CN101637170A - Difenoconazole-thiram water dispersible granules - Google Patents
Difenoconazole-thiram water dispersible granules Download PDFInfo
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- CN101637170A CN101637170A CN200910023832A CN200910023832A CN101637170A CN 101637170 A CN101637170 A CN 101637170A CN 200910023832 A CN200910023832 A CN 200910023832A CN 200910023832 A CN200910023832 A CN 200910023832A CN 101637170 A CN101637170 A CN 101637170A
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Abstract
The invention discloses a water dispersible granule sterilizer composition consisting of difenoconazole and thiram which serve as effectively active components, wherein the weight percent of the difenoconazole is 1-10%, the weight percent of the thiram is 60-80%, and the rest is adjuvant which comprises wetting agent, dispersant, disintegrant, carrier and bonder. Demonstrated by tests, the water dispersible granule sterilizer composition has good dispersity, realizes suspension with indefinite duration, achieves good heat storage stability and is highly adhesive and long-acting during the use;in addition, the water dispersible granule sterilizer composition has high sterilization efficiency during the application, and according to the tests, the water dispersible granule sterilizer composition achieves an effect which is more than 80 percent when used for preventing and curing a plurality of diseases of fruit trees and vegetables.
Description
Technical field
The present invention relates to a kind of water dispersible granules bactericidal composition, particularly the water dispersible granules bactericidal composition be made up of Difenoconazole and tmtd of effective active composition belongs to technical field of compounded pesticide.
Background technology
Difenoconazole belongs to an insecticides that contains triazole, english common name difenoconazole, its action site is to destroy ergosterol synzyme demethylation in the fungal cell wall chitin is synthetic, suppress the synthetic of ergosterol, cause that fungal cell wall is chitinous to break, cause cytoplasmic slime flux, cause cell death.The formulation of using has 3% difenoconazole suspending kind, 10% water dispersion granule etc. at present.
Tmtd, English common name thiram belongs to protective fungicide, to various crop downy mildew, eqpidemic disease, anthracnose, cereal class smut, seedling stage yellow blight the better prevention effect is arranged.Shortcomings such as at present, the pesticidal preparations that with the tmtd is effective ingredient in actual use, exists dust pollution serious based on 50%, 70%, 80% wetting powder, environment and health are had very big harm, and availability is low, and the lasting period is short.
The inventor finds tmtd and Difenoconazole active component be mixed to be become water dispersion granule and can improve its control efficiency and availability; compare the availability of single agent and higher to the protective effect of environment; can reduce the pharmacy application amount, save cost, the generation that slows down pest resistance.
Summary of the invention
The object of the present invention is to provide a kind of efficient, low-residual, high usage and the tmtd of environmental protection and the water dispersion granule of Difenoconazole.
In order to overcome the defective that existing single component formulations itself and wetting powder formulation exist, technical scheme of the present invention is to solve like this:
Difenoconazole and tmtd water dispersible granules, its component and percentage by weight are: Difenoconazole 1%～10%, tmtd 60%～80%, all the other are auxiliary agent.The Difenoconazole percentage by weight is preferably 3%～10% in the described water dispersible granules, and tmtd is 70%～80%.
Described auxiliary agent comprises wetting agent, dispersant, disintegrant, carrier and binding agent, and its percentage by weight is respectively: wetting agent 2%～8%, and dispersant 3%～10%, disintegrant 3%～8%, binding agent 2%～10%, carrier are surplus.
Described wetting agent is alkyl sulfate, alkylsulfonate, draw back in powder or the naphthalene sulfonate one or more.
Described dispersant is one or more in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate or the naphthalene sulfonic acid-formaldehyde condensation product sodium salt.
Described disintegrant is one or more in modified starch, ammonium sulfate or the glucose.
Described carrier is one or more in diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite or the potter's clay.
Described binding agent is one or more in corn starch, Sodium Polyacrylate or the carboxymethyl cellulose class.
The preparation method of above-mentioned Difenoconazole tmtd water dispersible granules comprises the steps:
1. choose raw material according to the prescription of Difenoconazole and tmtd water dispersible granules, it is mixed;
2. morcel through air-flow and obtain female powder after machine carries out ultramicro grinding with above mixture;
3. the female powder that obtains after the ultramicro grinding is mixed by prescription and binding agent;
4. above mixture is carried out granulation on comminutor;
5. above grain dress thing is dried.
