CN101755778B - Fungicidal composition containing kresoxim methyl and propineb - Google Patents
Fungicidal composition containing kresoxim methyl and propineb Download PDFInfo
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- CN101755778B CN101755778B CN 200910218522 CN200910218522A CN101755778B CN 101755778 B CN101755778 B CN 101755778B CN 200910218522 CN200910218522 CN 200910218522 CN 200910218522 A CN200910218522 A CN 200910218522A CN 101755778 B CN101755778 B CN 101755778B
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- propineb
- methyl
- kresoxim
- powder
- water dispersible
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- 239000005823 Propineb Substances 0.000 title claims abstract description 110
- KKMLIVYBGSAJPM-UHFFFAOYSA-L propineb Chemical compound [Zn+2].[S-]C(=S)NC(C)CNC([S-])=S KKMLIVYBGSAJPM-UHFFFAOYSA-L 0.000 title claims abstract description 110
- 239000005800 Kresoxim-methyl Substances 0.000 title claims abstract description 109
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical group CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 title claims abstract description 109
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 230000000855 fungicidal effect Effects 0.000 title abstract description 4
- 239000000375 suspending agent Substances 0.000 claims abstract description 17
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 17
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 11
- 241000221785 Erysiphales Species 0.000 claims abstract description 9
- 206010039509 Scab Diseases 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims description 38
- 230000000844 anti-bacterial effect Effects 0.000 claims description 16
- 238000009736 wetting Methods 0.000 claims description 13
- 230000035613 defoliation Effects 0.000 claims description 4
- 201000010099 disease Diseases 0.000 abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 12
- 241000223600 Alternaria Species 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 9
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000004563 wettable powder Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 39
- 238000012360 testing method Methods 0.000 description 21
- 230000003449 preventive effect Effects 0.000 description 20
- 239000002131 composite material Substances 0.000 description 18
- 239000000575 pesticide Substances 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 7
- 239000002270 dispersing agent Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- -1 polyoxyethylene Polymers 0.000 description 7
- 239000000080 wetting agent Substances 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 240000008067 Cucumis sativus Species 0.000 description 5
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 229920005646 polycarboxylate Polymers 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920001732 Lignosulfonate Polymers 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 240000001987 Pyrus communis Species 0.000 description 4
- 235000014443 Pyrus communis Nutrition 0.000 description 4
- 150000004996 alkyl benzenes Chemical class 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 229940077388 benzenesulfonate Drugs 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 230000002045 lasting effect Effects 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 239000011701 zinc Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 3
- 240000003377 Shepherdia canadensis Species 0.000 description 3
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 230000002528 anti-freeze Effects 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- 150000007942 carboxylates Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000007859 condensation product Substances 0.000 description 3
- 239000013530 defoamer Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 241000255789 Bombyx mori Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 229960000892 attapulgite Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 229910052625 palygorskite Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000198596 Alternaria tomatophila Species 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 241000510928 Erysiphe necator Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 239000012990 dithiocarbamate Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- KFSLWBXXFJQRDL-UHFFFAOYSA-N peroxyacetic acid Substances CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003161 proteinsynthetic effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Abstract
The invention relates to a synergistic fungicidal composition, the active components of which contain kresoxim methyl and propineb, wherein the weight ratio of the kresoxim methyl to the propineb is 40:1 to 1:100. Additives and excipients can be added in the active components to produce wettable powder, water dispersible granule and suspending agent, which are mainly used to control the diseases of vegetables and fruit trees, such as alternaria leaf spot, scab, powdery mildew and downy mildew.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on vegetables and fruit diseases that contains kresoxim-methyl and Propineb.
Technical background
Kresoxim-methyl (kresoxim-methyl) is the methoxy acrylic bactericide of BASF Aktiengesellschaft's exploitation.Molecular formula: C
18H
19NO
4, chemical name: methyl (E)-2-methoxyimino-2-[2-(0-toloxyl) phenyl] and acetate.
Kresoxim-methyl belongs to the mitochondrial respiratory inhibitor; it is a kind of wide-spectrum bactericide; and the lasting period is long; most of diseases that the pathomycetes such as Ascomycetes, Basidiomycetes, Fungi Imperfecti and oomycetes subclass are caused have protection, treat and root out activity; to crop, people, animal and beneficial organism safety, substantially pollution-free to environment, but the intrinsic pesticide resistance of this series bactericidal agent is high-caliber; develop immunity to drugs easily, and cost is high.
