CN101990895B - Germicidal composition of mandipropamid - Google Patents
Germicidal composition of mandipropamid Download PDFInfo
- Publication number
- CN101990895B CN101990895B CN 201010541987 CN201010541987A CN101990895B CN 101990895 B CN101990895 B CN 101990895B CN 201010541987 CN201010541987 CN 201010541987 CN 201010541987 A CN201010541987 A CN 201010541987A CN 101990895 B CN101990895 B CN 101990895B
- Authority
- CN
- China
- Prior art keywords
- mandipropamid
- kresoxim
- bactericidal composition
- pyraclostrobin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- KWLVWJPJKJMCSH-UHFFFAOYSA-N 2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)acetamide Chemical group C1=C(OCC#C)C(OC)=CC(CCNC(=O)C(OCC#C)C=2C=CC(Cl)=CC=2)=C1 KWLVWJPJKJMCSH-UHFFFAOYSA-N 0.000 title claims abstract description 77
- 239000005804 Mandipropamid Substances 0.000 title claims abstract description 77
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 230000002070 germicidal effect Effects 0.000 title abstract description 3
- 239000005869 Pyraclostrobin Substances 0.000 claims abstract description 44
- HZRSNVGNWUDEFX-UHFFFAOYSA-N pyraclostrobin Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NN(C=2C=CC(Cl)=CC=2)C=C1 HZRSNVGNWUDEFX-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000005800 Kresoxim-methyl Substances 0.000 claims abstract description 40
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 claims abstract description 40
- 239000000375 suspending agent Substances 0.000 claims abstract description 14
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 31
- 239000000843 powder Substances 0.000 claims description 16
- 241000233679 Peronosporaceae Species 0.000 claims description 13
- 238000009736 wetting Methods 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 9
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000012752 auxiliary agent Substances 0.000 abstract description 2
- 241000233654 Oomycetes Species 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000004563 wettable powder Substances 0.000 abstract 1
- -1 antifreeze Substances 0.000 description 21
- 239000003814 drug Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- 239000002131 composite material Substances 0.000 description 9
- 230000003449 preventive effect Effects 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 210000000481 breast Anatomy 0.000 description 7
- 238000009313 farming Methods 0.000 description 7
- 229920005646 polycarboxylate Polymers 0.000 description 7
- 235000006008 Brassica napus var napus Nutrition 0.000 description 6
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 6
- 241001674939 Caulanthus Species 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- 239000000575 pesticide Substances 0.000 description 6
- 241000233622 Phytophthora infestans Species 0.000 description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 150000004996 alkyl benzenes Chemical class 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 240000008067 Cucumis sativus Species 0.000 description 4
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920001732 Lignosulfonate Polymers 0.000 description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- 240000003377 Shepherdia canadensis Species 0.000 description 4
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 3
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 2
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000002528 anti-freeze Effects 0.000 description 2
- 229960000892 attapulgite Drugs 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 230000002438 mitochondrial effect Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 229910052625 palygorskite Inorganic materials 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- JCUDAMKYTWVICI-UHFFFAOYSA-N 4-benzyl-2,3-dimethylphenol Chemical compound C1=C(O)C(C)=C(C)C(CC=2C=CC=CC=2)=C1 JCUDAMKYTWVICI-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 239000005754 Cyazofamid Substances 0.000 description 1
- 102100025287 Cytochrome b Human genes 0.000 description 1
- 102000019265 Cytochrome c1 Human genes 0.000 description 1
- 108010075028 Cytochromes b Proteins 0.000 description 1
- 108010007528 Cytochromes c1 Proteins 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 229920005682 EO-PO block copolymer Polymers 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- ZCILODAAHLISPY-UHFFFAOYSA-N biphenyl ether Natural products C1=C(CC=C)C(O)=CC(OC=2C(=CC(CC=C)=CC=2)O)=C1 ZCILODAAHLISPY-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- YXKMMRDKEKCERS-UHFFFAOYSA-N cyazofamid Chemical compound CN(C)S(=O)(=O)N1C(C#N)=NC(Cl)=C1C1=CC=C(C)C=C1 YXKMMRDKEKCERS-UHFFFAOYSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 210000003495 flagella Anatomy 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000006540 mitochondrial respiration Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
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- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 230000028070 sporulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a germicidal composition with a synergistic function. Effective active ingredients of the composition comprise (A) mandipropamid and (B) one of kresoxim-methyl or pyraclostrobin, wherein the weight ratio of A to B is (1:20)-(20:1). Wettable powder, water dispersible granules and a suspending agent which are prepared by adding auxiliary agents and excipients into the effective active ingredients are mainly applied to preventing and treating oomycetes diseases.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains mandipropamid.
