CN101822264B - Bactericidal composition with pyriproxyfen and thiophanate-methyl - Google Patents
Bactericidal composition with pyriproxyfen and thiophanate-methyl Download PDFInfo
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- CN101822264B CN101822264B CN 201010301117 CN201010301117A CN101822264B CN 101822264 B CN101822264 B CN 101822264B CN 201010301117 CN201010301117 CN 201010301117 CN 201010301117 A CN201010301117 A CN 201010301117A CN 101822264 B CN101822264 B CN 101822264B
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- Prior art keywords
- thiophanate
- methyl
- propiconazole
- bactericidal composition
- suspending agent
- Prior art date
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- 239000005842 Thiophanate-methyl Substances 0.000 title claims abstract description 116
- QGHREAKMXXNCOA-UHFFFAOYSA-N thiophanate-methyl Chemical compound COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC QGHREAKMXXNCOA-UHFFFAOYSA-N 0.000 title claims abstract description 116
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 23
- 239000005927 Pyriproxyfen Substances 0.000 title abstract 3
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 claims abstract description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 19
- 241000233866 Fungi Species 0.000 claims abstract description 5
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 claims description 109
- 239000005822 Propiconazole Substances 0.000 claims description 108
- 239000000375 suspending agent Substances 0.000 claims description 40
- 241000221198 Basidiomycota Species 0.000 claims description 4
- 241000192128 Gammaproteobacteria Species 0.000 claims description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 8
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 241000235349 Ascomycota Species 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 35
- 238000012360 testing method Methods 0.000 description 21
- 230000003449 preventive effect Effects 0.000 description 19
- -1 antifreeze Substances 0.000 description 16
- 239000002131 composite material Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000008367 deionised water Substances 0.000 description 13
- 229910021641 deionized water Inorganic materials 0.000 description 13
- 229920005646 polycarboxylate Polymers 0.000 description 13
- 241000209140 Triticum Species 0.000 description 12
- 235000021307 Triticum Nutrition 0.000 description 12
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- 239000000575 pesticide Substances 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 239000002202 Polyethylene glycol Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 239000004495 emulsifiable concentrate Substances 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- 239000004562 water dispersible granule Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 7
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- 238000009313 farming Methods 0.000 description 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 238000012271 agricultural production Methods 0.000 description 5
- 238000011835 investigation Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 241000209094 Oryza Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
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- 235000018324 Shepherdia canadensis Nutrition 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 3
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- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 230000002528 anti-freeze Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 239000013530 defoamer Substances 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 3
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 230000000855 fungicidal effect Effects 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
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- 239000002562 thickening agent Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 2
- 241001530056 Athelia rolfsii Species 0.000 description 2
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- 206010067482 No adverse event Diseases 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical compound N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 description 1
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- JCUDAMKYTWVICI-UHFFFAOYSA-N 4-benzyl-2,3-dimethylphenol Chemical compound C1=C(O)C(C)=C(C)C(CC=2C=CC=CC=2)=C1 JCUDAMKYTWVICI-UHFFFAOYSA-N 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- TWFZGCMQGLPBSX-UHFFFAOYSA-N Carbendazim Natural products C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 229920005682 EO-PO block copolymer Polymers 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- ZCILODAAHLISPY-UHFFFAOYSA-N biphenyl ether Natural products C1=C(CC=C)C(O)=CC(OC=2C(=CC(CC=C)=CC=2)O)=C1 ZCILODAAHLISPY-UHFFFAOYSA-N 0.000 description 1
- 239000006013 carbendazim Substances 0.000 description 1
- JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 125000002328 sterol group Chemical group 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- YFNCATAIYKQPOO-UHFFFAOYSA-N thiophanate Chemical compound CCOC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OCC YFNCATAIYKQPOO-UHFFFAOYSA-N 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
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- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a synergetic bactericidal composition. The active ingredients of bactericidal composition are: pyriproxyfen and thiophanate-methyl, wherein the weight ratio of the pyriproxyfen to the thiophanate-methyl is 1-40 to 50-1; the active ingredients are added with an additive and an excipient to be formed into suspension; and the bactericidal composition is mainly used for preventing and curing disease caused by ascomycetes, bssidiomycetes and fungi inperfect.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on crop pest that contains propiconazole and thiophanate-methyl.
