CN101999390A - Antibacterial composition containing prochloraz and thiocatbamate compounds - Google Patents
Antibacterial composition containing prochloraz and thiocatbamate compounds Download PDFInfo
- Publication number
- CN101999390A CN101999390A CN2010105966250A CN201010596625A CN101999390A CN 101999390 A CN101999390 A CN 101999390A CN 2010105966250 A CN2010105966250 A CN 2010105966250A CN 201010596625 A CN201010596625 A CN 201010596625A CN 101999390 A CN101999390 A CN 101999390A
- Authority
- CN
- China
- Prior art keywords
- prochloraz
- salt
- carbatene
- zineb
- bactericidal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005820 Prochloraz Substances 0.000 title claims abstract description 91
- TVLSRXXIMLFWEO-UHFFFAOYSA-N prochloraz Chemical compound C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl TVLSRXXIMLFWEO-UHFFFAOYSA-N 0.000 title claims abstract description 91
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 34
- 150000001875 compounds Chemical class 0.000 title description 12
- 150000003839 salts Chemical class 0.000 claims abstract description 89
- 239000000375 suspending agent Substances 0.000 claims abstract description 11
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 84
- AMHNZOICSMBGDH-UHFFFAOYSA-L zineb Chemical compound [Zn+2].[S-]C(=S)NCCNC([S-])=S AMHNZOICSMBGDH-UHFFFAOYSA-L 0.000 claims description 45
- 239000011717 all-trans-retinol Substances 0.000 claims description 42
- 235000019169 all-trans-retinol Nutrition 0.000 claims description 42
- -1 thiocarbamates compound Chemical class 0.000 claims description 29
- 239000000839 emulsion Substances 0.000 claims description 10
- 239000000725 suspension Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 8
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 3
- 201000010099 disease Diseases 0.000 abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 14
- 239000004563 wettable powder Substances 0.000 abstract description 11
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 241000223600 Alternaria Species 0.000 abstract description 6
- 239000003899 bactericide agent Substances 0.000 abstract description 6
- 241000233679 Peronosporaceae Species 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 241000221785 Erysiphales Species 0.000 abstract description 3
- 239000012752 auxiliary agent Substances 0.000 abstract description 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 27
- 238000012360 testing method Methods 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 230000003449 preventive effect Effects 0.000 description 13
- 239000002131 composite material Substances 0.000 description 12
- 240000008067 Cucumis sativus Species 0.000 description 11
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 239000000575 pesticide Substances 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 229920005646 polycarboxylate Polymers 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 8
- 229910021641 deionized water Inorganic materials 0.000 description 8
- 235000011430 Malus pumila Nutrition 0.000 description 7
- 235000015103 Malus silvestris Nutrition 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 6
- 241000209140 Triticum Species 0.000 description 6
- 235000021307 Triticum Nutrition 0.000 description 6
- 150000004996 alkyl benzenes Chemical class 0.000 description 6
- 239000011575 calcium Substances 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- ZEVCJZRMCOYJSP-UHFFFAOYSA-N sodium;2-(dithiocarboxyamino)ethylcarbamodithioic acid Chemical compound [Na+].SC(=S)NCCNC(S)=S ZEVCJZRMCOYJSP-UHFFFAOYSA-N 0.000 description 6
- 239000008107 starch Substances 0.000 description 6
- 235000019698 starch Nutrition 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 5
- 229920001732 Lignosulfonate Polymers 0.000 description 5
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229910021380 Manganese Chloride Inorganic materials 0.000 description 4
- 206010067482 No adverse event Diseases 0.000 description 4
- 240000003377 Shepherdia canadensis Species 0.000 description 4
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000000440 bentonite Substances 0.000 description 4
- 229910000278 bentonite Inorganic materials 0.000 description 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 4
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 238000009313 farming Methods 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- 239000011565 manganese chloride Substances 0.000 description 4
- 229940099607 manganese chloride Drugs 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000007942 carboxylates Chemical class 0.000 description 3
