CN101940216A - Water dispersible granule compounded by difenoconazole and propineb - Google Patents
Water dispersible granule compounded by difenoconazole and propineb Download PDFInfo
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- CN101940216A CN101940216A CN2010102673671A CN201010267367A CN101940216A CN 101940216 A CN101940216 A CN 101940216A CN 2010102673671 A CN2010102673671 A CN 2010102673671A CN 201010267367 A CN201010267367 A CN 201010267367A CN 101940216 A CN101940216 A CN 101940216A
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- water dispersible
- difenoconazole
- propineb
- dispersible granules
- sodium salt
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Abstract
The invention relates to a sterilization composite with effective components consisting of difenoconazole and propineb, comprising the following components in percentage by weight: 5-11 percent of the difenoconazole, 50-70 percent of the propineb, 4-10 percent of dispersant, 2-5 percent of wetting agent, 5-10 percent of disintegrant, 2-6 percent of hard water resistant agent and the balance of filler, and the total percentage of all the components reaches 100 percent. The sterilization composition has the advantages of high efficiency, low toxicity, long efficacy duration, high product utilization rate, cost reduction and simple use, efficiently relieves the drug resistance and adopts extrusion granulation or boiling granulation as a granulation mode.
Description
Technical field
The invention belongs to the technical field of agriculture chemical compounding, be specifically related to the composite water dispersible granules bactericidal composition of Difenoconazole and Propineb.
Background technology
Difenoconazole belongs to triazole bactericidal agent, is sterol demethylation inhibitor, has good interior absorption, advantages such as this product has efficiently, low toxicity, fungicidal spectrum is wide, the lasting medicine time is long.This product is a colorless solid, 76 ℃ of fusing points, 220 ℃/4Pa of boiling point, vapour pressure 120nPa (20 ℃).Dissolubility (20 ℃): water 3.3 mg/litre, be soluble in organic solvent, K (ow) 20000 (by anti-phase TLC) ,≤300 ℃ are stable.The main preparation of Difenoconazole has 10% water dispersible granules, 25% missible oil, 3% suspension seed-coating agent at present.Mainly to Ascomycetes, Basidiomycetes and comprise Alternaria, Ascochyta, the mould genus of tail spore, Colletotrichum, ball Cuo Pseudomonas, Phoma, Ramularia, Septoria, Venturia partly know disease; Erysiphaceae, Uredinales and some are planted and passed pathogen lasting protection and therapeutic action are arranged, and be also fine to bitter rot or anthracnose of grape, white rot effect.
Propineb is a kind of wide spectrum, quick-acting protective fungicide, and its bactericidal mechanism is for suppressing the oxidation of pyruvic acid in the cause of disease thalline.These product are white or micro-yellow powder, decompose more than 160 ℃, and vapour pressure＜1mPa (20 ℃), dissolubility (20 ℃): water 0.01g/L, in the common solvent＜0.1g/L.Stable upon storage under cold, drying condition is decomposed in moist strong acid, highly basic medium.Main preparation is 70% Wettable propineb powder.Early late blight, mango anthracnose have good control efficiency to Chinese cabbage downy mildew, cucumber downy mildew, tomato.
The problem that exists is at present, in single agent use, produced pesticide resistance for above-mentioned Difenoconazole and Propineb, and control efficiency is affected the availability reduction of medicine, use cost is higher, and the use of single agent has increased the harm to environment to a certain extent.
Summary of the invention
The objective of the invention is at the problem of above-mentioned existence and a kind of Difenoconazole and the composite water dispersible granules of Propineb are provided; it has efficiently, low toxicity, lasting medicine phase long, product utilization rate height; can reduce cost; use simple advantage; and effectively alleviated drug-fast problem, granulation mode of the present invention is extruder grain or fluidized granulating.
The water dispersible granules bactericidal composition that Difenoconazole of the present invention and Propineb are composite, it consists of following component by weight:
Difenoconazole 5-11%; Propineb 50-70%; Dispersant 4-10%; Wetting agent 2-5%; Disintegrant 5-10%; Anti-hard water agent 2-6%; The filler surplus.
Dispersant described in the present invention is: one or more in acrylic copolymer sodium salt, polyoxyethylene polyoxypropylene block copolymer, lignin sulfonic acid sodium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt.
Wetting agent described in the present invention is: one or more in alkylsurfuric acid sodium salt, alkyl benzene sulphonate sodium salt, alkyl naphthalene sulfonic acid sodium salt, the alkylaryl polyoxyethylene ether sulfate.
Disintegrant described in the present invention is: one or more in ammonium sulfate, anhydrous sodium sulfate, sodium carboxymethyl starch, the polyvinylpyrrolidone.
