CN101965843B - Propamidine- and pyrimorph-containing bactericidal composition - Google Patents
Propamidine- and pyrimorph-containing bactericidal composition Download PDFInfo
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- CN101965843B CN101965843B CN 201010521354 CN201010521354A CN101965843B CN 101965843 B CN101965843 B CN 101965843B CN 201010521354 CN201010521354 CN 201010521354 CN 201010521354 A CN201010521354 A CN 201010521354A CN 101965843 B CN101965843 B CN 101965843B
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- propamidine
- pyrimorph
- bactericidal composition
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- gray mold
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Abstract
The invention relates to a bactericidal composition having a synergistic effect. The active ingredients of the bactericidal composition comprise propamidine and pyrimorph in a weight ratio of 1-60:80-1; and wettable powder, water dispersion and suspension can be prepared by adding an assistant and an excipient into the active ingredients. The bactericidal composition can effectively preventing and controlling gray mold, downy mildew, epidemic disease and the like in fruits and vegetables.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains propamidine and pyrimorph.
Technical background
Oomycetes is the characteristics such as more serious pathogenic occurs the class in the present agricultural production, and it has from generation to generation short, and sporulation quantity is large, and short incubation period is infecting often, and is destructive strong to host plant, and epidemic rate is fast.Accounting for 20% by the microbial disease of ovum in vegetable disease, is the large class of one in the vegetable disease.The chemical control medicament of oomycetes mainly contains two classes: protective fungicide and systemic fungicide.Protective fungicide mainly contains carbendazim, mancozeb, tpn and copper agent.These medicament disinfecting spectrums are wide, efficacy stability, and protective effect is strong, but germ is invaded the rear defence heterodyne, substantially without therapeutic action, should use in the prevention of morbidity previous crops.The oomycetes systemic fungicide mainly contains aliette, metalaxyl, Wakil, Propamocarb etc.These pharmacy securities are good, and interior absorption is strong, have treatment and protection double action.But above-mentioned medicament uses through long-term, a large amount of, and the pesticide resistance that made disease generation in various degree causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.Effect obviously descends in the actual production.
Propamidine (Propamidine), molecular formula: C
17H
20N
4O
22HCl, chemical name: 1,3-two (4-amidino groups phenoxy group) propane.
Propamidine is at the pioneering Huang Dezhi of China's cooperation by the Sino-U.S. Science man.This bactericide has unique treatment and prevention effect to the various plants germ, is a kind of novel, and low toxicity is efficient, nuisanceless disinfectant use in agriculture.Be mainly used in preventing and treating on the interior vegetables of field and booth, fruit tree and the economic crops by the fungus-caused plurality of plant diseases of oomycetes order.This medicine is systemic fungicide, can absorption in plant corpus, distribution and metabolism, have protection and treatment double effects.It is since the establishment of the nation one of rare several agricultural chemical compounds that have independent intellectual property right of China.
Pyrimorph (Pyrimorph), molecular formula: C
22H
25N
2C
1O
2, chemical name: (E)-3-(2-chloropyridine-4-yl)-3-(4-tert-butyl-phenyl)-acryloyl morpholine.
Pyrimorph is one of domestic novel pesticide that has China's independent intellectual property right few in number, and its mechanism of action causes protoplasm seepage in the cell for by changing the permeability of cell wall, suppresses simultaneously mycelium protein matter synthetic, thereby suppresses mycelial growth.Propamidine has excellent preventive effect to oomycetes order fungi, and fungicidal spectrum is wide, can be used for preventing and treating the various crop diseases such as cucumber downy mildew, tomato early epidemic, late blight, damping off, melon gray mold.
Propamidine is different from the pyrimorph mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about propamidine and pyrimorph there is not yet relevant report at present at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition that use cost is low, preventive effect is good.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains propamidine and pyrimorph, wherein propamidine and pyrimorph weight ratio are 1～60: 80～1.
The described bactericidal composition that contains propamidine and pyrimorph, wherein the weight ratio of propamidine and pyrimorph is 5～50: 60～5.
The described bactericidal composition that contains propamidine and pyrimorph, wherein the weight ratio of propamidine and pyrimorph is 5～40: 50～10.
The described bactericidal composition that contains the propamidine connection, wherein the effective active component content accounts for 1～90% of gross weight, is preferably 10～80%.
The described bactericidal composition of propamidine and pyrimorph that contains is according to method known in those skilled in the art, add corresponding additive and filler, can make any formulation that agricultural chemicals allows, wherein formulation has preferably: wetting powder, water dispersible granules or suspending agent.
