CN101828567A - Bactericidal composition containing propiconazole and propineb - Google Patents
Bactericidal composition containing propiconazole and propineb Download PDFInfo
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- CN101828567A CN101828567A CN201010301060A CN201010301060A CN101828567A CN 101828567 A CN101828567 A CN 101828567A CN 201010301060 A CN201010301060 A CN 201010301060A CN 201010301060 A CN201010301060 A CN 201010301060A CN 101828567 A CN101828567 A CN 101828567A
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- propineb
- propiconazole
- bactericidal composition
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- powder
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Abstract
The invention relates to a bactericide composition having a synergetic function. The bactericide composition contains the effectively active components of propiconazole and propineb, wherein the weight ratio of the propiconazole to the propineb is (1-60):(1-80), the effectively active components can be prepared into wettable powder and aqueous dispersing granules by adding assistants and excipients, and then the wettable powder and the aqueous dispersing granules are mainly used for preventing and treating powdery mildews, rust diseases, banded sclerotial blight and ring spots.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains propiconazole and Propineb.
Technical background
Propiconazole (propiconazol) is an azoles fungicide.Molecular formula is C
15H
17O
2N
3Cl
2, chemical name: 1-[2-(2,4 dichloro benzene base)-4-propyl group-1,3-dioxolanes-Alpha-Methyl]-1-hydrogen-1,2, the 4-triazole.
Propiconazole is a kind of the have protection and interior absorption triazole bactericidal agent of therapeutic action, can be absorbed by root, stem, leaf portion, and can be very fast in the plant body on conduct.It is sterol deoxidation methylation inhibitor.In the antithetical phrase due to the germ of Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti disease effective, invalid to oomycetes.
Propineb (propineb), molecular formula are (C
5H
8N
2S
4Zn)
x, chemical name: acrylic bisdithiocarbamic zinc.
Propineb belongs to the benzene thiocarbamates, acts on the synthetic of fungal cell wall and protein, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death.And this medicine contains and is easy to the zinc element that absorbed by crop, the quality that helps promoting plant growth and improve fruit.
No matter be propiconazole, Propineb or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.Propiconazole is different with the Propineb mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about propiconazole and Propineb do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains propiconazole and Propineb.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains propiconazole and Propineb, wherein propiconazole and Propineb weight ratio are 1～40: 1～80.
The described bactericidal composition that contains propiconazole and Propineb, wherein the weight ratio of propiconazole and Propineb is 1～30: 5～70.
The described bactericidal composition that contains propiconazole and Propineb, wherein the weight ratio of propiconazole and Propineb is 1～20: 10～60.
The described bactericidal composition that contains propiconazole and Propineb, wherein the weight ratio of propiconazole and Propineb is 1～15: 10～60.
The described bactericidal composition effective active composition propiconazole that contains propiconazole and Propineb, Propineb adds conventional auxiliary agent and excipient is made wetting powder, water dispersible granules.
Described auxiliary agent and excipient are selected from: one or more of dispersant, wetting agent, disintegrant, filler.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, rust, banded sclerotial blight, ring spot, the spot defoliation of control vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition propiconazole and Propineb belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single agent, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, rust, banded sclerotial blight, ring spot.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% propiconazole Wettable propineb powder
Propiconazole 40%, Propineb 40%, lignosulfonates 5%, soapberry powder 2%, spaonin powder 3%, bentonite 10%, mixture carries out comminution by gas stream, makes 80% propiconazole Wettable propineb powder.
Embodiment 2 70% propiconazole Wettable propineb powders
Propiconazole 10%, Propineb 60%, lignosulfonates 4%, lauryl sodium sulfate 4%, white carbon 12%, bentonite 10%, mixture carries out comminution by gas stream, makes 70% propiconazole Wettable propineb powder.
Embodiment 3 55% propiconazole Wettable propineb powders
Propiconazole 5%, Propineb 50%, alkyl benzene sulfonate calcium salt 4%, wetting and penetrating agent F 4%, white carbon 17%, bentonite 20%, mixture carries out comminution by gas stream, makes 55% propiconazole Wettable propineb powder.
Embodiment 4 42% propiconazole Wettable propineb powders
Propiconazole 2%, Propineb 40%, alkylaryl APEO 3%, sldium lauryl sulfate 2%, white carbon 20%, bentonite 23%, mixture carries out comminution by gas stream, makes 42% propiconazole Wettable propineb powder.
Embodiment 5 70% propiconazole Propineb water dispersible granules
Propiconazole 30%, Propineb 40%, tea are withered 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, bentonite 18%,, mixed 70% propiconazole Propineb water dispersible granules.