Anti-hard water agent described in the present invention is: one or more in sodium phosphate trimer, five polyphosphate sodiums, EDTA sodium salt, the laminated crystal of sodium disilicate.
Filler of the present invention is: one or more in corn starch, fine particle calcium carbonate, kaolin, talcum powder, the bentonite.
The preparation method of complex composition of the present invention is: carry out ultramicro grinding after Difenoconazole and the former medicine of Propineb and auxiliary agent, filler are mixed, pulverize and add water after finishing and mediate and carry out extruder grain, through obtaining finished product after the oven dry; Or after ultramicro grinding, adopt fluidized granulating to obtain finished product.
Beneficial effect of the present invention is, Difenoconazole and these two kinds of active ingredients of Propineb are prepared into water dispersible granules, its control efficiency and availability have been improved, compare single agent, availability with better bactericidal effect and active ingredient can reduce unit cost, alleviates the generation of disease insect pest resistance, and effectively alleviated harm to environment, alleviated the pressure of environment.While, the present invention was to these two kinds different granulation modes of extruder grain and fluidized granulating, the finished product suspensibility height that makes, and disintegration time is short, has good dispersiveness to reach suspension again, and heat storage stability is good.
Embodiment
Embodiment 1:
With the former powder 26Kg of Difenoconazole, the former powder 330Kg of Propineb, dispersant acrylic copolymer sodium salt 30Kg, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 20Kg, wetting agent alkylsurfuric acid sodium salt 25Kg, disintegrant ammonium sulfate 25Kg, anti-hard water agent EDTA disodium 15Kg, filler corn starch 20Kg, fine particle calcium carbonate 9Kg, put in the cone-type mixer, mixed 30 minutes, carry out comminution by gas stream, make its fineness can reach 800 orders; The material of pulverizing is added water mediate, amount of water is 80Kg, and the material of having mediated is carried out extruder grain, by the fluid bed dryer oven dry, obtains finished product through screening more again.Product index is as shown in table 1 after testing:
Table 1 product index parameter
Embodiment 2:
With the former powder 26Kg of Difenoconazole, the former powder 330Kg of Propineb, dispersant acrylic copolymer sodium salt 30Kg, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 20Kg, wetting agent alkylsurfuric acid sodium salt 25Kg, disintegrant ammonium sulfate 25Kg, anti-hard water agent EDTA disodium 15Kg, filler corn starch 20Kg, fine particle calcium carbonate 9Kg, put in the cone-type mixer, mixed 30 minutes, carry out comminution by gas stream, make its fineness can reach 800 orders; The material of pulverizing joined carry out granulation in the fluidized granulating machine, through obtaining finished product after the screening.Product index is as shown in table 2 after testing:
Table 2 product index parameter
Embodiment 3:
With the former powder 11Kg of Difenoconazole, the former powder 62Kg of Propineb, dispersant polyoxyethylene polyoxypropylene block copolymer 8Kg, wetting agent alkylaryl polyoxyethylene ether sulfate 3Kg, disintegrant ammonium sulfate 8Kg, anti-hard water agent sodium phosphate trimer 3Kg, filler corn starch 5Kg, put in the cone-type mixer, mixed 30 minutes, carry out comminution by gas stream, make its fineness can reach 800 orders; The material of pulverizing is added water mediate, amount of water is 16Kg, and the material of having mediated is carried out extruder grain, by the fluid bed dryer oven dry, obtains finished product through screening more again.Index is as shown in table 3 after testing:
Table 3 product index parameter
Embodiment 4
With the former powder 11Kg of Difenoconazole, the former powder 62Kg of Propineb, dispersant acrylic copolymer sodium salt 8Kg, wetting agent alkylaryl polyoxyethylene ether sulfate 3Kg, disintegrant ammonium sulfate 8Kg, anti-hard water agent sodium phosphate trimer 3Kg, filler corn starch 5Kg, put in the cone-type mixer, mixed 30 minutes, carry out comminution by gas stream, make its fineness can reach 800 orders; The material of pulverizing joins and carries out granulation in the fluidized granulating machine, obtains finished product through screening again.Index is as shown in table 4 after testing:
Table 4 product index parameter
The test of pesticide effectiveness
1, material and method
1.1 reagent agent
1.1.1 70% Wettable propineb powder, Shanggezhilu Biosciences Co., Ltd., Shaanxi; 10% micro-emulsion of phenyl ether methyl cyclic-azole, Shandong United Pesticide Industry Co., Ltd..