Described auxiliary agent has dispersant, wetting agent, disintegrant, binding agent, defoamer, antifreeze, thickener.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, soapberry powder, spaonin powder, the silkworm excrement.
Described binding agent is selected from: one or more in diatomite, starch, PVA, carboxymethyl (ethyl) cellulose.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, the glucose.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 1600
#In (phenethyl phenol polyoxy ethyl polypropylene-base ether), the ethylene oxide-propylene oxide block copolymer one or more.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating oomycetes order disease such as gray mold, downy mildew, epidemic disease etc.
Beneficial effect of the present invention: (1) present composition effective active composition propamidine and pyrimorph belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition shows good synergistic effect in given scope, and preventive effect is apparently higher than single dose, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to gray mold, downy mildew, epidemic disease to gourd, fruit and vegetable.
Embodiment
To further instruction of the present invention, but the present invention is not limited thereto below in conjunction with embodiment.Percentage in following examples all is weight percentage.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one: propamidine and pyrimorph are composite to the gray mold of cucumber Toxicity Determination
After each medicament establishment concentration range was determined in prerun, each medicament was established respectively 7 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of gray mold of cucumber.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively propamidine and pyrimorph shared ratio in combination
A is propamidine
B is pyrimorph
Result of the test is as shown in the table:
As shown in Table 1, propamidine, pyrimorph are to the EC of gray mold of cucumber
50Be respectively 2.57mg/L and 1.26mg/L.Propamidine and pyrimorph proportioning were mixed in the scope at 1: 10～4: 1 and all show obvious synergistic effect, and wherein synergy ratio SR is maximum when propamidine and pyrimorph weight ratio are 1: 4, and synergistic effect is the most obvious.
Implementation of an application example two the implementation of Formulation Example
Embodiment 1 80% propamidine pyrimorph water dispersible granules
Propamidine 20%, pyrimorph 60%, lignosulfonates 3%, alkyl benzene sulfonate calcium salt 3%, soapberry powder 4%, aluminium chloride 2%, starch 8% mix making 80% propamidine pyrimorph water dispersible granules.
Embodiment 2 70% propamidine pyrimorph water dispersible granules
Propamidine 10%, pyrimorph 60%, polycarboxylate 4%, lauryl sodium sulfate 3%, polyoxyethylene carboxylate 3%, urea 10%, diatomite 10% mix making 70% propamidine pyrimorph water dispersible granules.
Embodiment 3 55% propamidine pyrimorph water dispersible granules
Propamidine 5%, pyrimorph 50%, alkylphenol-polyethenoxy are phonetic 5%, wetting and penetrating agent F 5%, white carbon 10%, ammonium sulfate 10%, bentonite 15%, mix making 55% propamidine pyrimorph water dispersible granules.
Embodiment 4 72% propamidine pyrimorph wetting powders
Propamidine 8%, pyrimorph 64%, alkyl benzene sulfonate calcium salt 5%, lauryl sodium sulfate 3%, silkworm excrement 2%, white carbon 5%, bentonite 5%, mixture carries out air-flow crushing, makes 80% propamidine pyrimorph wetting powder.
Embodiment 5 60% propamidine pyrimorph wetting powders
Propamidine 20%, pyrimorph 40%, polycarboxylate 5%, silkworm excrement 3%, white carbon 10%, precipitated calcium carbonate 22%, mixture carries out air-flow crushing, makes 60% propamidine pyrimorph wetting powder.
Embodiment 6 50% propamidine pyrimorph wetting powders
Propamidine 10%, pyrimorph 40%, lignosulfonates 5%, spaonin powder 3%, white carbon 12%, diatomite 30%, mixture carries out air-flow crushing, makes 50% propamidine pyrimorph wetting powder.
Embodiment 7 50% propamidine pyrimorph suspending agents
Propamidine 40%, pyrimorph 10%, polyoxyethylene carboxylate 5%, ester polyoxyethylene are phonetic 2%, DBSA 4%, silicone compound 0.1%, xanthan gum 1%, phenyl phenol polyoxy ethyl ether 1%, deionized water adds to 100%, mixes to make 50% propamidine pyrimorph suspending agent.
Embodiment 8 30% propamidine pyrimorph suspending agents
Propamidine 20%, pyrimorph 10%, polycarboxylate 2%, Nekal BX 4%, saturated fat acid compounds 0.1%, polyethylene glycol 0.2%, propane diols 2%, alkyl benzene calcium sulfonate 1%, deionized water adds to 100%, mixes to make 30% propamidine pyrimorph suspending agent.
Embodiment 9 10% propamidine pyrimorph suspending agents
Propamidine 5%, pyrimorph 5%, sodium lignin sulfonate 4%, soapberry powder 2%, polyvinyl alcohol 3%, silicone oil 0.1%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, mixes to make 10% propamidine pyrimorph suspending agent.