Difenoconazole tmtd water dispersible granules is to disease tool special efficacys such as pear scab, rust class, powdery mildew class, the mould worry of apple, browns spot of grape.Interior absorption is extremely strong, consumption is low, low toxicity, free from environmental pollution be its maximum characteristics.Because interior absorption is extremely strong, absorbed by plant tissue in about 2 hours behind the spray cloth, its drug effect is not executed back 2 hours precipitation affects.Except that having high protective effect, also have strong therapeutic action, even germ invaded plants tissue also can kill it, disease no longer develops.Not only protect Lao Ye, and the protection young leaves.In preventing and treating the disease process, show prevention, treat, root out three large effects, resistance of rainwater washing against, lasting medicine, its lasting period was than other identical formulation bactericide long 3-4 days.After being sprayed onto on the crop, can slowly be converted into nontoxic compound, harmless, natural enemy is had no adverse effects.
Advantage of the present invention and good effect:
Water dispersible granules of the present invention has overcome the shortcoming of wetting powder and suspending agent, in processing and use, has reduced peasant's use cost and to the pollution of environment.The present invention has the active component content height owing to add the heterogeneity auxiliary agent, and disintegration rate is fast, and dispersive property is good, heat storage steady performance.Bactericidal property height in use, safety is good.
The Difenoconazole tmtd water dispersible granules that the present invention's prescription is processed the results showed that this product has good dispersiveness, and working substance suspends indefinite duration; Heat storage stability is good, and the height of adhesion rate in use, lasting period are long; The present invention is the bactericidal potency height in production application, through evidence multiple fruit tree and vegetable disease-controlling effect is reached more than 80%; Safety is good, and crops are not had poisoning.
Embodiment
Below in conjunction with embodiment content of the present invention is described further.
Example of formulations 1
Take by weighing the former powder 3% of Difenoconazole, the former powder 79% of tmtd, dispersant naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4%, wetting agent dodecyl sulphate hydrogen sodium 2% draws back powder 2%, disintegrant modified starch 4%, carrier kaolin 2%; It is pressed conventional method mix, after stirring, pulverize through airslide disintegrating mill and to obtain female powder, the binding agent Sodium Polyacrylate 80 of female powder and 4% is mixed, granulation is then dried, and sieving obtains about 96% Difenoconazole, tmtd water dispersible granules.Through the check active constituent content is Difenoconazole 2.4% tmtd 78.2%, moisture≤2.5%, pH value 7.4, screening (by the 75um sieve) 〉=98%, suspensibility 〉=65%, lasting foaming characteristic (1min)≤10mL, wetability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.
Example of formulations 2
Take by weighing the former powder 6% of Difenoconazole, the former powder 76% of tmtd, dispersant lignosulfonates 3%, wetting agent sodium butylnaphthalenesulfonate 3%, dodecyl sulphate hydrogen sodium 1%, disintegrant glucose 4%, carrier white carbon 3%; It is pressed conventional method mix, after stirring, pulverize through airslide disintegrating mill and to obtain female powder, the binding agent Sodium Polyacrylate 80 of female powder and 4% is mixed, granulation is then dried, and sieving obtains about 96% Difenoconazole, tmtd water dispersible granules.Through the check active constituent content is Difenoconazole 5.2% tmtd 75.1%, moisture≤2.5%, pH value 7.2 screenings (by the 75um sieve) 〉=98%, suspensibility 〉=65%, lasting foaming characteristic (1min)≤10mL, wetability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.
Example of formulations 3
Take by weighing the former powder 10% of Difenoconazole, the former powder 72% of tmtd, dispersant naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, wetting agent dodecyl sulphate hydrogen sodium 1% draws back powder 2.5%, disintegrant ammonium sulfate 5.5%; It is pressed conventional method mix, after stirring, pulverize through airslide disintegrating mill and to obtain female powder, the binding agent Sodium Polyacrylate 80 of female powder and 6% is mixed, granulation is then dried, and sieving obtains about 96% Difenoconazole, tmtd water dispersible granules.Through the check active constituent content is Difenoconazole 9% tmtd 71%, moisture≤2.5%, pH value 7.6 screenings (by the 75um sieve) 〉=98%, suspensibility 〉=65%, lasting foaming characteristic (1min)≤10mL, wetability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.
Toxicity Determination result
1, test medicine
Difenoconazole (Difenoconazole) 95% former medicine; Tmtd (Thiram) 96% former medicine.
