CN102067856B - Bactericidal composition containing polyoxin and oxazole compounds - Google Patents
Bactericidal composition containing polyoxin and oxazole compounds Download PDFInfo
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- CN102067856B CN102067856B CN201110043636.0A CN201110043636A CN102067856B CN 102067856 B CN102067856 B CN 102067856B CN 201110043636 A CN201110043636 A CN 201110043636A CN 102067856 B CN102067856 B CN 102067856B
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- China
- Prior art keywords
- polyoxin
- famoxadone
- bactericidal composition
- hymexazo
- mei
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- 229930182764 Polyoxin Natural products 0.000 title claims abstract description 71
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 23
- 150000002916 oxazoles Chemical class 0.000 title claims abstract 3
- PCCSBWNGDMYFCW-UHFFFAOYSA-N 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione Chemical compound O=C1C(C)(C=2C=CC(OC=3C=CC=CC=3)=CC=2)OC(=O)N1NC1=CC=CC=C1 PCCSBWNGDMYFCW-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000005772 Famoxadone Substances 0.000 claims abstract description 51
- 201000010099 disease Diseases 0.000 claims abstract description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 3
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 8
- 241000223218 Fusarium Species 0.000 claims description 8
- 241000233679 Peronosporaceae Species 0.000 claims description 6
- 241000221785 Erysiphales Species 0.000 claims description 4
- 230000035613 defoliation Effects 0.000 claims description 3
- 241000918585 Pythium aphanidermatum Species 0.000 claims 1
- 235000013339 cereals Nutrition 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
- 239000004562 water dispersible granule Substances 0.000 abstract description 18
- 241000233866 Fungi Species 0.000 abstract description 4
- 239000005794 Hymexazol Substances 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 3
- KGVPNLBXJKTABS-UHFFFAOYSA-N hymexazol Chemical compound CC1=CC(O)=NO1 KGVPNLBXJKTABS-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 241000221198 Basidiomycota Species 0.000 abstract description 2
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- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 239000004563 wettable powder Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 32
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- 239000000575 pesticide Substances 0.000 description 7
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- 238000000034 method Methods 0.000 description 6
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- 230000000694 effects Effects 0.000 description 4
- 241000193738 Bacillus anthracis Species 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 240000003377 Shepherdia canadensis Species 0.000 description 3
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
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- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 3
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000002528 anti-freeze Effects 0.000 description 2
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- 239000007884 disintegrant Substances 0.000 description 2
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- 239000000417 fungicide Substances 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
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- 230000007246 mechanism Effects 0.000 description 2
- 125000002971 oxazolyl group Chemical group 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
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- 229920001223 polyethylene glycol Polymers 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
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- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 206010027146 Melanoderma Diseases 0.000 description 1
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- 241000233678 Peronosporales Species 0.000 description 1
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- 206010039509 Scab Diseases 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 description 1
- 208000020282 anthrax disease Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
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- 229940077388 benzenesulfonate Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 description 1
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- ANGDWNBGPBMQHW-UHFFFAOYSA-N methyl cyanoacetate Chemical compound COC(=O)CC#N ANGDWNBGPBMQHW-UHFFFAOYSA-N 0.000 description 1
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Abstract
The invention relates to a bactericidal composition containing polyoxin and oxazole compounds. The bactericidal composition comprises the polyoxin, oxadixy, hymexazol and famoxadone serving as active ingredients, wherein the weight ratio of the polyoxin to the oxadixy, the hymexazol and the famoxadone is (64:1)-(1:64); and auxiliary agents and excipients are added into the active ingredients so as to prepare water dispersible granules, wettable powder and the like. The bactericidal composition is used for preventing and controlling diseases caused by ascomycetes, basidiomycetes and fungi inperfect pathogenic bacteria.
Description
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of combination sterilization composition containing polyoxin in crop pest.
Technical background
Polyoxin (polyoxin), molecular formula: C
17h
25n
5o
14, chemical name: peptide pyrimidine nucleoside.