Technical background
Propiconazole (propiconazol) is azoles fungicide.Molecular formula is C
15H
17O
2N
3Cl
2, chemical name: 1-[2-(2,4-dichlorophenyl)-4-propyl group-DOX-Alpha-Methyl]-1-hydrogen-1,2, the 4-triazole.
Propiconazole is a kind of have protection and interior absorption triazole bactericidal agent of therapeutic action, can be absorbed by root, stem, leaf section, and can be very fast in the plant body to conducting.It is sterol deoxidation methylation inhibitor.In the antithetical phrase due to the germ of Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti disease effective, invalid to oomycetes.
(thiophanate～methyl) belong to benzimidazole, molecular formula is (C to thiophanate-methyl
12H
14N
4S
2O
4), chemical name: Thiophanate-Methyl.
Thiophanate-methyl is a kind of broad spectrum activity systemic fungicide, can prevent and treat the various crop disease, has interior suction, preventive and therapeutic action.It is converted into carbendazim in plant corpus, disturb the formation of spindle in the germ mitosis, affects cell division.
No matter be propiconazole, thiophanate-methyl or other efficient germicides, long-term separately use makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can enlarge fungicidal spectrum, improves germicidal efficiency.Propiconazole is different from the thiophanate-methyl mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about propiconazole and thiophanate-methyl there is not yet relevant report at present at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains propiconazole and thiophanate-methyl.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains propiconazole and thiophanate-methyl, wherein propiconazole and thiophanate-methyl percentage by weight are 1～40: 50～1.
The described bactericidal composition that contains propiconazole and thiophanate-methyl, wherein the percentage by weight of propiconazole and thiophanate-methyl is 1～30: 40～5.
The described bactericidal composition that contains propiconazole and thiophanate-methyl, wherein the percentage by weight of propiconazole and thiophanate-methyl is 1～20: 30～10.
The described bactericidal composition that contains propiconazole and thiophanate-methyl, wherein the percentage by weight of propiconazole and thiophanate-methyl is 1～10: 30～10.
The described bactericidal composition that contains propiconazole and thiophanate-methyl, wherein the effective active component content accounts for 1～50% of gross weight, is preferably 10～45%.
The described bactericidal composition that contains propiconazole and thiophanate-methyl is made suspending agent.
Comprise following constituent content when composition is made suspending agent: propiconazole 1～40%, thiophanate-methyl 1～50%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, emulsifier 0.5%～5%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze, emulsifier in the above-mentioned formulation material are mixed through high speed shear, add propiconazole, thiophanate-methyl, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make propiconazole thiophanate-methyl suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20Saturated fat acid compounds, C
8-10In the aliphatic alcohols compound one or more.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described emulsifier is selected from: agricultural newborn 500# (alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600# phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming newborn 400# (benzyl dimethyl phenol polyoxy ethyl ether), farming newborn 600# (phenyl phenol polyoxy ethyl ether), Nongru-700 # (alkylphenol-formaldehyde resin polyoxy ethyl ether), farming newborn 36# (phenethyl fluosite polyoxy ethyl ether), farming newborn 1600# (phenethyl phenol polyoxy ethyl polypropylene-base ether), the ethylene oxide propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), farming newborn 33# (alkylaryl polyoxyethylene polyoxypropylene ether), farming newborn 34# (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), in the AEO series (the pure APEO of fat) one or more.
The described bactericidal composition that contains propiconazole and thiophanate-methyl is used for disease due to the germ of control Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti, especially the microbial disease powdery mildew of basidiomycetes, imperfect fungus and ascus, rust, banded sclerotial blight, leaf spot, leaf blight is had good preventive effect.
Beneficial effect of the present invention: (1) present composition effective active composition propiconazole and thiophanate-methyl belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, rust, banded sclerotial blight, leaf spot.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 50% propiconazole thiophanate-methyl suspending agent
Propiconazole 20%, thiophanate-methyl 30%, polycarboxylate 4%, sodium lignin sulfonate 3%, soapberry powder 4%, silicone oil 0.1%, polyvinyl alcohol 0.3%, deionized water adds to 100%, mixes to make 50% propiconazole thiophanate-methyl suspending agent.
