CN101595878A - A kind of bactericidal composition that contains Flutriafol and cyprodinil - Google Patents
A kind of bactericidal composition that contains Flutriafol and cyprodinil Download PDFInfo
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- CN101595878A CN101595878A CNA2009100233104A CN200910023310A CN101595878A CN 101595878 A CN101595878 A CN 101595878A CN A2009100233104 A CNA2009100233104 A CN A2009100233104A CN 200910023310 A CN200910023310 A CN 200910023310A CN 101595878 A CN101595878 A CN 101595878A
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- cyprodinil
- flutriafol
- bactericidal composition
- powdery mildew
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Abstract
The invention discloses a kind of bactericidal composition, its effective active composition contains Flutriafol and cyprodinil, wherein the percentage by weight of Flutriafol and cyprodinil is 1～15: 80～1, the effective active composition adds auxiliary agent and excipients is made wetting powder, water dispersible granules, suspending agent, is mainly used in powdery mildew, scab, the spot defoliation of control vegetables and fruit tree.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on the vegetables fruit diseases that contains Flutriafol and cyprodinil.
Technical background
Flutriafol (flutriafol) is the triazole bactericidal agent that American Cyanamid Company produces.Molecular formula: C16H13F2N30, chemical name: α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol.
Flutriafol belongs to triazole bactericidal agent, has interior absorption, conducts in plant corpus, and disease is had protection and therapeutic action.Can prevent and treat the cereal crop powdery mildew, Helminthosporium, Puccinia, shell pin Pseudomonas pathogen also can be cooked seed treatment, prevents and treats soil-borne disease and seed-borne disease.The cereal powdery mildew there is special efficacy.
Cyprodinil (cyprodinil), structural formula are 4-cyclopropyl-6-methyl-N-phenyl pyrimidine-2-amine, molecular formula: C
14H
15N
3
Cyprodinil is by the miazines bactericide of Syngenta Co.,Ltd exploitation, has protection, treatment, blade penetrates and the root systemic activity.Suppress the biosynthesis of secretion of fungi hydrolase and methionine.No cross resistances such as same triazole type, imidazoles, morpholine class, dicarboximide class, phenylpyrrole class.Be mainly used in and prevent and treat gray mold, powdery mildew, scab, net blotch and wheat eyeprint disease etc.
On the one hand, the use of organic solvent on agricultural chemicals is restricted day by day, and need not or lack with organic solvent has been the inexorable trend of agricultural chemicals development as far as possible.The formulation of agricultural chemicals needs constantly to upgrade, thereby impels agricultural chemicals to develop along the good direction of efficient, low toxicity, safety and Environmental compatibility.The present composition does not contain organic solvent, is difficult for producing poisoning, to crop safety, can effectively overcome existing problem.On the other hand, the single agent of long-term use makes plant disease develop immunity to drugs easily and can not reach therapeutic purposes, adopts composite bactericidal composition can obviously improve control and result of treatment, has reduced the usage amount of agricultural chemicals, reduce cost, become the important means of the various diseases of integrated control.
According to repeatedly the test of pesticide effectiveness, prescription screening report draw, Flutriafol and cyprodinil be composite to have good synergistic effects, obviously improved control efficiency, and dosage and medication number of times have been reduced, thereby having delayed the generation of disease drug resistance greatly, is the important means of integrated control powdery mildew, scab, spot defoliation.
Do not see the report of the bactericidal composition that relevant Flutriafol and cyprodinil are composite up to now as yet.
Summary of the invention
Purpose of the present invention proposes a kind of have synergistic effect, use cost is low, preventive effect the is good bactericidal composition that contains Flutriafol and cyprodinil.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Flutriafol and cyprodinil, wherein Flutriafol and cyprodinil percentage by weight are 1～15: 80～1.
The described bactericidal composition that contains Flutriafol and cyprodinil, wherein the percentage by weight of Flutriafol and cyprodinil is 1～10: 70～10.
The described bactericidal composition that contains Flutriafol and cyprodinil, wherein the percentage by weight of Flutriafol and cyprodinil is 1～5: 60～20.
The described bactericidal composition that contains Flutriafol and cyprodinil can be made into wetting powder, water dispersible granules, suspending agent.
When making wetting powder, composition comprises following constituent content: Flutriafol 1～15%, cyprodinil 1～80%, dispersant 3～15%, wetting agent 2～12%, filler 8～84%.
Flutriafol, cyprodinil, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into Flutriafol cyprodinil wetting powder product.
When making water dispersible granules, composition comprises following constituent content: Flutriafol 1～15%, cyprodinil 1～80%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0～8%, filler 8～84%.
Flutriafol, cyprodinil, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes Flutriafol cyprodinil water dispersible granules product.
When making suspending agent, composition comprises following constituent content: Flutriafol 1～10%, cyprodinil 1～40%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0～2%, antifreeze 0～8%, deionized water surplus.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add Flutriafol, cyprodinil, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes Flutriafol cyprodinil suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, the silicone compound.