Structural formula:
Polyoxin broad-spectrum antibiotics class, in having preferably, inhale conduction, its mechanism of action is to disturb the chitinous biosynthesis of bacterial cell wall, after germ tube contacts medicament with mycelium, expand part, break, overflow cell inclusion, and can not normal development, cause death, suppress in addition germ and produce spore and scab expansion effect, this medicine does not have toxicity to animal, and plant is not had to poisoning.Main controlling object has wheat powdery mildew, Alternaria alternate, cucumber downy mildew, cucurbits fusarium wilt, black fleck disease of ginseng, rice seedling blight, alternaria leaf spot of apple, strawberry and work grape grey mould, the multiple fungal diseases such as forest spike top and Pear black spot.
Evil frost spirit (oxadixy), molecular formula is C14H18N2O4, chemical name: 2-methoxyl group-N-(2-oxo-1,3-oxazoles alkane-3-yl) acetyl-2 ', 6 '-dimethylaniline.
The spirit of Evil frost is systemic fungicide, has protection and therapeutic action and lasting period long.Peronosporales pathogen is had to special efficacy.
Hymexazo (hymexazol), molecular formula is C4H5NO2, chemical name: 3-hydroxy-5-methyl base isoxazole.
Hymexazo is systemic fungicide, is again a kind of soil disinfectant simultaneously.Iron, the aluminium ion of this medicine in soil is combined, and suppresses the germination of spore.Disliking mould spirit can and move by the root absorption of plant in root system, at plant intracellular metabolite, produces two kinds of glucosides, crop is improved to the effect of physiologically active, thereby can promotes plant strain growth, and minute evil, the increase of root hair and the activity of root of root improve.
Famoxadone (famoxadone), molecular formula is C22H18N2O4, chemical name: 3-anilino--5-methyl-5-(4-Phenoxyphenyl)-1,3-azoles quinoline-2,4-diketone.
Famoxadone is that inhibitor of energy is mitochondria electron transfer inhibitor; Cromoci oxidoreductase in complex III is had to inhibitory action.The bactericide inhibitory action comparison (IC50, ppb) that multiple inhibition is breathed: JE874 (4.5); ICIA 5504 (170.0); BAS 490F (75.0); SSF-126 (3500.0).Other mechanism of action is in further research, and it has protection, treats, roots out, infiltration, systemic activity.
No matter be polyoxin, Evil frost Ling, hymexazo, famoxadone or other efficient germicides, long-term use separately, easily makes disease develop immunity to drugs, and causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease conventional method that develops immunity to drugs, and according to the effect in production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can expand fungicidal spectrum, improves germicidal efficiency.In the present composition, two kinds of active component mechanism of action points are different, and mutually composite have good synergistic effect within the specific limits.And about polyoxin Yu Evil frost Ling, hymexazo, famoxadone composite there is not yet relevant report at present at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains polyoxin.
The present invention is achieved through the following technical solutions:
A kind of polyoxin that contains is Yu the bactericidal composition of oxazole compounds, it is characterized in that bactericidal composition effective active composition polyoxin Yu the weight ratio of Evil frost Ling, hymexazo, famoxadone is 64: 1 to 1: 64, preferred weight ratio is 16: 1 to 1: 16.
Described bactericidal composition, is characterized in that: wherein polyoxin, Yu the weight ratio of Evil frost spirit is 16: 1 to 1: 16, is preferably 8: 1 to 1: 8.
Described bactericidal composition, is characterized in that: wherein polyoxin, Yu the weight ratio of hymexazo is 16: 1 to 1: 16, is preferably 8: 1 to 1: 8.
Described bactericidal composition, is characterized in that: wherein polyoxin, Yu the weight ratio of famoxadone is 16: 1 to 1: 16, is preferably 8: 1 to 1: 8.
The amount of application when content of active component depends on independent use in the present composition, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target fungi.Conventionally in composition, active weight percentage is gross weight 1～90%, is preferably 10%～80%.
Bactericidal composition of the present invention, can add corresponding additive and excipient on demand, is processed into acceptable formulation on any agricultural chemicals, and wherein the excellent formulation of selecting is wetting powder, water dispersible granules or aqua.
Described auxiliary agent and excipient are selected from: one or more of dispersant, wetting agent, disintegrant, binding agent, antifreeze, filler.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, one or more in phonetic of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, glucose, aluminium chloride.
Described binding agent is selected from: one or more in diatomite, starch, PVA, carboxymethyl (ethyl) cellulose.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate, deionized water.
