CN101601397A - A kind of bactericidal composition that contains Flutriafol and zineb - Google Patents
A kind of bactericidal composition that contains Flutriafol and zineb Download PDFInfo
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- CN101601397A CN101601397A CNA2009100233763A CN200910023376A CN101601397A CN 101601397 A CN101601397 A CN 101601397A CN A2009100233763 A CNA2009100233763 A CN A2009100233763A CN 200910023376 A CN200910023376 A CN 200910023376A CN 101601397 A CN101601397 A CN 101601397A
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- zineb
- flutriafol
- bactericidal composition
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Abstract
The invention discloses a kind of bactericidal composition, its effective active composition contains Flutriafol and zineb, wherein the percentage by weight of Flutriafol and zineb is 1～15: 80～1, the effective active composition adds auxiliary agent and excipients is made wetting powder, water dispersible granules, suspending agent, is mainly used in powdery mildew, scab, the spot defoliation of control cereal, vegetables and fruit tree.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on the vegetables fruit diseases that contains Flutriafol and zineb.
Technical background
Flutriafol (flutriafol) is the triazole bactericidal agent that American Cyanamid Company produces.Molecular formula: C16H13F2N30, chemical name: α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol.
Flutriafol belongs to triazole bactericidal agent, has interior absorption, conducts in plant corpus, and disease is had protection and therapeutic action.Can prevent and treat the cereal crop powdery mildew, Helminthosporium, Puccinia, shell pin Pseudomonas pathogen also can be cooked seed treatment, prevents and treats soil-borne disease and seed-borne disease.The cereal powdery mildew there is special efficacy.
Zineb (zineb), structural formula are zinc ethylenebisdithiocarbamate, molecular formula: C
4H
6N
2S
4Zn.
Zineb is to be the protectant that a kind of foliage spray is used, and many germs such as Pseudoperonospora cubensis, late disease bacteria and anthrax bacteria etc. are had strong action of contace poison.To plant safety, the active ingredient chemical property is more active, in water, easily be oxidized to different thiocyanation compound, to the cause of disease thalline contain-enzyme of SH base has had strong inhibitory effects, and the direct kill pathogens spore of energy, suppress the germination of spore, stop in the germ invaded plants body, but very little to the mycelial lethal effect of cause of disease in the invaded plants body.Therefore, use zineb to prevent and treat disease and should grasp in the disease beginning and see that the phase carries out, just can obtain effect preferably.The drug effect phase of zineb is short, decomposes comparatively fast about 7 days of its longevity of residure at solar radiation and after absorbing airborne moisture.
Because single agent such as long-term use zineb, thiophanate-methyl, carbendazim, plant disease is developed immunity to drugs and therapeutic purposes can not be reached, adopt composite bactericidal composition can obviously improve control and result of treatment, reduce the usage amount of agricultural chemicals, reduce cost, become the important means of the various diseases of integrated control.
According to repeatedly the test of pesticide effectiveness, prescription screening report draw, Flutriafol and zineb be composite to have good synergistic effects, obviously improved control efficiency, and dosage and medication number of times have been reduced, thereby having delayed the generation of disease drug resistance greatly, is the important means of integrated control powdery mildew, scab, spot defoliation.
Do not see the report of the bactericidal composition that relevant Flutriafol and zineb are composite up to now as yet.
Summary of the invention
Purpose of the present invention proposes a kind of have synergistic effect, use cost is low, preventive effect the is good bactericidal composition that contains Flutriafol and zineb.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Flutriafol and zineb, wherein Flutriafol and zineb percentage by weight are 1～15: 80～1.
The described bactericidal composition that contains Flutriafol and zineb, wherein the percentage by weight of Flutriafol and zineb is 1～10: 70～10.
The described bactericidal composition that contains Flutriafol and zineb, wherein the percentage by weight of Flutriafol and zineb is 1～5: 60～20.
The described bactericidal composition that contains Flutriafol and zineb can be made into wetting powder, water dispersible granules, suspending agent.
The described bactericidal composition effective active component content that contains Flutriafol and zineb is 2～80%.
The described bactericidal composition effective active component content that contains Flutriafol and zineb is 5～70%.
The described bactericidal composition effective active component content that contains Flutriafol and zineb is 10～50%.
When making wetting powder, composition comprises following constituent content: Flutriafol 1～15%, zineb 1～80%, dispersant 3～15%, wetting agent 2～12%, filler 10～83%.
Flutriafol, zineb, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into Flutriafol Zineb wettable powder product.
When making water dispersible granules, composition comprises following constituent content: Flutriafol 1～15%, zineb 1～80%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0～8%, filler 8～83%.
Flutriafol, zineb, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes Flutriafol water dispersion granules agent of dithane product.