Propineb (propineb) is that molecular formula is (C by the dithiocarbamate fungicide of Bayer AG exploitation
5H
8N
2S
4Zn)
x, chemical name is acrylic bisdithiocarbamic zinc.
Propineb has good protection, treatment and eradicant action to Peronosporaceae and the fungus-caused disease of Phytophthora.Its mechanism of action is act on fungal cell wall and protein synthetic, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death.And this medicine contains and is easy to zinc element absorbed by crops, the quality that is conducive to promote plant growth and improves fruit.The test of pesticide effectiveness shows that Propineb has good preventive effect to apple mildew, vegetables downy mildew, downy mildew of garpe, spot defoliation, early blight of tomato, late blight etc.
No matter be kresoxim-methyl, Propineb or other efficient germicides, long-term separately use makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can enlarge fungicidal spectrum, improves germicidal efficiency.Kresoxim-methyl is different from the Propineb mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about kresoxim-methyl and Propineb there is not yet relevant report at present at home and abroad.
Summary of the invention
Purpose of the present invention proposes a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains kresoxim-methyl and Propineb.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains kresoxim-methyl and Propineb, wherein kresoxim-methyl and Propineb weight ratio are 40: 1 to 1: 100.
The described bactericidal composition that contains kresoxim-methyl and Propineb, wherein the weight ratio of kresoxim-methyl and Propineb is 20: 1 to 1: 40.
The described bactericidal composition that contains kresoxim-methyl and Propineb, wherein the weight ratio of kresoxim-methyl and Propineb is 8: 1 to 1: 24.
The described bactericidal composition that contains kresoxim-methyl and Propineb is made wetting powder, water dispersible granules or suspending agent.
When making wetting powder, composition comprises following constituent content: kresoxim-methyl 1～40%, Propineb 10～80%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
Kresoxim-methyl, Propineb, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, namely can be made into kresoxim-methyl Wettable propineb powder product.
When making water dispersible granules, composition comprises following constituent content: kresoxim-methyl 1～40%, Propineb 10～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
Kresoxim-methyl, Propineb, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through air-flow crushing together, add again other auxiliary agents such as adhesive, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make kresoxim-methyl Propineb water dispersible granules product.
Comprise following constituent content when composition is made suspending agent: kresoxim-methyl 1～20%, Propineb 5～40%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05%～3%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add kresoxim-methyl, Propineb, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes kresoxim-methyl Propineb suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, the polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating spot defoliation, scab, powdery mildew, downy mildew.
Beneficial effect of the present invention: (1) present composition effective active composition kresoxim-methyl and Propineb belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to spot defoliation, scab, powdery mildew, downy mildew.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% kresoxim-methyl Wettable propineb powder
Kresoxim-methyl 40%, Propineb 40%, polycarboxylate 5%, lauryl sodium sulfate 3%, spaonin powder 2%, kaolin 10%, mixture carries out air-flow crushing, makes 80% kresoxim-methyl Wettable propineb powder.
Embodiment 2 60% kresoxim-methyl Wettable propineb powders
Kresoxim-methyl 20%, Propineb 40%, lignosulfonates 4%, tea are withered 4%, white carbon 8%, kaolin 24%, and mixture carries out air-flow crushing, makes 60% kresoxim-methyl Wettable propineb powder.
Embodiment 3 45% kresoxim-methyl Wettable propineb powders
Kresoxim-methyl 15%, Propineb 30%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F 3%, white carbon 8%, bentonite 39%, mixture carries out air-flow crushing, makes 45% kresoxim-methyl Wettable propineb powder.
Embodiment 4 17% kresoxim-methyl Wettable propineb powders
Kresoxim-methyl 1%, Propineb 16%, lignosulfonates 2%, silkworm excrement 3%, white carbon 5%, attapulgite 80%, mixture carries out air-flow crushing, makes 17% kresoxim-methyl Wettable propineb powder.
Embodiment 5 75% kresoxim-methyl Propineb water dispersible granules
Kresoxim-methyl 5%, Propineb 70%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 13% mix making 75% kresoxim-methyl Propineb water dispersible granules.