Technical background
Mandipropamid (cyazofamid), molecular formula: C
23H
22CINO
4, chemical name: 2-(4-chloro-phenyl)-N-[2-(3-methoxyl group-4-(2-propargyl alcoholate)-phenyl-ethyl group]-2-(2-propargyl alcoholate)-acetamide.
Mandipropamid is acid amide fungicides.Its mechanism of action all has good preventive effect to large absolutely number by ovum microbial leaf section and fruit disease for suppressing the biosynthesis of phosphatide.The spore that is in the sprouting stage is had higher activity, and can suppress mycelia and grow up and sporulation.Can be rapidly absorbed by blade, and rest in the leaf table wax coat, blade is shielded.
Use separately but mandipropamid is long-term, disease is developed immunity to drugs, cause the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, be unfavorable for environment sustainable development.If a kind ofly do not have the novel pesticide of cross resistance to prevent and treat pathogen and want newly developed, then need screen 10,000～1.5 ten thousand compounds, expensive 1～1.5 hundred million dollar, the construction cycle is 6～10 years.And that the active ingredient of the different mechanisms of action is carried out is composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Kresoxim-methyl (kresoxim-methyl) is the methoxy acrylic new type bactericide of BASF Aktiengesellschaft.Molecular formula: C
18H
19NO
4, chemical name: methyl (E)-2-methoxyimino-2-[2-(0-toloxyl) phenyl] and acetate.Kresoxim-methyl belongs to the cell mitochondrial respiration inhibitor, shifts to suppress mitochondrial respiratory by electronics between cytochrome b and C1, and the interference cell energy supply makes the pathogen cell death.Tool is protected, treats, is rooted out, infiltration, systemic activity, and fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has preferably control efficiency.
Pyraclostrobin (Pyraclostrobin) molecular formula: C
19H
18CIN
3O
4, chemical name: N-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] and the oxygen methyl] phenyl]-N-methoxyl group methyl carbamate.Be the efficient mitochondrial respiratory inhibitor after improve on the kresoxim-methyl basis, have protection, treatment, blade infiltration conduction.
Mandipropamid is different from kresoxim-methyl or the pyraclostrobin mechanism of action, and mutually composite have good synergistic effect within the specific limits.And relevant composite, there is not yet at present relevant report at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition that use cost is low, preventive effect is good.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition, wherein mandipropamid and kresoxim-methyl or pyraclostrobin weight ratio are 1: 20～20: 1.
Described bactericidal composition, wherein the weight ratio of mandipropamid and kresoxim-methyl or pyraclostrobin is 1: 10～10: 1.
Described bactericidal composition, wherein the weight ratio of mandipropamid and kresoxim-methyl or pyraclostrobin is 1: 5～5: 1.
Described bactericidal composition, wherein the weight ratio of mandipropamid and kresoxim-methyl or pyraclostrobin is 1: 3～3: 1.
Described bactericidal composition adds corresponding additive, solvent or filler according to method known in those skilled in the art, can make wetting powder, water dispersible granules, suspending agent, aqueous emulsion or microemulsion.
Described bactericidal composition, wherein the effective active component content accounts for 1～85% of gross weight, when bactericidal composition when making solid pharmaceutical preparation wetting powder and water dispersible granules, wherein the effective active component content accounts for 10～85% of gross weight; When bactericidal composition when making liquid preparation aqueous emulsion, microemulsion and suspending agent, wherein the effective active component content accounts for 10～50% of gross weight.
Described auxiliary agent has dispersant, wetting agent, disintegrant, binding agent, defoamer, antifreeze, thickener, emulsifier etc.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described binding agent is selected from: one or more in diatomite, starch, PVA, carboxymethyl (ethyl) cellulose.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20Saturated fat acid compounds, C
8-10In the aliphatic alcohols compound one or more.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, the glucose.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 36
#(phenethyl fluosite polyoxy ethyl ether), farming breast 1600
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), By series (castor oil polyoxyethylene ether), farming breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether), farming breast 34
#In (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), the AEO series (alkyl polyoxyethylene ether) one or more.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating downy mildew, epidemic disease etc.
Beneficial effect of the present invention: (1) present composition effective active composition mandipropamid and kresoxim-methyl or pyraclostrobin belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition shows good synergistic effect in given scope, and preventive effect is apparently higher than single dose, and dosage is little; (3) consumption of organic solvent of the present invention is few, is difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to downy mildew, the epidemic disease of gourd, fruit and vegetable.