Embodiment 2 38% propiconazole thiophanate-methyl suspending agents
Propiconazole 5%, thiophanate-methyl 33%, polycarboxylate 4%, DBSA 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 38% propiconazole thiophanate-methyl suspending agent.
Embodiment 3 30% propiconazole thiophanate-methyl suspending agents
Propiconazole 5%, thiophanate-methyl 25%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, propane diols 4%, deionized water add to 100%, mix to make 30% propiconazole thiophanate-methyl suspending agent.
Embodiment 420% propiconazole thiophanate-methyl suspending agent
Propiconazole 10%, thiophanate-methyl 10%, polycarboxylate 2%, dodecyl benzene sulfonate 2%, silicone oil 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 20% propiconazole thiophanate-methyl suspending agent.
Embodiment 5 48% propiconazole thiophanate-methyl suspending agents
Propiconazole 15%, thiophanate-methyl 33%, polycarboxylate 4%, sodium lignin sulfonate 3%, soapberry powder 4%, silicone oil 0.1%, polyvinyl alcohol 0.3%, deionized water adds to 100%, mixes to make 48% propiconazole thiophanate-methyl suspending agent.
Embodiment 6 35% propiconazole thiophanate-methyl suspending agents
Propiconazole 5%, thiophanate-methyl 30%, polycarboxylate 4%, DBSA 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 35% propiconazole thiophanate-methyl suspending agent.
Embodiment 7 27% propiconazole thiophanate-methyl suspending agents
Propiconazole 6%, thiophanate-methyl 21%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, propane diols 4%, deionized water add to 100%, mix to make 27% propiconazole thiophanate-methyl suspending agent.
Embodiment 8 22% propiconazole thiophanate-methyl suspending agents
Propiconazole 2%, thiophanate-methyl 20%, polycarboxylate 2%, dodecyl benzene sulfonate 2%, silicone oil 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 22% propiconazole thiophanate-methyl suspending agent.
Embodiment 9 42% propiconazole thiophanate-methyl suspending agents
Propiconazole 14%, thiophanate-methyl 28%, polycarboxylate 4%, sodium lignin sulfonate 3%, soapberry powder 4%, silicone oil 0.1%, polyvinyl alcohol 0.3%, deionized water adds to 100%, mixes to make 42% propiconazole thiophanate-methyl suspending agent.
Embodiment 10 25% propiconazole thiophanate-methyl suspending agents
Propiconazole 3%, thiophanate-methyl 22%, polycarboxylate 4%, DBSA 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 25% propiconazole thiophanate-methyl suspending agent.
Embodiment 11 20% propiconazole thiophanate-methyl suspending agents
Propiconazole 4%, thiophanate-methyl 16%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, propane diols 4%, deionized water add to 100%, mix to make 20% propiconazole thiophanate-methyl suspending agent.
Embodiment 12 13% propiconazole thiophanate-methyl suspending agents
Propiconazole 1%, thiophanate-methyl 12%, polycarboxylate 2%, dodecyl benzene sulfonate 2%, silicone oil 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 13% propiconazole thiophanate-methyl suspending agent.
Implementation of an application example two: propiconazole and thiophanate-methyl are composite to the wheat powdery mildew Toxicity Determination
Test medicine provides by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation.