Embodiment uses three: the bactericidal composition control gray mold of cucumber test of pesticide effectiveness that contains propamidine and pyrimorph
This experimental establishment is in the Heyang County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 20% pyrimorph suspending agent (commercial), 2% propamidine aqua (commercial).
Investigation gray mold of cucumber state of an illness radix before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates respectively disease index and calculates preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 2 contains the bactericidal composition control gray mold of cucumber test of pesticide effectiveness of propamidine and pyrimorph
As can be seen from Table 2, can effectively prevent and treat gray mold of cucumber after propamidine and pyrimorph are composite and occur, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and preventive effect reaches more than 90%.
Implementation of an application example four: the bactericidal composition control cucumber downy mildew test of pesticide effectiveness that contains propamidine and pyrimorph
This experimental establishment is in suburb, Lantian County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 20% pyrimorph suspending agent (commercial), 2% propamidine aqua (commercial).
The investigation cucumber downy mildew state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively the gray mold of cucumber disease index and calculated preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 3 contains the bactericidal composition control cucumber downy mildew test of pesticide effectiveness of propamidine and pyrimorph
As can be seen from Table 3, can effectively prevent and treat cucumber downy mildew after propamidine and pyrimorph are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects.
Implementation of an application example five: the bactericidal composition control tomato late blight test of pesticide effectiveness that contains propamidine and pyrimorph
This experimental establishment is at coming from L inze County, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 20% pyrimorph suspending agent (commercial), 2% propamidine aqua (commercial).
Investigation tomato late blight state of an illness radix before the medicine.In the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates respectively disease index and calculates preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 4 contains the bactericidal composition control tomato late blight test of pesticide effectiveness of propamidine and pyrimorph
As can be seen from Table 4, can effectively prevent and treat tomato late blight after propamidine and pyrimorph are composite and occur, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and preventive effect reaches more than 90%.
Claims (6)
1. bactericidal composition that contains propamidine and pyrimorph, the weight ratio that it is characterized in that bactericidal composition effective active composition propamidine and pyrimorph is 1:10～4:1.
2. the bactericidal composition that contains propamidine and pyrimorph according to claim 1, it is characterized in that: wherein the effective active component content accounts for 1～90% of gross weight.
3. the bactericidal composition that contains propamidine and pyrimorph according to claim 2, it is characterized in that: wherein the effective active component content accounts for 10～80% of gross weight.
4. the bactericidal composition that contains propamidine and pyrimorph according to claim 1, it is characterized in that: bactericidal composition is made wetting powder, water dispersible granules or suspending agent.
5. the bactericidal composition that contains propamidine and pyrimorph according to claim 1 is used for the purposes of control oomycetes order disease.
6. purposes according to claim 5, it is characterized in that: described oomycetes order disease is gray mold, downy mildew or epidemic disease.
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| CN104273124B (en) * | 2014-09-15 | 2017-11-28 | 广东中迅农科股份有限公司 | A kind of composition pesticide containing trifloxystrobin and propamidine |
| CN108308182A (en) * | 2018-04-06 | 2018-07-24 | 刘西芳 | Bactericidal composition containing propamidine and triforine |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1930972A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing propamidine and myclobutanil and its application |
| CN1930980A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing propamidine and thiophanate-methyl and its application |
| CN101669512A (en) * | 2009-10-14 | 2010-03-17 | 成都皇牌作物科学有限公司 | Pyrimorph-containing bactericide composition |
| CN101720771A (en) * | 2008-10-14 | 2010-06-09 | 江苏耕耘化学有限公司 | Wettable powder compounded by pyrimorph and mancozeb and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2003258983A1 (en) * | 2002-06-28 | 2004-01-19 | Combinatorx Incorporated | Combinations for the treatment of fungal infections |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1930972A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing propamidine and myclobutanil and its application |
| CN1930980A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing propamidine and thiophanate-methyl and its application |
| CN101720771A (en) * | 2008-10-14 | 2010-06-09 | 江苏耕耘化学有限公司 | Wettable powder compounded by pyrimorph and mancozeb and preparation method thereof |
| CN101669512A (en) * | 2009-10-14 | 2010-03-17 | 成都皇牌作物科学有限公司 | Pyrimorph-containing bactericide composition |
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Address after: 715500 middle section of North Ring Road, Pucheng County, Shaanxi Patentee after: Shanxi Thompson Biological Technology Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Patentee before: Shanxi Thompson Biological Technology Co., Ltd. |
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Granted publication date: 20130123 Termination date: 20161027 |