Embodiment 6 50% propiconazole Propineb water dispersible granules
Propiconazole 20%, Propineb 30%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 4%, white carbon 20%, starch 16%, the mixed 50% propiconazole Propineb water dispersible granules that gets.
Embodiment 7 30% propiconazole Propineb water dispersible granules
Propiconazole 6%, Propineb 24%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 4%, citric acid 1%, starch 10%, white carbon 20%, bentonite 30%, the mixed 30% propiconazole Propineb water dispersible granules that gets.
Embodiment 8 20% propiconazole Propineb water dispersible granules
Propiconazole 10%, Propineb 10%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, calcium chloride 1%, starch 20%, diatomite 52%, mixed 20% propiconazole Propineb water dispersible granules.
Implementation of an application example two: propiconazole and Propineb are composite to the apple mildew Toxicity Determination
Test medicine provides by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament apple mildew.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (mg/L) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5=SR=1.5 is a summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively propiconazole and Propineb shared ratio in combination
A is a propiconazole
B is a Propineb
Result of the test is as shown in table 1:
Table 1 propiconazole, Propineb and composite toxicity test analysis of results table thereof to apple mildew
| Reagent agent | Proportioning | Regression equation (y=a+bx) | EC 50(mg/L) observed value | EC 50(mg/L) theoretical value | Synergy ratio (SR) |
| Propiconazole | y＝3.9351+0.8136x | 1.65 | |||
| Propineb | y＝2.1251+1.6582x | 31.68 | |||
| Propiconazole: Propineb | 1∶1 | y＝3.7355+1.5565x | 2.01 | 3.14 | 1.56 |
| Propiconazole: Propineb | 1∶5 | y＝3.3157+1.4756x | 4.23 | 7.85 | 1.86 |
| Propiconazole: Propineb | 1∶10 | y＝2.9835+1.2838x | 5.67 | 11.93 | 2.10 |
| Propiconazole: Propineb | 1∶15 | y＝2.5243+1.1211x | 7.92 | 14.82 | 1.87 |
| Propiconazole: Propineb | 1∶20 | y＝2.2367+0.9537x | 10.34 | 16.97 | 1.64 |
As shown in Table 1, propiconazole, Propineb are to the EC of apple mildew
50Be respectively 1.65mg/L and 31.68mg/L.The virulence of propiconazole is higher than the virulence of Propineb.1: 1,1: 5,1: 10,1: 15,1: 20 synergy ratio of propiconazole and Propineb proportioning is respectively 1.56,1.86,2.10,1.87,1.64, illustrating that propiconazole and Propineb were mixed in the scope at 1: 1～1: 20 all shows obvious synergistic effect, synergy ratio SR maximum when propiconazole and Propineb weight ratio are 1: 10 wherein, synergistic effect is the most obvious.
Embodiment uses three propiconazoles and the Propineb and the composite ring rot of apple test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Luochuan County suburb, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% propiconazole emulsifiable concentrate (commercial).
The investigation ring rot of apple state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated the apple mildew disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the third time.Experimental result is as follows:
Table 2 propiconazole, Propineb and the composite ring rot of apple test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 80% propiconazole Wettable propineb powder | 1200 times | 88.43 | 93.31 | 93.28 |
| 50% propiconazole Propineb water dispersible granules | 700 times | 89.71 | 95.18 | 94.25 |
| 70% Wettable propineb powder | 550 times | 58.13 | 65.28 | 65.45 |
| 25% propiconazole emulsifiable concentrate | 500 times | 63.51 | 70.64 | 70.43 |
As can be seen from Table 2, can effectively prevent and treat ring rot of apple after propiconazole and Propineb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects, and apple mildew, spot defoliation are had preventive effect preferably.
Implementation of an application example four: propiconazole and Propineb and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This experimental establishment is in the Lantian County, Xian City, Shanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% propiconazole emulsifiable concentrate (commercial).
The investigation wheat powdery mildew state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated the wheat powdery mildew disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
Table 3 propiconazole, Propineb and the composite control wheat powdery mildew test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the second time | 14 days preventive effects (%) behind the medicine for the second time |
| 70% propiconazole Wettable propineb powder | 35 gram/mus | 90.65 | 95.21 |
| 30% propiconazole Propineb water dispersible granules | 60 gram/mus | 90.56 | 95.85 |
| 70% Wettable propineb powder | 100 gram/mus | 62.65 | 70.58 |
| 25% propiconazole emulsifiable concentrate | 40 gram/mus | 71.32 | 79.14 |
As can be seen from Table 3, energy effectively preventing wheat powdery mildew after propiconazole and Propineb are composite, control efficiency all is better than contrasting medicament, and dosage is little, and the lasting period is long.In the test scope of medication, the target crop there is not harm.