2, test method
With reference to giving birth to the accurate method NY/T1156.2-2006 of mark, adopt the pastille medium therapy: get the soup 3mL of each single agent and mixture series concentration, add in the PDA medium of the 27mL that is cooled to 45 ℃, make the pastille culture medium flat plate of required final concentration.Produce 6mm diameter mycelia piece from the pear cucumerinum colony edge of cultivating 4 days then, move on each serial pastille medium, mycelia faces down, and every processing repeats for 4 times.Dispose, place 28 ℃ the biochemical incubator of constant temperature to cultivate, measure colony diameter after 5 days, calculate growth inhibition ratio.
3, interpretation of result
With reference to giving birth to the accurate method NY/T1156.6-2006 of mark, according to Sun﹠amp; The co-toxicity coefficient method (CTC) of Johnson (1960) is estimated the synergistic effect of pharmacy mix, and promptly CTC≤80 are antagonism, and 80＜CTC＜120 are summation action, and CTC 〉=120 are synergistic effect.
The percentage composition of B medicament in toxicity index * 100 mixtures of the percentage composition+medicament B of A medicament in toxicity index * 100 mixtures of the theoretical toxicity index (TTI) of mixture=medicament A
Table 1 Difenoconazole and tmtd are mixed to the toxicity test result of pear cucumerinum
| Medicament and proportioning | Regression equation (Y=a+bx) | Correlation coefficient (r) | ??EC 50Value (mg/L) | 95% confidence limit (mg/L) | Co-toxicity coefficient (CTC) |
| Difenoconazole (A) | ??Y＝4.9380+1.3398x | ??0.9933 | ??1.11 | ??0.67～1.85 | ??- |
| Tmtd (B) | ??Y＝3.4717+1.1134x | ??0.9953 | ??23.59 | ??15.47～35.97 | ??- |
| ??A∶B＝1∶1 | ??Y＝4.7569+1.0223x | ??0.9934 | ??1.73 | ??1.05～2.85 | ??122.55 |
| ??A∶B＝1∶5 | ??Y＝4.4590+0.9395x | ??0.9953 | ??3.77 | ??2.45～5.81 | ??142.98 |
| ??A∶B＝1∶10 | ??Y＝4.0875+1.2452x | ??0.9991 | ??5.41 | ??4.44～6.60 | ??153.43 |
| ??A∶B＝1∶15 | ??Y＝4.1276+1.1390x | ??0.9974 | ??5.83 | ??4.18～8.14 | ??178.51 |
| ??A∶B＝1∶20 | ??Y＝3.9867+1.1191x | ??0.9966 | ??8.04 | ??5.38～12.00 | ??149.29 |
Conclusion: Difenoconazole and tmtd are mixed to the virulence of pear cucumerinum in the ratio of 1: 1,1: 5,1: 10,1: 15 and 1: 20, the result shows, Difenoconazole and tmtd are mixed with above-mentioned 5 ratios, pear cucumerinum are all shown as synergistic effect, its EC
50Value is respectively 1.73,3.77,5.41,5.83 and 8.04mg/L, and co-toxicity coefficient is respectively 122.55,142.98,153.43,178.51 and 149.29, and wherein the two is the most obvious with 1: 15 ratio mixed synergies.
Biological Examples 1 is prevented and treated the pear scab test
80% Difenoconazole tmtd water dispersible granules (embodiment 1～3) of the present invention has carried out the theatre field trial in 2007, test main points and result are as follows:
(1), materials and methods:
1, the Difenoconazole tmtd water dispersible granules of test medicine: embodiment 1～3;
2, contrast medicament: 60% Difenoconazole thiram wettable powder, 10% difenoconazole water dispersible granule, 70% thiram wettable powder
3, controlling object: pear scab
4, experiment is handled and method:
(2), experiment is handled:
(1) 1500 times of liquid of Difenoconazole tmtd water dispersible granules
1000 times of liquid of (2) 60% Difenoconazole thiram wettable powders
(Shandong Dongtai Agrochemical Co., Ltd)
1500 times of liquid of (3) 10% difenoconazole water dispersible granules
(Shandong Province Qingdao Dongsheng Pharmaceutical Industry Co. Ltd. produces)
1500 times of liquid of (4) 70% thiram wettable powders
(Tai Yuan development in science and technology Co., Ltd in Qingdao, Shandong Province produces)
(5) blank (clear water)
Randomized arrangement, every processing sub-district 3-5 strain tree, 3 repetitions; Respectively on July 9th, 2007, July 24, August 9 with power driven sprayer (operating pressure 2.0-2.3kg/m
3, shower nozzle aperture 1.2mm) evenly spray four processing, blank does not spray medicine, and treatment measures such as other waters, fertilising are all identical.