Described containing polyoxin Yu the bactericidal composition of Evil frost Ling, hymexazo, famoxadone, for preventing and treating disease due to the germ of sub-Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti, especially all has good preventive effect to downy mildew, gray mold, epidemic disease, spot defoliation, powdery mildew, anthracnose, fusarium wilt, damping off, bakanae disease.
Beneficial effect of the present invention:
(1) present composition effective active composition polyoxin from Evil frost Ling, hymexazo, famoxadone belongs to the bactericide of two kinds of different mechanisms of action, and both are mutually mixed and can produce conflict;
(2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little;
(3) the present invention not with an organic solvent, is difficult for producing poisoning, is convenient to transportation and storage;
(4) present composition has special efficacy to downy mildew, gray mold, epidemic disease, spot defoliation, powdery mildew, anthracnose, fusarium wilt, damping off, bakanae disease etc.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one the implementation of Formulation Example
The clever wetting powder of embodiment Kang Mei Duo in the of 1 70% Su Evil frost
Polyoxin 8%, Evil frost spirit 62%, lignosulfonates 5%, spaonin powder 3%, white carbon 7%, starch add to 100%, and mixture carries out air-flow crushing, makes the clever wetting powder of the Mei of Kang Duo in the of 70% Su Evil frost.
The clever wetting powder of embodiment Kang Mei Duo in the of 2 50% Su Evil frost
Polyoxin 5%, Evil frost spirit 45%, alkylphenol-polyethenoxy are phonetic 5%, neopelex 3%, kaolin add to 100%, and mixture carries out air-flow crushing, makes the clever wetting powder of the Mei of Kang Duo in the of 50% Su Evil frost.
The clever wetting powder of embodiment Kang Mei Duo in the of 3 20% Su Evil frost
Polyoxin 15%, Evil frost spirit 5%, lignosulfonates 5%, wetting and penetrating agent F 3%, kaolin add to 100%, and mixture carries out air-flow crushing, makes the clever wetting powder of the Mei of Kang Duo in the of 20% Su Evil frost.
Embodiment Kang Mei Duo in the of 4 80% Su Evil frost Lingshui Spring dispersible granule
Polyoxin 10%, Evil frost spirit 70%, alkylphenol-polyethenoxy are phonetic 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, bentonite add to 100%, mix and make the Mei of Kang Duo in the of 80% Su Evil frost Lingshui Spring dispersible granule.
Embodiment Kang Mei Duo in the of 5 60% Su Evil frost Lingshui Spring dispersible granule
Polyoxin 20%, Evil frost spirit 40%, polycarboxylate 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, sodium chloride 5%, diatomite add to 100%, mix and make the Mei of Kang Duo in the of 60% Su Evil frost Lingshui Spring dispersible granule.
Embodiment Kang Mei Duo in the of 6 20% Su Evil frost Lingshui Spring dispersible granule
Polyoxin 10%, Evil frost spirit 10%, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, starch 10%, bentonite add to 100%, mix and make the Mei of Kang Duo in the of 20% Su Evil frost Lingshui Spring dispersible granule.
Embodiment Kang Mei Duo in the of 7 80% Su hymexazo wetting powder
Polyoxin 15%, hymexazo 65%, polycarboxylate 5%, neopelex 3%, soapberry powder 2%, starch add to 100%, and mixture carries out air-flow crushing, make the Mei of Kang Duo in the of 80% Su hymexazo wetting powder.
Embodiment Kang Mei Duo in the of 8 50% Su hymexazo wetting powder
Polyoxin 5%, hymexazo 45%, lignosulfonates 5%, spaonin powder 3%, white carbon 7%, diatomite add to 100%, and mixture carries out air-flow crushing, make the Mei of Kang Duo in the of 50% Su hymexazo wetting powder.
Embodiment Kang Mei Duo in the of 9 10% Su hymexazo wetting powder
Polyoxin 8%, hymexazo 2%, alkylphenol-polyethenoxy are phonetic 5%, neopelex 3%, white carbon 8%, bentonite add to 100%, and mixture carries out air-flow crushing, makes the Mei of Kang Duo in the of 10% Su hymexazo wetting powder.
Embodiment Kang Mei Duo in the of 10 70% Su hymexazo water dispersible granules
Polyoxin 15%, hymexazo 55%, alkylphenol-polyethenoxy are phonetic 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, bentonite add to 100%, mix and make the Mei of Kang Duo in the of 70% Su hymexazo water dispersible granules.