1.1.2 55% Difenoconazole Propineb water dispersible granules, 60% Difenoconazole Propineb water dispersible granules, 70% Difenoconazole Propineb water dispersible granules, 80% Difenoconazole Propineb water dispersible granules.
1.2 Treatment Design
1.2.1 700 times of 70% Wettable propineb powders; 1500 times of 10% micro-emulsion of phenyl ether methyl cyclic-azole.
1.2.2 1000 times of 55% Difenoconazole Propineb water dispersible granules; 1500 times of 60% Difenoconazole Propineb water dispersible granules; 2000 times of 70% Difenoconazole Propineb water dispersible granules agent; 2500 times of 80% Difenoconazole Propineb water dispersible granules.
1.2.3 blank (ck)
1.3 using method
The sub-district is provided with: 5 apple trees in every sub-district, establish four repetitions, totally 20 sub-districts.Arrange by random groups the sub-district, each small plot experiment apple variety, growing way, rich water quality management condition basically identical.
Spraying time and method: in the dispenser for the first time of alternaria leaf spot of apple their early stage, later on every dispenser in 10 days once, the full phase is total to dispenser three times.Evenly squirt apple leaf degree of being with the manual compression sprayer.
1.4 investigation method
1.4.1 security survey
Sub-district apple development situation is respectively handled in irregular observation after the dispenser, and the record apple is analyzed the safety of medicament to apple to the reaction or the symptom of chemical damage of medicament.
1.4.2 preventive effect effect research
Respectively investigated once in 7 days before each dispenser and after the dispenser for the third time, the full phase is investigated four times altogether.Method is whole plant and a blade in the investigation sub-district, and record the investigation number of blade, the sick number of sheets and blade occurring degree calculate disease index and preventive effect.
The blade grade scale:
0 grade: no scab
1 grade: lesion area accounts for the whole blade area below 5%;
3 grades: lesion area accounts for below the whole blade area 6%-15%;
5 grades: lesion area accounts for below the whole blade area 16%-25%;
7 grades: lesion area accounts for below the whole blade area 26%-50%;
9 grades: lesion area accounts for the whole blade area more than 51%;
Disease index (%)=∑ [(the sick numbers of sheets at different levels * relative level numerical value)]/(investigating total number of sheets * 9) * 100
Preventive effect (%)=[1-(the preceding clear area of dispenser disease refer to * dispenser post processing zone disease refer to)]/(after the dispenser clear area disease refer to * dispenser pre-treatment district disease refers to) * 100
2 medicaments are to the safety of apple
Observe after the dispenser, each sub-district apple development is normal, any poisoning situation do not occur.
3 results and analysis
3.1 1000 times of 55% Difenoconazole Propineb water dispersible granules are to alternaria leaf spot of apple control efficiency (seeing Table 5)
The table 5 control efficiency table of comparisons
By table 5 as seen, composite water dispersible granules all has better preventive effect to alternaria leaf spot of apple, illustrates that Difenoconazole and Propineb have obvious synergistic effect after composite, can also save medication, reduces use cost.
3.2 1500 times of 60% Difenoconazole Propineb water dispersible granules are to alternaria leaf spot of apple control efficiency (seeing Table 6)
The table 6 control efficiency table of comparisons
By table 6 as seen, composite water dispersible granules all has better preventive effect to alternaria leaf spot of apple, illustrates that Difenoconazole and Propineb have obvious synergistic effect after composite, can also save medication, reduces use cost.
3.3 2000 times of 70% Difenoconazole Propineb water dispersible granules agent are to alternaria leaf spot of apple control efficiency (seeing Table 7)
The table 7 control efficiency table of comparisons
By table 7 as seen, composite water dispersible granules has better preventive effect to alternaria leaf spot of apple, illustrates that Difenoconazole and Tebuconazole have obvious synergistic effect after composite, can also save medication, reduces use cost.
3.4 2500 times of 80% Difenoconazole Propineb water dispersible granules are to alternaria leaf spot of apple control efficiency (seeing Table 8)
The table 8 control efficiency table of comparisons
By table 8 as seen, composite water dispersible granules has better preventive effect to alternaria leaf spot of apple, illustrates that Difenoconazole and Tebuconazole have obvious synergistic effect after composite, can also save medication, reduces use cost.
Claims (6)
1. the composite water dispersible granules bactericidal composition of Difenoconazole and Propineb, it consists of following component by weight:
Difenoconazole 5-11%; Propineb 50-70%; Dispersant 4-10%; Wetting agent 2-5%; Disintegrant 5-10%; Anti-hard water agent 2-6%; The filler surplus.
2. according to claims 1 described water dispersible granules bactericidal composition, it is characterized in that described dispersant is one or more in acrylic copolymer sodium salt, polyoxyethylene polyoxypropylene block copolymer, lignin sulfonic acid sodium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt.