- 230000002070 germicidal effect Effects 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 235000021003 saturated fats Nutrition 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- 241000255789 Bombyx mori Species 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 241000220324 Pyrus Species 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000002528 anti-freeze Effects 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 230000035613 defoliation Effects 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 2
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- WZZLDXDUQPOXNW-UHFFFAOYSA-N propamocarb Chemical compound CCCOC(=O)NCCCN(C)C WZZLDXDUQPOXNW-UHFFFAOYSA-N 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- JCUDAMKYTWVICI-UHFFFAOYSA-N 4-benzyl-2,3-dimethylphenol Chemical compound C1=C(O)C(C)=C(C)C(CC=2C=CC=CC=2)=C1 JCUDAMKYTWVICI-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- 229920005682 EO-PO block copolymer Polymers 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 206010064458 Penicilliosis Diseases 0.000 description 1
- 239000005821 Propamocarb Substances 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- HEEYEDNZYXRUQB-UHFFFAOYSA-N benzene;carbamothioic s-acid Chemical class NC(S)=O.C1=CC=CC=C1 HEEYEDNZYXRUQB-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- HYFPVPNWNRFTMP-UHFFFAOYSA-N formic acid;manganese Chemical compound [Mn].OC=O HYFPVPNWNRFTMP-UHFFFAOYSA-N 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000002867 manganese chloride Nutrition 0.000 description 1
- OXOKTPUZOHPXSA-UHFFFAOYSA-L manganese(2+);n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide;dichloride Chemical compound Cl[Mn]Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl OXOKTPUZOHPXSA-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 238000006365 thiocyanation reaction Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to an antibacterial composition with synergistic effect, which comprises one of (A) prochloraz or a salt thereof and (B) thiocatbamate bactericide as the effective active ingredient, wherein the weight ratio of A to B is 32:1-1:32, and auxiliary agents and excipients are added into the effective active ingredient to prepare wettable powder, suspending agents and the like. The antibacterial composition is mainly used for preventing and treating plant diseases, such as powdery mildew, anthracnose, alternaria leaf spot, leaf spot, downy mildew, rust disease and the like.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains Prochloraz or its salt and thiocarbamates compound.
Technical background
Prochloraz (propamocarb), molecular formula are C
9H
21N
2O
2C1, chemical name: 3-(dimethylamino) propyl carbamic acid propyl ester.
Prochloraz belongs to carbamates, mainly suppresses the biosynthesis of the phosphatide and the fatty acid of germ cell membrane component, suppresses mycelial growth, sporangial formation and sprouting.Inhale the conductivity bactericide in Prochloraz belongs to, when handling, can be absorbed very soon and be distributed in the blade, play a protective role rapidly by blade as cauline leaf.Its complex compound prochloraz-manganese chloride complex (prochloraz-manganesechloride complex) is composited by Prochloraz and manganese chloride, is the imidazoles broad-spectrum germicide.Pure product are dark-brown crystalloid solid.Molecular formula is [C
15H
16C
13N
3O
2] 4MnCl
2, chemical name is: N-propyl group-N-[2-(2,4, the 6-Trichlorophenoxy) ethyl]-1H imidazoles-1-formamide-manganese chloride.
Carbatene (metriam), molecular formula: (C4H6N2S4Zn) x chemical name: the co-ordination complex of two two sulphur deoxidation base formic acid manganese of ethylene and zinc ion.
Carbatene is a kind of good protective fungicide, belongs to low-toxin farm chemicals.Because wide, the difficult resistance that produces of its bactericidal range, control efficiency obviously is better than other same series bactericidal agents, so consumption is a large tonnage product in the world always.Be the substitute products of present other protective fungicides; domestic most composite bactericide is all formulated with Carbatene processing; by field application in recent years; remarkable to preventing and treating effects such as pear scab, alternaria leaf spot of apple, vegetable category eqpidemic disease, downy mildew, field crop rust, steady quality, reliable.
Zineb (zineb), molecular formula are C4H6N2S4Zn, chemical name: zinc ethylenebisdithiocarbamate.