Embodiment Kang Mei Duo in the of 11 50% Su hymexazo water dispersible granules
Polyoxin 10%, hymexazo 40%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, bentonite 8%, kaolin add to 100%, mix and make the Mei of Kang Duo in the of 50% Su hymexazo water dispersible granules.
Embodiment Kang Mei Duo in the of 12 18% Su hymexazo water dispersible granules
Polyoxin 16%, hymexazo 2%, alkylphenol-polyethenoxy are phonetic 4%, DBSA 4%, urea 10%, diatomite add to 100%, mix and make the Mei of Kang Duo in the of 18% Su hymexazo water dispersible granules.
Embodiment Kang Mei Duo in the of 13 55% Su hymexazo aqua
Polyoxin 15%, hymexazo 40%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, neopelex 2%, ethylene glycol 2%, deionized water add to 100%, mix and make the Mei of Kang Duo in the of 55% Su hymexazo aqua.
Embodiment Kang Mei Duo in the of 14 35% Su hymexazo aqua
Polyoxin 5%, hymexazo 30%, polycarboxylate 3%, sodium lignin sulfonate 4%, polyethylene glycol 3%, deionized water add to 100%, mix and make the Mei of Kang Duo in the of 35% Su hymexazo aqua.
Embodiment Kang Mei Duo in the of 15 15% Su hymexazo aqua
Polyoxin 10%, hymexazo 5%, lignosulfonates 4%, 120,000 base sodium sulphate 3%, propane diols 3%, deionized water add to 100%, mix and make the Mei of Kang Duo in the of 15% Su hymexazo aqua.
Embodiment Kang Mei Duo in the of 16 60% Su famoxadone wetting powder
Polyoxin 15%, famoxadone 45%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 5%, neopelex 3%, soapberry powder 2%, kaolin add to 100%, and mixture carries out air-flow crushing, make the Mei of Kang Duo in the of 60% Su famoxadone wetting powder.
Embodiment Kang Mei Duo in the of 17 50% Su famoxadone wetting powder
Polyoxin 10%, famoxadone 40%, lignosulfonates 5%, spaonin powder 3%, diatomite add to 100%, and mixture carries out air-flow crushing, make the Mei of Kang Duo in the of 50% Su famoxadone wetting powder.
Embodiment Kang Mei Duo in the of 18 20% Su famoxadone wetting powder
Polyoxin 5%, famoxadone 15%, alkylphenol-polyethenoxy are phonetic 5%, neopelex 3%, bentonite add to 100%, and mixture carries out air-flow crushing, makes the Mei of Kang Duo in the of 20% Su famoxadone wetting powder.
Embodiment Kang Mei Duo in the of 19 70% Su famoxadone water dispersible granules
Polyoxin 15%, famoxadone 55%, alkylphenol-polyethenoxy are phonetic 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, bentonite add to 100%, mix and make the Mei of Kang Duo in the of 70% Su famoxadone water dispersible granules.
Embodiment Kang Mei Duo in the of 20 50% Su famoxadone water dispersible granules
Polyoxin 10%, famoxadone 40%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, urea 3%, bentonite 6%, kaolin add to 100%, mix and make the Mei of Kang Duo in the of 50% Su famoxadone water dispersible granules.
Embodiment Kang Mei Duo in the of 21 10% Su famoxadone water dispersible granules
Polyoxin 8%, famoxadone 2%, alkylphenol-polyethenoxy are phonetic 4%, DBSA 4%, urea 10%, diatomite add to 100%, mix and make the Mei of Kang Duo in the of 10% Su famoxadone water dispersible granules.
Implementation of an application example two: polyoxin is Yu Evil frost Ling, hymexazo, famoxadone is composite to target bacterium Toxicity Determination
Test medicine provides by Shaanxi Mei Bang agricultural chemicals Co., Ltd.
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage by active constituent content and is processed, and establishes clear water contrast.With reference to < < farm-chemical indoor determination test rule bactericide > >, carry out, adopt mycelial growth rate method to measure the virulence of medicament to target fungus.After 72h, by right-angled intersection method, measure colony diameter, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, with method of least squares, tries to achieve virulence regression equation (y=a+bx), and calculates thus the EC of every kind of medicament
50value.According to Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively polyoxin with Evil frost Ling, hymexazo, famoxadone shared ratio in combination.