After each medicament establishment concentration range was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of wheat powdery mildew.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (mg/L) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively propiconazole and thiophanate-methyl shared ratio in combination
A is propiconazole
B is thiophanate-methyl
Result of the test is as shown in table 1:
Table 1 propiconazole, thiophanate-methyl and composite toxicity test analysis of results table to wheat powdery mildew thereof
| Reagent agent | Proportioning | Regression equation (y=a+bx) | EC 50(mg/L) observed value | EC 50(mg/L) theoretical value | Synergy ratio (SR) |
| Propiconazole | y＝6.1751+0.5489x | 0.13 | |||
| Thiophanate-methyl | y＝4.1834+1.1379x | 35.17 | |||
| Propiconazole: thiophanate-methyl | 1∶1 | y＝4.2535+1.0924x | 0.16 | 0.26 | 1.62 |
| Propiconazole: thiophanate-methyl | 1∶3 | y＝4.5245+1.2238x | 0.27 | 0.51 | 1.90 |
| Propiconazole: thiophanate-methyl | 1∶6 | y＝4.8214+1.1854x | 0.39 | 0.89 | 2.28 |
| Propiconazole: thiophanate-methyl | 1∶9 | y＝5.1253+1.0431x | 0.68 | 1.26 | 1.85 |
| Propiconazole: thiophanate-methyl | 1∶12 | y＝5.3464+0.9287x | 1.00 | 1.62 | 1.62 |
As shown in Table 1, propiconazole, thiophanate-methyl are to the EC of wheat powdery mildew
50Be respectively 0.13mg/L and 35.17mg/L.The virulence of propiconazole is higher than the virulence of thiophanate-methyl.1: 1,1: 3,1: 6,1: 9,1: 12 synergy ratio of propiconazole and thiophanate-methyl proportioning is respectively 1.62,1.90,2.28,1.85,1.62, illustrating that propiconazole and thiophanate-methyl were mixed in the scope at 1: 1 to 1: 12 all shows obvious synergistic effect, wherein synergy ratio SR is maximum when propiconazole and thiophanate-methyl weight ratio are 1: 6, and synergistic effect is the most obvious.
Embodiment uses three propiconazoles and thiophanate-methyl and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Chang'an town, Guangxi province Liuzhou City, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 25% propiconazole emulsifiable concentrate (commercial), 70% thiophanate-methyl water dispersible granules (commercial).
Investigation sigatoka disease index before the medicine, in the their early stage dispenser, dispenser in per 7 days once, dispenser is 3 times altogether, for the third time 7 days, 15 days, 30 days investigation disease indexs and calculate preventive effect after the dispenser.Experimental result is as follows:
Table 2 propiconazole, thiophanate-methyl and the composite sigatoka test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the medicine for the third time | 15 days preventive effects (%) behind the medicine for the third time | 30 days preventive effects (%) behind the medicine for the third time |
| 50% propiconazole thiophanate-methyl suspending agent | 1200 times | 89.66 | 93.36 | 93.37 |
| 35% propiconazole thiophanate-methyl suspending agent | 400 times | 92.27 | 95.28 | 95.16 |
| 20% propiconazole thiophanate-methyl suspending agent | 300 times | 91.28 | 94.03 | 94.35 |
| 25% propiconazole emulsifiable concentrate | 800 times | 75.13 | 79.54 | 80.25 |
| 70% thiophanate-methyl water dispersible granules | 500 times | 68.51 | 73.02 | 73.34 |
As can be seen from Table 2, can effectively prevent and treat sigatoka after propiconazole and thiophanate-methyl are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects.
Implementation of an application example four propiconazoles and thiophanate-methyl and the composite rice sheath blight disease test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Si Xi town, Shanggao County, Jiangxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 25% propiconazole emulsifiable concentrate (commercial), 70% thiophanate-methyl water dispersible granules (commercial).
In the dispenser of rice sheath blight disease their early stage, dispenser in per 7 days once is total to dispenser 2 times, and the investigation disease index was investigated respectively disease index in 10 days, 20 days after the 3rd dispenser before the dispenser, and the calculation correction preventive effect, and result of the test is as follows:
Table 3 propiconazole and thiophanate-methyl and the composite rice sheath blight disease test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | The preparation dosage | 10 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 38% propiconazole thiophanate-methyl suspending agent | 90 g/acres | 90.52 | 92.25 |
| 25% propiconazole thiophanate-methyl suspending agent | 120 g/acres | 90.28 | 92.83 |
| 13% propiconazole thiophanate-methyl suspending agent | 120 g/acres | 89.52 | 91.73 |
| 25% propiconazole emulsifiable concentrate | 60 g/acres | 74.51 | 80.46 |
| 70% thiophanate-methyl water dispersible granules | 95 g/acres | 70.75 | 76.91 |
As can be seen from Table 3, propiconazole, thiophanate-methyl can the effectively preventing rice sheath blight diseases, and control efficiency all is better than contrasting medicament, and dosage is little, in the test scope of medication to the target crop without harm.