Described thickener is selected from: one or more in xanthan gum, aluminium-magnesium silicate, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, scab, the spot defoliation of control vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition Flutriafol and cyprodinil belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition within the specific limits the antagonism disease have good synergistic effect, preventive effect is higher than single agent, dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, scab, spot defoliation.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.By Toxicity Determination, the synergy ratio after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, carries out field trial more earlier.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% Flutriafol cyprodinil wetting powder
Flutriafol 15%, cyprodinil 65%, polycarboxylate 3%, sodium lignin sulfonate 2%, lauryl sodium sulfate 3%, Nekal BX 2%, white carbon 10%, mixture carries out comminution by gas stream, makes 80% Flutriafol cyprodinil wetting powder.
Embodiment 2 60% Flutriafol cyprodinil wetting powders
Flutriafol 8%, cyprodinil 52%, alkyl benzene sulfonate calcium salt 5%, neopelex 3%, white carbon 8%, kaolin 24%, mixture carries out comminution by gas stream, makes 60% Flutriafol cyprodinil wetting powder.
Embodiment 3 20% Flutriafol cyprodinil wetting powders
Flutriafol 2%, cyprodinil 18%, polyoxyethylene carboxylate 3%, silkworm excrement 3%, white carbon 8%, bentonite 66%, mixture carries out comminution by gas stream, makes 20% Flutriafol cyprodinil wetting powder.
Embodiment 4 70% Flutriafol cyprodinil water dispersible granules
Flutriafol 10%, cyprodinil 60%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, urea 2%, starch 18%, the mixed 70% Flutriafol cyprodinil water dispersible granules that gets.
Embodiment 5 50% Flutriafol cyprodinil water dispersible granules
Flutriafol 6%, cyprodinil 44%, fatty acid glyceride polyoxyethylene are phonetic 3%, lauryl sodium sulfate 3%, soapberry powder 2%, sodium bicarbonate 3%, starch 39%, mixed 50% Flutriafol cyprodinil water dispersible granules.
Embodiment 6 30% Flutriafol cyprodinil water dispersible granules
Flutriafol 3%, cyprodinil 27%, polycarboxylate 3%, Nekal BX 5%, succinic acid 3%, citric acid 1%, starch 58%, the mixed 30% Flutriafol cyprodinil water dispersible granules that gets.
Embodiment 7 45% Flutriafol cyprodinil suspending agents
Flutriafol 5%, cyprodinil 40%, polycarboxylate 4%, sodium lignin sulfonate 2%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, the mixed 45% Flutriafol cyprodinil suspending agent that gets.
Embodiment 8 35% Flutriafol cyprodinil suspending agents
Flutriafol 4%, cyprodinil 31%, aliphatic amine polyoxyethylene are phonetic 4%, spaonin powder 4%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mixed 35% Flutriafol cyprodinil suspending agent.
Embodiment 9 10% Flutriafol cyprodinil suspending agents
Flutriafol 1%, cyprodinil 9%, alkylphenol-polyethenoxy are phonetic 2%, lauryl sodium sulfate 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mixed 10% Flutriafol cyprodinil suspending agent.
Implementation of an application example two Flutriafols and cyprodinil are mixed to the grape powdery mildew Toxicity Determination
This experimental establishment is in plant protection institute of Shandong Agricultural University, and the grape powdery mildew germ is picked up from Shandong Agricultural University's germ cultivating chamber.Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is provided with 5 dose concentrations respectively to be handled, if there is not the medicine contrast, each concentration is handled and is repeated 4 times, carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", the incidence of routine observation inoculation blade and newborn blade, after treating that control treatment was fully fallen ill about 8-10 days, begin to put down in writing an incidence of handling, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Computing formula is as follows:
Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.
Wherein: a, b are respectively Flutriafol and cyprodinil shared ratio in combination
A is a Flutriafol;
B is a cyprodinil;
Experimental result is as follows:
Table 1 Flutriafol, cyprodinil and composite to the grape powdery mildew toxicity test
As shown in Table 1, Flutriafol and cyprodinil are composite to the grape powdery mildew toxicity test, the Flutriafol virulence is lower than the cyprodinil virulence, its proportioning is that 1: 1,1: 4,1: 7,1: 11,1: 14 o'clock synergy ratio is respectively 1.33,1.80,2.13,2.06,1.34, wherein proportioning is all to show as synergistic effect in 1: 4,1: 7,1: 11,1: 14, so Flutriafol and cyprodinil had synergistic effect at 1: 4 to 1: 11 in the scope.
Implementation of an application example three Flutriafols, cyprodinil and composite control wheat powdery mildew field efficacy thereof
This experimental establishment is in Han Jing town, Pucheng County, Shaanxi Province, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and the contrast medicament is commercial.Begin dispenser in the wheat powdery mildew initial stage of origination, dispenser in per seven days once is total to dispenser 2 times, and the last dispenser was observed disease index in 10 days, 20 days and also calculated preventive effect.Result of the test is as follows:
Table 2 Flutriafol, cyprodinil and the composite control wheat powdery mildew test of pesticide effectiveness thereof
Result of the test shows, after Flutriafol and cyprodinil are composite, can effectively prevent and treat wheat powdery mildew, compare with single agent have the preventive effect height, medication is few, the lasting period is long advantage, in the test scope of medication, crop is had no adverse effects.