Zineb belongs to the benzene thiocarbamates; it is the protectant that a kind of foliage spray is used; to plant safety; the active ingredient chemical property is more active, easily is oxidized to different thiocyanation compound in water, to the cause of disease thalline contain-enzyme of SH base has had strong inhibitory effects; and the direct kill pathogens spore of energy; suppress the germination of spore, stop in the germ invaded plants body, but very little to the mycelial lethal effect of cause of disease in the invaded plants body.No matter be Prochloraz or its salt, Carbatene (zineb) or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.And a kind ofly do not have the novel pesticide of cross resistance to prevent and treat pathogen if want newly developed, and then need screen 10,000～1.5 ten thousand compounds, expensive 1～1.5 hundred million dollar, the construction cycle is 6～10 years.And that the active ingredient of the different mechanisms of action is carried out is composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Prochloraz or its salt are different with Carbatene (zineb) mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about Prochloraz or its salt and Carbatene (zineb) do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition that use cost is low, preventive effect is good.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Prochloraz or its salt, wherein Prochloraz or its salt and Carbatene or zineb weight ratio are 32: 1～1: 32, are preferably 16: 1～1: 16, more preferably 8: 1～1: 8.
The described bactericidal composition that contains Prochloraz or its salt, wherein the weight ratio of Prochloraz or its salt and Carbatene or zineb is 8: 1～1: 8, and preferred weight ratio is 4: 1～1: 4, and further preferred weight ratio is 2: 1～1: 2.
The described bactericidal composition that contains Prochloraz or its salt, wherein the weight ratio of Prochloraz or its salt and Carbatene or zineb is 8: 1～1: 8, and preferred weight ratio is 4: 1～1: 4, and further preferred weight ratio is 2: 1～1: 2.
The described bactericidal composition that contains Prochloraz or its salt, wherein the effective active component content accounts for 1～90% of gross weight, is preferably 10～80%.
The described bactericidal composition that contains Prochloraz or its salt is according to method known in those skilled in the art, adds corresponding additive and filler, make agricultural and go up any formulation that allows, more preferably as: wetting powder, water dispersible granules, suspending agent, suspension emulsion.
Described auxiliary agent has dispersant, wetting agent, disintegrant, emulsifier, binding agent, defoamer, antifreeze, thickener.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described binding agent is selected from: one or more in diatomite, starch, PVA, carboxymethyl (ethyl) cellulose.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, the glucose.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 1600
#In (phenethyl phenol polyoxy ethyl polypropylene-base ether), the ethylene oxide-propylene oxide block copolymer one or more.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition applicable object of the present invention has: rape, soybean, sunflower, beet, water paddy and wheat class, oranges and tangerines, mango, apple, pears, banana, grape and various vegetables, flowers etc.Be used to prevent and treat bakanae disease, banded sclerotial blight, rust, powdery mildew, anthracnose, scab, ring spot, spot defoliation, penicilliosis, green mould, leaf spot, black rot, blossom-end rot, downy mildew, eqpidemic disease etc.
Beneficial effect of the present invention: (1) present composition effective active composition Prochloraz or its salt and Carbatene or zineb belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition shows good synergistic effect in given scope, and preventive effect is apparently higher than single agent, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to the powdery mildew of vegetables and fruit tree, anthracnose, spot defoliation, leaf spot, downy mildew, rust etc.
Embodiment
To further instruction of the present invention, but the present invention is not limited thereto below in conjunction with embodiment.Percentage in following examples all is weight percentage.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one: Prochloraz or its salt and Carbatene (or zineb) are composite to the cucumber anthracnose Toxicity Determination
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament cucumber anthracnose.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively Prochloraz or its salt and Carbatene (or zineb) shared ratio in combination
A is Prochloraz or its salt
B is Carbatene (or zineb)
Result of the test is as shown in the table:
Table 1 Prochloraz or its salt, Carbatene and composite toxicity test analysis of results table thereof to cucumber anthracnose
As shown in Table 1, Prochloraz or its salt, Carbatene are to the EC of cucumber anthracnose
50Be respectively 20.42mg/L and 22.68mg/L.Prochloraz or its salt and Carbatene were mixed in the scope at 32: 1～1: 32 and all show obvious synergistic effect.Wherein, both mixed synergies in 16: 1～1: 16 scope are comparatively desirable, and mixed synergies is particularly outstanding in 8: 1～1: 8 scope.