A is polyoxin
B Wei Evil frost Ling, hymexazo, famoxadone
It is as shown in the table for result of the test:
Toxicity test result one:
The spirit of table 1 polyoxin, Evil frost and the composite toxicity test analysis of results table to bacterium of downy mildew of cucumber thereof
As shown in Table 1, the EC of polyoxin, Evil frost spirit to bacterium of downy mildew of cucumber
50be respectively 1.26mg/L and 1.14mg/L.Polyoxin Yu Evil frost spirit both at 64: 1 to 1: 64, in scope, be mixed and all show obvious synergistic effect, wherein when polyoxin Yu the white clever weight ratio of Evil in 8: 1 to 1: 8 scopes time synergistic effect the most obvious.
Toxicity test result two:
Table 2 polyoxin, hymexazo and the composite toxicity test analysis of results table to rice wilt pathogens thereof
As shown in Table 2, the EC of polyoxin, hymexazo to rice wilt pathogens
50be respectively 1.15mg/L and 1.07mg/L.Polyoxin Yu hymexazo at 64: 1 to 1: 64, in scope, be mixed and all show obvious synergistic effect, wherein when polyoxin Yu hymexazo weight ratio in 8: 1 to 1: 8 scopes time synergistic effect the most obvious.
Toxicity test result three:
Table 3 polyoxin, famoxadone and the composite toxicity test analysis of results table to tomato early blight bacterium thereof
As shown in Table 2, the EC of polyoxin, famoxadone to early blight of tomato germ
50be respectively 1.14mg/L and 1.05mg/L.Polyoxin Yu hymexazo at 64: 1 to 1: 64, in scope, be mixed and all show obvious synergistic effect, wherein when polyoxin Yu famoxadone weight ratio in 8: 1 to 1: 8 scopes time synergistic effect the most obvious.
Implementation of an application example three polyoxins are Yu Evil frost Ling, hymexazo, famoxadone and the composite control cucumber fusarium axysporum test of pesticide effectiveness thereof
This experimental establishment is in Pucheng County, Shaanxi Province, test medicine is researched and developed, is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 8% Evil frost clever wetting powder (commercial), 15% hymexazo aqua (commercial), 6% famoxadone water dispersible granules.
In the dispenser of cucumber fusarium axysporum their early stage, once, dispenser is 2 times altogether in dispenser in every 7 days, and before dispenser, investigation disease index, investigates respectively disease index in after the 2nd dispenser 10 days, 20 days, and calculation correction preventive effect, and result of the test is as follows:
Table 3 polyoxin is Yu Evil frost Ling, hymexazo, famoxadone and the composite control cucumber fusarium axysporum test of pesticide effectiveness thereof
As can be seen from Table 3, polyoxin, Evil frost Ling, hymexazo, famoxadone energy effectively preventing cucumber fusarium axysporum, control efficiency is all better than contrasting medicament, dosage is little, in test scope of medication to target crop without harm.
Embodiment applies four polyoxins Yu Evil frost Ling, hymexazo, famoxadone and the composite control watermelon anthrax test of pesticide effectiveness thereof
This experimental establishment is in Dali County, Shaanxi Province, test medicine is researched and developed, is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 8% Evil frost clever wetting powder (commercial), 15% hymexazo aqua (commercial), 6% famoxadone water dispersible granules.
Investigation watermelon anthrax disease index before medicine, in their early stage dispenser, once, dispenser is 3 times altogether in dispenser in every 7 days, within after dispenser 7 days, 15 days, 30 days for the third time, investigates disease indexs and calculates preventive effect.Experimental result is as follows:
Table 4 polyoxin is Yu Evil frost Ling, hymexazo, famoxadone and the composite control watermelon anthrax test of pesticide effectiveness thereof
As can be seen from Table 4, polyoxin is Yu Evil frost Ling, hymexazo, famoxadone can effectively be prevented and treated watermelon anthrax after composite, and control efficiency is all better than contrasting medicament, and the lasting period is long.In test scope of medication, target crop is had no adverse effects.
