Basidiomycetes, Fungi Imperfecti and oomycetes subclass are caused have protection, treat and root out activity; to crop, people, animal and beneficial organism safety, substantially pollution-free to environment, but the intrinsic pesticide resistance of this series bactericidal agent is high-caliber; develop immunity to drugs easily, and cost is high.
No matter be the phonetic phenol of second, kresoxim-methyl or other efficient germicides, long-term separately use makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can enlarge fungicidal spectrum, improves germicidal efficiency.The phonetic phenol of second is different from the kresoxim-methyl mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about the phonetic phenol of second and kresoxim-methyl there is not yet relevant report at present at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl, wherein the phonetic phenol of second and kresoxim-methyl weight ratio are 5～70: 40～1.
The described bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl, wherein the weight ratio of the phonetic phenol of second and kresoxim-methyl is 10～60: 30～5.
The described bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl, wherein the weight ratio of the phonetic phenol of second and kresoxim-methyl is 20～40: 20～10.
The described bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl is made wetting powder, water dispersible granules or suspending agent.
When making wetting powder, composition comprises following constituent content: the phonetic phenol 5～70% of second, kresoxim-methyl 1～40%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
The phonetic phenol of second, kresoxim-methyl, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, namely can be made into the phonetic phenol kresoxim-methyl of second wetting powder product.
When making water dispersible granules, composition comprises following constituent content: the phonetic phenol 5～70% of second, kresoxim-methyl 1～40%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
The phonetic phenol of second, kresoxim-methyl, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through air-flow crushing together, add again other auxiliary agents such as adhesive, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make the phonetic phenol water dispersion granules agent of Kresoxim of second product.
Comprise following constituent content when composition is made suspending agent: the phonetic phenol 5～40% of second, kresoxim-methyl 1～30%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05%～3%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add the phonetic phenol of second, kresoxim-methyl, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes the phonetic phenol kresoxim-methyl of second suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, the polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating black spot of fruit tree, downy mildew, powdery mildew.
Beneficial effect of the present invention: the phonetic phenol of (1) present composition effective active composition second and kresoxim-methyl belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition is to black spot of fruit tree, downy mildew, powdery mildew.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Implementation of an application example one the implementation of Formulation Example
The phonetic phenol kresoxim-methyl of embodiment 1 80% second wetting powder
The phonetic phenol 70% of second, kresoxim-methyl 10%, polycarboxylate 5%, lauryl sodium sulfate 3%, spaonin powder 2%, kaolin 10%, mixture carries out air-flow crushing, makes the phonetic phenol kresoxim-methyl of 80% second wetting powder.
The phonetic phenol kresoxim-methyl of embodiment 2 60% second wetting powder
The phonetic phenol 40% of second, kresoxim-methyl 20%, lignosulfonates 4%, tea are withered 4%, white carbon 8%, kaolin 24%, and mixture carries out air-flow crushing, makes the phonetic phenol kresoxim-methyl of 60% second wetting powder.
The phonetic phenol kresoxim-methyl of embodiment 3 45% second wetting powder
The phonetic phenol 15% of second, kresoxim-methyl 30%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F 3%, white carbon 8%, bentonite 39%, mixture carries out air-flow crushing, makes the phonetic phenol kresoxim-methyl of 45% second wetting powder.
The phonetic phenol water dispersion granules agent of Kresoxim of embodiment 4 80% second
The phonetic phenol 40% of second, kresoxim-methyl 40%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 8% mix making the phonetic phenol water dispersion granules agent of Kresoxim of 80% second.
The phonetic phenol water dispersion granules agent of Kresoxim of embodiment 5 55% second
The phonetic phenol 30% of second, kresoxim-methyl 25%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 20%, kaolin 12% mix making the phonetic phenol water dispersion granules agent of Kresoxim of 55% second.
The phonetic phenol water dispersion granules agent of Kresoxim of embodiment 6 28% second
The phonetic phenol 21% of second, kresoxim-methyl 7%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, starch 20%, diatomite 45%, mix making the phonetic phenol water dispersion granules agent of Kresoxim of 28% second.
The phonetic phenol kresoxim-methyl of embodiment 7 50% second suspending agent
The phonetic phenol 40% of second, kresoxim-methyl 10%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, mixes to make the phonetic phenol kresoxim-methyl of 50% second suspending agent.
The phonetic phenol kresoxim-methyl of embodiment 8 35% second suspending agent
The phonetic phenol 20% of second, kresoxim-methyl 15%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make the phonetic phenol kresoxim-methyl of 35% second suspending agent.
The phonetic phenol kresoxim-methyl of embodiment 9 10% second suspending agent
The phonetic phenol 5% of second, kresoxim-methyl 5%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make the phonetic phenol kresoxim-methyl of 10% second suspending agent.