Table 2 Prochloraz or its salt, zineb and composite toxicity test analysis of results table thereof to cucumber anthracnose
As shown in Table 1, Prochloraz or its salt, zineb are to the EC of cucumber anthracnose
50Be respectively 20.42mg/L and 23.35mg/L.Prochloraz or its salt and zineb were mixed in the scope at 32: 1～1: 32 and all show obvious synergistic effect.Wherein, both mixed synergies in 16: 1～1: 16 scope are comparatively desirable, and mixed synergies is particularly outstanding in 8: 1～1: 8 scope.
Implementation of an application example two the implementation of Formulation Example
(1) Prochloraz or its salt Carbatene:
Embodiment 1 80% Prochloraz or its salt thioneb wettable powder
Prochloraz or its salt 10%, Carbatene 70%, lignosulfonates 3%, lauryl sodium sulfate 4%, kaolin add to 100%, mixed 80% Prochloraz or its salt thioneb wettable powder of getting.
Embodiment 2 60% Prochlorazs or its salt thioneb wettable powder
Prochloraz or its salt 20%, Carbatene 40%, polycarboxylate 3%, silkworm excrement 4%, starch 5%, diatomite add to 100%, mixed 60% Prochloraz or its salt thioneb wettable powder of getting.
Embodiment 3 70% Prochlorazs or its salt Carbatene water dispersible granules
Prochloraz or its salt 10%, Carbatene 60%, polycarboxylate 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, starch 7%, kaolin add to 100%, mixed 70% Prochloraz or its salt Carbatene water dispersible granules of getting.
Embodiment 4 62% Prochlorazs or its salt Carbatene water dispersible granules
Prochloraz or its salt 2%, Carbatene 60%, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, white carbon 8%, bentonite add to 100%, mixed 62% Prochloraz or its salt Carbatene water dispersible granules.
Embodiment 5 40% Prochlorazs or its salt Carbatene suspending agent
Prochloraz or its salt 30%, Carbatene 10%, alkyl benzene sulfonate calcium salt 5%, Sodium Polyacrylate 2%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, phenyl phenol polyoxy ethyl ether 2%, deionized water adds to 100%, mixed 40% Prochloraz or its salt Carbatene suspending agent of getting.
Embodiment 6 30% Prochlorazs or its salt Carbatene suspending agent
Prochloraz or its salt 25%, Carbatene 5%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, mixed 30% Prochloraz or its salt Carbatene suspending agent of getting.
Embodiment 7 50% Prochlorazs or its salt Carbatene suspension emulsion
Prochloraz or its salt 40%, Carbatene 10%, phenyl phenol polyoxy ethyl ether 8%, polycarboxylate 2%, Nekal BX 2%, C10-20 saturated fat acid compounds 0.1%, polyethylene glycol 0.5%, ethylene glycol 4%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, mixed 28% Prochloraz or its salt Carbatene suspension emulsion of getting.
Embodiment 8 30% Prochlorazs or its salt Carbatene suspension emulsion
Prochloraz or its salt 20%, Carbatene 10%, phenethyl phenol polyoxy ethyl polypropylene-base ether 6%, lignosulfonates 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, mixed 30% Prochloraz or its salt Carbatene suspension emulsion of getting.
(2) Prochloraz or its salt zineb
Embodiment 9 80% Prochlorazs or its salt Zineb wettable powder
Prochloraz or its salt 20%, zineb 60%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, kaolin add to 100%, mixed 80% Prochloraz or its salt Zineb wettable powder of getting.
Embodiment 10 68% Prochlorazs or its salt Zineb wettable powder
Prochloraz or its salt 4%, zineb 64%, alkylphenol-polyethenoxy be phonetic 3%, draw back powder 4%, kaolin adds to 100%, mixed 68% Prochloraz or its salt Zineb wettable powder.