Embodiment 6 55% kresoxim-methyl Propineb water dispersible granules
Kresoxim-methyl 20%, Propineb 35%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 20%, kaolin 12% mix making 55% kresoxim-methyl Propineb water dispersible granules.
Embodiment 7 40% kresoxim-methyl Propineb water dispersible granules
Kresoxim-methyl 2%, Propineb 38%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 6%, succinic acid 3%, citric acid 1%, starch 20%, precipitated calcium carbonate 35% mix making 40% kresoxim-methyl Propineb water dispersible granules.
Embodiment 8 20% kresoxim-methyl Propineb water dispersible granules
Kresoxim-methyl 10%, Propineb 10%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, starch 20%, diatomite 53%, mix making 20% kresoxim-methyl Propineb water dispersible granules.
Embodiment 9 50% kresoxim-methyl Propineb suspending agents
Kresoxim-methyl 13%, Propineb 37%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, mixes to make 50% kresoxim-methyl Propineb suspending agent.
Embodiment 10 35% kresoxim-methyl Propineb suspending agents
Kresoxim-methyl 3%, Propineb 32%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 35% kresoxim-methyl Propineb suspending agent.
Embodiment 11 20% kresoxim-methyl Propineb suspending agents
Kresoxim-methyl 4%, Propineb 16%, polyoxyethylene carboxylate 4%, spaonin powder 5%, silicone compound 0.1%, polyvinyl alcohol 0.4%, propane diols 2%, deionized water add to 100%, mix to make 20% kresoxim-methyl Propineb suspending agent.
Embodiment 12 10% kresoxim-methyl Propineb suspending agents
Kresoxim-methyl 1%, Propineb 9%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 10% kresoxim-methyl Propineb suspending agent.
Implementation of an application example two: kresoxim-methyl and Propineb are composite to the alternaria leaf spot of apple Toxicity Determination
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
After each medicament establishment concentration range was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of alternaria leaf spot of apple.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively kresoxim-methyl and Propineb shared ratio in combination
A is kresoxim-methyl
B is Propineb
Result of the test is as shown in table 1:
Table 1 kresoxim-methyl, Propineb and composite toxicity test analysis of results table to alternaria leaf spot of apple thereof
As shown in Table 1, kresoxim-methyl, Propineb are to the EC of alternaria leaf spot of apple
50Be respectively 1.41mg/L and 90.65mg/L.The virulence of kresoxim-methyl is higher than the virulence of Propineb.8: 1,1: 1,1: 8,1: 16,1: 24 synergy ratio of kresoxim-methyl and Propineb proportioning is respectively 1.54,1.69,2.47,1.93,1.75, illustrating that kresoxim-methyl and Propineb were mixed in the scope at 8: 1～1: 24 all shows obvious synergistic effect, wherein synergy ratio SR is maximum when kresoxim-methyl and Propineb weight ratio are 1: 8, and synergistic effect is the most obvious.
Embodiment uses three kresoxim-methyls and Propineb and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in the large exit of valley of Xian City, Shanxi Province Changan District town, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 70% Wettable propineb powder (commercial), 30% kresoxim-methyl wetting powder (commercial).
For the first time dispenser on June 7 is investigated before the medicine and is calculated the downy mildew of garpe disease index, for the second time dispenser on June 14, and dispenser is 2 times altogether, investigates disease indexs in 7 days, 15 days after for the second time dispenser and calculates preventive effect.Experimental result is as follows:
Table 2 kresoxim-methyl Propineb and the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the medicine for the second time | 15 days preventive effects (%) behind the medicine for the second time |
| 80% kresoxim-methyl Wettable propineb powder | 4000 times | 86.74 | 92.44 |
| 55% kresoxim-methyl Propineb water dispersible granules | 2000 times | 88.89 | 93.62 |
| 20% kresoxim-methyl Propineb suspending agent | 800 times | 89.66 | 93.27 |
| 70% Wettable propineb powder | 500 times | 50.26 | 60.14 |
| 30% kresoxim-methyl wetting powder | 2000 times | 67.41 | 70.12 |
As can be seen from Table 2, can effectively prevent and treat downy mildew of garpe after kresoxim-methyl and Propineb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects, and grape powdery mildew is had preferably preventive effect.
Implementation of an application example four: kresoxim-methyl and Propineb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
This experimental establishment is in suburb, Liquan County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 70% Wettable propineb powder (commercial), 30% kresoxim-methyl wetting powder (commercial).