Embodiment
To further instruction of the present invention, but the present invention is not limited thereto below in conjunction with embodiment.Percentage in following examples all is weight percentage.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one: mandipropamid and kresoxim-methyl (or pyraclostrobin) are composite to wild cabbage downy mildew Toxicity Determination
After each medicament establishment concentration range was determined in prerun, each medicament was established respectively 7 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of wild cabbage downy mildew.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively mandipropamid and kresoxim-methyl (or pyraclostrobin) shared ratio in combination
A is mandipropamid
B is kresoxim-methyl (or pyraclostrobin)
Result of the test is as shown in the table:
Table 1 mandipropamid, kresoxim-methyl and composite toxicity test analysis of results table to wild cabbage downy mildew thereof
As shown in Table 1, mandipropamid, kresoxim-methyl are to the EC of wild cabbage downy mildew
50Be respectively 0.31mg/L and 0.52mg/L.20: 1,10: 1,5: 1,1: 1,1: 5,1: 10,1: 20 synergy ratio of mandipropamid and kresoxim-methyl proportioning is respectively 1.58,1.79,2.08,2.59,2.12,1.95,1.57, illustrating that mandipropamid and kresoxim-methyl were mixed in the scope at 20: 1～1: 20 all shows obvious synergistic effect, wherein synergy ratio SR is maximum when mandipropamid and kresoxim-methyl weight ratio are 1: 1, and synergistic effect is the most obvious.
Table 2 mandipropamid, pyraclostrobin and composite toxicity test analysis of results table to wild cabbage downy mildew thereof
As shown in Table 1, mandipropamid, pyraclostrobin are to the EC of wild cabbage downy mildew
50Be respectively 0.31mg/L and 0.46mg/L.20: 1,10: 1,5: 1,1: 1,1: 5,1: 10,1: 20 synergy ratio of mandipropamid and pyraclostrobin proportioning is respectively 1.57,1.88,2.05,2.47,1.94,1.84,1.55, illustrating that mandipropamid and pyraclostrobin were mixed in the scope at 20: 1～1: 20 all shows obvious synergistic effect, wherein synergy ratio SR is maximum when mandipropamid and pyraclostrobin weight ratio are 1: 1, and synergistic effect is the most obvious.
Implementation of an application example two the implementation of Formulation Example
(1) mandipropamid kresoxim-methyl:
Embodiment 177% mandipropamid kresoxim-methyl wetting powder
Mandipropamid 7%, kresoxim-methyl 70%, alkylphenol-polyethenoxy are phonetic 5%, neopelex 3%, soapberry powder 2%, white carbon 13%, and mixture carries out air-flow crushing, makes 80% mandipropamid kresoxim-methyl wetting powder.
Embodiment 260% mandipropamid kresoxim-methyl wetting powder
Mandipropamid 50%, kresoxim-methyl 10%, lignosulfonates 5%, wetting and penetrating agent F3%, white carbon 10%, diatomite 12%, mixture carries out air-flow crushing, makes 60% mandipropamid kresoxim-methyl wetting powder.
Embodiment 380% mandipropamid water dispersion granules agent of Kresoxim
Mandipropamid 60%, kresoxim-methyl 20%, polycarboxylate 3%, polyoxyethylene carboxylate salt 3%, lauryl sodium sulfate 4%, corn starch 10% mix making 80% mandipropamid water dispersion granules agent of Kresoxim.
Embodiment 463% mandipropamid water dispersion granules agent of Kresoxim
Mandipropamid 3%, kresoxim-methyl 60%, alkylphenol-polyethenoxy are phonetic 3%, lignin sulfonic acid 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, starch 4%, kaolin 20%, mix making 63% mandipropamid water dispersion granules agent of Kresoxim.
Embodiment 545% mandipropamid kresoxim-methyl suspending agent
Mandipropamid 5%, kresoxim-methyl 40%, polycarboxylate 5%, Sodium Polyacrylate 2%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.4%, phenyl phenol polyoxy ethyl ether 2%, deionized water adds to 100%, mixes to make 45% mandipropamid kresoxim-methyl suspending agent.
Embodiment 630% mandipropamid kresoxim-methyl suspending agent
Mandipropamid 15%, kresoxim-methyl 15%, alkyl benzene sulphonate sodium salt 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.2%, propane diols 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, mixes to make 30% mandipropamid kresoxim-methyl suspending agent.
(2) mandipropamid pyraclostrobin
Embodiment 777% mandipropamid pyraclostrobin wetting powder
Mandipropamid 70%, pyraclostrobin 7%, lignosulfonates 5%, Nekal BX 5%, white carbon 13%, mixture carries out air-flow crushing, makes 77% mandipropamid pyraclostrobin wetting powder.
Embodiment 860% mandipropamid pyraclostrobin wetting powder
Mandipropamid 10%, pyraclostrobin 50%, polycarboxylate 5%, neopelex 5%, white carbon 10%, attapulgite 20%, mixture carries out air-flow crushing, makes 60% mandipropamid pyraclostrobin wetting powder.