When making suspending agent, composition comprises following constituent content: Flutriafol 1～10%, zineb 1～40%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0～2%, antifreeze 0～8%, deionized water surplus.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add Flutriafol, zineb, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes Flutriafol zineb suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, aluminium-magnesium silicate, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, scab, the spot defoliation of control cereal, vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition Flutriafol and zineb belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition within the specific limits the antagonism disease have good synergistic effect, preventive effect is higher than single agent, dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.By Toxicity Determination, the synergy ratio after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, carries out field trial more earlier.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% Flutriafol Zineb wettable powder
Flutriafol 13%, zineb 67%, sodium lignin sulfonate 5%, moistening bleeding agent F 4%, white carbon 11%, mixture carries out comminution by gas stream, makes 80% Flutriafol Zineb wettable powder.
Embodiment 2 60% Flutriafol Zineb wettable powders
Flutriafol 5%, zineb 55%, lignosulfonates 4%, tea are withered 4%, white carbon 8%, kaolin 24%, and mixture carries out comminution by gas stream, makes 60% Flutriafol Zineb wettable powder.
Embodiment 3 20% Flutriafol Zineb wettable powders
Flutriafol 2%, zineb 18%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F 3%, white carbon 10%, bentonite 52%, mixture carries out comminution by gas stream, makes 20% Flutriafol Zineb wettable powder.
Embodiment 4 75% Flutriafol water dispersion granules agent of dithane
Flutriafol 10%, zineb 65%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 13%, the mixed 75% Flutriafol water dispersion granules agent of dithane that gets.
Embodiment 5 65% Flutriafol water dispersion granules agent of dithane
Flutriafol 7%, zineb 58%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 22%, the mixed 65% Flutriafol water dispersion granules agent of dithane that gets.
Embodiment 6 55% Flutriafol water dispersion granules agent of dithane
Flutriafol 5%, zineb 50%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 6%, succinic acid 3%, citric acid 1%, starch 30%, the mixed 55% Flutriafol water dispersion granules agent of dithane that gets.
Embodiment 7 50% Flutriafol zineb suspending agents
Flutriafol 4%, zineb 46%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, the mixed 50% Flutriafol zineb suspending agent that gets.
Embodiment 8 35% Flutriafol zineb suspending agents
Flutriafol 3%, zineb 32%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed 35% Flutriafol zineb suspending agent that gets.
Embodiment 9 10% Flutriafol zineb suspending agents
Flutriafol 1%, zineb 9%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, the mixed 10% Flutriafol zineb suspending agent that gets.
Implementation of an application example two Flutriafols and zineb are mixed to the wheat powdery mildew Toxicity Determination
This experimental establishment is in plant protection institute of Shandong Agricultural University; wheat breed is for raising wheat 158, is 8 centimetres cuvette with diameter, 10 in the seed of the full stalwartness of every glass of sowing vernalization; standby when waiting to grow to 3 leaves, the wheat powdery mildew germ is picked up from Shandong Agricultural University wheat cultivation greenhouse.Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is provided with 5 dose concentrations respectively to be handled, if there is not the medicine contrast, each concentration is handled and is repeated 4 times, carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", in culturing room, evenly shake off to receive on the cultured 3 leaf phase wheat seedlings with the fresh spore of white powder germ on the wheat seedling of inoculation in advance and fully morbidity.When treating that wheat has slightly been fallen ill, handle with the medicine liquid spray of above-mentioned concentration.Every processing repeats 4 times, 2 glasss of every repetitions, 4 every glass, put into 20 ℃, 16L:8D cultivates in the illumination box of 60% relative moisture, the incidence of routine observation inoculation blade and newborn blade, after treating that control treatment was fully fallen ill about 8-10 days, begin to put down in writing an incidence of handling, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Computing formula is as follows:
Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.
Wherein: a, b are respectively Flutriafol and zineb shared ratio in combination
A is a Flutriafol;
B is a zineb;
Result of the test is as shown in the table:
Table 1 Flutriafol, zineb and composite to the wheat powdery mildew toxicity test
As shown in Table 1, Flutriafol and zineb are composite to the wheat powdery mildew toxicity test, the Flutriafol virulence is higher than the zineb virulence, its proportioning is that 1: 2,1: 5,1: 8,1: 11,1: 14 o'clock synergy ratio is respectively 1.40,1.94,2.28,1.85,1.55, wherein proportioning is all to show as synergistic effect in 1: 5,1: 8,1: 11,1: 14, so Flutriafol and zineb had synergistic effect at 1: 5 to 1: 14 in the scope.
Implementation of an application example three Flutriafols, zineb and composite control wheat powdery mildew field efficacy thereof
This experimental establishment is at the Shaanxi Changan District, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 2 times, observes disease index behind the last medicine after 10 days, 20 days and calculates preventive effect.Result of the test is as follows:
Table 2 Flutriafol, zineb and the composite control wheat powdery mildew test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 10 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 80% Flutriafol Zineb wettable powder | 30 gram/mus | 80.29 | 91.00 |
| 55% Flutriafol water dispersion granules agent of dithane | 50 gram/mus | 81.62 | 90.72 |
| 35% Flutriafol zineb suspending agent | 80 gram/mus | 83.44 | 92.36 |
| 12.5% Flutriafol suspending agent | 50 gram/mus | 77.29 | 83.36 |
| 65% Zineb wettable powder | 120 gram/mus | 60.39 | 65.02 |
Result of the test shows, the complex composition of Flutriafol and zineb is compared with two single agent and to be had following advantage: (1) has significantly improved the control efficiency to wheat powdery mildew; (2) have concurrently quick-actingly and long-acting, bactericidal effect is significantly higher than each single agent after the dispenser.