(3), investigation method:
Investigation morbidity radix before the dispenser for the first time, 7 days investigation prevention results after each dispenser, each handles 2 trees in sub-district, and whole fruits are investigated in every strain.
(4), result and analysis
Table 2 Difenoconazole tmtd water dispersible granules control pear scab result of the test
| Repeat | Preventive effect |
| 1000 times of liquid of 60% Difenoconazole thiram wettable powder | ??77.17 |
| 600 times of liquid of 10% difenoconazole water dispersible granule | ??71.16 |
| 1000 times of liquid of 70% thiram wettable powder | ??70.59 |
| 1 1500 times of liquid of embodiment | ??84.40 |
| 2 1500 times of liquid of embodiment | ??86.35 |
| 3 1500 times of liquid of embodiment | ??88.14 |
| Blank (clear water) |
In sum, Difenoconazole tmtd water dispersible granules has good effect and its bactericidal effect apparently higher than single agent and other formulations to the control of pear scab; The present composition can slow down the generation of resistance, and the preparation less residue is pollution-free to crop, and safety is good, meets the security requirement of pesticidal preparations.
Claims (9)
1, Difenoconazole and tmtd water dispersible granules, its weight percentages is: Difenoconazole 1%～10%, tmtd 60%～80%, all the other are auxiliary agent.
2, water dispersible granules according to claim 1 is characterized in that: the Difenoconazole percentage by weight is 3%～10%, and tmtd is 70%～80%.
3, water dispersible granules according to claim 1 and 2 is characterized in that: described auxiliary agent is a wetting agent 2%～8%, dispersant 3%～10%, and disintegrant 3%～8%, binding agent 2%～10%, carrier are surplus.
4, water dispersible granules according to claim 3 is characterized in that: described wetting agent is alkyl sulfate, alkylsulfonate, draw back in powder or the naphthalene sulfonate one or more.
5, water dispersible granules according to claim 3 is characterized in that: described dispersant is one or more in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate or the naphthalene sulfonic acid-formaldehyde condensation product sodium salt.
6, water dispersible granules according to claim 3 is characterized in that: described disintegrant is one or more in modified starch, ammonium sulfate or the glucose.
7, water dispersible granules according to claim 3 is characterized in that: described carrier is one or more in diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite or the potter's clay.
8, water dispersible granules according to claim 3 is characterized in that: described binding agent is one or more in corn starch, Sodium Polyacrylate or the carboxymethyl cellulose class.
9, described Difenoconazole of claim 1 and the tmtd water dispersible granules application in pear scab, rust class, powdery mildew class, the mould worry of apple and brown spot of grape control.
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| CN200910023832A CN101637170A (en) | 2009-09-08 | 2009-09-08 | Difenoconazole-thiram water dispersible granules |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940216A (en) * | 2010-08-31 | 2011-01-12 | 周保东 | Water dispersible granule compounded by difenoconazole and propineb |
| CN105340931A (en) * | 2015-11-03 | 2016-02-24 | 北京市农林科学院 | Sterilization and bacteriostasis composition for preventing and treating grape powdery mildew and its preparation and use |
| US20160270392A1 (en) * | 2013-12-05 | 2016-09-22 | Upl Limited | Agrochemical compositions having increased rainfastness |
| CN113693078A (en) * | 2021-10-28 | 2021-11-26 | 潍坊新绿化工有限公司 | Herbicide containing anilofos, preparation method and application thereof |
-
2009
- 2009-09-08 CN CN200910023832A patent/CN101637170A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940216A (en) * | 2010-08-31 | 2011-01-12 | 周保东 | Water dispersible granule compounded by difenoconazole and propineb |
| US20160270392A1 (en) * | 2013-12-05 | 2016-09-22 | Upl Limited | Agrochemical compositions having increased rainfastness |
| US10694741B2 (en) * | 2013-12-05 | 2020-06-30 | Upl Limited | Agrochemical compositions having increased rainfastness |
| CN105340931A (en) * | 2015-11-03 | 2016-02-24 | 北京市农林科学院 | Sterilization and bacteriostasis composition for preventing and treating grape powdery mildew and its preparation and use |
| CN113693078A (en) * | 2021-10-28 | 2021-11-26 | 潍坊新绿化工有限公司 | Herbicide containing anilofos, preparation method and application thereof |
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Application publication date: 20100203 |