Implementation of an application example two: the phonetic phenol of second and kresoxim-methyl are composite to the apple mildew Toxicity Determination
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
After each medicament establishment concentration range was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of apple mildew.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively the phonetic phenol of second and kresoxim-methyl shared ratio in combination
A is the phonetic phenol of second
B is kresoxim-methyl
Result of the test is as shown in table 1:
The phonetic phenol of table 1 second, kresoxim-methyl and composite toxicity test analysis of results table to apple mildew thereof
As shown in Table 1, the phonetic phenol of second, kresoxim-methyl are to the EC of apple mildew
50Be respectively 1.79mg/L and 0.68mg/L.The virulence of the phonetic phenol of second is lower than the virulence of kresoxim-methyl.9: 1,6: 1,3: 1,1: 1,1: 3 synergy ratio of the phonetic phenol of second and kresoxim-methyl proportioning is respectively 1.51,1.60,1.74,1.62,1.52, illustrating that the phonetic phenol of second and kresoxim-methyl were mixed in the scope at 9: 1～1: 3 all shows obvious synergistic effect, wherein synergy ratio SR is maximum when the phonetic phenol of second and kresoxim-methyl weight ratio are 3: 1, and synergistic effect is the most obvious.
Embodiment uses the phonetic phenol of three second and kresoxim-methyl and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in one vineyard, suburb, Ningxia Province Yinchuan City, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 30% kresoxim-methyl wetting powder (commercial).
The front investigation of medicine downy mildew of garpe disease index, in the their early stage dispenser, afterwards for the second time dispenser on the 10th, dispenser is 2 times altogether, investigates disease indexs in 7 days, 15 days after for the second time dispenser and calculates preventive effect.Experimental result is as follows:
The phonetic phenol of table 2 second, kresoxim-methyl and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the medicine for the second time | 15 days preventive effects (%) behind the medicine for the second time |
| The phonetic phenol kresoxim-methyl of 80% second wetting powder | 4000 times | 87.83 | 94.24 |
| The phonetic phenol water dispersion granules agent of Kresoxim of 55% second | 4000 times | 88.89 | 91.62 |
| The phonetic phenol kresoxim-methyl of 35% second suspending agent | 2500 times | 92.96 | 96.32 |
| The phonetic phenol suspending agent of 25% second | 1000 times | 62.13 | 74.14 |
| 30% kresoxim-methyl wetting powder | 2000 times | 68.51 | 73.12 |
As can be seen from Table 2, can effectively prevent and treat downy mildew of garpe after the phonetic phenol of second and kresoxim-methyl are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects, and grape powdery mildew is had good preventive effect.
The phonetic phenol of implementation of an application example tetrem, kresoxim-methyl and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 30% kresoxim-methyl wetting powder (commercial).
Investigation state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates respectively disease index and calculates preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
The phonetic phenol of table 4 second, kresoxim-methyl and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| The phonetic phenol kresoxim-methyl of 60% second wetting powder | 3500 times | 85.65 | 94.02 | 92.54 |
| The phonetic phenol water dispersion granules agent of Kresoxim of 28% second | 2000 times | 87.59 | 93.64 | 93.69 |
| The phonetic phenol kresoxim-methyl of 50% second suspending agent | 5000 times | 84.97 | 90.24 | 90.84 |
| The phonetic phenol suspending agent of 25% second | 800 times | 66.86 | 74.65 | 59.38 |
| 50% water dispersion granules agent of Kresoxim | 4000 times | 75.27 | 77.42 | 62.42 |
As can be seen from Table 4, can effectively prevent and treat apple mildew after the phonetic phenol of second and kresoxim-methyl are composite and occur, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and alternaria leaf spot of apple is had preferably preventive effect.
The phonetic phenol of implementation of an application example five second and kresoxim-methyl and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 30% kresoxim-methyl wetting powder (commercial).
In the dispenser of pear tree their early stage, dispenser in per 7 days once, altogether dispenser is 3 times, investigation disease index before the dispenser was investigated respectively disease index in 7 days, 15 days after the dispenser for the third time, and the calculation correction preventive effect, result of the test is as follows:
The phonetic phenol of table 5 second and kresoxim-methyl and the composite control pear scab test of pesticide effectiveness thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the medicine for the third time | 15 days preventive effects (%) behind the medicine for the third time |
| The phonetic phenol kresoxim-methyl of 45% second wetting powder | 3500 times | 91.53 | 95.78 |
| The phonetic phenol water dispersion granules agent of Kresoxim of 80% second | 6500 times | 91.07 | 93.64 |
| The phonetic phenol kresoxim-methyl of 10% second suspending agent | 1000 times | 89.52 | 90.55 |
| 25% kresoxim-methyl suspending agent | 800 times | 63.34 | 72.13 |
| 50% ethirimol water dispersible granules | 4000 times | 79.75 | 83.06 |
As can be seen from Table 5, the phonetic phenol of second, kresoxim-methyl can the effectively preventing pear scabs, and control efficiency all is better than contrasting medicament, and dosage is little, in the test scope of medication to the target crop without harm.
Claims (3)
1. bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl, it is characterized in that: the weight ratio of the phonetic phenol of bactericidal composition effective active composition second and kresoxim-methyl is 1: 3～1: 2 or 6: 5～4: 1 or 6: 1～9: 1.
2. the bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl according to claim 1, it is characterized in that: bactericidal composition is made wetting powder, water dispersible granules or suspending agent.
3. the bactericidal composition that contains the phonetic phenol of second and kresoxim-methyl according to claim 1 is used for the purposes of control black spot of fruit tree, downy mildew, powdery mildew.
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