Implementation of an application example four Flutriafols, zineb and the composite pear scab field trial of preventing and treating thereof
This experimental establishment is closed the town at the county town, Pucheng, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 4 times, checks disease index and calculates preventive effect in 7 days, 14 days, 30 days behind the last medicine.Result of the test is as follows:
Table 3 Flutriafol, zineb and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 60% Flutriafol Zineb wettable powder | 3000 times | 80.32 | 87.16 | 90.22 |
| 75% Flutriafol water dispersion granules agent of dithane | 4000 times | 79.22 | 88.36 | 89.14 |
| 10% Flutriafol zineb suspending agent | 500 times | 84.07 | 89.77 | 93.00 |
| 12.5% Flutriafol suspending agent | 3500 times | 67.35 | 74.06 | 76.47 |
| 65% Zineb wettable powder | 500 times | 52.44 | 69.45 | 60.04 |
Result of the test shows, the composite back of Flutriafol and zineb has obvious synergistic effect to the control of pear scab, have quick-acting and long-acting, crop safety in this experimental drug scope.Implementation of an application example five Flutriafols, zineb and the test of composite control alternaria leaf spot of apple thereof
This experimental establishment is at Shaanxi Province's Luochuan County, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., begins dispenser in the alternaria leaf spot of apple their early stage, and dispenser in per seven days once, dispenser is 5 times altogether, checks disease index and calculates preventive effect in 7 days, 14 days, 30 days behind the last medicine.Result of the test is as follows:
Table 4 Flutriafol, zineb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 20% Flutriafol Zineb wettable powder | 800 times | 79.36 | 88.77 | 94.37 |
| 65% Flutriafol water dispersion granules agent of dithane | 3000 times | 82.04 | 89.62 | 95.18 |
| 50% Flutriafol zineb suspending agent | 2000 times | 84.66 | 90.40 | 93.45 |
| 12.5% Flutriafol suspending agent | 3000 times | 67.45 | 80.02 | 80.17 |
| 65% Zineb wettable powder | 500 times | 52.66 | 60.54 | 58.43 |
Result of the test shows, the composite back of Flutriafol and zineb has obvious synergistic effect to the control of alternaria leaf spot of apple, have quick-acting and long-acting, crop safety in this experimental drug scope, and to apple mildew after 14 days preventive effect reach more than 80%.
Claims (8)
1, a kind of bactericidal composition that contains Flutriafol, its effective active composition contains Flutriafol and zineb, and wherein the percentage by weight of Flutriafol and zineb is 1～15: 80～1.
2, the bactericidal composition that contains Flutriafol and zineb according to claim 1 is characterized in that: the percentage by weight of Flutriafol and zineb is 1～10: 70～10.
3, the bactericidal composition that contains Flutriafol and zineb according to claim 2 is characterized in that: the percentage by weight of Flutriafol and zineb is 1～5: 60～20.
4, can be made into wetting powder, water dispersible granules, suspending agent according to the described bactericidal composition that contains Flutriafol and zineb of claim 1 to 3.
5, the bactericidal composition effective active component content that contains Flutriafol and zineb according to claim 1 is 2～80%.
6, the bactericidal composition effective active component content that contains Flutriafol and zineb according to claim 5 is 5～70%.
7, the bactericidal composition effective active component content that contains Flutriafol and zineb according to claim 6 is 10～50%.
8, the bactericidal composition that contains Flutriafol and zineb according to claim 1 is mainly used in powdery mildew, scab, the spot defoliation of control cereal, vegetables and fruit tree.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910023376 CN101601397B (en) | 2009-07-20 | 2009-07-20 | Sterilization composite containing flutriafol and zineb |
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|---|---|---|---|
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| CN101601397B CN101601397B (en) | 2013-01-02 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102084865A (en) * | 2011-03-25 | 2011-06-08 | 陕西先农生物科技有限公司 | Bactericidal composition containing flutriafol and propineb |
| EP3986133A4 (en) * | 2019-06-24 | 2023-06-28 | UPL Limited | Synergistic fungicide composition |
-
2009
- 2009-07-20 CN CN 200910023376 patent/CN101601397B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102084865A (en) * | 2011-03-25 | 2011-06-08 | 陕西先农生物科技有限公司 | Bactericidal composition containing flutriafol and propineb |
| CN102084865B (en) * | 2011-03-25 | 2013-10-30 | 陕西先农生物科技有限公司 | Bactericidal composition containing flutriafol and propineb |
| EP3986133A4 (en) * | 2019-06-24 | 2023-06-28 | UPL Limited | Synergistic fungicide composition |
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