Embodiment 11 75% Prochlorazs or its salt water dispersion granules agent of dithane
Prochloraz or its salt 10%, zineb 65%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, starch 7%, bentonite add to 100%, mixed 75% Prochloraz or its salt water dispersion granules agent of dithane of getting.
Embodiment 12 40% Prochlorazs or its salt water dispersion granules agent of dithane
Prochloraz or its salt 8%, zineb 32%, alkylphenol-polyethenoxy are phonetic 4%, DBSA 4%, sodium chloride 2%, starch 15%, diatomite add to 100%, mixed 40% Prochloraz or its salt water dispersion granules agent of dithane.
Embodiment 13 40% Prochlorazs or its salt zineb suspending agent
Prochloraz or its salt 20%, zineb 20%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, mixed 40% Prochloraz or its salt zineb suspending agent of getting.
Embodiment 14 15% Prochlorazs or its salt zineb suspending agent
Prochloraz or its salt 5%, zineb 10%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, mixed 15% Prochloraz or its salt zineb suspending agent of getting.
Embodiment 15 36% Prochlorazs or its salt zineb suspension emulsion
Prochloraz or its salt 30%, zineb 6%, polycarboxylate 2%, Nekal BX 2%, C10-20 saturated fat acid compounds 0.1%, polyethylene glycol 0.5%, ethylene glycol 4%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, mixed 36% Prochloraz or its salt zineb suspension emulsion of getting.
Embodiment 16 30% Prochlorazs or its salt zineb suspension emulsion
Prochloraz or its salt 20%, zineb 10%, lignosulfonates 2%, dodecyl benzene sulfonate 3%, silicone oil 0.1%, polyethylene glycol 1%, propane diols 4%, deionized water add to 100%, mixed 30% Prochloraz or its salt zineb suspension emulsion of getting.
Embodiment uses three bactericidal compositions that contain Prochloraz or its salt and prevents and treats the wheat rust test of pesticide effectiveness
This experimental establishment is in suburb, Fuping County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 70% water dispersion granules agent of dithane (commercial), 25% Prochloraz missible oil (commercial).
The investigation wheat rust state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated the wheat rust disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 3 contains the bactericidal composition of Prochloraz or its salt and prevents and treats the wheat rust test of pesticide effectiveness
As can be seen from Table 3, can effectively prevent and treat wheat rust after Prochloraz or its salt and Carbatene or zineb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.
Implementation of an application example four: the bactericidal composition control cucumber anthracnose test of pesticide effectiveness that contains Prochloraz or its salt
This experimental establishment is at the Xian City, Shanxi Province Changan District, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 70% water dispersion granules agent of dithane (commercial), 25% Prochloraz missible oil (commercial).
Investigation cucumber anthracnose state of an illness radix before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 4 contains the bactericidal composition control cucumber anthracnose test of pesticide effectiveness of Prochloraz or its salt
As can be seen from Table 4, can effectively prevent and treat cucumber anthracnose after Prochloraz or its salt and Carbatene or zineb are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and cucumber downy mildew had good preventive effect, preventive effect reaches more than 90%.
Implementation of an application example five: the bactericidal composition control alternaria leaf spot of apple test of pesticide effectiveness that contains Prochloraz or its salt
This experimental establishment is in Liang Jia village, Liquan County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 80% thioneb wettable powder (commercial), 25% Prochloraz missible oil (commercial).
Investigation alternaria leaf spot of apple state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 5 contains the bactericidal composition control alternaria leaf spot of apple test of pesticide effectiveness of Prochloraz or its salt
As can be seen from Table 5, can effectively prevent and treat alternaria leaf spot of apple after Prochloraz or its salt and Carbatene are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.And apple mildew had good preventive effect, preventive effect reaches more than 90%.
Implementation of an application example five: the bactericidal composition that contains Prochloraz or its salt is prevented and treated the sigatoka test of pesticide effectiveness
This experimental establishment is in Red River, Yunnan Province Zhouhe mouth county, and test medicine is researched and developed, provided by Shaanxi Welch Crop Protection Co., Ltd., contrast medicament 80% thioneb wettable powder (commercial), 25% Prochloraz missible oil (commercial).
