CN102461503B - Mandipropamid and ethirimol containing fungicides combination - Google Patents
Mandipropamid and ethirimol containing fungicides combination Download PDFInfo
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- CN102461503B CN102461503B CN 201010535246 CN201010535246A CN102461503B CN 102461503 B CN102461503 B CN 102461503B CN 201010535246 CN201010535246 CN 201010535246 CN 201010535246 A CN201010535246 A CN 201010535246A CN 102461503 B CN102461503 B CN 102461503B
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- mandipropamid amine
- phonetic phenol
- mandipropamid
- bactericidal composition
- phonetic
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Abstract
The invention relates to a fungicides combination which possesses synergistic effects. The effective active component of the fungicides combination contains mandipropamid and ethirimol with the weight ratio of mandipropamid and ethirimol being 1 to 60/80 to 1. By addition of an additive and an excipient, the effective active component is prepared into wettable powder, water dispersible granule and suspension concentrate. The fungicides combination provided by the invention has fairly high bioactivity on oomycete fungi such as phytophthora, peronosporceae, pseudoperonospora, pythium and plasmodiophoromycetes such as plasmodiophora brassicae woron.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains mandipropamid amine and the phonetic phenol of second.
Technical background
Mandipropamid amine (cyazofamid), molecular formula: C
23H
22CINO
4, chemical name: 2-(4-chloro-phenyl)-N-[2-(3-methoxyl group-4-(2-third alkynyloxy group)-phenyl-ethyl group]-2-(2-third alkynyloxy group)-acetamide.
Mandipropamid amine is acid amide fungicides.Its mechanism of action is for suppressing the biosynthesis of phosphatide, and leaf portion and fruit disease that exhausted big number is caused by oomycetes all have good preventive effect.The spore that is in the sprouting stage is had higher activity, and can suppress mycelia and grow up and sporulation.Can be absorbed rapidly by blade, and be rested in the leaf table wax coat, blade is shielded.
The phonetic phenol of second (ethirimol) is the miazines bactericide of Syngenta Co.,Ltd's exploitation.Molecular formula is: C
11H
19N
3O, chemical name: 5-butyl-2-ethylamino-4-hydroxyl-6-methylpyrimidine.
The phonetic phenol of second belongs to heterocyclic nitrogen-group fungicide.Belong to adenosine deaminase inhibitors, have stronger interior absorption, can be absorbed rapidly by plant roots, stem, leaf, and in plant corpus, run to each position, have preventive and therapeutic action.
But no matter be mandipropamid amine, the phonetic phenol of second, or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.And that the active ingredient of the different mechanisms of action is carried out is composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The objective of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition that use cost is low, preventive effect is good.
The inventor is by a large amount of indoor biometricses and field control effectiveness test, finds the use that is mixed within the specific limits of the phonetic phenol of mandipropamid amine and second unexpectedly, and diseases such as downy mildew, eqpidemic disease are had good synergistic effect.Mandipropamid amine is different with the phonetic phenol mechanism of action of second, and mutually composite have good synergistic effect within the specific limits.And composite about mandipropamid amine and the phonetic phenol of second do not see relevant report at present at home and abroad as yet.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains mandipropamid amine and the phonetic phenol of second, wherein the phonetic phenol weight ratio of mandipropamid amine and second is 1～60: 80～1.
The described bactericidal composition that contains mandipropamid amine and the phonetic phenol of second, wherein the weight ratio of mandipropamid amine and the phonetic phenol of second is preferably 5～45: 60～5.
The described bactericidal composition that contains mandipropamid amine and the phonetic phenol of second, wherein the weight ratio of mandipropamid amine and the phonetic phenol of second more preferably 5～30: 45～10.
The described bactericidal composition that contains mandipropamid amine connection, wherein the effective active component content accounts for 1～90% of gross weight, is preferably 10～80%.
The described bactericidal composition that contains mandipropamid amine and the phonetic phenol of second adds corresponding additive and filler according to method known in those skilled in the art, can make wetting powder, water dispersible granules or suspending agent.
Described auxiliary agent has dispersant, wetting agent, disintegrant, binding agent, defoamer, antifreeze, thickener.
Described dispersant is selected from that polycarboxylate, lignosulfonates, alkylphenol-polyethenoxy are phonetic, formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, sldium lauryl sulfate, spaonin powder, silkworm excrement, the soapberry powder.
Described binding agent is selected from: one or more in diatomite, starch, PVA, carboxymethyl (ethyl) cellulose.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, calcium chloride, the glucose.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 1600
#In (phenethyl phenol polyoxy ethyl polypropylene-base ether), the ethylene oxide-propylene oxide block copolymer one or more.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating oomycetes order disease such as downy mildew, eqpidemic disease etc.
Beneficial effect of the present invention: (1) present composition effective active composition mandipropamid amine and the phonetic phenol of second belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition shows good synergistic effect in given scope, and preventive effect is apparently higher than single agent, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has very high biologically active to the plasmodiophora brassica bacteria of Oomycete fungi such as phytophthora, downy mildew, false downy mildew, pythium spp and Plasmodiophoromycetes.Downy mildew, eqpidemic disease to vegetables and fruit tree have special efficacy.