Implementation of an application example four Flutriafols, cyprodinil and composite control banana freckle field trial thereof
This experimental establishment is in the Guangxi province Nanning suburban district, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and the contrast medicament is commercial.Begin dispenser in the banana freckle initial stage of origination, dispenser in per seven days once is total to dispenser 5 times.Checked the state of an illness and calculated preventive effect that result of the test is as follows after the last dispenser in 7 days, 14 days, 30 days:
Table 3 Flutriafol, cyprodinil and the composite control banana freckle test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 80% Flutriafol cyprodinil wetting powder | 6000 times | 82.71 | 93.90 | 89.18 |
| 50% Flutriafol cyprodinil water dispersible granules | 3000 times | 85.85 | 92.24 | 90.36 |
| 35% Flutriafol cyprodinil suspending agent | 2500 times | 84.30 | 92.61 | 89.56 |
| 12.5% Flutriafol suspending agent | 3500 times | 70.27 | 85.22 | 86.31 |
| 50% cyprodinil water dispersible granules | 1000 times | 63.49 | 79.39 | 67.55 |
| CK (blank) | - | - | - | - |
Result of the test shows, the composite back of Flutriafol and cyprodinil has obvious synergistic effect to banana freckle, have quick-acting and long-acting, crop safety in this experimental drug scope, the present composition also has certain preventive effect to sigatoka.
Implementation of an application example four Flutriafols, cyprodinil and composite control alternaria leaf spot of apple field trial thereof
This experimental establishment is at Shaanxi Province's Luochuan County, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and the contrast medicament is all commercial.Begin dispenser in the alternaria leaf spot of apple their early stage, dispenser in per seven days once is total to dispenser 6 times.Checked the state of an illness respectively in 7 days, 20 days, 50 days after the last dispenser and calculate preventive effect, result of the test is as follows:
Table 4 Flutriafol, cyprodinil and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine | 50 days preventive effects (%) behind the last medicine |
| 20% Flutriafol cyprodinil wetting powder | 1000 times | 78.62 | 93.66 | 89.77 |
| 70% Flutriafol cyprodinil water dispersible granules | 4000 times | 80.29 | 92.75 | 88.69 |
| 45% Flutriafol cyprodinil suspending agent | 2500 times | 81.36 | 91.42 | 90.18 |
| 12.5% Flutriafol suspending agent | 3500 times | 65.42 | 78.46 | 65.42 |
| 50% cyprodinil water dispersible granules | 1000 times | 60.27 | 80.17 | 63.05 |
Result of the test shows, the composite back of Flutriafol and cyprodinil has obvious synergistic effect to alternaria leaf spot of apple, have quick-acting and long-acting, crop safety in this experimental drug scope, and 20 days preventive effects behind apple mildew, the scab last medicine are reached more than 85%.
Claims (5)
1, a kind of bactericidal composition that contains Flutriafol, its effective active composition contains Flutriafol and cyprodinil, and wherein the percentage by weight of Flutriafol and cyprodinil is 1～15: 80～1.
2, the bactericidal composition that contains Flutriafol and cyprodinil according to claim 1 is characterized in that: the percentage by weight of Flutriafol and cyprodinil is 1～10: 70～10.
3, the bactericidal composition that contains Flutriafol and cyprodinil according to claim 1 is characterized in that: the percentage by weight of Flutriafol and cyprodinil is 1～5: 60～20.
4, the bactericidal composition that contains Flutriafol and cyprodinil according to claim 1 can be made into wetting powder, water dispersible granules, suspending agent.
5, the bactericidal composition that contains Flutriafol and cyprodinil according to claim 1 is mainly used in powdery mildew, scab, the spot defoliation of control vegetables and fruit tree.
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| Application Number | Priority Date | Filing Date | Title |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101971851A (en) * | 2010-11-30 | 2011-02-16 | 陕西美邦农药有限公司 | Sterilizing composition containing cyprodinil and iprodione |
| CN103563960A (en) * | 2012-08-10 | 2014-02-12 | 陕西美邦农药有限公司 | Fungicidal composition |
-
2009
- 2009-07-13 CN CNA2009100233104A patent/CN101595878A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101971851A (en) * | 2010-11-30 | 2011-02-16 | 陕西美邦农药有限公司 | Sterilizing composition containing cyprodinil and iprodione |
| CN101971851B (en) * | 2010-11-30 | 2013-07-24 | 陕西美邦农药有限公司 | Sterilizing composition containing cyprodinil and iprodione |
| CN103563960A (en) * | 2012-08-10 | 2014-02-12 | 陕西美邦农药有限公司 | Fungicidal composition |
| CN103563960B (en) * | 2012-08-10 | 2015-10-28 | 陕西美邦农药有限公司 | A kind of bactericidal composition |
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Application publication date: 20091209 |