The investigation alternaria leaf spot of apple state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated respectively the apple disease index and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the third time.Experimental result is as follows:
Table 3 kresoxim-methyl Propineb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 45% kresoxim-methyl Wettable propineb powder | 2500 times | 84.16 | 93.05 | 92.44 |
| 20% kresoxim-methyl Propineb water dispersible granules | 1500 times | 88.74 | 95.26 | 93.69 |
| 35% kresoxim-methyl Propineb suspending agent | 1000 times | 87.36 | 92.23 | 90.74 |
| 70% Wettable propineb powder | 500 times | 56.25 | 62.30 | 47.38 |
| 30% kresoxim-methyl wetting powder | 2500 times | 75.36 | 77.42 | 62.42 |
As can be seen from Table 3, energy effectively preventing alternaria leaf spot of apple after kresoxim-methyl and Propineb are composite, control efficiency all is better than contrasting medicament, and dosage is little, and the lasting period is long.In the test scope of medication to the target crop without harm, and ring rot of apple had preferably preventive effect, control efficiency reaches more than 80%.
Implementation of an application example five: kresoxim-methyl and Propineb and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 70% Wettable propineb powder (commercial), 30% kresoxim-methyl wetting powder (commercial).
Investigation powdery mildew of cucumber state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the dispenser of powdery mildew of cucumber initial stage of origination, dispenser in per 7 days once is total to dispenser 2 times, investigates respectively disease index and calculates preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 4 kresoxim-methyl, Propineb and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | The preparation dosage | 7 days preventive effects (%) behind the medicine for the third time | 14 days preventive effects (%) behind the medicine for the third time |
| 60% kresoxim-methyl Wettable propineb powder | 30 g/acres | 89.72 | 88.08 |
| 40% kresoxim-methyl Propineb water dispersible granules | 150 g/acres | 90.16 | 91.32 |
| 10% kresoxim-methyl Propineb suspending agent | 300 g/acres | 89.30 | 91.59 |
| 70% Wettable propineb powder | 150 g/acres | 53.44 | 66.34 |
| 30% kresoxim-methyl wetting powder | 40 g/acres | 67.28 | 73.45 |
As can be seen from Table 4, can effectively prevent and treat powdery mildew of cucumber after kresoxim-methyl and Propineb are composite and occur, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.
Implementation of an application example six: kresoxim-methyl and Propineb and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in area just outside a city gate town, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 70% Wettable propineb powder (commercial), 30% kresoxim-methyl wetting powder (commercial).
In the dispenser of pear tree their early stage, dispenser in per 7 days once, altogether dispenser is 3 times, investigation disease index before the dispenser was investigated respectively disease index in 7 days, 15 days after the dispenser for the third time, and the calculation correction preventive effect, result of the test is as follows:
Table 5 kresoxim-methyl and the third vast zinc and the composite control pear scab test of pesticide effectiveness thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the medicine for the third time | 15 days preventive effects (%) behind the medicine for the third time |
| 17% kresoxim-methyl Wettable propineb powder | 300 times | 86.62 | 90.18 |
| 75% kresoxim-methyl Propineb water dispersible granules | 1800 times | 90.16 | 90.74 |
| 50% kresoxim-methyl Propineb suspending agent | 2500 times | 89.52 | 92.55 |
| 70% Wettable propineb powder | 600 times | 64.34 | 74.13 |
| 30% kresoxim-methyl wetting powder | 3000 times | 80.75 | 83.06 |
As can be seen from Table 5, kresoxim-methyl, Propineb can the effectively preventing pear scabs, and control efficiency all is better than contrasting medicament, and dosage is little, in the test scope of medication to the target crop without harm.
Claims (3)
1. bactericidal composition that contains kresoxim-methyl and Propineb, the weight ratio that it is characterized in that bactericidal composition effective active composition kresoxim-methyl and Propineb is 8: 1 to 1: 24.
2. the bactericidal composition that contains kresoxim-methyl and Propineb according to claim 1, it is characterized in that: bactericidal composition is made wetting powder, water dispersible granules or suspending agent.
3. the bactericidal composition that contains kresoxim-methyl and Propineb according to claim 1 is used for the purposes of control spot defoliation, scab, powdery mildew, downy mildew.
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