Embodiment
Below in conjunction with the further instruction of the present invention of embodiment, but the present invention is not limited thereto.Percentage in following examples all is weight percentage.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one: the phonetic phenol of mandipropamid amine and second is composite to the cucumber downy mildew Toxicity Determination
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of cucumber downy mildew.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively mandipropamid amine and the phonetic phenol of second shared ratio in combination
A is mandipropamid amine
B is the phonetic phenol of second
Result of the test is as shown in the table:
Table 1 mandipropamid amine, the phonetic phenol of second and composite toxicity test analysis of results table to cucumber downy mildew thereof
As shown in Table 1, mandipropamid amine, the phonetic phenol of second are to the EC of cucumber downy mildew
50Be respectively 0.31mg/L and 1.65mg/L.The phonetic phenol proportioning of mandipropamid amine and second was mixed in the scope at 3: 1～1: 9 and all shows obvious synergistic effect, synergy ratio SR maximum when mandipropamid amine and the phonetic phenol weight ratio of second are 1: 3 wherein, and synergistic effect is the most obvious.
Implementation of an application example two the implementation of Formulation Example
The phonetic phenol wetting powder of embodiment 1 80% mandipropamid amine second
Mandipropamid amine 60%, the phonetic phenol 20% of second, sodium lignin sulfonate 5%, neopelex 3%, silkworm excrement 3%, bentonite add to 100%, and mixture carries out air-flow to be pulverized, and makes the phonetic phenol wetting powder of 80% mandipropamid amine second.
The phonetic phenol wetting powder of embodiment 2 60% mandipropamid amine second
Mandipropamid amine 30%, the phonetic phenol 30% of second, sldium lauryl sulfate 3%, polycarboxylate 5%, soapberry powder 2%, white carbon 5%, kaolin add to 100%, and mixture carries out air-flow to be pulverized, and makes the phonetic phenol wetting powder of 66% mandipropamid amine second.
The phonetic phenol wetting powder of embodiment 3 50% mandipropamid amine second
Mandipropamid amine 5%, the phonetic phenol 45% of second, alkyl benzene sulfonate calcium salt 5%, draw back powder 3%, starch 10%, diatomite and add to 100%, mixture carries out air-flow to be pulverized, and makes the phonetic phenol wetting powder of 50% mandipropamid amine second.
Embodiment 4 80% mandipropamid amine ethirimol water dispersible granules
Mandipropamid amine 20%, the phonetic phenol 60% of second, lauryl sodium sulfate 4%, alkyl benzene sulfonate calcium salt 3%, lignosulfonates 3%, talcum powder add to 100%, the mixed 80% mandipropamid amine ethirimol water dispersible granules that gets.
Embodiment 5 60% mandipropamid amine ethirimol water dispersible granules
Mandipropamid amine 45%, the phonetic phenol 15% of second, polycarboxylic acids sodium 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, polyvinyl alcohol 5%, bentonite add to 100%, the mixed 60% mandipropamid amine ethirimol water dispersible granules that gets.
Embodiment 6 50% mandipropamid amine ethirimol water dispersible granules
Mandipropamid amine 10%, the phonetic phenol 40% of second, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, calcium chloride 5%, ammonium sulfate 5%, bentonite add to 100%, mixed 50% mandipropamid amine ethirimol water dispersible granules.
The phonetic phenol suspending agent of embodiment 7 40% mandipropamid amine second
Mandipropamid amine 10%, the phonetic phenol 30% of second, polyoxyethylene are phonetic 5%, Sodium Polyacrylate 2%, pelopon A 4%, silicone oil 0.1%, polyvinyl alcohol 0.3%, phenyl phenol polyoxy ethyl ether 2%, deionized water adds to 100%, the mixed phonetic phenol suspending agent of 40% mandipropamid amine second that gets.
The phonetic phenol suspending agent of embodiment 8 15% mandipropamid amine second
Mandipropamid amine 5%, the phonetic phenol 10% of second, sodium lignin sulfonate 4%, draw back powder 5%, silicone compound 0.1%, xanthans 0.2%, polyethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, the mixed phonetic phenol suspending agent of 30% mandipropamid amine second that gets.
The phonetic phenol suspending agent of embodiment 9 10% mandipropamid amine second
Mandipropamid amine 5%, the phonetic phenol 5% of second, polycarboxylate 2%, draw back powder 2%, C
10-20Saturated fat acid compounds 0.1%, glycerine 3%, alkylphenol-formaldehyde resin polyoxy ethyl ether 1%, deionized water adds to 100%, the mixed phonetic phenol suspending agent of 10% mandipropamid amine second that gets.
Embodiment uses three bactericidal compositions that contain mandipropamid amine and the phonetic phenol of second and prevents and treats the cucumber downy mildew test of pesticide effectiveness
This experimental establishment is in the Lantian County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 250g/L mandipropamid amine suspending agent (commercial).