Implementation of an application example five propiconazoles and thiophanate-methyl and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Bozhou City Lixin County, Anhui Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 25% propiconazole emulsifiable concentrate (commercial), 70% thiophanate-methyl water dispersible granules (commercial).
In the dispenser of wheat rust their early stage, dispenser in per 7 days once is total to dispenser 2 times, and the investigation disease index was investigated respectively disease index in 10 days, 20 after the 3rd dispenser everyday before the dispenser, and the calculation correction preventive effect, and result of the test is as follows:
Table 4 propiconazole and thiophanate-methyl and the composite wheat rust test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | The preparation dosage | 10 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 30% propiconazole thiophanate-methyl suspending agent | 110 g/acres | 89.52 | 92.51 |
| 48% propiconazole thiophanate-methyl suspending agent | 80 g/acres | 92.45 | 95.07 |
| 27% propiconazole thiophanate-methyl suspending agent | 120 g/acres | 90.75 | 93.58 |
| 25% propiconazole emulsifiable concentrate | 40 g/acres | 74.25 | 82.82 |
| 70% thiophanate-methyl water dispersible granules | 80 g/acres | 70.21 | 78.34 |
As can be seen from Table 4, propiconazole, thiophanate-methyl can effectively preventing wheat rust, and control efficiency all is better than contrasting medicament, and dosage is little, in the test scope of medication to the target crop without harm.
Implementation of an application example six propiconazoles, thiophanate-methyl and the composite control wheat powdery mildew test of pesticide effectiveness thereof
This experimental establishment is in Hu County, Xian City, Shanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 25% propiconazole emulsifiable concentrate (commercial), 70% thiophanate-methyl water dispersible granules (commercial).
Investigation wheat powdery mildew state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates respectively disease index and calculates preventive effect in 10 days, 20 days after for the second time dispenser.Experimental result is as follows:
Table 5 propiconazole, thiophanate-methyl and the composite control wheat powdery mildew test of pesticide effectiveness thereof
| Treatment agent | The preparation dosage | 10 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 20% propiconazole thiophanate-methyl suspending agent | 100 g/acres | 90.68 | 94.28 |
| 22% propiconazole thiophanate-methyl suspending agent | 110 g/acres | 88.74 | 90.36 |
| 42% propiconazole thiophanate-methyl suspending agent | 60 g/acres | 88.74 | 90.36 |
| 25% propiconazole emulsifiable concentrate | 40 g/acres | 78.72 | 82.45 |
| 70% thiophanate-methyl water dispersible granules | 80 g/acres | 71.27 | 75.42 |
As can be seen from Table 5, can effectively prevent and treat wheat powdery mildew after propiconazole and thiophanate-methyl are composite and occur, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects.
Claims (5)
1. bactericidal composition that contains propiconazole and thiophanate-methyl, the weight ratio that it is characterized in that bactericidal composition effective active composition propiconazole and thiophanate-methyl is 1:1 ~ 1:12.
2. the bactericidal composition that contains propiconazole and thiophanate-methyl according to claim 1, it is characterized in that: bactericidal composition is made suspending agent.
3. the bactericidal composition that contains propiconazole and thiophanate-methyl according to claim 1, it is characterized in that: wherein the effective active component content accounts for 1～50% of gross weight.
4. the bactericidal composition that contains propiconazole and thiophanate-methyl according to claim 3, it is characterized in that: wherein the effective active component content accounts for 10～45% of gross weight.
5. the bactericidal composition that contains propiconazole and thiophanate-methyl according to claim 1 is used for the purposes of disease due to the germ of control Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti.
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| CN103875695A (en) * | 2012-12-19 | 2014-06-25 | 陕西汤普森生物科技有限公司 | Sterilization composite containing propiconazole and thiophanate methyl |
| CN103918686B (en) * | 2014-05-07 | 2016-09-07 | 陕西上格之路生物科学有限公司 | A kind of dispersible oil-suspending agent containing thiophanate-methyl |
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