3. according to claims 1 described water dispersible granules bactericidal composition, it is characterized in that described wetting agent is one or more in alkylsurfuric acid sodium salt, alkyl benzene sulphonate sodium salt, alkyl naphthalene sulfonic acid sodium salt, the alkylaryl polyoxyethylene ether sulfate.
4. according to claims 1 described water dispersible granules bactericidal composition, it is characterized in that described disintegrant is one or more in ammonium sulfate, anhydrous sodium sulfate, sodium carboxymethyl starch, the polyvinylpyrrolidone.
5. according to claims 1 described water dispersible granules bactericidal composition, it is characterized in that described anti-hard water agent is one or more in sodium phosphate trimer, five polyphosphate sodiums, EDTA sodium salt, the laminated crystal of sodium disilicate.
6. according to claims 1 described water dispersible granules bactericidal composition, it is characterized in that described filler is one or more in corn starch, fine particle calcium carbonate, kaolin, talcum powder, the bentonite.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102673671A CN101940216A (en) | 2010-08-31 | 2010-08-31 | Water dispersible granule compounded by difenoconazole and propineb |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102673671A CN101940216A (en) | 2010-08-31 | 2010-08-31 | Water dispersible granule compounded by difenoconazole and propineb |
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| CN101940216A true CN101940216A (en) | 2011-01-12 |
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| CN2010102673671A Pending CN101940216A (en) | 2010-08-31 | 2010-08-31 | Water dispersible granule compounded by difenoconazole and propineb |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999380A (en) * | 2010-12-03 | 2011-04-06 | 陕西美邦农药有限公司 | Difenoconazole- and propineb-containing pesticidal composition |
| CN102077839A (en) * | 2011-03-10 | 2011-06-01 | 陕西美邦农药有限公司 | Antibacterial composition containing ipconazole and triazole compounds |
| CN102349525A (en) * | 2011-09-29 | 2012-02-15 | 云南省林业科学院 | Medicine for preventing powdery mildew of Jatropha curcas L. and prevention method |
| CN110870475A (en) * | 2019-10-31 | 2020-03-10 | 浙江中山化工集团股份有限公司 | Chlorantraniliprole water dispersible granule with high hard water resistance and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2036438A1 (en) * | 2007-09-12 | 2009-03-18 | Bayer CropScience AG | Post-harvest treatment |
| CN101637170A (en) * | 2009-09-08 | 2010-02-03 | 陕西先农生物科技有限公司 | Difenoconazole-thiram water dispersible granules |
| CN101703057A (en) * | 2009-11-13 | 2010-05-12 | 陕西上格之路生物科学有限公司 | Agricultural germicide composite containing famoxadone |
| CN101755780A (en) * | 2010-01-12 | 2010-06-30 | 惠州市中迅化工有限公司 | Pesticidal composition containing tebuconazole and propineb and application thereof |
-
2010
- 2010-08-31 CN CN2010102673671A patent/CN101940216A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2036438A1 (en) * | 2007-09-12 | 2009-03-18 | Bayer CropScience AG | Post-harvest treatment |
| CN101637170A (en) * | 2009-09-08 | 2010-02-03 | 陕西先农生物科技有限公司 | Difenoconazole-thiram water dispersible granules |
| CN101703057A (en) * | 2009-11-13 | 2010-05-12 | 陕西上格之路生物科学有限公司 | Agricultural germicide composite containing famoxadone |
| CN101755780A (en) * | 2010-01-12 | 2010-06-30 | 惠州市中迅化工有限公司 | Pesticidal composition containing tebuconazole and propineb and application thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101999380A (en) * | 2010-12-03 | 2011-04-06 | 陕西美邦农药有限公司 | Difenoconazole- and propineb-containing pesticidal composition |
| CN101999380B (en) * | 2010-12-03 | 2013-10-09 | 陕西美邦农药有限公司 | Difenoconazole- and propineb-containing pesticidal composition |
| CN102077839A (en) * | 2011-03-10 | 2011-06-01 | 陕西美邦农药有限公司 | Antibacterial composition containing ipconazole and triazole compounds |
| CN102349525A (en) * | 2011-09-29 | 2012-02-15 | 云南省林业科学院 | Medicine for preventing powdery mildew of Jatropha curcas L. and prevention method |
| CN110870475A (en) * | 2019-10-31 | 2020-03-10 | 浙江中山化工集团股份有限公司 | Chlorantraniliprole water dispersible granule with high hard water resistance and preparation method thereof |
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Application publication date: 20110112 |