The investigation cucumber downy mildew state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigate the cucumber downy mildew disease index respectively in 7 days, 14 days after the last dispenser and calculate preventive effect.Experimental result is as follows:
Table 2 contains the bactericidal composition control cucumber downy mildew test of pesticide effectiveness of mandipropamid amine and the phonetic phenol of second
As can be seen from Table 2, can effectively prevent and treat cucumber downy mildew after the phonetic phenol of mandipropamid amine and second is composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.
Implementation of an application example four: the bactericidal composition that contains mandipropamid amine and the phonetic phenol of second is prevented and treated the potato late blight test of pesticide effectiveness
This experimental establishment is in the Dongxiang County, Gansu Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 250g/L mandipropamid amine suspending agent (commercial).
Investigation potato late blight state of an illness radix before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 3 times, investigates disease index respectively in 7 days, 14 days after the last dispenser and calculates preventive effect.Experimental result is as follows:
Table 3 contains the bactericidal composition of mandipropamid amine and the phonetic phenol of second and prevents and treats the potato late blight test of pesticide effectiveness
As can be seen from Table 3, can effectively prevent and treat potato late blight after the phonetic phenol of mandipropamid amine and second is composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and preventive effect reaches more than 90%.
Implementation of an application example five: the bactericidal composition control capsicum epidemic disease test of pesticide effectiveness that contains mandipropamid amine and the phonetic phenol of second
This experimental establishment is in the Qiaojia County, Yunnan Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., the contrast medicament phonetic phenol suspending agent of 25% second (commercial), 250g/L mandipropamid amine suspending agent (commercial).
Investigation capsicum epidemic disease state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 3 times, investigates disease index respectively in 7 days, 14 days after the last dispenser and calculates preventive effect.Experimental result is as follows:
Table 4 contains the bactericidal composition control capsicum epidemic disease test of pesticide effectiveness of mandipropamid amine and the phonetic phenol of second
As can be seen from Table 4, can effectively prevent and treat capsicum epidemic disease after the phonetic phenol of mandipropamid amine and second is composite and take place, control efficiency all is better than contrasting medicament, in this test scope of medication the target crop is had no adverse effects, and preventive effect reaches more than 90%.
Claims (7)
1. bactericidal composition that contains mandipropamid amine and the phonetic phenol of second, the weight ratio that it is characterized in that bactericidal composition effective active composition mandipropamid amine and the phonetic phenol of second is 5～45 ︰ 60～5.
2. the bactericidal composition that contains mandipropamid amine and the phonetic phenol of second according to claim 1, it is characterized in that: wherein the weight ratio of mandipropamid amine and the phonetic phenol of second is 5～30 ︰ 45～10.
3. the bactericidal composition that contains mandipropamid amine and the phonetic phenol of second according to claim 1, it is characterized in that: wherein the effective active component content accounts for 1～90% of gross weight.
4. the bactericidal composition that contains mandipropamid amine and the phonetic phenol of second according to claim 3, it is characterized in that: wherein the effective active component content accounts for 10～80% of gross weight.
5. the bactericidal composition that contains mandipropamid amine and the phonetic phenol of second according to claim 1, it is characterized in that: bactericidal composition is made wetting powder, water dispersible granules or suspending agent.
6. the bactericidal composition of mandipropamid amine and the phonetic phenol of second that contains according to claim 1 is for the purposes of the oomycetes order disease of control gourd, fruit and vegetable.
7. the purposes that contains the bactericidal composition of mandipropamid amine and the phonetic phenol of second according to claim 6 is characterized in that: bactericidal composition is used for the downy mildew of control gourd, fruit and vegetable and the purposes of eqpidemic disease.
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| CN 201010535246 CN102461503B (en) | 2010-11-08 | 2010-11-08 | Mandipropamid and ethirimol containing fungicides combination |
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| CN 201010535246 CN102461503B (en) | 2010-11-08 | 2010-11-08 | Mandipropamid and ethirimol containing fungicides combination |
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| CN102461503B true CN102461503B (en) | 2013-08-14 |
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Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1182584A (en) * | 1966-03-31 | 1970-02-25 | Ici Ltd | Pyrimidine derivates and the use thereof as fungicides |
| GB0011944D0 (en) * | 2000-05-17 | 2000-07-05 | Novartis Ag | Organic compounds |
| AU2006260959B2 (en) * | 2005-06-21 | 2011-11-24 | Bayer Intellectual Property Gmbh | Fungicide composition comprising a phosphorous acid derivative, a mandelamide type compound and a further fungicide compound |
| CN101785461B (en) * | 2009-12-18 | 2012-11-07 | 陕西美邦农资贸易有限公司 | Sterilization composition containing ethirimol and ZJ0712 |
| CN101743980B (en) * | 2010-01-08 | 2012-11-14 | 深圳诺普信农化股份有限公司 | Fungicidal composition containing flumorph |
| CN101822256A (en) * | 2010-01-27 | 2010-09-08 | 深圳诺普信农化股份有限公司 | Sterilization compound containing ZJ0712 |
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Address after: 715500 middle section of North Ring Road, Pucheng County, Shaanxi Patentee after: Shanxi Thompson Biological Technology Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Patentee before: Shanxi Thompson Biological Technology Co., Ltd. |