Implementation of an application example five: propiconazole, Propineb and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Bozhou City Lixin County, Anhui Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% propiconazole emulsifiable concentrate (commercial).
Investigation wheat rust state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 4 propiconazole, Propineb and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the second time | 14 days preventive effects (%) behind the medicine for the second time |
| 55% propiconazole Wettable propineb powder | 45 gram/mus | 91.83 | 95.61 |
| 70% propiconazole Propineb water dispersible granules | 35 gram/mus | 89.46 | 94.45 |
| 70% Wettable propineb powder | 100 gram/mus | 63.44 | 71.26 |
| 25% propiconazole emulsifiable concentrate | 40 gram/mus | 68.33 | 76.15 |
As can be seen from Table 4, can effectively prevent and treat wheat rust after propiconazole and Propineb are composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.
Implementation of an application example six: propiconazole and Propineb and the composite rice sheath blight disease test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Si Xi town, Shanggao County, Jiangxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 70% Wettable propineb powder (commercial), 25% propiconazole emulsifiable concentrate (commercial).
In the dispenser of paddy rice tree their early stage, dispenser in per 7 days once, dispenser is 3 times altogether, investigation disease index before the dispenser was investigated disease index respectively in 7 days, 15 days, 30 days after the dispenser for the third time, and the calculation correction preventive effect, result of the test is as follows:
Table 5 propiconazole and Propineb and the composite rice sheath blight disease test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the last medicine | 15 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 42% propiconazole Wettable propineb powder | 60 gram/mus | 88.15 | 93.32 | 93.35 |
| 20% propiconazole Propineb water dispersible granules | 80 gram/mus | 88.86 | 93.57 | 93.31 |
| 70% Wettable propineb powder | 100 gram/mus | 62.51 | 69.13 | 69.34 |
| 25% propiconazole emulsifiable concentrate | 50 gram/mus | 70.78 | 77.63 | 77.12 |
As can be seen from Table 5, propiconazole, Propineb energy effectively preventing rice sheath blight disease, control efficiency all is better than contrasting medicament, in the test scope of medication target crop is not had harm.
Claims (7)
1. bactericidal composition that contains propiconazole and Propineb, the weight ratio that it is characterized in that microbicide compositions effective active composition propiconazole and Propineb is 1～40: 1～80.
2. the bactericidal composition that contains propiconazole and Propineb according to claim 1 is characterized in that: wherein the weight ratio of propiconazole and Propineb is 1～30: 5～70.
3. the bactericidal composition that contains propiconazole and Propineb according to claim 2 is characterized in that: wherein the weight ratio of propiconazole and Propineb is 1～20: 10～60.
4. the bactericidal composition that contains propiconazole and Propineb according to claim 1 is characterized in that: microbicide compositions is made wetting powder, water dispersible granules.
5. the bactericidal composition that contains propiconazole and Propineb according to claim 1 is characterized in that: wherein the effective active component content accounts for 1～80% of gross weight.
6. the bactericidal composition that contains propiconazole and Propineb according to claim 5 is characterized in that: wherein the effective active component content accounts for 10～70% of gross weight.
7. the bactericidal composition that contains propiconazole and Propineb according to claim 1 is used to prevent and treat powdery mildew, rust, banded sclerotial blight, ring spot, spot defoliation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010301060A CN101828567A (en) | 2010-02-02 | 2010-02-02 | Bactericidal composition containing propiconazole and propineb |
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|---|---|---|---|
| CN201010301060A CN101828567A (en) | 2010-02-02 | 2010-02-02 | Bactericidal composition containing propiconazole and propineb |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907448A (en) * | 2012-11-13 | 2013-02-06 | 利民化工股份有限公司 | Binary compound wettable powder and preparation method and application thereof |
| EP3986133A4 (en) * | 2019-06-24 | 2023-06-28 | UPL Limited | Synergistic fungicide composition |
-
2010
- 2010-02-02 CN CN201010301060A patent/CN101828567A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907448A (en) * | 2012-11-13 | 2013-02-06 | 利民化工股份有限公司 | Binary compound wettable powder and preparation method and application thereof |
| EP3986133A4 (en) * | 2019-06-24 | 2023-06-28 | UPL Limited | Synergistic fungicide composition |
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Application publication date: 20100915 |