Embodiment 980% mandipropamid pyraclostrobin water dispersible granules
Mandipropamid 20%, pyraclostrobin 60%, polycarboxylate 3%, aliphatic acid polyethenoxy ether 3%, lauryl sodium sulfate 4%, starch 10% mix making 80% mandipropamid pyraclostrobin water dispersible granules.
Embodiment 1063% mandipropamid pyraclostrobin water dispersible granules
Mandipropamid 60%, pyraclostrobin 3%, alkylphenol-polyethenoxy are phonetic 3%, lignosulfonates 3%, neopelex 4%, sodium bicarbonate 3%, starch 14%, kaolin 10%, mix making 63% mandipropamid pyraclostrobin water dispersible granules.
Embodiment 1145% mandipropamid pyraclostrobin suspending agent
Mandipropamid 40%, pyraclostrobin 5%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, mixes to make 45% mandipropamid pyraclostrobin suspending agent.
Embodiment 1215% mandipropamid pyraclostrobin suspending agent
Mandipropamid 10%, pyraclostrobin 5%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, phenethyl phenol polyoxy ethyl polypropylene-base ether 1%, deionized water adds to 100%, mixes to make 15% mandipropamid pyraclostrobin suspending agent.
Embodiment uses three bactericidal compositions that contain mandipropamid and prevents and treats the potato late blight test of pesticide effectiveness
This experimental establishment is in Tongxu County, Kaifeng, Henan Province, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% water dispersion granules agent of Kresoxim (commercial), 250g/L pyraclostrobin missible oil (commercial), 20% mandipropamid suspending agent (commercial).
The investigation potato late blight state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively the potato late blight disease index and calculated preventive effect in 7 days, 14 days, 30 days after for the second time dispenser.Experimental result is as follows:
Table 3 contains the bactericidal composition of mandipropamid and prevents and treats the potato late blight test of pesticide effectiveness
As can be seen from Table 3, can effectively prevent and treat potato late blight after mandipropamid and kresoxim-methyl or pyraclostrobin are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.
Implementation of an application example four: the bactericidal composition control cucumber downy mildew test of pesticide effectiveness that contains mandipropamid
This experimental establishment is in Hu County, Shaanxi Province, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 50% water dispersion granules agent of Kresoxim (commercial), 250g/L pyraclostrobin missible oil (commercial), 20% mandipropamid suspending agent (commercial).
Investigation cucumber downy mildew state of an illness radix before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates respectively disease index and calculates preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 4 contains the bactericidal composition control cucumber downy mildew test of pesticide effectiveness of mandipropamid
As can be seen from Table 4, can effectively prevent and treat cucumber downy mildew after mandipropamid and kresoxim-methyl or pyraclostrobin are composite and occur, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and preventive effect reaches more than 90%.
Claims (8)
1. a bactericidal composition is characterized in that bactericidal composition effective active composition is mandipropamid and kresoxim-methyl or pyraclostrobin, and the weight ratio of mandipropamid and kresoxim-methyl or pyraclostrobin is 1:20～20:1.
2. bactericidal composition according to claim 1, it is characterized in that: wherein the weight ratio of mandipropamid and kresoxim-methyl or pyraclostrobin is 1:10～10:1.
3. bactericidal composition according to claim 2, it is characterized in that: wherein the weight ratio of mandipropamid and kresoxim-methyl is 1:5～5:1.
4. bactericidal composition according to claim 2, it is characterized in that: wherein the weight ratio of mandipropamid and pyraclostrobin is 1:5～5:1.
5. bactericidal composition according to claim 1, it is characterized in that: bactericidal composition is made wetting powder, water dispersible granules, suspending agent.
6. bactericidal composition according to claim 5, it is characterized in that: bactericidal composition is when making solid pharmaceutical preparation, and wherein the effective active component content accounts for 1～90% of gross weight.
7. bactericidal composition according to claim 5, it is characterized in that: bactericidal composition is when making liquid preparation, and wherein the effective active component content accounts for 15～80% of gross weight.
8. arbitrary described bactericidal composition according to claim 1～7 is characterized in that: bactericidal composition is used for preventing and treating the purposes of downy mildew, epidemic disease.
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| CN102919255A (en) * | 2012-10-31 | 2013-02-13 | 青岛润生农化有限公司 | Agricultural compound fungicide |
| CN115039776B (en) * | 2021-03-08 | 2023-12-08 | 东莞市东阳光农药研发有限公司 | Composition containing mandipropamid and preparation method and application thereof |
| WO2024126744A1 (en) | 2022-12-16 | 2024-06-20 | Syngenta Crop Protection Ag | Improved pesticidal compositions |
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| CN101755749B (en) * | 2009-11-10 | 2012-08-22 | 深圳诺普信农化股份有限公司 | Synergistic fungicide composition |
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