Implementation of an application example five polyoxin, Evil frost Ling, hymexazo, famoxadone and the composite early blight of tomato tests of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Jingyuan County, Baiyin City, gansu Province, test medicine is researched and developed, is provided by Shaanxi Mei Bang agricultural chemicals Co., Ltd, contrast medicament 10% polyoxin wetting powder (commercial), 8% Evil frost clever wetting powder (commercial), 15% hymexazo aqua (commercial), 6% famoxadone water dispersible granules, 6% famoxadone water dispersible granules.
Investigation early blight of tomato state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before medicine, in their early stage dispenser, once, dispenser is 2 times altogether, within after dispenser 10 days, 20 days for the second time, investigates respectively disease index and calculates preventive effect in dispenser in every 7 days.Experimental result is as follows:
Table 5 polyoxin is Yu Evil frost Ling, hymexazo, famoxadone and the composite early blight of tomato test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 5, polyoxin is Yu Evil frost Ling, hymexazo, famoxadone can effectively be prevented and treated early blight of tomato after composite occurs, and control efficiency is all better than contrasting medicament, in this test scope of medication, target crop is had no adverse effects.
Claims (7)
1. containing a bactericidal composition for polyoxin and oxazole compounds, it is characterized in that: bactericidal composition is comprised of effective active composition and auxiliary agent, the weight ratio of effective active composition polyoxin and famoxadone is 64:1 to 1:64.
2. according to the bactericidal composition described in claim l, it is characterized in that: wherein polyoxin is Yu the weight ratio of famoxadone is 16:1 to 1:16.
3. bactericidal composition according to claim 2, is characterized in that: wherein polyoxin is Yu the weight ratio of famoxadone is 8:1 to 1:8.
4. according to the bactericidal composition described in claim l, it is characterized in that: wherein effective active component content accounts for 1～90% of gross weight.
5. bactericidal composition according to claim 4, is characterized in that: wherein effective active component content accounts for 10～80% of gross weight.
6. according to the bactericidal composition described in claim l, be used for preventing and treating the application of the disease on fruit tree, vegetables, cereal crop.
7. application according to claim 6, is characterized in that: described disease is downy mildew, gray mold, epidemic disease, spot defoliation, powdery mildew, anthracnose, fusarium wilt, damping off, bakanae disease.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0460575A1 (en) * | 1990-06-05 | 1991-12-11 | Ciba-Geigy Ag | Aromatic compounds |
| CN1802910A (en) * | 2006-01-24 | 2006-07-19 | 浙江林学院 | Agricultural chemicals preparation containing pyracetic acid |
| CN1930991A (en) * | 2006-10-01 | 2007-03-21 | 黄高 | Re-compounded germicide containing Bucillus licheniformis |
| WO2009082939A1 (en) * | 2007-12-19 | 2009-07-09 | Rotam Agrochem International Co., Ltd | Agrochemical composition and method for preparing the same |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0460575A1 (en) * | 1990-06-05 | 1991-12-11 | Ciba-Geigy Ag | Aromatic compounds |
| CN1802910A (en) * | 2006-01-24 | 2006-07-19 | 浙江林学院 | Agricultural chemicals preparation containing pyracetic acid |
| CN1930991A (en) * | 2006-10-01 | 2007-03-21 | 黄高 | Re-compounded germicide containing Bucillus licheniformis |
| WO2009082939A1 (en) * | 2007-12-19 | 2009-07-09 | Rotam Agrochem International Co., Ltd | Agrochemical composition and method for preparing the same |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
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Address after: 715500 Weinan City, Shaanxi province Pucheng County agricultural base industrial park Applicant after: Shaanxi Meibang Pesticide Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Applicant before: Shaanxi Meibang Pesticide Co., Ltd. |
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Inventor after: Zhong Zhong Inventor after: Liu An Inventor after: Huang Xiong Inventor after: Cao Junyang Inventor after: Deng Song Inventor before: Zhang Wei Inventor before: Gao Chao Inventor before: Cao Qiaoli |
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Effective date of registration: 20170421 Address after: 414000 Hunan Province, Yueyang economic and Technological Development Zone Agricultural seed market building 4 baling Road No. 11 Patentee after: Hunan Xinsheng HuaFeng seeds Co. Ltd. Address before: 715500 Weinan City, Shaanxi province Pucheng County agricultural base industrial park Patentee before: Shaanxi Meibang Pesticide Co., Ltd. |
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