Investigation sigatoka state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 3 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 6 contains the bactericidal composition of Prochloraz or its salt and prevents and treats the sigatoka test of pesticide effectiveness
As can be seen from Table 6, can effectively prevent and treat sigatoka after Prochloraz or its salt and Carbatene are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.
Claims (7)
1. bactericidal composition that contains Prochloraz and thiocarbamates compound is characterized in that bactericidal composition effective active composition (A) Prochloraz or its salt and (B) weight ratio of Carbatene or zineb are 32: 1～1: 32.
2. the bactericidal composition that contains Prochloraz and thiocarbamates compound according to claim 1 is characterized in that: wherein (A) Prochloraz or its salt are 16: 1～1: 16 with the weight ratio of (B) Carbatene or zineb.
3. the bactericidal composition that contains Prochloraz and thiocarbamates compound according to claim 2 is characterized in that: wherein (A) Prochloraz or its salt are 8: 1～1: 8 with (B) weight ratio of Carbatene.
4. the bactericidal composition that contains Prochloraz and thiocarbamates compound according to claim 2 is characterized in that: wherein (A) Prochloraz or its salt are 8: 1～1: 8 with (B) weight ratio of zineb.
5. the bactericidal composition that contains Prochloraz and thiocarbamates compound according to claim 1 is characterized in that: wherein the effective active component content accounts for 1～90% of gross weight.
6. the bactericidal composition that contains Prochloraz and thiocarbamates compound according to claim 5 is characterized in that: wherein the effective active component content accounts for 10～80% of gross weight.
7. the bactericidal composition that contains Prochloraz and thiocarbamates compound according to claim 1 is characterized in that: bactericidal composition is made wetting powder, water dispersible granules, suspending agent or suspension emulsion.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103348998A (en) * | 2012-09-07 | 2013-10-16 | 浙江农林大学 | Prochloraz-containing compound bactericide and application thereof |
| CN106508943A (en) * | 2015-09-15 | 2017-03-22 | 南京华洲药业有限公司 | Bactericidal composition containing benthiavalicarb-isopropyl and prochloraz, and applications thereof |
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| CN101444217A (en) * | 2008-12-27 | 2009-06-03 | 深圳诺普信农化股份有限公司 | Composite with tericidal action containing prochloraz-manganese chloride complex and mancozeb |
| CN101861871A (en) * | 2010-03-02 | 2010-10-20 | 陕西美邦农资贸易有限公司 | Sterilization compound containing imazalil and prochloraz |
| CN101861872A (en) * | 2010-07-07 | 2010-10-20 | 南通宝叶化工有限公司 | Sterilizing composite containing prochloraz and propineb |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1288663A (en) * | 2000-06-22 | 2001-03-28 | 张长兴 | Germicide for preventing and controlling grey mold of vegetable |
| CN101444217A (en) * | 2008-12-27 | 2009-06-03 | 深圳诺普信农化股份有限公司 | Composite with tericidal action containing prochloraz-manganese chloride complex and mancozeb |
| CN101861871A (en) * | 2010-03-02 | 2010-10-20 | 陕西美邦农资贸易有限公司 | Sterilization compound containing imazalil and prochloraz |
| CN101861872A (en) * | 2010-07-07 | 2010-10-20 | 南通宝叶化工有限公司 | Sterilizing composite containing prochloraz and propineb |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103348998A (en) * | 2012-09-07 | 2013-10-16 | 浙江农林大学 | Prochloraz-containing compound bactericide and application thereof |
| CN103348998B (en) * | 2012-09-07 | 2015-10-28 | 浙江农林大学 | Containing Prochloraz composite bactericide with and uses thereof |
| CN106508943A (en) * | 2015-09-15 | 2017-03-22 | 南京华洲药业有限公司 | Bactericidal composition containing benthiavalicarb-isopropyl and prochloraz, and applications thereof |
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